PubMed:1712226 JSONTXT

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{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"S2","span":{"begin":106,"end":228},"obj":"Sentence"},{"id":"S3","span":{"begin":229,"end":304},"obj":"Sentence"},{"id":"S4","span":{"begin":305,"end":453},"obj":"Sentence"},{"id":"S5","span":{"begin":454,"end":546},"obj":"Sentence"},{"id":"S6","span":{"begin":547,"end":687},"obj":"Sentence"},{"id":"S7","span":{"begin":688,"end":887},"obj":"Sentence"},{"id":"S8","span":{"begin":888,"end":1039},"obj":"Sentence"},{"id":"S9","span":{"begin":1040,"end":1196},"obj":"Sentence"},{"id":"S10","span":{"begin":1197,"end":1273},"obj":"Sentence"},{"id":"S11","span":{"begin":1274,"end":1395},"obj":"Sentence"},{"id":"S12","span":{"begin":1396,"end":1684},"obj":"Sentence"}],"text":"Regulation of jun and fos gene expression in human monocytes by the macrophage colony-stimulating factor.\nThe macrophage colony-stimulating factor (M-CSF) is required for the growth and differentiation of mononuclear phagocytes. However, the signaling events responsible for these effects remain unclear. The present studies have examined the effects of M-CSF on potential signaling pathways involving expression of the jun and fos early response genes. Low levels of c-jun transcripts were detectable in resting human peripheral blood monocytes. Treatment of these cells with 10(3) units/ml human recombinant M-CSF was associated with rapid and transient increases in c-jun mRNA levels. Nuclear run-on assays and mRNA stability studies demonstrated that M-CSF regulates c-jun expression by both an increase in transcription rate and a prolongation in the half-life of c-jun transcripts. M-CSF treatment was also associated with a rapid induction of the jun-B gene, although expression of this gene was prolonged compared to that of c-jun. We further demonstrate that M-CSF increases c-fos mRNA levels in human monocytes through control at both the transcriptional and posttranscriptional levels. Maximal induction of the c-fos gene was followed by that for the fos-B gene. Moreover, M-CSF-induced expression of the fos-related gene, fra-1, was delayed compared to that for both c-fos and fos-B. Taken together, the results indicate that M-CSF treatment is associated with differential activation of multiple members of the jun/fos family and that expression of these genes could contribute to nuclear signaling mechanisms that regulate a specific program of monocyte differentiation."}

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