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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-151 Sentence denotes Distinct patterns of germ-line deletions in MLH1 and MSH2: the implication of Alu repetitive element in the genetic etiology of Lynch syndrome (HNPCC).
T2 152-323 Sentence denotes A relatively high frequency of germ-line genomic rearrangements in MLH1 and MSH2 has been reported among Lynch Syndrome (HNPCC) patients from different ethnic populations.
T3 324-471 Sentence denotes To investigate the underlying molecular mechanisms, we characterized the DNA breakpoints of 11 germ-line deletions, six for MLH1 and five for MSH2.
T4 472-528 Sentence denotes Distinct deletion patterns were found for the two genes.
T5 529-656 Sentence denotes The five cases of MSH2 deletions result exclusively from intragenic unequal recombination mediated by repetitive Alu sequences.
T6 657-788 Sentence denotes In contrast, five out of the six MLH1 deletions are due to recombinations involving sequences of no significant homology (P=0.015).
T7 789-1037 Sentence denotes A detailed analysis of the DNA breakpoints in the two genes, previously characterized by other groups, validated the observation that Alu-mediated unequal recombination is the main type of deletion in MSH2 (n=34), but not in MLH1 (n=21) (P<0.0001).
T8 1038-1213 Sentence denotes Plotting the distribution of known DNA breakpoints among the introns of the two genes showed that, the highest breakpoint density is co-localized with the highest Alu density.
T9 1214-1392 Sentence denotes Our study suggests that Alu is a promoting factor for the genomic recombinations in both MLH1 and MSH2, and the local Alu density may be involved in shaping the deletion pattern.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
2819 44-48 GeneOrGeneProduct denotes MLH1 NCBIGene:4292
2820 53-57 GeneOrGeneProduct denotes MSH2 NCBIGene:4436
2821 128-142 DiseaseOrPhenotypicFeature denotes Lynch syndrome MESH:D003123
2822 144-149 DiseaseOrPhenotypicFeature denotes HNPCC MESH:D003123
2823 219-223 GeneOrGeneProduct denotes MLH1 NCBIGene:4292
2824 228-232 GeneOrGeneProduct denotes MSH2 NCBIGene:4436
2825 257-271 DiseaseOrPhenotypicFeature denotes Lynch Syndrome MESH:D003123
2826 273-278 DiseaseOrPhenotypicFeature denotes HNPCC MESH:D003123
2827 280-288 OrganismTaxon denotes patients NCBITaxon:9606
2828 448-452 GeneOrGeneProduct denotes MLH1 NCBIGene:4292
2829 466-470 GeneOrGeneProduct denotes MSH2 NCBIGene:4436
2830 547-551 GeneOrGeneProduct denotes MSH2 NCBIGene:4436
2831 690-694 GeneOrGeneProduct denotes MLH1 NCBIGene:4292
2832 990-994 GeneOrGeneProduct denotes MSH2 NCBIGene:4436
2833 1014-1018 GeneOrGeneProduct denotes MLH1 NCBIGene:4292
2834 1303-1307 GeneOrGeneProduct denotes MLH1 NCBIGene:4292
2835 1312-1316 GeneOrGeneProduct denotes MSH2 NCBIGene:4436

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 128-142 DiseaseOrPhenotypicFeature denotes Lynch syndrome 0005835
T2 257-271 DiseaseOrPhenotypicFeature denotes Lynch Syndrome 0005835

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 44-48 GeneOrGeneProduct denotes MLH1
T2 53-57 GeneOrGeneProduct denotes MSH2
T3 134-142 GeneOrGeneProduct denotes syndrome
T4 144-149 GeneOrGeneProduct denotes HNPCC
T5 165-169 GeneOrGeneProduct denotes high
T6 170-179 GeneOrGeneProduct denotes frequency
T7 219-223 GeneOrGeneProduct denotes MLH1
T8 228-232 GeneOrGeneProduct denotes MSH2
T9 263-271 GeneOrGeneProduct denotes Syndrome
T10 273-278 GeneOrGeneProduct denotes HNPCC
T11 448-452 GeneOrGeneProduct denotes MLH1
T12 466-470 GeneOrGeneProduct denotes MSH2
T13 547-551 GeneOrGeneProduct denotes MSH2
T14 605-618 GeneOrGeneProduct denotes recombination
T15 690-694 GeneOrGeneProduct denotes MLH1
T16 716-730 GeneOrGeneProduct denotes recombinations
T17 878-883 GeneOrGeneProduct denotes other
T18 944-957 GeneOrGeneProduct denotes recombination
T19 990-994 GeneOrGeneProduct denotes MSH2
T20 1014-1018 GeneOrGeneProduct denotes MLH1
T21 1257-1263 GeneOrGeneProduct denotes factor
T22 1280-1294 GeneOrGeneProduct denotes recombinations
T23 1303-1307 GeneOrGeneProduct denotes MLH1
T24 1312-1316 GeneOrGeneProduct denotes MSH2

