> top > docs > PubMed:17006606 > annotations

PubMed:17006606 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-138 Sentence denotes A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population.
T2 139-379 Sentence denotes Proinflammatory cytokine gene polymorphisms have been demonstrated to associate with gastric cancer risk, of which IL1B-31T/C and -511C/T changes have been well investigated due to the possibility that they may alter the IL1B transcription.
T3 380-642 Sentence denotes The signal transduction target upon interleukin 1 beta (IL1beta) stimulation, the nuclear factor of kappa B (NFkappaB) activation, supports cancer development, signal transduction in which is mediated by FS-7 cell-associated cell surface antigen (FAS) signaling.
T4 643-889 Sentence denotes Based on recent papers describing the prognostic roles of the polymorphisms and the NFkappaB functions on cancer development, we sought to determine if Japanese gastric cancer patients were affected by the IL1B -31/-511 and FAS-670 polymorphisms.
T5 890-1035 Sentence denotes A case-control study was conducted on incident gastric adenocarcinoma patients (n=271) and age-gender frequency-matched control subjects (n=271).
T6 1036-1240 Sentence denotes We observed strong linkage disequilibrium between the T allele at -511 and the C allele at -31 and between the C allele at -511 and the T allele at -31 in IL1B in both the cases and controls (R (2)=0.94).
T7 1241-1352 Sentence denotes Neither IL1B-31, -511 nor FAS-670 polymorphisms showed significantly different risks of gastric adenocarcinoma.
T8 1353-1526 Sentence denotes Though FAS-670 polymorphisms did not show any significant difference, the proportion of subjects with IL1B-31TT (or IL1B-511CC) increased according to stage (trend P=0.019).
T9 1527-1683 Sentence denotes In particular, subjects with stage IV had a two times higher probability of having either IL1B-31TT (or IL1B-511CC) genotype compared with stage I subjects.
T10 1684-1781 Sentence denotes These observations suggest that IL1B-31TT and IL1B-511CC are associated with disease progression.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
3401 18-44 SequenceVariant denotes C-to-T substitution at -31 DBSNP:rs1143627
3402 45-49 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3403 90-112 DiseaseOrPhenotypicFeature denotes gastric adenocarcinoma MESH:D013274
3404 139-163 GeneOrGeneProduct denotes Proinflammatory cytokine NCBIGene:3553
3405 224-238 DiseaseOrPhenotypicFeature denotes gastric cancer MESH:D013274
3406 254-258 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3407 258-264 SequenceVariant denotes -31T/C DBSNP:rs1143627
3408 269-276 SequenceVariant denotes -511C/T DBSNP:rs1143634
3409 360-364 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3410 416-434 GeneOrGeneProduct denotes interleukin 1 beta NCBIGene:3553
3411 436-443 GeneOrGeneProduct denotes IL1beta NCBIGene:3553
3412 462-487 GeneOrGeneProduct denotes nuclear factor of kappa B NCBIGene:4790
3413 489-497 GeneOrGeneProduct denotes NFkappaB NCBIGene:4790
3414 520-526 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369
3415 584-625 GeneOrGeneProduct denotes FS-7 cell-associated cell surface antigen NCBIGene:355
3416 627-630 GeneOrGeneProduct denotes FAS NCBIGene:355
3417 727-735 GeneOrGeneProduct denotes NFkappaB NCBIGene:4790
3418 749-755 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369
3419 804-818 DiseaseOrPhenotypicFeature denotes gastric cancer MESH:D013274
3420 819-827 OrganismTaxon denotes patients NCBITaxon:9606
3421 849-853 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3422 867-870 GeneOrGeneProduct denotes FAS NCBIGene:355
3423 937-959 DiseaseOrPhenotypicFeature denotes gastric adenocarcinoma MESH:D013274
3424 960-968 OrganismTaxon denotes patients NCBITaxon:9606
3425 1090-1106 SequenceVariant denotes T allele at -511 DBSNP:rs1143634
3426 1115-1130 SequenceVariant denotes C allele at -31 DBSNP:rs1143627
3427 1147-1163 SequenceVariant denotes C allele at -511 DBSNP:rs1143634
3428 1172-1187 SequenceVariant denotes T allele at -31 DBSNP:rs1143627
3429 1191-1195 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3430 1249-1253 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3431 1267-1270 GeneOrGeneProduct denotes FAS NCBIGene:355
3432 1329-1351 DiseaseOrPhenotypicFeature denotes gastric adenocarcinoma MESH:D013274
3433 1360-1363 GeneOrGeneProduct denotes FAS NCBIGene:355
3434 1455-1459 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3435 1459-1464 SequenceVariant denotes -31TT DBSNP:rs1143627
3436 1469-1473 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3437 1473-1479 SequenceVariant denotes -511CC DBSNP:rs1143634
3438 1617-1621 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3439 1621-1626 SequenceVariant denotes -31TT DBSNP:rs1143627
3440 1631-1635 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3441 1635-1641 SequenceVariant denotes -511CC DBSNP:rs1143634
3442 1716-1720 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3443 1720-1725 SequenceVariant denotes -31TT DBSNP:rs1143627
3444 1730-1734 GeneOrGeneProduct denotes IL1B NCBIGene:3553
3445 1734-1740 SequenceVariant denotes -511CC DBSNP:rs1143634

