PubMed:1707027 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":19,"end":53},"obj":"cell_type"},{"id":"T2","span":{"begin":57,"end":68},"obj":"protein"},{"id":"T3","span":{"begin":95,"end":119},"obj":"DNA"},{"id":"T4","span":{"begin":130,"end":168},"obj":"protein"},{"id":"T5","span":{"begin":180,"end":185},"obj":"protein"},{"id":"T6","span":{"begin":255,"end":274},"obj":"cell_type"},{"id":"T7","span":{"begin":282,"end":307},"obj":"protein"},{"id":"T8","span":{"begin":318,"end":323},"obj":"protein"},{"id":"T9","span":{"begin":348,"end":382},"obj":"cell_type"},{"id":"T10","span":{"begin":530,"end":535},"obj":"protein"},{"id":"T11","span":{"begin":635,"end":655},"obj":"protein"},{"id":"T12","span":{"begin":663,"end":676},"obj":"protein"},{"id":"T13","span":{"begin":683,"end":696},"obj":"cell_line"},{"id":"T14","span":{"begin":712,"end":726},"obj":"protein"},{"id":"T15","span":{"begin":742,"end":764},"obj":"protein"},{"id":"T16","span":{"begin":768,"end":773},"obj":"protein"},{"id":"T17","span":{"begin":818,"end":856},"obj":"cell_line"},{"id":"T18","span":{"begin":898,"end":903},"obj":"protein"}],"text":"Immune response of peripheral blood mononuclear cells to HBx-antigen of hepatitis B virus.\nThe hepatitis B virus genome encodes a transcriptional transactivator protein designated HBxAg. We have investigated whether this antigen is a target structure for human T-lymphocytes. Using recombinant HBxAg protein, we found HBxAg-specific stimulation of peripheral blood mononuclear cells in patients with acute hepatitis B virus infection (6 of 6) and chronic hepatitis B virus infection (6 of 17) but not in healthy individuals. With HBxAg-specific synthetic polypeptides, several T-cell epitopes were identified. Most were located in the carboxyterminal half of the HBxAg protein. Five T-cell clones specific for a T-cell epitope located at the carboxyterminal region of HBxAg were established and found to belong to the CD2/CD4-positive, CD8-negative subtype. These data establish for the first time HBxAg as an antigen in the cellular immune response."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":90},"obj":"Sentence"},{"id":"S2","span":{"begin":91,"end":186},"obj":"Sentence"},{"id":"S3","span":{"begin":187,"end":275},"obj":"Sentence"},{"id":"S4","span":{"begin":276,"end":524},"obj":"Sentence"},{"id":"S5","span":{"begin":525,"end":609},"obj":"Sentence"},{"id":"S6","span":{"begin":610,"end":677},"obj":"Sentence"},{"id":"S7","span":{"begin":678,"end":857},"obj":"Sentence"},{"id":"S8","span":{"begin":858,"end":950},"obj":"Sentence"}],"text":"Immune response of peripheral blood mononuclear cells to HBx-antigen of hepatitis B virus.\nThe hepatitis B virus genome encodes a transcriptional transactivator protein designated HBxAg. We have investigated whether this antigen is a target structure for human T-lymphocytes. Using recombinant HBxAg protein, we found HBxAg-specific stimulation of peripheral blood mononuclear cells in patients with acute hepatitis B virus infection (6 of 6) and chronic hepatitis B virus infection (6 of 17) but not in healthy individuals. With HBxAg-specific synthetic polypeptides, several T-cell epitopes were identified. Most were located in the carboxyterminal half of the HBxAg protein. Five T-cell clones specific for a T-cell epitope located at the carboxyterminal region of HBxAg were established and found to belong to the CD2/CD4-positive, CD8-negative subtype. These data establish for the first time HBxAg as an antigen in the cellular immune response."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":19,"end":53},"obj":"NP"},{"id":"C3","span":{"begin":72,"end":89},"obj":"NP"},{"id":"C2","span":{"begin":57,"end":89},"obj":"NP"},{"id":"C4","span":{"begin":91,"end":112},"obj":"NP"},{"id":"C5","span":{"begin":128,"end":168},"obj":"NP"},{"id":"C6","span":{"begin":180,"end":185},"obj":"NP"},{"id":"C7","span":{"begin":216,"end":228},"obj":"NP"},{"id":"C8","span":{"begin":282,"end":307},"obj":"NP"},{"id":"C9","span":{"begin":348,"end":382},"obj":"NP"},{"id":"C10","span":{"begin":406,"end":423},"obj":"NP"},{"id":"C11","span":{"begin":455,"end":472},"obj":"NP"},{"id":"C12","span":{"begin":659,"end":676},"obj":"NP"},{"id":"C13","span":{"begin":768,"end":773},"obj":"NP"},{"id":"C14","span":{"begin":898,"end":903},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C3"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C6"},{"id":"R3","pred":"coref-other","subj":"C6","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C9","obj":"C1"},{"id":"R6","pred":"coref-ident","subj":"C10","obj":"C4"},{"id":"R7","pred":"coref-ident","subj":"C11","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C12","obj":"C8"},{"id":"R9","pred":"coref-ident","subj":"C13","obj":"C6"},{"id":"R10","pred":"coref-ident","subj":"C14","obj":"C13"}],"text":"Immune response of peripheral blood mononuclear cells to HBx-antigen of hepatitis B virus.