PubMed:16920333 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/16920333","sourcedb":"PubMed","sourceid":"16920333","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/16920333","text":"Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats.\nEslicarbazepine acetate (BIA 2-093, S-(-)-10-acetoxy-10,11-dihydro-5H-dibenzo/b,f/azepine-5-carboxamide) is a novel antiepileptic drug, now in Phase III clinical trials, designed with the aim of improving efficacy and safety in comparison with the structurally related drugs carbamazepine (CBZ) and oxcarbazepine (OXC). We have studied the effects of oral treatment with eslicarbazepine acetate on a whole-animal model in which partial seizures can be elicited repeatedly on different days without changes in threshold or seizure patterns. In the animals treated with threshold doses of picrotoxin, the average number of seizures was 2.3+/-1.2, and average seizure duration was 39.5+/-8.4s. Pre-treatment with a dose of 30 mg/kg 2h before picrotoxin microperfusion prevented seizures in the 75% of the rats. Lower doses (3 and 10mg/kg) did not suppress seizures, however, after administration of 10mg/kg, significant reductions in seizures duration (24.3+/-6.8s) and seizure number (1.6+/-0.34) were found. No adverse effects of eslicarbazepine acetate were observed in the behavioral/EEG patterns studied, including sleep/wakefulness cycle, at the doses studied.","tracks":[{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":154},"obj":"Sentence"},{"id":"T2","span":{"begin":155,"end":474},"obj":"Sentence"},{"id":"T3","span":{"begin":475,"end":694},"obj":"Sentence"},{"id":"T4","span":{"begin":695,"end":845},"obj":"Sentence"},{"id":"T5","span":{"begin":846,"end":962},"obj":"Sentence"},{"id":"T6","span":{"begin":963,"end":1161},"obj":"Sentence"},{"id":"T7","span":{"begin":1162,"end":1318},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-sentences"},{"subj":"T2","pred":"source","obj":"LitCoin-sentences"},{"subj":"T3","pred":"source","obj":"LitCoin-sentences"},{"subj":"T4","pred":"source","obj":"LitCoin-sentences"},{"subj":"T5","pred":"source","obj":"LitCoin-sentences"},{"subj":"T6","pred":"source","obj":"LitCoin-sentences"},{"subj":"T7","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":120,"end":131},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":149,"end":153},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":957,"end":961},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:72046"},{"id":"A2","pred":"db_id","subj":"T2","obj":"NCBItxid:10118"},{"id":"A3","pred":"db_id","subj":"T2","obj":"NCBItxid:10116"},{"id":"A4","pred":"db_id","subj":"T2","obj":"NCBItxid:10114"},{"id":"A5","pred":"db_id","subj":"T5","obj":"NCBItxid:10118"},{"id":"A6","pred":"db_id","subj":"T5","obj":"NCBItxid:10116"},{"id":"A7","pred":"db_id","subj":"T5","obj":"NCBItxid:10114"},{"subj":"T1","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T2","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T5","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"}]},{"project":"LitCoin-entities","denotations":[{"id":"3353","span":{"begin":25,"end":48},"obj":"ChemicalEntity"},{"id":"3354","span":{"begin":50,"end":59},"obj":"ChemicalEntity"},{"id":"3355","span":{"begin":64,"end":72},"obj":"DiseaseOrPhenotypicFeature"},{"id":"3356","span":{"begin":102,"end":112},"obj":"ChemicalEntity"},{"id":"3357","span":{"begin":149,"end":153},"obj":"OrganismTaxon"},{"id":"3358","span":{"begin":155,"end":178},"obj":"ChemicalEntity"},{"id":"3359","span":{"begin":180,"end":189},"obj":"ChemicalEntity"},{"id":"3360","span":{"begin":191,"end":258},"obj":"ChemicalEntity"},{"id":"3361","span":{"begin":271,"end":289},"obj":"ChemicalEntity"},{"id":"3362","span":{"begin":430,"end":443},"obj":"ChemicalEntity"},{"id":"3363","span":{"begin":445,"end":448},"obj":"ChemicalEntity"},{"id":"3364","span":{"begin":454,"end":467},"obj":"ChemicalEntity"},{"id":"3365","span":{"begin":469,"end":472},"obj":"ChemicalEntity"},{"id":"3366","span":{"begin":526,"end":549},"obj":"ChemicalEntity"},{"id":"3367","span":{"begin":591,"end":599},"obj":"DiseaseOrPhenotypicFeature"},{"id":"3368","span":{"begin":677,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"3369","span":{"begin":742,"end":752},"obj":"ChemicalEntity"},{"id":"3370","span":{"begin":776,"end":784},"obj":"DiseaseOrPhenotypicFeature"},{"id":"3371","span":{"begin":812,"end":819},"obj":"DiseaseOrPhenotypicFeature"},{"id":"3372","span":{"begin":894,"end":904},"obj":"ChemicalEntity"},{"id":"3373","span":{"begin":930,"end":938},"obj":"DiseaseOrPhenotypicFeature"},{"id":"3374","span":{"begin":957,"end":961},"obj":"OrganismTaxon"},{"id":"3375","span":{"begin":1008,"end":1016},"obj":"DiseaseOrPhenotypicFeature"},{"id":"3376","span":{"begin":1086,"end":1094},"obj":"DiseaseOrPhenotypicFeature"},{"id":"3377","span":{"begin":1122,"end":1129},"obj":"DiseaseOrPhenotypicFeature"},{"id":"3378","span":{"begin":1184,"end":1207},"obj":"ChemicalEntity"}],"attributes":[{"id":"A3","pred":"db_id","subj":"3355","obj":"MESH:D012640"},{"id":"A18","pred":"db_id","subj":"3370","obj":"MESH:D012640"},{"id":"A8","pred":"db_id","subj":"3360","obj":"MESH:C416835"},{"id":"A10","pred":"db_id","subj":"3362","obj":"MESH:D002220"},{"id":"A25","pred":"db_id","subj":"3377","obj":"MESH:D012640"},{"id":"A22","pred":"db_id","subj":"3374","obj":"NCBITaxon:10116"},{"id":"A15