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 90-112 DiseaseOrPhenotypicFeature denotes gastric adenocarcinoma 0005036
T2 98-112 DiseaseOrPhenotypicFeature denotes adenocarcinoma 0004970
T3 224-238 DiseaseOrPhenotypicFeature denotes gastric cancer 0001056
T4 232-238 DiseaseOrPhenotypicFeature denotes cancer 0004992
T5 520-526 DiseaseOrPhenotypicFeature denotes cancer 0004992
T6 749-755 DiseaseOrPhenotypicFeature denotes cancer 0004992
T7 804-818 DiseaseOrPhenotypicFeature denotes gastric cancer 0001056
T8 812-818 DiseaseOrPhenotypicFeature denotes cancer 0004992
T9 937-959 DiseaseOrPhenotypicFeature denotes gastric adenocarcinoma 0005036
T10 945-959 DiseaseOrPhenotypicFeature denotes adenocarcinoma 0004970
T11 1329-1351 DiseaseOrPhenotypicFeature denotes gastric adenocarcinoma 0005036
T12 1337-1351 DiseaseOrPhenotypicFeature denotes adenocarcinoma 0004970

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 258-262 SequenceVariant denotes -31T
T2 270-274 SequenceVariant denotes 511C
T3 1459-1464 SequenceVariant denotes -31TT
T4 1473-1479 SequenceVariant denotes -511CC
T5 1621-1626 SequenceVariant denotes -31TT
T6 1635-1641 SequenceVariant denotes -511CC
T7 1720-1725 SequenceVariant denotes -31TT
T8 1734-1740 SequenceVariant denotes -511CC

