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PubMed:16434401 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T3 58-61 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T5 112-124 Glycan_Motif denotes Sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T6 266-269 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T8 301-312 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T9 329-343 Glycan_Motif denotes 9-O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74121RX
T10 340-343 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T12 345-351 Glycan_Motif denotes 9AcGD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH
T13 486-489 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T15 559-562 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T17 695-698 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T19 726-729 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T21 782-785 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T23 868-874 Glycan_Motif denotes 9AcGD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH
T24 929-932 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T26 955-961 Glycan_Motif denotes 9AcGD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH
T27 1247-1250 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T29 1345-1348 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T31 1521-1524 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T33 1647-1650 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T35 1705-1708 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T37 1943-1954 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 49-52 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T2 49-52 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T3 58-61 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T4 58-61 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T5 112-124 https://glytoucan.org/Structures/Glycans/G81533KY denotes Sialic acids
T6 266-269 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T7 266-269 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T8 301-312 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T9 329-343 https://glytoucan.org/Structures/Glycans/G74121RX denotes 9-O-acetyl-GD3
T10 340-343 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T11 340-343 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T12 486-489 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T13 486-489 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T14 559-562 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T15 559-562 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T16 695-698 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T17 695-698 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T18 726-729 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T19 726-729 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T20 782-785 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T21 782-785 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T22 929-932 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T23 929-932 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T24 1247-1250 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T25 1247-1250 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T26 1345-1348 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T27 1345-1348 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T28 1521-1524 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T29 1521-1524 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T30 1647-1650 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T31 1647-1650 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T32 1705-1708 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T33 1705-1708 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T34 1943-1954 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

sentences

Id Subject Object Predicate Lexical cue
T1 0-53 Sentence denotes 9-O-acetylation of exogenously added ganglioside GD3.
T2 54-111 Sentence denotes The GD3 molecule induces its own O-acetylation machinery.
T3 112-215 Sentence denotes Sialic acids are sometimes 9-O-acetylated in a developmentally regulated and cell-type-specific manner.
T4 216-418 Sentence denotes Cells naturally expressing the disialoganglioside GD3 often O-acetylate the terminal sialic acid residue, giving 9-O-acetyl-GD3 (9AcGD3), a marker of neural differentiation and malignant transformation.
T5 419-563 Sentence denotes We also reported that Chinese hamster ovary cells transfected with GD3 synthase can spontaneously O-acetylate some of the newly synthesized GD3.
T6 564-746 Sentence denotes It is unclear whether such phenomena result from induction of the 9-O-acetylation machinery and whether induction is caused by the GD3 synthase protein or by the GD3 molecule itself.
T7 747-911 Sentence denotes We now show that exogenously added GD3 rapidly incorporates into the plasma membrane of Chinese hamster ovary cells, and 9AcGD3 is detected after approximately 6 h.
T8 912-1001 Sentence denotes The incorporated GD3 and newly synthesized 9AcGD3 have a half-life of approximately 24 h.
T9 1002-1086 Sentence denotes This phenomenon is also seen in other cell types, such as human diploid fibroblasts.
T10 1087-1265 Sentence denotes Inhibitors of gene transcription, protein translation, or endoplasmic reticulum-to-Golgi transport each prevent induction of 9-O-acetylation, without affecting GD3 incorporation.
T11 1266-1390 Sentence denotes Inhibition of the initial clathrin-independent internalization of incorporated GD3 also blocks induction of 9-O-acetylation.
T12 1391-1525 Sentence denotes Thus, new synthesis of one or more components of the 9-O-acetylation machinery is induced by incorporation and internalization of GD3.
T13 1526-1709 Sentence denotes Prepriming with structurally related gangliosides fails to accelerate the onset of 9-O-acetylation of subsequently added GD3, indicating a requirement for specific recognition of GD3.
T14 1710-1969 Sentence denotes To our knowledge, this is the first example wherein a newly expressed or exogenously introduced ganglioside induces de novo synthesis of an enzymatic machinery to modify itself, and the first evidence for a mechanism of induction of sialic acid O-acetylation.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 329-343 GlycoEpitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2 58-61 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T3 266-269 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4 331-343 Glycan denotes O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T5 345-351 Glycan denotes 9AcGD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T6 486-489 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T7 559-562 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T8 695-698 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T9 726-729 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T10 782-785 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T11 868-874 Glycan denotes 9AcGD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T12 929-932 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T13 955-961 Glycan denotes 9AcGD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T14 1247-1250 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T15 1345-1348 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T16 1521-1524 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T17 1647-1650 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T18 1705-1708 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 329-343 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064
T2 345-351 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9AcGD3 http://www.glycoepitope.jp/epitopes/EP0064
T3 868-874 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9AcGD3 http://www.glycoepitope.jp/epitopes/EP0064
T4 955-961 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9AcGD3 http://www.glycoepitope.jp/epitopes/EP0064