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 21-25 GeneOrGeneProduct denotes germ
T2 26-30 GeneOrGeneProduct denotes line
T3 44-48 GeneOrGeneProduct denotes MLH1
T4 53-57 GeneOrGeneProduct denotes MSH2
T5 134-142 GeneOrGeneProduct denotes syndrome
T6 144-149 GeneOrGeneProduct denotes HNPCC
T7 165-169 GeneOrGeneProduct denotes high
T8 170-179 GeneOrGeneProduct denotes frequency
T9 183-187 GeneOrGeneProduct denotes germ
T10 188-192 GeneOrGeneProduct denotes line
T11 219-223 GeneOrGeneProduct denotes MLH1
T12 228-232 GeneOrGeneProduct denotes MSH2
T13 263-271 GeneOrGeneProduct denotes Syndrome
T14 273-278 GeneOrGeneProduct denotes HNPCC
T15 419-423 GeneOrGeneProduct denotes germ
T16 424-428 GeneOrGeneProduct denotes line
T17 448-452 GeneOrGeneProduct denotes MLH1
T18 466-470 GeneOrGeneProduct denotes MSH2
T19 538-543 GeneOrGeneProduct denotes cases
T20 547-551 GeneOrGeneProduct denotes MSH2
T21 605-618 GeneOrGeneProduct denotes recombination
T22 619-627 GeneOrGeneProduct denotes mediated
T23 660-668 GeneOrGeneProduct denotes contrast
T24 675-678 GeneOrGeneProduct denotes out
T25 690-694 GeneOrGeneProduct denotes MLH1
T26 716-730 GeneOrGeneProduct denotes recombinations
T27 769-777 GeneOrGeneProduct denotes homology
T28 878-883 GeneOrGeneProduct denotes other
T29 927-935 GeneOrGeneProduct denotes mediated
T30 944-957 GeneOrGeneProduct denotes recombination
T31 965-969 GeneOrGeneProduct denotes main
T32 990-994 GeneOrGeneProduct denotes MSH2
T33 1014-1018 GeneOrGeneProduct denotes MLH1
T34 1020-1024 GeneOrGeneProduct denotes n=21
T35 1257-1263 GeneOrGeneProduct denotes factor
T36 1280-1294 GeneOrGeneProduct denotes recombinations
T37 1303-1307 GeneOrGeneProduct denotes MLH1
T38 1312-1316 GeneOrGeneProduct denotes MSH2

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 128-142 DiseaseOrPhenotypicFeature denotes Lynch syndrome D003123
T2 144-149 DiseaseOrPhenotypicFeature denotes HNPCC DISEASE
T3 257-271 DiseaseOrPhenotypicFeature denotes Lynch Syndrome D003123
T4 273-278 DiseaseOrPhenotypicFeature denotes HNPCC DISEASE

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 44-48 GeneOrGeneProduct denotes MLH1
T2 53-57 GeneOrGeneProduct denotes MSH2
T3 219-223 GeneOrGeneProduct denotes MLH1
T4 228-232 GeneOrGeneProduct denotes MSH2
T5 448-452 GeneOrGeneProduct denotes MLH1
T6 466-470 GeneOrGeneProduct denotes MSH2
T7 547-551 GeneOrGeneProduct denotes MSH2
T8 690-694 GeneOrGeneProduct denotes MLH1
T9 990-994 GeneOrGeneProduct denotes MSH2
T10 1014-1018 GeneOrGeneProduct denotes MLH1
T11 1303-1307 GeneOrGeneProduct denotes MLH1
T12 1312-1316 GeneOrGeneProduct denotes MSH2

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 128-142 DiseaseOrPhenotypicFeature denotes Lynch syndrome 0005835
T2 144-149 DiseaseOrPhenotypicFeature denotes HNPCC 0018630
T3 257-271 DiseaseOrPhenotypicFeature denotes Lynch Syndrome 0005835
T4 273-278 DiseaseOrPhenotypicFeature denotes HNPCC 0018630

