PubMed:16574813 / 876-1163 JSONTXT

{"project":"Glycan-Motif","denotations":[{"id":"T7","span":{"begin":41,"end":44},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T8","span":{"begin":41,"end":44},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T7","span":{"begin":41,"end":44},"obj":"Glycan_Motif"}],"attributes":[{"id":"A7","pred":"image","subj":"T7","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK"},{"id":"A8","pred":"image","subj":"T7","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T7","span":{"begin":41,"end":44},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T8","span":{"begin":41,"end":44},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":268,"end":273},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"PubmedHPO","denotations":[{"id":"T4","span":{"begin":268,"end":280},"obj":"HP_0003003"},{"id":"T5","span":{"begin":268,"end":280},"obj":"HP_0100273"},{"id":"T6","span":{"begin":274,"end":280},"obj":"HP_0002664"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"uniprot-human","denotations":[{"id":"T3","span":{"begin":192,"end":196},"obj":"http://www.uniprot.org/uniprot/P60484"},{"id":"T9","span":{"begin":124,"end":127},"obj":"http://www.uniprot.org/uniprot/P38936"},{"id":"T14","span":{"begin":128,"end":132},"obj":"http://www.uniprot.org/uniprot/P38936"},{"id":"T30","span":{"begin":224,"end":226},"obj":"http://www.uniprot.org/uniprot/Q86U18"},{"id":"T35","span":{"begin":224,"end":226},"obj":"http://www.uniprot.org/uniprot/P01298"},{"id":"T41","span":{"begin":234,"end":238},"obj":"http://www.uniprot.org/uniprot/Q13301"},{"id":"T42","span":{"begin":78,"end":84},"obj":"http://www.uniprot.org/uniprot/P12004"},{"id":"T45","span":{"begin":119,"end":122},"obj":"http://www.uniprot.org/uniprot/P35790"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"uniprot-mouse","denotations":[{"id":"T2","span":{"begin":124,"end":127},"obj":"http://www.uniprot.org/uniprot/P63028"},{"id":"T8","span":{"begin":124,"end":127},"obj":"http://www.uniprot.org/uniprot/Q62092"},{"id":"T14","span":{"begin":124,"end":127},"obj":"http://www.uniprot.org/uniprot/P39689"},{"id":"T20","span":{"begin":78,"end":84},"obj":"http://www.uniprot.org/uniprot/P17918"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T5","span":{"begin":274,"end":280},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/6754"},{"id":"T6","span":{"begin":281,"end":286},"obj":"http://purl.bioontology.org/ontology/STY/T025"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GO-BP","denotations":[{"id":"T20","span":{"begin":248,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T23","span":{"begin":78,"end":84},"obj":"http://purl.obolibrary.org/obo/GO_0016538"},{"id":"T26","span":{"begin":103,"end":106},"obj":"http://purl.obolibrary.org/obo/GO_0004693"},{"id":"T27","span":{"begin":103,"end":117},"obj":"http://purl.obolibrary.org/obo/GO_0004861"},{"id":"T28","span":{"begin":103,"end":117},"obj":"http://purl.obolibrary.org/obo/GO_0045736"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GO-CC","denotations":[{"id":"T6","span":{"begin":281,"end":286},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"UBERON-AE","denotations":[{"id":"T1","span":{"begin":268,"end":273},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"EDAM-topics","denotations":[{"id":"T13","span":{"begin":25,"end":30},"obj":"http://edamontology.org/topic_3678"},{"id":"T14","span":{"begin":177,"end":184},"obj":"http://edamontology.org/topic_0078"},{"id":"T15","span":{"begin":274,"end":280},"obj":"http://edamontology.org/topic_2640"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"EDAM-DFO","denotations":[{"id":"T4","span":{"begin":177,"end":184},"obj":"http://edamontology.org/format_1208"},{"id":"T5","span":{"begin":177,"end":184},"obj":"http://edamontology.org/data_1467"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"16574813-4#78#84#gene5111","span":{"begin":78,"end":84},"obj":"gene5111"},{"id":"16574813-4#128#132#gene1026","span":{"begin":128,"end":132},"obj":"gene1026"},{"id":"16574813-4#234#238#gene4193","span":{"begin":234,"end":238},"obj":"gene4193"},{"id":"16574813-4#268#280#diseaseC0007102","span":{"begin":268,"end":280},"obj":"diseaseC0007102"},{"id":"16574813-4#268#280#diseaseC0699790","span":{"begin":268,"end":280},"obj":"diseaseC0699790"},{"id":"16574813-4#268#280#diseaseC0007102","span":{"begin":268,"end":280},"obj":"diseaseC0007102"},{"id":"16574813-4#268#280#diseaseC0699790","span":{"begin":268,"end":280},"obj":"diseaseC0699790"},{"id":"16574813-4#268#280#diseaseC0007102","span":{"begin":268,"end":280},"obj":"diseaseC0007102"},{"id":"16574813-4#268#280#diseaseC0699790","span":{"begin":268,"end":280},"obj":"diseaseC0699790"}],"relations":[{"id":"78#84#gene5111268#280#diseaseC0007102","pred":"associated_with","subj":"16574813-4#78#84#gene5111","obj":"16574813-4#268#280#diseaseC0007102"},{"id":"78#84#gene5111268#280#diseaseC0699790","pred":"associated_with","subj":"16574813-4#78#84#gene5111","obj":"16574813-4#268#280#diseaseC0699790"},{"id":"78#84#gene5111268#280#diseaseC0007102","pred":"associated_with","subj":"16574813-4#78#84#gene5111","obj":"16574813-4#268#280#diseaseC0007102"},{"id":"78#84#gene5111268#280#diseaseC0699790","pred":"associated_with","subj":"16574813-4#78#84#gene5111","obj":"16574813-4#268#280#diseaseC0699790"},{"id":"78#84#gene5111268#280#diseaseC0007102","pred