\nThe hepatitis B virus genome encodes a transcriptional transactivator protein designated HBxAg. We have investigated whether this antigen is a target structure for human T-lymphocytes. Using recombinant HBxAg protein, we found HBxAg-specific stimulation of peripheral blood mononuclear cells in patients with acute hepatitis B virus infection (6 of 6) and chronic hepatitis B virus infection (6 of 17) but not in healthy individuals. With HBxAg-specific synthetic polypeptides, several T-cell epitopes were identified. Most were located in the carboxyterminal half of the HBxAg protein. Five T-cell clones specific for a T-cell epitope located at the carboxyterminal region of HBxAg were established and found to belong to the CD2/CD4-positive, CD8-negative subtype. These data establish for the first time HBxAg as an antigen in the cellular immune response."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":15},"obj":"other_name"},{"id":"T2","span":{"begin":19,"end":53},"obj":"cell_type"},{"id":"T3","span":{"begin":57,"end":68},"obj":"protein_molecule"},{"id":"T4","span":{"begin":72,"end":89},"obj":"virus"},{"id":"T5","span":{"begin":95,"end":112},"obj":"virus"},{"id":"T6","span":{"begin":130,"end":168},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":180,"end":185},"obj":"protein_family_or_group"},{"id":"T8","span":{"begin":255,"end":260},"obj":"cell_type"},{"id":"T9","span":{"begin":261,"end":274},"obj":"cell_type"},{"id":"T10","span":{"begin":282,"end":293},"obj":"protein_molecule"},{"id":"T11","span":{"begin":294,"end":299},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":318,"end":323},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":348,"end":382},"obj":"cell_type"},{"id":"T14","span":{"begin":386,"end":394},"obj":"multi_cell"},{"id":"T15","span":{"begin":406,"end":423},"obj":"virus"},{"id":"T16","span":{"begin":424,"end":433},"obj":"other_name"},{"id":"T17","span":{"begin":447,"end":454},"obj":"other_name"},{"id":"T18","span":{"begin":455,"end":472},"obj":"virus"},{"id":"T19","span":{"begin":504,"end":523},"obj":"multi_cell"},{"id":"T20","span":{"begin":530,"end":535},"obj":"protein_family_or_group"},{"id":"T21","span":{"begin":635,"end":655},"obj":"protein_domain_or_region"},{"id":"T22","span":{"begin":663,"end":668},"obj":"protein_family_or_group"},{"id":"T23","span":{"begin":683,"end":696},"obj":"cell_line"},{"id":"T24","span":{"begin":742,"end":764},"obj":"protein_domain_or_region"},{"id":"T25","span":{"begin":768,"end":773},"obj":"protein_family_or_group"},{"id":"T26","span":{"begin":818,"end":856},"obj":"cell_line"},{"id":"T27","span":{"begin":898,"end":903},"obj":"protein_family_or_group"},{"id":"T28","span":{"begin":910,"end":917},"obj":"other_name"},{"id":"T29","span":{"begin":925,"end":949},"obj":"other_name"}],"text":"Immune response of peripheral blood mononuclear cells to HBx-antigen of hepatitis B virus.\nThe hepatitis B virus genome encodes a transcriptional transactivator protein designated HBxAg. We have investigated whether this antigen is a target structure for human T-lymphocytes. Using recombinant HBxAg protein, we found HBxAg-specific stimulation of peripheral blood mononuclear cells in patients with acute hepatitis B virus infection (6 of 6) and chronic hepatitis B virus infection (6 of 17) but not in healthy individuals. With HBxAg-specific synthetic polypeptides, several T-cell epitopes were identified. Most were located in the carboxyterminal half of the HBxAg protein. Five T-cell clones specific for a T-cell epitope located at the carboxyterminal region of HBxAg were established and found to belong to the CD2/CD4-positive, CD8-negative subtype. These data establish for the first time HBxAg as an antigen in the cellular immune response."}