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 128-142 DiseaseOrPhenotypicFeature denotes Lynch syndrome D003123
T2 144-149 DiseaseOrPhenotypicFeature denotes HNPCC DISEASE
T3 257-271 DiseaseOrPhenotypicFeature denotes Lynch Syndrome D003123
T4 273-278 DiseaseOrPhenotypicFeature denotes HNPCC DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 128-142 DiseaseOrPhenotypicFeature denotes Lynch syndrome D003123
T2 144-149 DiseaseOrPhenotypicFeature denotes HNPCC DISEASE
T3 257-271 DiseaseOrPhenotypicFeature denotes Lynch Syndrome D003123
T4 273-278 DiseaseOrPhenotypicFeature denotes HNPCC DISEASE

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 280-288 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label
T12 1312-1316 GeneOrGeneProduct denotes MSH2
T11 1303-1307 GeneOrGeneProduct denotes MLH1
T10 1014-1018 GeneOrGeneProduct denotes MLH1
T9 990-994 GeneOrGeneProduct denotes MSH2
T8 690-694 GeneOrGeneProduct denotes MLH1
T7 547-551 GeneOrGeneProduct denotes MSH2
T6 466-470 GeneOrGeneProduct denotes MSH2
T5 448-452 GeneOrGeneProduct denotes MLH1
T4 228-232 GeneOrGeneProduct denotes MSH2
T3 219-223 GeneOrGeneProduct denotes MLH1
T2 53-57 GeneOrGeneProduct denotes MSH2
T1 44-48 GeneOrGeneProduct denotes MLH1
T78466 273-278 DiseaseOrPhenotypicFeature denotes HNPCC DISEASE
T52266 257-271 DiseaseOrPhenotypicFeature denotes Lynch Syndrome D003123
T50621 144-149 DiseaseOrPhenotypicFeature denotes HNPCC DISEASE
T52589 128-142 DiseaseOrPhenotypicFeature denotes Lynch syndrome D003123
T18884 280-288 OrganismTaxon denotes patients

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
16541406-0#44#48#gene4292 44-48 gene4292 denotes MLH1
16541406-0#53#57#gene4436 53-57 gene4436 denotes MSH2
16541406-0#128#142#diseaseC1333990 128-142 diseaseC1333990 denotes Lynch syndrome
16541406-0#144#149#diseaseC1333990 144-149 diseaseC1333990 denotes HNPCC
16541406-0#128#142#diseaseC1333990 128-142 diseaseC1333990 denotes Lynch syndrome
16541406-0#144#149#diseaseC1333990 144-149 diseaseC1333990 denotes HNPCC
44#48#gene4292128#142#diseaseC1333990 16541406-0#44#48#gene4292 16541406-0#128#142#diseaseC1333990 associated_with MLH1,Lynch syndrome
44#48#gene4292144#149#diseaseC1333990 16541406-0#44#48#gene4292 16541406-0#144#149#diseaseC1333990 associated_with MLH1,HNPCC
44#48#gene4292128#142#diseaseC1333990 16541406-0#44#48#gene4292 16541406-0#128#142#diseaseC1333990 associated_with MLH1,Lynch syndrome
44#48#gene4292144#149#diseaseC1333990 16541406-0#44#48#gene4292 16541406-0#144#149#diseaseC1333990 associated_with MLH1,HNPCC
53#57#gene4436128#142#diseaseC1333990 16541406-0#53#57#gene4436 16541406-0#128#142#diseaseC1333990 associated_with MSH2,Lynch syndrome
53#57#gene4436144#149#diseaseC1333990 16541406-0#53#57#gene4436 16541406-0#144#149#diseaseC1333990 associated_with MSH2,HNPCC
53#57#gene4436128#142#diseaseC1333990 16541406-0#53#57#gene4436 16541406-0#128#142#diseaseC1333990 associated_with MSH2,Lynch syndrome
53#57#gene4436144#149#diseaseC1333990 16541406-0#53#57#gene4436 16541406-0#144#149#diseaseC1333990 associated_with MSH2,HNPCC

DisGeNET

Id Subject Object Predicate Lexical cue
T0 219-223 gene:4292 denotes MLH1
T1 257-271 disease:C1333990 denotes Lynch Syndrome
T2 219-223 gene:4292 denotes MLH1
T3 273-278 disease:C1333990 denotes HNPCC
T4 228-232 gene:4436 denotes MSH2
T5 257-271 disease:C1333990 denotes Lynch Syndrome
T6 228-232 gene:4436 denotes MSH2
T7 273-278 disease:C1333990 denotes HNPCC
R1 T0 T1 associated_with MLH1,Lynch Syndrome
R2 T2 T3 associated_with MLH1,HNPCC
R3 T4 T5 associated_with MSH2,Lynch Syndrome
R4 T6 T7 associated_with MSH2,HNPCC