","pred":"db_id","subj":"3367","obj":"MESH:D012640"},{"id":"A19","pred":"db_id","subj":"3371","obj":"MESH:D012640"},{"id":"A5","pred":"db_id","subj":"3357","obj":"NCBITaxon:10116"},{"id":"A21","pred":"db_id","subj":"3373","obj":"MESH:D012640"},{"id":"A16","pred":"db_id","subj":"3368","obj":"MESH:D012640"},{"id":"A23","pred":"db_id","subj":"3375","obj":"MESH:D012640"},{"id":"A6","pred":"db_id","subj":"3358","obj":"MESH:C416835"},{"id":"A4","pred":"db_id","subj":"3356","obj":"MESH:D010852"},{"id":"A11","pred":"db_id","subj":"3363","obj":"MESH:D002220"},{"id":"A2","pred":"db_id","subj":"3354","obj":"MESH:C416835"},{"id":"A13","pred":"db_id","subj":"3365","obj":"MESH:C036006"},{"id":"A7","pred":"db_id","subj":"3359","obj":"MESH:C416835"},{"id":"A12","pred":"db_id","subj":"3364","obj":"MESH:C036006"},{"id":"A1","pred":"db_id","subj":"3353","obj":"MESH:C416835"},{"id":"A26","pred":"db_id","subj":"3378","obj":"MESH:C416835"},{"id":"A17","pred":"db_id","subj":"3369","obj":"MESH:D010852"},{"id":"A14","pred":"db_id","subj":"3366","obj":"MESH:C416835"},{"id":"A20","pred":"db_id","subj":"3372","obj":"MESH:D010852"},{"id":"A24","pred":"db_id","subj":"3376","obj":"MESH:D012640"},{"id":"A9","pred":"db_id","subj":"3361","obj":"MESH:D000927"},{"subj":"3353","pred":"source","obj":"LitCoin-entities"},{"subj":"3354","pred":"source","obj":"LitCoin-entities"},{"subj":"3355","pred":"source","obj":"LitCoin-entities"},{"subj":"3356","pred":"source","obj":"LitCoin-entities"},{"subj":"3357","pred":"source","obj":"LitCoin-entities"},{"subj":"3358","pred":"source","obj":"LitCoin-entities"},{"subj":"3359","pred":"source","obj":"LitCoin-entities"},{"subj":"3360","pred":"source","obj":"LitCoin-entities"},{"subj":"3361","pred":"source","obj":"LitCoin-entities"},{"subj":"3362","pred":"source","obj":"LitCoin-entities"},{"subj":"3363","pred":"source","obj":"LitCoin-entities"},{"subj":"3364","pred":"source","obj":"LitCoin-entities"},{"subj":"3365","pred":"source","obj":"LitCoin-entities"},{"subj":"3366","pred":"source","obj":"LitCoin-entities"},{"subj":"3367","pred":"source","obj":"LitCoin-entities"},{"subj":"3368","pred":"source","obj":"LitCoin-entities"},{"subj":"3369","pred":"source","obj":"LitCoin-entities"},{"subj":"3370","pred":"source","obj":"LitCoin-entities"},{"subj":"3371","pred":"source","obj":"LitCoin-entities"},{"subj":"3372","pred":"source","obj":"LitCoin-entities"},{"subj":"3373","pred":"source","obj":"LitCoin-entities"},{"subj":"3374","pred":"source","obj":"LitCoin-entities"},{"subj":"3375","pred":"source","obj":"LitCoin-entities"},{"subj":"3376","pred":"source","obj":"LitCoin-entities"},{"subj":"3377","pred":"source","obj":"LitCoin-entities"},{"subj":"3378","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":41,"end":48},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":50,"end":55},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":64,"end":72},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":73,"end":80},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":171,"end":178},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":180,"end":185},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":265,"end":270},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":304,"end":307},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":542,"end":549},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":591,"end":599},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":677,"end":684},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":776,"end":784},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":789,"end":792},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":812,"end":819},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":878,"end":880},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":930,"end":938},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":976,"end":981},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1008,"end":1016},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1086,"end":1094},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1122,"end":1129},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1200,"end":1207},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1229,"end":1239},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1278,"end":1289},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1290,"end":1295},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":50,"end":55},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":64,"end":72},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":180,"end":185},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":265,"end":270},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":591,"end":599},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":677,"end":684},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":776,"end":784},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":812,"end":819},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":930,"end":938},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":1008,"end":1016},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1086,"end":1094},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1122,"end":1129},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1290,"end":1295},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":64,"end":72},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