PubMed:16920333
Annnotations
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-154 | Sentence | denotes | Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats. |
| T2 | 155-474 | Sentence | denotes | Eslicarbazepine acetate (BIA 2-093, S-(-)-10-acetoxy-10,11-dihydro-5H-dibenzo/b,f/azepine-5-carboxamide) is a novel antiepileptic drug, now in Phase III clinical trials, designed with the aim of improving efficacy and safety in comparison with the structurally related drugs carbamazepine (CBZ) and oxcarbazepine (OXC). |
| T3 | 475-694 | Sentence | denotes | We have studied the effects of oral treatment with eslicarbazepine acetate on a whole-animal model in which partial seizures can be elicited repeatedly on different days without changes in threshold or seizure patterns. |
| T4 | 695-845 | Sentence | denotes | In the animals treated with threshold doses of picrotoxin, the average number of seizures was 2.3+/-1.2, and average seizure duration was 39.5+/-8.4s. |
| T5 | 846-962 | Sentence | denotes | Pre-treatment with a dose of 30 mg/kg 2h before picrotoxin microperfusion prevented seizures in the 75% of the rats. |
| T6 | 963-1161 | Sentence | denotes | Lower doses (3 and 10mg/kg) did not suppress seizures, however, after administration of 10mg/kg, significant reductions in seizures duration (24.3+/-6.8s) and seizure number (1.6+/-0.34) were found. |
| T7 | 1162-1318 | Sentence | denotes | No adverse effects of eslicarbazepine acetate were observed in the behavioral/EEG patterns studied, including sleep/wakefulness cycle, at the doses studied. |
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 120-131 | OrganismTaxon | denotes | hippocampus | NCBItxid:72046 |
| T2 | 149-153 | OrganismTaxon | denotes | rats | NCBItxid:10118|NCBItxid:10116|NCBItxid:10114 |
| T5 | 957-961 | OrganismTaxon | denotes | rats | NCBItxid:10118|NCBItxid:10116|NCBItxid:10114 |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 3353 | 25-48 | ChemicalEntity | denotes | eslicarbazepine acetate | MESH:C416835 |
| 3354 | 50-59 | ChemicalEntity | denotes | BIA 2-093 | MESH:C416835 |
| 3355 | 64-72 | DiseaseOrPhenotypicFeature | denotes | seizures | MESH:D012640 |
| 3356 | 102-112 | ChemicalEntity | denotes | picrotoxin | MESH:D010852 |
| 3357 | 149-153 | OrganismTaxon | denotes | rats | NCBITaxon:10116 |
| 3358 | 155-178 | ChemicalEntity | denotes | Eslicarbazepine acetate | MESH:C416835 |
| 3359 | 180-189 | ChemicalEntity | denotes | BIA 2-093 | MESH:C416835 |
| 3360 | 191-258 | ChemicalEntity | denotes | S-(-)-10-acetoxy-10,11-dihydro-5H-dibenzo/b,f/azepine-5-carboxamide | MESH:C416835 |
| 3361 | 271-289 | ChemicalEntity | denotes | antiepileptic drug | MESH:D000927 |
| 3362 | 430-443 | ChemicalEntity | denotes | carbamazepine | MESH:D002220 |
| 3363 | 445-448 | ChemicalEntity | denotes | CBZ | MESH:D002220 |
| 3364 | 454-467 | ChemicalEntity | denotes | oxcarbazepine | MESH:C036006 |
| 3365 | 469-472 | ChemicalEntity | denotes | OXC | MESH:C036006 |
| 3366 | 526-549 | ChemicalEntity | denotes | eslicarbazepine acetate | MESH:C416835 |
| 3367 | 591-599 | DiseaseOrPhenotypicFeature | denotes | seizures | MESH:D012640 |
| 3368 | 677-684 | DiseaseOrPhenotypicFeature | denotes | seizure | MESH:D012640 |
| 3369 | 742-752 | ChemicalEntity | denotes | picrotoxin | MESH:D010852 |
| 3370 | 776-784 | DiseaseOrPhenotypicFeature | denotes | seizures | MESH:D012640 |
| 3371 | 812-819 | DiseaseOrPhenotypicFeature | denotes | seizure | MESH:D012640 |
| 3372 | 894-904 | ChemicalEntity | denotes | picrotoxin | MESH:D010852 |
| 3373 | 930-938 | DiseaseOrPhenotypicFeature | denotes | seizures | MESH:D012640 |
| 3374 | 957-961 | OrganismTaxon | denotes | rats | NCBITaxon:10116 |
| 3375 | 1008-1016 | DiseaseOrPhenotypicFeature | denotes | seizures | MESH:D012640 |
| 3376 | 1086-1094 | DiseaseOrPhenotypicFeature | denotes | seizures | MESH:D012640 |
| 3377 | 1122-1129 | DiseaseOrPhenotypicFeature | denotes | seizure | MESH:D012640 |
| 3378 | 1184-1207 | ChemicalEntity | denotes | eslicarbazepine acetate | MESH:C416835 |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 41-48 | GeneOrGeneProduct | denotes | acetate |
| T2 | 50-55 | GeneOrGeneProduct | denotes | BIA 2 |
| T3 | 64-72 | GeneOrGeneProduct | denotes | seizures |
| T4 | 73-80 | GeneOrGeneProduct | denotes | induced |
| T5 | 171-178 | GeneOrGeneProduct | denotes | acetate |