":"associated_with","subj":"16574813-4#78#84#gene5111","obj":"16574813-4#268#280#diseaseC0007102"},{"id":"78#84#gene5111268#280#diseaseC0699790","pred":"associated_with","subj":"16574813-4#78#84#gene5111","obj":"16574813-4#268#280#diseaseC0699790"},{"id":"128#132#gene1026268#280#diseaseC0007102","pred":"associated_with","subj":"16574813-4#128#132#gene1026","obj":"16574813-4#268#280#diseaseC0007102"},{"id":"128#132#gene1026268#280#diseaseC0699790","pred":"associated_with","subj":"16574813-4#128#132#gene1026","obj":"16574813-4#268#280#diseaseC0699790"},{"id":"128#132#gene1026268#280#diseaseC0007102","pred":"associated_with","subj":"16574813-4#128#132#gene1026","obj":"16574813-4#268#280#diseaseC0007102"},{"id":"128#132#gene1026268#280#diseaseC0699790","pred":"associated_with","subj":"16574813-4#128#132#gene1026","obj":"16574813-4#268#280#diseaseC0699790"},{"id":"128#132#gene1026268#280#diseaseC0007102","pred":"associated_with","subj":"16574813-4#128#132#gene1026","obj":"16574813-4#268#280#diseaseC0007102"},{"id":"128#132#gene1026268#280#diseaseC0699790","pred":"associated_with","subj":"16574813-4#128#132#gene1026","obj":"16574813-4#268#280#diseaseC0699790"},{"id":"234#238#gene4193268#280#diseaseC0007102","pred":"associated_with","subj":"16574813-4#234#238#gene4193","obj":"16574813-4#268#280#diseaseC0007102"},{"id":"234#238#gene4193268#280#diseaseC0699790","pred":"associated_with","subj":"16574813-4#234#238#gene4193","obj":"16574813-4#268#280#diseaseC0699790"},{"id":"234#238#gene4193268#280#diseaseC0007102","pred":"associated_with","subj":"16574813-4#234#238#gene4193","obj":"16574813-4#268#280#diseaseC0007102"},{"id":"234#238#gene4193268#280#diseaseC0699790","pred":"associated_with","subj":"16574813-4#234#238#gene4193","obj":"16574813-4#268#280#diseaseC0699790"},{"id":"234#238#gene4193268#280#diseaseC0007102","pred":"associated_with","subj":"16574813-4#234#238#gene4193","obj":"16574813-4#268#280#diseaseC0007102"},{"id":"234#238#gene4193268#280#diseaseC0699790","pred":"associated_with","subj":"16574813-4#234#238#gene4193","obj":"16574813-4#268#280#diseaseC0699790"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlycoBiology-MAT","denotations":[{"id":"T1","span":{"begin":268,"end":273},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T5","span":{"begin":0,"end":287},"obj":"Sentence"},{"id":"T5","span":{"begin":0,"end":287},"obj":"Sentence"},{"id":"T5","span":{"begin":0,"end":287},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":268,"end":273},"obj":"http://purl.obolibrary.org/obo/UBERON_0001155"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":268,"end":273},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000526"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"mondo_disease","denotations":[{"id":"T5","span":{"begin":268,"end":280},"obj":"Disease"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0021063"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T4","span":{"begin":41,"end":44},"obj":"Glycan"}],"attributes":[{"id":"A4","pred":"glycosmos_id","subj":"T4","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A14","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlyCosmos15-HP","denotations":[{"id":"T5","span":{"begin":268,"end":280},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"HP:0003003"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlyCosmos15-MONDO","denotations":[{"id":"T5","span":{"begin":268,"end":280},"obj":"Disease"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0021063"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlyCosmos15-CL","denotations":[{"id":"T2","span":{"begin":274,"end":286},"obj":"Cell"}],"attributes":[{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0001064"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlyCosmos15-UBERON","denotations":[{"id":"T3","span":{"begin":268,"end":273},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlyCosmos15-MAT","denotations":[{"id":"T1","span":{"begin":268,"end":273},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000526"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T5","span":{"begin":0,"end":287},"obj":"Sentence"},{"id":"T5","span":{"begin":0,"end":287},"obj":"Sentence"},{"id":"T5","span":{"begin":0,"end":287},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T5","span":{"begin":0,"end":287},"obj":"Sentence"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T4","span":{"begin":41,"end":44},"obj":"Glycan"}],"attributes":[{"id":"A4","pred":"glycosmos_id","subj":"T4","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A14","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T3","span":{"begin":268,"end":273},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"HP-phenotype","denotations":[{"id":"T5","span":{"begin":268,"end":280},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"HP:0003003"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}

{"project":"CL-cell","denotations":[{"id":"T2","span":{"begin":274,"end":286},"obj":"Cell"}],"attributes":[{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0001064"}],"text":"Results from our current study show that GM3 treatment dramatically increases cyclin-dependent kinase (CDK) inhibitor (CKI) p21(WAF1) expression through the accumulation of p53 protein by the PTEN-mediated inhibition of the PI-3K/AKT/MDM2 survival signaling in HCT116 colon cancer cells."}