PubMed:16446133 JSONTXT

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":21,"end":25},"obj":"gene:627"},{"id":"T1","span":{"begin":29,"end":42},"obj":"disease:C0035372"},{"id":"T2","span":{"begin":21,"end":25},"obj":"gene:497258"},{"id":"T3","span":{"begin":29,"end":42},"obj":"disease:C0035372"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"The ups and downs of BDNF in Rett syndrome.\nRett syndrome (RTT) is an X-linked postnatal neurodevelopmental disorder, which is primarily caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2). A number of MeCP2 target genes have been identified, including the neurotrophic factor BDNF; however, the functional relevance of these targets has not been established. In this issue of Neuron, Chang et al. provide the first in vivo evidence for a functional interaction between BDNF and MeCP2."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"16446133-0#21#25#gene627","span":{"begin":21,"end":25},"obj":"gene627"},{"id":"16446133-0#29#42#diseaseC0035372","span":{"begin":29,"end":42},"obj":"diseaseC0035372"},{"id":"16446133-1#164#169#gene4204","span":{"begin":208,"end":213},"obj":"gene4204"},{"id":"16446133-1#0#13#diseaseC0035372","span":{"begin":44,"end":57},"obj":"diseaseC0035372"}],"relations":[{"id":"21#25#gene62729#42#diseaseC0035372","pred":"associated_with","subj":"16446133-0#21#25#gene627","obj":"16446133-0#29#42#diseaseC0035372"},{"id":"164#169#gene42040#13#diseaseC0035372","pred":"associated_with","subj":"16446133-1#164#169#gene4204","obj":"16446133-1#0#13#diseaseC0035372"}],"text":"The ups and downs of BDNF in Rett syndrome.\nRett syndrome (RTT) is an X-linked postnatal neurodevelopmental disorder, which is primarily caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2). A number of MeCP2 target genes have been identified, including the neurotrophic factor BDNF; however, the functional relevance of these targets has not been established. In this issue of Neuron, Chang et al. provide the first in vivo evidence for a functional interaction between BDNF and MeCP2."}