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PubMed:17028180 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation.
T2 120-260 Sentence denotes Regulatory T cells (T(reg)) express Foxp3, a forkhead family member that is necessary and sufficient for T(reg) lineage choice and function.
T3 261-535 Sentence denotes Ectopic expression of Foxp3 in non-T(reg) leads to repression of the interleukin 2 (IL-2) and interferon gamma (IFNgamma) genes, gain of suppressor function, and induction of genes such as CD25, GITR, and CTLA-4, but the mode by which Foxp3 enforces this program is unclear.
T4 536-707 Sentence denotes Using chromatin immunoprecipitation, we have demonstrated that Foxp3 binds to the endogenous IL-2 and IFNgamma loci in T cells, but only after T cell receptor stimulation.
T5 708-846 Sentence denotes This activation-induced Foxp3 binding was abrogated by cyclosporin A, suggesting a role for the phosphatase calcineurin in Foxp3 function.
T6 847-1039 Sentence denotes We have also shown that binding of Foxp3 to the IL-2 and IFNgamma genes induces active deacetylation of histone H3, a process that inhibits chromatin remodeling and opposes gene transcription.
T7 1040-1146 Sentence denotes Conversely, binding of Foxp3 to the GITR, CD25, and CTLA-4 genes results in increased histone acetylation.
T8 1147-1308 Sentence denotes These data indicate that Foxp3 may regulate transcription through direct chromatin remodeling and show that Foxp3 function is influenced by signals from the TCR.

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 30-35 Protein denotes Foxp3
T2 99-106 Protein denotes histone
T3 156-161 Protein denotes Foxp3
T4 283-288 Protein denotes Foxp3
T5 330-343 Protein denotes interleukin 2
T6 345-349 Protein denotes IL-2
T7 355-371 Protein denotes interferon gamma
T8 373-381 Protein denotes IFNgamma
T9 450-454 Protein denotes CD25
T10 456-460 Protein denotes GITR
T11 466-472 Protein denotes CTLA-4
T12 496-501 Protein denotes Foxp3
T13 599-604 Protein denotes Foxp3
T14 629-633 Protein denotes IL-2
T15 638-646 Protein denotes IFNgamma
T16 732-737 Protein denotes Foxp3
T17 831-836 Protein denotes Foxp3
T18 882-887 Protein denotes Foxp3
T19 895-899 Protein denotes IL-2
T20 904-912 Protein denotes IFNgamma
T21 951-961 Protein denotes histone H3
T22 1063-1068 Protein denotes Foxp3
T23 1076-1080 Protein denotes GITR
T24 1082-1086 Protein denotes CD25
T25 1092-1098 Protein denotes CTLA-4
T26 1126-1133 Protein denotes histone
T27 1172-1177 Protein denotes Foxp3
T28 1255-1260 Protein denotes Foxp3

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 679-685 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 120-138 Cell denotes Regulatory T cells http://purl.obolibrary.org/obo/CL:0000815
T2 140-146 Cell denotes T(reg) http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815
T4 225-231 Cell denotes T(reg) http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815
T6 296-302 Cell denotes T(reg) http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815
T8 655-662 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T9 679-685 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084