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PubMed:1712226 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 45-60 cell_type denotes human monocytes
T2 68-104 protein denotes macrophage colony-stimulating factor
T3 110-146 protein denotes macrophage colony-stimulating factor
T4 148-153 protein denotes M-CSF
T5 205-227 cell_type denotes mononuclear phagocytes
T6 354-359 protein denotes M-CSF
T7 420-452 DNA denotes jun and fos early response genes
T8 468-485 protein denotes c-jun transcripts
T9 505-545 cell_type denotes resting human peripheral blood monocytes
T10 592-615 protein denotes human recombinant M-CSF
T11 669-679 RNA denotes c-jun mRNA
T12 755-760 protein denotes M-CSF
T13 771-776 DNA denotes c-jun
T14 869-886 RNA denotes c-jun transcripts
T15 888-893 protein denotes M-CSF
T16 954-964 DNA denotes jun-B gene
T17 1033-1038 DNA denotes c-jun
T18 1068-1073 protein denotes M-CSF
T19 1084-1094 RNA denotes c-fos mRNA
T20 1105-1120 cell_type denotes human monocytes
T21 1222-1232 DNA denotes c-fos gene
T22 1262-1272 DNA denotes fos-B gene
T23 1284-1289 protein denotes M-CSF
T24 1316-1332 DNA denotes fos-related gene
T25 1334-1339 DNA denotes fra-1
T26 1379-1384 DNA denotes c-fos
T27 1389-1394 DNA denotes fos-B
T28 1438-1443 protein denotes M-CSF
T29 1524-1538 DNA denotes jun/fos family

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-105 Sentence denotes Regulation of jun and fos gene expression in human monocytes by the macrophage colony-stimulating factor.
S2 106-228 Sentence denotes The macrophage colony-stimulating factor (M-CSF) is required for the growth and differentiation of mononuclear phagocytes.
S3 229-304 Sentence denotes However, the signaling events responsible for these effects remain unclear.
S4 305-453 Sentence denotes The present studies have examined the effects of M-CSF on potential signaling pathways involving expression of the jun and fos early response genes.
S5 454-546 Sentence denotes Low levels of c-jun transcripts were detectable in resting human peripheral blood monocytes.
S6 547-687 Sentence denotes Treatment of these cells with 10(3) units/ml human recombinant M-CSF was associated with rapid and transient increases in c-jun mRNA levels.
S7 688-887 Sentence denotes Nuclear run-on assays and mRNA stability studies demonstrated that M-CSF regulates c-jun expression by both an increase in transcription rate and a prolongation in the half-life of c-jun transcripts.
S8 888-1039 Sentence denotes M-CSF treatment was also associated with a rapid induction of the jun-B gene, although expression of this gene was prolonged compared to that of c-jun.
S9 1040-1196 Sentence denotes We further demonstrate that M-CSF increases c-fos mRNA levels in human monocytes through control at both the transcriptional and posttranscriptional levels.
S10 1197-1273 Sentence denotes Maximal induction of the c-fos gene was followed by that for the fos-B gene.
S11 1274-1395 Sentence denotes Moreover, M-CSF-induced expression of the fos-related gene, fra-1, was delayed compared to that for both c-fos and fos-B.