":583,"end":599},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":677,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":776,"end":784},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":812,"end":819},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":930,"end":938},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1008,"end":1016},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1086,"end":1094},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1122,"end":1129},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D012640"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D012640"},{"id":"A6","pred":"originalLabel","subj":"T6","obj":"D012640"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D012640"},{"id":"A9","pred":"originalLabel","subj":"T9","obj":"D012640"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D012640"},{"id":"A7","pred":"originalLabel","subj":"T7","obj":"D012640"},{"id":"A8","pred":"originalLabel","subj":"T8","obj":"D012640"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D012640"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T6","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T7","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T8","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T9","pred":"source","obj":"LitCoin-Disease-MeSH"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":600,"end":603},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0012833"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":64,"end":72},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":583,"end":599},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":677,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":776,"end":784},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":812,"end":819},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":930,"end":938},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1008,"end":1016},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1086,"end":1094},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1122,"end":1129},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A2","pred":"ID:","subj":"T2","obj":"D012640"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D012640"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D012640"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D012640"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D012640"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D012640"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D012640"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D012640"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D012640"},{"subj":"T1","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T2","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T3","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T4","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T5","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T6","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T7","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T8","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T9","pred":"source","obj":"LitCoin-MeSH-Disease-2"}]},{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":64,"end":72},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":583,"end":599},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":677,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":776,"end":784},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":812,"end":819},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":930,"end":938},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1008,"end":1016},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1086,"end":1094},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1122,"end":1129},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"#label","subj":"T4","obj":"D012640"},{"id":"A2","pred":"#label","subj":"T2","obj":"D012640"},{"id":"A7","pred":"#label","subj":"T7","obj":"D012640"},{"id":"A8","pred":"#label","subj":"T8","obj":"D012640"},{"id":"A1","pred":"#label","subj":"T1","obj":"D012640"},{"id":"A9","pred":"#label","subj":"T9","obj":"D012640"},{"id":"A6","pred":"#label","subj":"T6","obj":"D012640"},{"id":"A3","pred":"#label","subj":"T3","obj":"D012640"},{"id":"A5","pred":"#label","subj":"T5","obj":"D012640"},{"subj":"T1","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T2","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T3","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T4","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T5","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T6","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T7","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T8","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T9","pred":"source","obj":"LitCoin-MONDO_bioort2019"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":25,"end":48},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":50,"end":59},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":102,"end":112},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":155,"end":178},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":180,"end":189},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":200,"end":207},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":222,"end