PubMed:1707027 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	19-53	cell_type	denotes	peripheral blood mononuclear cells
T2	57-68	protein	denotes	HBx-antigen
T3	95-119	DNA	denotes	hepatitis B virus genome
T4	130-168	protein	denotes	transcriptional transactivator protein
T5	180-185	protein	denotes	HBxAg
T6	255-274	cell_type	denotes	human T-lymphocytes
T7	282-307	protein	denotes	recombinant HBxAg protein
T8	318-323	protein	denotes	HBxAg
T9	348-382	cell_type	denotes	peripheral blood mononuclear cells
T10	530-535	protein	denotes	HBxAg
T11	635-655	protein	denotes	carboxyterminal half
T12	663-676	protein	denotes	HBxAg protein
T13	683-696	cell_line	denotes	T-cell clones
T14	712-726	protein	denotes	T-cell epitope
T15	742-764	protein	denotes	carboxyterminal region
T16	768-773	protein	denotes	HBxAg
T17	818-856	cell_line	denotes	CD2/CD4-positive, CD8-negative subtype
T18	898-903	protein	denotes	HBxAg

Id	Subject	Object	Predicate	Lexical cue
S1	0-90	Sentence	denotes	Immune response of peripheral blood mononuclear cells to HBx-antigen of hepatitis B virus.
S2	91-186	Sentence	denotes	The hepatitis B virus genome encodes a transcriptional transactivator protein designated HBxAg.
S3	187-275	Sentence	denotes	We have investigated whether this antigen is a target structure for human T-lymphocytes.
S4	276-524	Sentence	denotes	Using recombinant HBxAg protein, we found HBxAg-specific stimulation of peripheral blood mononuclear cells in patients with acute hepatitis B virus infection (6 of 6) and chronic hepatitis B virus infection (6 of 17) but not in healthy individuals.
S5	525-609	Sentence	denotes	With HBxAg-specific synthetic polypeptides, several T-cell epitopes were identified.
S6	610-677	Sentence	denotes	Most were located in the carboxyterminal half of the HBxAg protein.
S7	678-857	Sentence	denotes	Five T-cell clones specific for a T-cell epitope located at the carboxyterminal region of HBxAg were established and found to belong to the CD2/CD4-positive, CD8-negative subtype.
S8	858-950	Sentence	denotes	These data establish for the first time HBxAg as an antigen in the cellular immune response.

Id	Subject	Object	Predicate	Lexical cue
C1	19-53	NP	denotes	peripheral blood mononuclear cells
C3	72-89	NP	denotes	hepatitis B virus
C2	57-89	NP	denotes	HBx-antigen of hepatitis B virus
C4	91-112	NP	denotes	The hepatitis B virus
C5	128-168	NP	denotes	a transcriptional transactivator protein
C6	180-185	NP	denotes	HBxAg
C7	216-228	NP	denotes	this antigen
C8	282-307	NP	denotes	recombinant HBxAg protein
C9	348-382	NP	denotes	peripheral blood mononuclear cells
C10	406-423	NP	denotes	hepatitis B virus
C11	455-472	NP	denotes	hepatitis B virus
C12	659-676	NP	denotes	the HBxAg protein
C13	768-773	NP	denotes	HBxAg
C14	898-903	NP	denotes	HBxAg
R1	C4	C3	coref-ident	The hepatitis B virus,hepatitis B virus
R2	C5	C6	coref-ident	a transcriptional transactivator protein,HBxAg
R3	C6	C2	coref-other	HBxAg,HBx-antigen of hepatitis B virus
R4	C7	C6	coref-ident	this antigen,HBxAg
R5	C9	C1	coref-ident	peripheral blood mononuclear cells,peripheral blood mononuclear cells
R6	C10	C4	coref-ident	hepatitis B virus,The hepatitis B virus
R7	C11	C10	coref-ident	hepatitis B virus,hepatitis B virus
R8	C12	C8	coref-ident	the HBxAg protein,recombinant HBxAg protein
R9	C13	C6	coref-ident	HBxAg,HBxAg
R10	C14	C13	coref-ident	HBxAg,HBxAg

Id	Subject	Object	Predicate	Lexical cue
T1	0-15	other_name	denotes	Immune response
T2	19-53	cell_type	denotes	peripheral blood mononuclear cells
T3	57-68	protein_molecule	denotes	HBx-antigen
T4	72-89	virus	denotes	hepatitis B virus
T5	95-112	virus	denotes	hepatitis B virus
T6	130-168	protein_family_or_group	denotes	transcriptional transactivator protein
T7	180-185	protein_family_or_group	denotes	HBxAg
T8	255-260	cell_type	denotes	human
T9	261-274	cell_type	denotes	T-lymphocytes
T10	282-293	protein_molecule	denotes	recombinant
T11	294-299	protein_family_or_group	denotes	HBxAg
T12	318-323	protein_family_or_group	denotes	HBxAg
T13	348-382	cell_type	denotes	peripheral blood mononuclear cells
T14	386-394	multi_cell	denotes	patients
T15	406-423	virus	denotes	hepatitis B virus
T16	424-433	other_name	denotes	infection
T17	447-454	other_name	denotes	chronic
T18	455-472	virus	denotes	hepatitis B virus
T19	504-523	multi_cell	denotes	healthy individuals
T20	530-535	protein_family_or_group	denotes	HBxAg
T21	635-655	protein_domain_or_region	denotes	carboxyterminal half
T22	663-668	protein_family_or_group	denotes	HBxAg
T23	683-696	cell_line	denotes	T-cell clones
T24	742-764	protein_domain_or_region	denotes	carboxyterminal region
T25	768-773	protein_family_or_group	denotes	HBxAg
T26	818-856	cell_line	denotes	CD2/CD4-positive, CD8-negative subtype
T27	898-903	protein_family_or_group	denotes	HBxAg
T28	910-917	other_name	denotes	antigen
T29	925-949	other_name	denotes	cellular immune response