PubMed:16445891 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":115},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":116,"end":324},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":325,"end":653},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":115},"obj":"Sentence"},{"id":"T2","span":{"begin":116,"end":324},"obj":"Sentence"},{"id":"T3","span":{"begin":325,"end":653},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Artificial N-functionalized UDP-glucosamine analogues as modified substrates for N-acetylglucosaminyl transferases.\nAnalogues of UDP-GlcNAc modified at the 2-acetamido group of the GlcNAc moiety were prepared in order to study their role in the mechanism of N-acetylglucosaminyl transferase mediated glycosylation reactions. The structural analogues with N-formyl-, N-propionyl-, N-butyryl- and N-isobutyryl-groups were synthesized, utilizing the morpholidate coupling method starting from d-glucosaminyl-1-phosphate after selective N-acylation of its amino group with the appropriate N-acyloxysuccinimide esters as well as a chlorinated formylformiate."}

{"project":"NGLY1-deficiency","denotations":[{"id":"PD-NGLY1-deficiency-B_T1","span":{"begin":81,"end":101},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T2","span":{"begin":133,"end":139},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T3","span":{"begin":181,"end":187},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T4","span":{"begin":258,"end":278},"obj":"chem:24139"}],"namespaces":[{"prefix":"hgnc","uri":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:"},{"prefix":"omim","uri":"https://www.omim.org/entry/"},{"prefix":"chem","uri":"https://pubchem.ncbi.nlm.nih.gov/compound/"}],"text":"Artificial N-functionalized UDP-glucosamine analogues as modified substrates for N-acetylglucosaminyl transferases.\nAnalogues of UDP-GlcNAc modified at the 2-acetamido group of the GlcNAc moiety were prepared in order to study their role in the mechanism of N-acetylglucosaminyl transferase mediated glycosylation reactions. The structural analogues with N-formyl-, N-propionyl-, N-butyryl- and N-isobutyryl-groups were synthesized, utilizing the morpholidate coupling method starting from d-glucosaminyl-1-phosphate after selective N-acylation of its amino group with the appropriate N-acyloxysuccinimide esters as well as a chlorinated formylformiate."}