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 45-49 GeneOrGeneProduct denotes IL1B
T2 113-117 GeneOrGeneProduct denotes in a
T3 254-258 GeneOrGeneProduct denotes IL1B
T4 360-364 GeneOrGeneProduct denotes IL1B
T5 365-378 GeneOrGeneProduct denotes transcription
T6 384-403 GeneOrGeneProduct denotes signal transduction
T7 416-434 GeneOrGeneProduct denotes interleukin 1 beta
T8 436-443 GeneOrGeneProduct denotes IL1beta
T9 470-476 GeneOrGeneProduct denotes factor
T10 480-485 GeneOrGeneProduct denotes kappa
T11 489-497 GeneOrGeneProduct denotes NFkappaB
T12 499-509 GeneOrGeneProduct denotes activation
T13 540-559 GeneOrGeneProduct denotes signal transduction
T14 572-580 GeneOrGeneProduct denotes mediated
T15 584-586 GeneOrGeneProduct denotes FS
T16 589-593 GeneOrGeneProduct denotes cell
T17 605-625 GeneOrGeneProduct denotes cell surface antigen
T18 627-630 GeneOrGeneProduct denotes FAS
T19 643-648 GeneOrGeneProduct denotes Based
T20 727-735 GeneOrGeneProduct denotes NFkappaB
T21 782-791 GeneOrGeneProduct denotes determine
T22 849-853 GeneOrGeneProduct denotes IL1B
T23 867-870 GeneOrGeneProduct denotes FAS
T24 892-896 GeneOrGeneProduct denotes case
T25 992-1001 GeneOrGeneProduct denotes frequency
T26 1191-1195 GeneOrGeneProduct denotes IL1B
T27 1204-1213 GeneOrGeneProduct denotes the cases
T28 1249-1253 GeneOrGeneProduct denotes IL1B
T29 1267-1270 GeneOrGeneProduct denotes FAS
T30 1360-1363 GeneOrGeneProduct denotes FAS
T31 1455-1459 GeneOrGeneProduct denotes IL1B
T32 1469-1473 GeneOrGeneProduct denotes IL1B
T33 1565-1570 GeneOrGeneProduct denotes had a
T34 1575-1580 GeneOrGeneProduct denotes times
T35 1588-1599 GeneOrGeneProduct denotes probability
T36 1617-1621 GeneOrGeneProduct denotes IL1B
T37 1631-1635 GeneOrGeneProduct denotes IL1B
T38 1716-1720 GeneOrGeneProduct denotes IL1B
T39 1730-1734 GeneOrGeneProduct denotes IL1B

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 45-49 GeneOrGeneProduct denotes IL1B
T2 254-258 GeneOrGeneProduct denotes IL1B
T3 360-364 GeneOrGeneProduct denotes IL1B
T4 365-378 GeneOrGeneProduct denotes transcription
T5 384-403 GeneOrGeneProduct denotes signal transduction
T6 416-434 GeneOrGeneProduct denotes interleukin 1 beta
T7 436-443 GeneOrGeneProduct denotes IL1beta
T8 470-476 GeneOrGeneProduct denotes factor
T9 480-485 GeneOrGeneProduct denotes kappa
T10 489-497 GeneOrGeneProduct denotes NFkappaB
T11 540-559 GeneOrGeneProduct denotes signal transduction
T12 589-593 GeneOrGeneProduct denotes cell
T13 605-625 GeneOrGeneProduct denotes cell surface antigen
T14 727-735 GeneOrGeneProduct denotes NFkappaB
T15 849-853 GeneOrGeneProduct denotes IL1B
T16 992-1001 GeneOrGeneProduct denotes frequency
T17 1191-1195 GeneOrGeneProduct denotes IL1B
T18 1249-1253 GeneOrGeneProduct denotes IL1B
T19 1455-1459 GeneOrGeneProduct denotes IL1B
T20 1469-1473 GeneOrGeneProduct denotes IL1B
T21 1617-1621 GeneOrGeneProduct denotes IL1B
T22 1631-1635 GeneOrGeneProduct denotes IL1B
T23 1716-1720 GeneOrGeneProduct denotes IL1B
T24 1730-1734 GeneOrGeneProduct denotes IL1B

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T7 945-959 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T8 1337-1351 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T9 1761-1780 DiseaseOrPhenotypicFeature denotes disease progression D018450
T1 98-112 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T2 139-154 DiseaseOrPhenotypicFeature denotes Proinflammatory DISEASE
T3 224-238 DiseaseOrPhenotypicFeature denotes gastric cancer D013274
T4 520-526 DiseaseOrPhenotypicFeature denotes cancer D009369
T5 749-755 DiseaseOrPhenotypicFeature denotes cancer D009369
T6 804-818 DiseaseOrPhenotypicFeature denotes gastric cancer D013274