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 441-456 OrganismTaxon denotes Chinese hamster 10029
T2 835-850 OrganismTaxon denotes Chinese hamster 10029
T3 1060-1065 OrganismTaxon denotes human 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1074-1085 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 457-462 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T2 816-831 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T3 851-856 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T4 1074-1085 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T5 1157-1166 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T6 1170-1175 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794

sentences

Id Subject Object Predicate Lexical cue
T1 0-53 Sentence denotes 9-O-acetylation of exogenously added ganglioside GD3.
T2 54-111 Sentence denotes The GD3 molecule induces its own O-acetylation machinery.
T3 112-215 Sentence denotes Sialic acids are sometimes 9-O-acetylated in a developmentally regulated and cell-type-specific manner.
T4 216-418 Sentence denotes Cells naturally expressing the disialoganglioside GD3 often O-acetylate the terminal sialic acid residue, giving 9-O-acetyl-GD3 (9AcGD3), a marker of neural differentiation and malignant transformation.
T5 419-563 Sentence denotes We also reported that Chinese hamster ovary cells transfected with GD3 synthase can spontaneously O-acetylate some of the newly synthesized GD3.
T6 564-746 Sentence denotes It is unclear whether such phenomena result from induction of the 9-O-acetylation machinery and whether induction is caused by the GD3 synthase protein or by the GD3 molecule itself.
T7 747-911 Sentence denotes We now show that exogenously added GD3 rapidly incorporates into the plasma membrane of Chinese hamster ovary cells, and 9AcGD3 is detected after approximately 6 h.
T8 912-1001 Sentence denotes The incorporated GD3 and newly synthesized 9AcGD3 have a half-life of approximately 24 h.
T9 1002-1086 Sentence denotes This phenomenon is also seen in other cell types, such as human diploid fibroblasts.
T10 1087-1265 Sentence denotes Inhibitors of gene transcription, protein translation, or endoplasmic reticulum-to-Golgi transport each prevent induction of 9-O-acetylation, without affecting GD3 incorporation.
T11 1266-1390 Sentence denotes Inhibition of the initial clathrin-independent internalization of incorporated GD3 also blocks induction of 9-O-acetylation.
T12 1391-1525 Sentence denotes Thus, new synthesis of one or more components of the 9-O-acetylation machinery is induced by incorporation and internalization of GD3.
T13 1526-1709 Sentence denotes Prepriming with structurally related gangliosides fails to accelerate the onset of 9-O-acetylation of subsequently added GD3, indicating a requirement for specific recognition of GD3.
T14 1710-1969 Sentence denotes To our knowledge, this is the first example wherein a newly expressed or exogenously introduced ganglioside induces de novo synthesis of an enzymatic machinery to modify itself, and the first evidence for a mechanism of induction of sialic acid O-acetylation.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-53 Sentence denotes 9-O-acetylation of exogenously added ganglioside GD3.
T2 54-111 Sentence denotes The GD3 molecule induces its own O-acetylation machinery.
T3 112-215 Sentence denotes Sialic acids are sometimes 9-O-acetylated in a developmentally regulated and cell-type-specific manner.
T4 216-418 Sentence denotes Cells naturally expressing the disialoganglioside GD3 often O-acetylate the terminal sialic acid residue, giving 9-O-acetyl-GD3 (9AcGD3), a marker of neural differentiation and malignant transformation.
T5 419-563 Sentence denotes We also reported that Chinese hamster ovary cells transfected with GD3 synthase can spontaneously O-acetylate some of the newly synthesized GD3.
T6 564-746 Sentence denotes It is unclear whether such phenomena result from induction of the 9-O-acetylation machinery and whether induction is caused by the GD3 synthase protein or by the GD3 molecule itself.
T7 747-911 Sentence denotes We now show that exogenously added GD3 rapidly incorporates into the plasma membrane of Chinese hamster ovary cells, and 9AcGD3 is detected after approximately 6 h.
T8 912-1001 Sentence denotes The incorporated GD3 and newly synthesized 9AcGD3 have a half-life of approximately 24 h.
T9 1002-1086 Sentence denotes This phenomenon is also seen in other cell types, such as human diploid fibroblasts.
T10 1087-1265 Sentence denotes Inhibitors of gene transcription, protein translation, or endoplasmic reticulum-to-Golgi transport each prevent induction of 9-O-acetylation, without affecting GD3 incorporation.
T11 1266-1390 Sentence denotes Inhibition of the initial clathrin-independent internalization of incorporated GD3 also blocks induction of 9-O-acetylation.
T12 1391-1525 Sentence denotes Thus, new synthesis of one or more components of the 9-O-acetylation machinery is induced by incorporation and internalization of GD3.
T13 1526-1709 Sentence denotes Prepriming with structurally related gangliosides fails to accelerate the onset of 9-O-acetylation of subsequently added GD3, indicating a requirement for specific recognition of GD3.
T14 1710-1969 Sentence denotes To our knowledge, this is the first example wherein a newly expressed or exogenously introduced ganglioside induces de novo synthesis of an enzymatic machinery to modify itself, and the first evidence for a mechanism of induction of sialic acid O-acetylation.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2 58-61 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T3 266-269 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4 331-343 Glycan denotes O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T5 345-351 Glycan denotes 9AcGD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T6 486-489 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T7 559-562 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T8 695-698 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T9 726-729 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T10 782-785 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T11 868-874 Glycan denotes 9AcGD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T12 929-932 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T13 955-961 Glycan denotes 9AcGD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T14 1247-1250 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T15 1345-1348 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T16 1521-1524 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T17 1647-1650 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T18 1705-1708 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 329-343 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064
T2 345-351 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9AcGD3 http://www.glycoepitope.jp/epitopes/EP0064
T3 868-874 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9AcGD3 http://www.glycoepitope.jp/epitopes/EP0064
T4 955-961 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9AcGD3 http://www.glycoepitope.jp/epitopes/EP0064

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 441-456 OrganismTaxon denotes Chinese hamster 10029
T2 835-850 OrganismTaxon denotes Chinese hamster 10029
T3 1060-1065 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 457-462 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T2 816-831 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T3 851-856 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T4 1074-1085 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T5 1157-1166 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T6 1170-1175 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1074-1085 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057