| T6 | 180-185 | GeneOrGeneProduct | denotes | BIA 2 |
| T7 | 265-270 | GeneOrGeneProduct | denotes | novel |
| T8 | 304-307 | GeneOrGeneProduct | denotes | III |
| T9 | 542-549 | GeneOrGeneProduct | denotes | acetate |
| T10 | 591-599 | GeneOrGeneProduct | denotes | seizures |
| T11 | 677-684 | GeneOrGeneProduct | denotes | seizure |
| T12 | 776-784 | GeneOrGeneProduct | denotes | seizures |
| T13 | 789-792 | GeneOrGeneProduct | denotes | 2.3 |
| T14 | 812-819 | GeneOrGeneProduct | denotes | seizure |
| T15 | 878-880 | GeneOrGeneProduct | denotes | mg |
| T16 | 930-938 | GeneOrGeneProduct | denotes | seizures |
| T17 | 976-981 | GeneOrGeneProduct | denotes | 3 and |
| T18 | 1008-1016 | GeneOrGeneProduct | denotes | seizures |
| T19 | 1086-1094 | GeneOrGeneProduct | denotes | seizures |
| T20 | 1122-1129 | GeneOrGeneProduct | denotes | seizure |
| T21 | 1200-1207 | GeneOrGeneProduct | denotes | acetate |
| T22 | 1229-1239 | GeneOrGeneProduct | denotes | behavioral |
| T23 | 1278-1289 | GeneOrGeneProduct | denotes | wakefulness |
| T24 | 1290-1295 | GeneOrGeneProduct | denotes | cycle |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 50-55 | GeneOrGeneProduct | denotes | BIA 2 |
| T2 | 64-72 | GeneOrGeneProduct | denotes | seizures |
| T3 | 180-185 | GeneOrGeneProduct | denotes | BIA 2 |
| T4 | 265-270 | GeneOrGeneProduct | denotes | novel |
| T5 | 591-599 | GeneOrGeneProduct | denotes | seizures |
| T6 | 677-684 | GeneOrGeneProduct | denotes | seizure |
| T7 | 776-784 | GeneOrGeneProduct | denotes | seizures |
| T8 | 812-819 | GeneOrGeneProduct | denotes | seizure |
| T9 | 930-938 | GeneOrGeneProduct | denotes | seizures |
| T10 | 1008-1016 | GeneOrGeneProduct | denotes | seizures |
| T11 | 1086-1094 | GeneOrGeneProduct | denotes | seizures |
| T12 | 1122-1129 | GeneOrGeneProduct | denotes | seizure |
| T13 | 1290-1295 | GeneOrGeneProduct | denotes | cycle |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 64-72 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T2 | 583-599 | DiseaseOrPhenotypicFeature | denotes | partial seizures | D012640 |
| T3 | 677-684 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 |
| T4 | 776-784 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T5 | 812-819 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 |
| T6 | 930-938 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T7 | 1008-1016 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T8 | 1086-1094 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T9 | 1122-1129 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 600-603 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 64-72 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T2 | 583-599 | DiseaseOrPhenotypicFeature | denotes | partial seizures | D012640 |
| T3 | 677-684 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 |
| T4 | 776-784 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T5 | 812-819 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 |
| T6 | 930-938 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T7 | 1008-1016 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T8 | 1086-1094 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T9 | 1122-1129 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 64-72 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T2 | 583-599 | DiseaseOrPhenotypicFeature | denotes | partial seizures | D012640 |
| T3 | 677-684 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 |
| T4 | 776-784 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T5 | 812-819 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 |
| T6 | 930-938 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T7 | 1008-1016 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T8 | 1086-1094 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 |
| T9 | 1122-1129 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 25-48 | ChemicalEntity | denotes | eslicarbazepine acetate | C416835|http://purl.obolibrary.org/obo/CHEBI_87016 |
| T3 | 50-59 | ChemicalEntity | denotes | BIA 2-093 | C416835 |
| T4 | 102-112 | ChemicalEntity | denotes | picrotoxin | D010852|http://purl.obolibrary.org/obo/CHEBI_134126 |
| T6 | 155-178 | ChemicalEntity | denotes | Eslicarbazepine acetate | C416835|http://purl.obolibrary.org/obo/CHEBI_87016 |
| T8 | 180-189 | ChemicalEntity | denotes | BIA 2-093 | C416835 |
| T9 | 200-207 | ChemicalEntity | denotes | acetoxy | http://purl.obolibrary.org/obo/CHEBI_48076 |