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 45-49 GeneOrGeneProduct denotes IL1B
T2 254-258 GeneOrGeneProduct denotes IL1B
T3 360-364 GeneOrGeneProduct denotes IL1B
T4 416-434 GeneOrGeneProduct denotes interleukin 1 beta
T5 436-443 GeneOrGeneProduct denotes IL1beta
T6 462-476 GeneOrGeneProduct denotes nuclear factor
T7 489-497 GeneOrGeneProduct denotes NFkappaB
T8 605-625 GeneOrGeneProduct denotes cell surface antigen
T9 727-735 GeneOrGeneProduct denotes NFkappaB
T10 849-853 GeneOrGeneProduct denotes IL1B
T11 1191-1195 GeneOrGeneProduct denotes IL1B
T12 1249-1253 GeneOrGeneProduct denotes IL1B
T13 1455-1459 GeneOrGeneProduct denotes IL1B
T14 1469-1473 GeneOrGeneProduct denotes IL1B
T15 1617-1621 GeneOrGeneProduct denotes IL1B
T16 1631-1635 GeneOrGeneProduct denotes IL1B
T17 1716-1720 GeneOrGeneProduct denotes IL1B
T18 1730-1734 GeneOrGeneProduct denotes IL1B

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 90-112 DiseaseOrPhenotypicFeature denotes gastric adenocarcinoma 0005036
T2 224-238 DiseaseOrPhenotypicFeature denotes gastric cancer 0004950|0001056
T4 584-586 DiseaseOrPhenotypicFeature denotes FS 0043257|0015267
T6 627-630 DiseaseOrPhenotypicFeature denotes FAS 0020708|0016011
T8 804-818 DiseaseOrPhenotypicFeature denotes gastric cancer 0004950|0001056
T10 867-870 DiseaseOrPhenotypicFeature denotes FAS 0020708|0016011
T12 937-959 DiseaseOrPhenotypicFeature denotes gastric adenocarcinoma 0005036
T13 1267-1270 DiseaseOrPhenotypicFeature denotes FAS 0020708|0016011
T15 1329-1351 DiseaseOrPhenotypicFeature denotes gastric adenocarcinoma 0005036
T16 1360-1363 DiseaseOrPhenotypicFeature denotes FAS 0020708|0016011

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 98-112 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T2 139-154 DiseaseOrPhenotypicFeature denotes Proinflammatory DISEASE
T3 224-238 DiseaseOrPhenotypicFeature denotes gastric cancer D013274
T4 520-526 DiseaseOrPhenotypicFeature denotes cancer D009369
T5 749-755 DiseaseOrPhenotypicFeature denotes cancer D009369
T6 804-818 DiseaseOrPhenotypicFeature denotes gastric cancer D013274
T7 945-959 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T8 1337-1351 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T9 1761-1780 DiseaseOrPhenotypicFeature denotes disease progression D018450

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 98-112 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T2 139-154 DiseaseOrPhenotypicFeature denotes Proinflammatory DISEASE
T3 224-238 DiseaseOrPhenotypicFeature denotes gastric cancer D013274
T4 520-526 DiseaseOrPhenotypicFeature denotes cancer D009369
T5 749-755 DiseaseOrPhenotypicFeature denotes cancer D009369
T6 804-818 DiseaseOrPhenotypicFeature denotes gastric cancer D013274
T7 945-959 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T8 1337-1351 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 605-625 ChemicalEntity denotes cell surface antigen D000954
T2 627-630 ChemicalEntity denotes FAS http://purl.obolibrary.org/obo/CHEBI_76181
T3 867-870 ChemicalEntity denotes FAS http://purl.obolibrary.org/obo/CHEBI_76181
T4 1267-1270 ChemicalEntity denotes FAS http://purl.obolibrary.org/obo/CHEBI_76181
T5 1360-1363 ChemicalEntity denotes FAS http://purl.obolibrary.org/obo/CHEBI_76181