":244},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":247,"end":258},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":271,"end":289},"obj":"ChemicalEntity"},{"id":"T14","span":{"begin":430,"end":443},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":445,"end":448},"obj":"ChemicalEntity"},{"id":"T17","span":{"begin":454,"end":467},"obj":"ChemicalEntity"},{"id":"T19","span":{"begin":469,"end":472},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":526,"end":549},"obj":"ChemicalEntity"},{"id":"T22","span":{"begin":742,"end":752},"obj":"ChemicalEntity"},{"id":"T24","span":{"begin":894,"end":904},"obj":"ChemicalEntity"},{"id":"T26","span":{"begin":1184,"end":1207},"obj":"ChemicalEntity"},{"id":"T28","span":{"begin":1240,"end":1243},"obj":"ChemicalEntity"}],"attributes":[{"id":"A8","pred":"ID:","subj":"T8","obj":"C416835"},{"id":"A17","pred":"ID:","subj":"T17","obj":"D000078330"},{"id":"A18","pred":"ID:","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_7824"},{"id":"A13","pred":"ID:","subj":"T13","obj":"ChemicalEntity"},{"id":"A26","pred":"ID:","subj":"T26","obj":"C416835"},{"id":"A27","pred":"ID:","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_87016"},{"id":"A20","pred":"ID:","subj":"T20","obj":"C416835"},{"id":"A21","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_87016"},{"id":"A6","pred":"ID:","subj":"T6","obj":"C416835"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_87016"},{"id":"A9","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_48076"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D010852"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_134126"},{"id":"A1","pred":"ID:","subj":"T1","obj":"C416835"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_87016"},{"id":"A28","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_73494"},{"id":"A24","pred":"ID:","subj":"T24","obj":"D010852"},{"id":"A25","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_134126"},{"id":"A3","pred":"ID:","subj":"T3","obj":"C416835"},{"id":"A14","pred":"ID:","subj":"T14","obj":"D002220"},{"id":"A15","pred":"ID:","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_3387"},{"id":"A11","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_37622"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_23004"},{"id":"A10","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_47802"},{"id":"A19","pred":"ID:","subj":"T19","obj":"D000078330"},{"id":"A22","pred":"ID:","subj":"T22","obj":"D010852"},{"id":"A23","pred":"ID:","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_134126"},{"id":"A16","pred":"ID:","subj":"T16","obj":"D002220"},{"subj":"T1","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T14","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T16","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T17","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T19","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T20","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T22","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T24","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T26","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T28","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":50,"end":53},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":149,"end":153},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":180,"end":183},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":957,"end":961},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T2","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T3","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T4","pred":"source","obj":"LitCoin-NCBITaxon-2"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T28","span":{"begin":1240,"end":1243},"obj":"ChemicalEntity"},{"id":"T26","span":{"begin":1184,"end":1207},"obj":"ChemicalEntity"},{"id":"T24","span":{"begin":894,"end":904},"obj":"ChemicalEntity"},{"id":"T22","span":{"begin":742,"end":752},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":526,"end":549},"obj":"ChemicalEntity"},{"id":"T19","span":{"begin":469,"end":472},"obj":"ChemicalEntity"},{"id":"T17","span":{"begin":454,"end":467},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":445,"end":448},"obj":"ChemicalEntity"},{"id":"T14","span":{"begin":430,"end":443},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":271,"end":289},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":247,"end":258},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":222,"end":244},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":200,"end":207},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":180,"end":189},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":155,"end":178},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":102,"end":112},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":50,"end":59},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":25,"end":48},"obj":"ChemicalEntity"},{"id":"T30246","span":{"begin":1122,"end":1129},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4732","span":{"begin":1086,"end":1094},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1008,"end":1016},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T54817","span":{"begin":930,"end":938},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":812,"end":819},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