S12 1396-1684 Sentence denotes Taken together, the results indicate that M-CSF treatment is associated with differential activation of multiple members of the jun/fos family and that expression of these genes could contribute to nuclear signaling mechanisms that regulate a specific program of monocyte differentiation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-41 NP denotes jun and fos gene expression
C2 64-104 NP denotes the macrophage colony-stimulating factor
C3 106-154 NP denotes The macrophage colony-stimulating factor (M-CSF)
C4 354-359 NP denotes M-CSF
C5 416-452 NP denotes the jun and fos early response genes
C6 468-485 NP denotes c-jun transcripts
C7 560-571 NP denotes these cells
C8 592-615 NP denotes human recombinant M-CSF
C9 669-686 NP denotes c-jun mRNA levels
C10 755-760 NP denotes M-CSF
C11 771-787 NP denotes c-jun expression
C12 869-886 NP denotes c-jun transcripts
C14 888-893 NP denotes M-CSF
C13 888-903 NP denotes M-CSF treatment
C15 950-964 NP denotes the jun-B gene
C16 989-998 NP denotes this gene
C17 1033-1038 NP denotes c-jun
C18 1068-1073 NP denotes M-CSF
C19 1197-1214 NP denotes Maximal induction
C20 1218-1232 NP denotes the c-fos gene
C21 1249-1253 NP denotes that
C22 1258-1272 NP denotes the fos-B gene
C23 1284-1332 NP denotes M-CSF-induced expression of the fos-related gene
C24 1334-1339 NP denotes fra-1
C25 1365-1369 NP denotes that
C26 1379-1384 NP denotes c-fos
C27 1389-1394 NP denotes fos-B
C29 1438-1443 NP denotes M-CSF
C28 1438-1453 NP denotes M-CSF treatment
C30 1524-1538 NP denotes jun/fos family
C31 1562-1573 NP denotes these genes
C32 1594-1622 NP denotes nuclear signaling mechanisms
C33 1623-1627 NP denotes that
R1 C3 C2 coref-ident The macrophage colony-stimulating factor (M-CSF),the macrophage colony-stimulating factor
R2 C4 C3 coref-ident M-CSF,The macrophage colony-stimulating factor (M-CSF)
R3 C5 C1 coref-other the jun and fos early response genes,jun and fos gene expression
R4 C7 C6 coref-ident these cells,c-jun transcripts
R5 C8 C4 coref-other human recombinant M-CSF,M-CSF
R6 C9 C6 coref-other c-jun mRNA levels,c-jun transcripts
R7 C10 C4 coref-ident M-CSF,M-CSF
R8 C11 C6 coref-other c-jun expression,c-jun transcripts
R9 C12 C6 coref-ident c-jun transcripts,c-jun transcripts
R10 C14 C10 coref-ident M-CSF,M-CSF
R11 C16 C15 coref-ident this gene,the jun-B gene
R12 C17 C12 coref-other c-jun,c-jun transcripts
R13 C18 C14 coref-ident M-CSF,M-CSF
R14 C21 C19 coref-pron that,Maximal induction
R15 C23 C24 coref-appos M-CSF-induced expression of the fos-related gene,fra-1
R16 C25 C23 coref-pron that,M-CSF-induced expression of the fos-related gene
R17 C26 C20 coref-ident c-fos,the c-fos gene
R18 C27 C22 coref-ident fos-B,the fos-B gene
R19 C29 C18 coref-ident M-CSF,M-CSF
R20 C28 C13 coref-ident M-CSF treatment,M-CSF treatment
R21 C31 C30 coref-ident these genes,jun/fos family
R22 C33 C32 coref-relat that,nuclear signaling mechanisms

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 45-60 cell_type denotes human monocytes
T2 68-104 protein_molecule denotes macrophage colony-stimulating factor
T3 110-146 protein_molecule denotes macrophage colony-stimulating factor
T4 148-153 protein_molecule denotes M-CSF
T5 175-181 other_name denotes growth
T6 186-201 other_name denotes differentiation
T7 205-227 cell_type denotes mononuclear phagocytes
T8 354-359 protein_molecule denotes M-CSF
T9 373-391 other_name denotes signaling pathways
T10 468-485 protein_molecule denotes c-jun transcripts
T11 505-545 cell_type denotes resting human peripheral blood monocytes
T12 592-609 protein_molecule denotes human recombinant
T13 610-615 protein_molecule denotes M-CSF
T14 669-679 RNA_molecule denotes c-jun mRNA
T15 688-709 other_name denotes Nuclear run-on assays
T16 714-736 other_name denotes mRNA stability studies
T17 755-760 protein_molecule denotes M-CSF
T18 771-776 DNA_domain_or_region denotes c-jun
T19 869-886 RNA_family_or_group denotes c-jun transcripts
T20 888-893 protein_molecule denotes M-CSF
T21 954-964 DNA_domain_or_region denotes jun-B gene
T22 1033-1038 DNA_domain_or_region denotes c-jun
T23 1068-1073 protein_molecule denotes M-CSF
T24 1084-1094 RNA_molecule denotes c-fos mRNA
T25 1105-1120 cell_type denotes human monocytes
T26 1222-1232 DNA_domain_or_region denotes c-fos gene
T27 1262-1272 DNA_domain_or_region denotes fos-B gene
T28 1284-1289 protein_molecule denotes M-CSF
T29 1316-1332 DNA_domain_or_region denotes fos-related gene
T30 1334-1339 DNA_domain_or_region denotes fra-1
T31 1379-1384 DNA_domain_or_region denotes c-fos
T32 1389-1394 DNA_domain_or_region denotes fos-B
T33 1438-1443 protein_molecule denotes M-CSF
T34 1524-1538 DNA_family_or_group denotes jun/fos family
T35 1594-1622 other_name denotes nuclear signaling mechanisms
T36 1659-1667 other_name denotes monocyte
T37 1668-1683 other_name denotes differentiation