| T10 | 222-244 | ChemicalEntity | denotes | 5H-dibenzo/b,f/azepine | http://purl.obolibrary.org/obo/CHEBI_47802 |
| T11 | 247-258 | ChemicalEntity | denotes | carboxamide | http://purl.obolibrary.org/obo/CHEBI_37622|http://purl.obolibrary.org/obo/CHEBI_23004 |
| T13 | 271-289 | ChemicalEntity | denotes | antiepileptic drug | ChemicalEntity |
| T14 | 430-443 | ChemicalEntity | denotes | carbamazepine | D002220|http://purl.obolibrary.org/obo/CHEBI_3387 |
| T16 | 445-448 | ChemicalEntity | denotes | CBZ | D002220 |
| T17 | 454-467 | ChemicalEntity | denotes | oxcarbazepine | D000078330|http://purl.obolibrary.org/obo/CHEBI_7824 |
| T19 | 469-472 | ChemicalEntity | denotes | OXC | D000078330 |
| T20 | 526-549 | ChemicalEntity | denotes | eslicarbazepine acetate | C416835|http://purl.obolibrary.org/obo/CHEBI_87016 |
| T22 | 742-752 | ChemicalEntity | denotes | picrotoxin | D010852|http://purl.obolibrary.org/obo/CHEBI_134126 |
| T24 | 894-904 | ChemicalEntity | denotes | picrotoxin | D010852|http://purl.obolibrary.org/obo/CHEBI_134126 |
| T26 | 1184-1207 | ChemicalEntity | denotes | eslicarbazepine acetate | C416835|http://purl.obolibrary.org/obo/CHEBI_87016 |
| T28 | 1240-1243 | ChemicalEntity | denotes | EEG | http://purl.obolibrary.org/obo/CHEBI_73494 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 50-53 | OrganismTaxon | denotes | BIA |
| T2 | 149-153 | OrganismTaxon | denotes | rats |
| T3 | 180-183 | OrganismTaxon | denotes | BIA |
| T4 | 957-961 | OrganismTaxon | denotes | rats |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T28 | 1240-1243 | ChemicalEntity | denotes | EEG | http://purl.obolibrary.org/obo/CHEBI_73494 | |
| T26 | 1184-1207 | ChemicalEntity | denotes | eslicarbazepine acetate | http://purl.obolibrary.org/obo/CHEBI_87016|C416835 | |
| T24 | 894-904 | ChemicalEntity | denotes | picrotoxin | http://purl.obolibrary.org/obo/CHEBI_134126|D010852 | |
| T22 | 742-752 | ChemicalEntity | denotes | picrotoxin | http://purl.obolibrary.org/obo/CHEBI_134126|D010852 | |
| T20 | 526-549 | ChemicalEntity | denotes | eslicarbazepine acetate | C416835|http://purl.obolibrary.org/obo/CHEBI_87016 | |
| T19 | 469-472 | ChemicalEntity | denotes | OXC | D000078330 | |
| T17 | 454-467 | ChemicalEntity | denotes | oxcarbazepine | http://purl.obolibrary.org/obo/CHEBI_7824|D000078330 | |
| T16 | 445-448 | ChemicalEntity | denotes | CBZ | D002220 | |
| T14 | 430-443 | ChemicalEntity | denotes | carbamazepine | D002220|http://purl.obolibrary.org/obo/CHEBI_3387 | |
| T13 | 271-289 | ChemicalEntity | denotes | antiepileptic drug | ChemicalEntity | |
| T11 | 247-258 | ChemicalEntity | denotes | carboxamide | http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622 | |
| T10 | 222-244 | ChemicalEntity | denotes | 5H-dibenzo/b,f/azepine | http://purl.obolibrary.org/obo/CHEBI_47802 | |
| T9 | 200-207 | ChemicalEntity | denotes | acetoxy | http://purl.obolibrary.org/obo/CHEBI_48076 | |
| T8 | 180-189 | ChemicalEntity | denotes | BIA 2-093 | C416835 | |
| T6 | 155-178 | ChemicalEntity | denotes | Eslicarbazepine acetate | http://purl.obolibrary.org/obo/CHEBI_87016|C416835 | |
| T4 | 102-112 | ChemicalEntity | denotes | picrotoxin | http://purl.obolibrary.org/obo/CHEBI_134126|D010852 | |
| T3 | 50-59 | ChemicalEntity | denotes | BIA 2-093 | C416835 | |
| T1 | 25-48 | ChemicalEntity | denotes | eslicarbazepine acetate | http://purl.obolibrary.org/obo/CHEBI_87016|C416835 | |
| T30246 | 1122-1129 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 | |
| T4732 | 1086-1094 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 | |
| T7 | 1008-1016 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 | |
| T54817 | 930-938 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 | |
| T5 | 812-819 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 | |
| T78533 | 776-784 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 | |
| T74100 | 677-684 | DiseaseOrPhenotypicFeature | denotes | seizure | D012640 | |
| T2 | 583-599 | DiseaseOrPhenotypicFeature | denotes | partial seizures | D012640 | |
| T27790 | 64-72 | DiseaseOrPhenotypicFeature | denotes | seizures | D012640 | |
| T14038 | 957-961 | OrganismTaxon | denotes | rats | ||
| T36705 | 180-183 | OrganismTaxon | denotes | BIA | ||
| T24825 | 149-153 | OrganismTaxon | denotes | rats | ||
| T44035 | 50-53 | OrganismTaxon | denotes | BIA |