T78533","span":{"begin":776,"end":784},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T74100","span":{"begin":677,"end":684},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":583,"end":599},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T27790","span":{"begin":64,"end":72},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14038","span":{"begin":957,"end":961},"obj":"OrganismTaxon"},{"id":"T36705","span":{"begin":180,"end":183},"obj":"OrganismTaxon"},{"id":"T24825","span":{"begin":149,"end":153},"obj":"OrganismTaxon"},{"id":"T44035","span":{"begin":50,"end":53},"obj":"OrganismTaxon"}],"attributes":[{"id":"A36300","pred":"#label","subj":"T30246","obj":"D012640"},{"id":"A95846","pred":"#label","subj":"T74100","obj":"D012640"},{"id":"A20","pred":"ID:","subj":"T20","obj":"C416835"},{"id":"A19","pred":"ID:","subj":"T19","obj":"D000078330"},{"id":"A54136","pred":"#label","subj":"T27790","obj":"D012640"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_23004"},{"id":"A11","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_37622"},{"id":"A66892","pred":"#label","subj":"T2","obj":"D012640"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_134126"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D010852"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_87016"},{"id":"A1","pred":"ID:","subj":"T1","obj":"C416835"},{"id":"A18","pred":"ID:","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_7824"},{"id":"A17","pred":"ID:","subj":"T17","obj":"D000078330"},{"id":"A17299","pred":"#label","subj":"T4732","obj":"D012640"},{"id":"A14","pred":"ID:","subj":"T14","obj":"D002220"},{"id":"A15","pred":"ID:","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_3387"},{"id":"A25","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_134126"},{"id":"A24","pred":"ID:","subj":"T24","obj":"D010852"},{"id":"A3","pred":"ID:","subj":"T3","obj":"C416835"},{"id":"A13437","pred":"#label","subj":"T5","obj":"D012640"},{"id":"A9","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_48076"},{"id":"A683","pred":"#label","subj":"T54817","obj":"D012640"},{"id":"A83511","pred":"#label","subj":"T78533","obj":"D012640"},{"id":"A16","pred":"ID:","subj":"T16","obj":"D002220"},{"id":"A28","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_73494"},{"id":"A23","pred":"ID:","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_134126"},{"id":"A22","pred":"ID:","subj":"T22","obj":"D010852"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_87016"},{"id":"A6","pred":"ID:","subj":"T6","obj":"C416835"},{"id":"A27","pred":"ID:","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_87016"},{"id":"A26","pred":"ID:","subj":"T26","obj":"C416835"},{"id":"A8","pred":"ID:","subj":"T8","obj":"C416835"},{"id":"A21","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_87016"},{"id":"A13","pred":"ID:","subj":"T13","obj":"ChemicalEntity"},{"id":"A10","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_47802"},{"id":"A29554","pred":"#label","subj":"T7","obj":"D012640"},{"subj":"T28","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T26","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T24","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T22","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T20","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T19","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T17","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T16","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T14","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T13","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T11","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T10","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T9","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T8","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T6","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T1","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T30246","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4732","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T54817","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T5","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T78533","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T74100","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T2","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T27790","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T14038","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T36705","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T24825","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T44035","pred":"source","obj":"LitCoin-training-merged"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-sentences","color":"#ec9a93","default":true},{"id":"LitCoin-entities-OrganismTaxon-PD","color":"#93a6ec"},{"id":"LitCoin-entities","color":"#c0ec93"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#ec93da"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#93ece4"},{"id":"LitCoin-Disease-MeSH","color":"#ecca93"},{"id":"LitCoin_Mondo_095","color":"#b093ec"},{"id":"LitCoin-MeSH-Disease-2","color":"#93ec96"},{"id":"LitCoin-MONDO_bioort2019","color":"#ec93a9"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#93c3ec"},{"id":"LitCoin-NCBITaxon-2","color":"#ddec93"},{"id":"LitCoin-training-merged","color":"#e093ec"}]}]}}