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 819-827 OrganismTaxon denotes patients
T2 960-968 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T5 1360-1363 ChemicalEntity denotes FAS http://purl.obolibrary.org/obo/CHEBI_76181
T4 1267-1270 ChemicalEntity denotes FAS http://purl.obolibrary.org/obo/CHEBI_76181
T3 867-870 ChemicalEntity denotes FAS http://purl.obolibrary.org/obo/CHEBI_76181
T2 627-630 ChemicalEntity denotes FAS http://purl.obolibrary.org/obo/CHEBI_76181
T1 605-625 ChemicalEntity denotes cell surface antigen D000954
T18 1730-1734 GeneOrGeneProduct denotes IL1B
T17 1716-1720 GeneOrGeneProduct denotes IL1B
T16 1631-1635 GeneOrGeneProduct denotes IL1B
T15 1617-1621 GeneOrGeneProduct denotes IL1B
T14 1469-1473 GeneOrGeneProduct denotes IL1B
T13 1455-1459 GeneOrGeneProduct denotes IL1B
T12 1249-1253 GeneOrGeneProduct denotes IL1B
T11 1191-1195 GeneOrGeneProduct denotes IL1B
T10 849-853 GeneOrGeneProduct denotes IL1B
T9 727-735 GeneOrGeneProduct denotes NFkappaB
T8 605-625 GeneOrGeneProduct denotes cell surface antigen
T7 489-497 GeneOrGeneProduct denotes NFkappaB
T6 462-476 GeneOrGeneProduct denotes nuclear factor
T25791 436-443 GeneOrGeneProduct denotes IL1beta
T35267 416-434 GeneOrGeneProduct denotes interleukin 1 beta
T34800 360-364 GeneOrGeneProduct denotes IL1B
T59822 254-258 GeneOrGeneProduct denotes IL1B
T3161 45-49 GeneOrGeneProduct denotes IL1B
T70721 1337-1351 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T70602 945-959 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T66957 804-818 DiseaseOrPhenotypicFeature denotes gastric cancer D013274
T57082 749-755 DiseaseOrPhenotypicFeature denotes cancer D009369
T23236 520-526 DiseaseOrPhenotypicFeature denotes cancer D009369
T19941 224-238 DiseaseOrPhenotypicFeature denotes gastric cancer D013274
T1843 139-154 DiseaseOrPhenotypicFeature denotes Proinflammatory DISEASE
T50743 98-112 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T7921 960-968 OrganismTaxon denotes patients
T75314 819-827 OrganismTaxon denotes patients
T31038 1734-1740 SequenceVariant denotes -511CC
T16876 1720-1725 SequenceVariant denotes -31TT
T66692 1635-1641 SequenceVariant denotes -511CC
T10474 1621-1626 SequenceVariant denotes -31TT
T51514 1473-1479 SequenceVariant denotes -511CC
T84638 1459-1464 SequenceVariant denotes -31TT
T67438 270-274 SequenceVariant denotes 511C
T77909 258-262 SequenceVariant denotes -31T

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1267-1270 gene:355 denotes FAS
T1 1329-1351 disease:C0278701 denotes gastric adenocarcinoma
T2 1267-1270 gene:2194 denotes FAS
T3 1329-1351 disease:C0278701 denotes gastric adenocarcinoma
R1 T0 T1 associated_with FAS,gastric adenocarcinoma
R2 T2 T3 associated_with FAS,gastric adenocarcinoma

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 224-238 HP_0012126 denotes gastric cancer
T2 232-238 HP_0002664 denotes cancer
T3 520-526 HP_0002664 denotes cancer
T4 749-755 HP_0002664 denotes cancer
T5 804-818 HP_0012126 denotes gastric cancer
T1 224-238 HP_0012126 denotes gastric cancer
T2 232-238 HP_0002664 denotes cancer
T3 520-526 HP_0002664 denotes cancer
T4 749-755 HP_0002664 denotes cancer
T5 804-818 HP_0012126 denotes gastric cancer
T6 812-818 HP_0002664 denotes cancer
T6 812-818 HP_0002664 denotes cancer