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PubMed:16288199 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes The promoter of inducible nitric oxide synthase implicated in glaucoma based on genetic analysis and nuclear factor binding.
T2 125-133 Sentence denotes PURPOSE:
T3 134-390 Sentence denotes Nitric oxide has many beneficial functions in the human body at the right amounts, but it can also be hazardous if it is produced in amounts more than needed and has therefore been studied in relation to several neurological and non-neurological disorders.
T4 391-599 Sentence denotes In vitro and in vivo studies demonstrate a connection between the inducible form of Nitric Oxide Synthase, iNOS, and the neuropathological disorder glaucoma, one of the major causes of blindness in the world.
T5 600-799 Sentence denotes In this study, we sought to establish the genetic association between iNOS and primary open angle glaucoma, POAG, and to find the functional element(s) connected with the pathogenesis of the disease.
T6 800-808 Sentence denotes METHODS:
T7 809-995 Sentence denotes Two microsatellites, 1 insertion/deletion, and 8 single nucleotide polymorphisms (SNPs) in the regulatory region of iNOS were genotyped in 200 POAG patients and 200 age-matched controls.
T8 996-1124 Sentence denotes Also, the CCTTT-microsatellite was examined for its protein-binding capability in an electrophoretic mobility shift assay, EMSA.
T9 1125-1133 Sentence denotes RESULTS:
T10 1134-1435 Sentence denotes There was a significant difference in allele distribution of the CCTTT-microsatellite, between patients and controls. (CCTTT)14, which has been reported to have a higher activity in a reporter-construct, was significantly more abundant in POAG patients, while (CCTTT)10 and (CCTTT)13 were less common.
T11 1436-1513 Sentence denotes In EMSA, the (CCTTT)14 allele exhibited specific binding of nuclear proteins.
T12 1514-1526 Sentence denotes CONCLUSIONS:
T13 1527-1741 Sentence denotes These results, together with other studies on this gene and the CCTTT-microsatellite, establish, for the first time, a genetic association of iNOS with POAG and suggest a regulatory function for the microsatellite.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 62-70 OrganismTaxon denotes glaucoma NCBItxid:5882
T2 184-189 OrganismTaxon denotes human NCBItxid:9606
T3 539-547 OrganismTaxon denotes glaucoma NCBItxid:5882
T4 698-706 OrganismTaxon denotes glaucoma NCBItxid:5882
T5 1638-1645 OrganismTaxon denotes time, a NCBItxid:269051

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
2543 26-47 GeneOrGeneProduct denotes nitric oxide synthase NCBIGene:4843
2544 62-70 DiseaseOrPhenotypicFeature denotes glaucoma MESH:D005901
2545 134-146 ChemicalEntity denotes Nitric oxide MESH:D009569
2546 184-189 OrganismTaxon denotes human NCBITaxon:9606
2547 346-389 DiseaseOrPhenotypicFeature denotes neurological and non-neurological disorders MESH:D009422
2548 475-496 GeneOrGeneProduct denotes Nitric Oxide Synthase NCBIGene:4843
2549 498-502 GeneOrGeneProduct denotes iNOS NCBIGene:4843
2550 512-547 DiseaseOrPhenotypicFeature denotes neuropathological disorder glaucoma MESH:D005901
2551 576-585 DiseaseOrPhenotypicFeature denotes blindness MESH:D001766
2552 670-674 GeneOrGeneProduct denotes iNOS NCBIGene:4843
2553 679-706 DiseaseOrPhenotypicFeature denotes primary open angle glaucoma MESH:D005902
2554 708-712 DiseaseOrPhenotypicFeature denotes POAG MESH:D005902
2555 925-929 GeneOrGeneProduct denotes iNOS NCBIGene:4843
2556 952-956 DiseaseOrPhenotypicFeature denotes POAG MESH:D005902
2557 957-965 OrganismTaxon denotes patients NCBITaxon:9606
2558 1229-1237 OrganismTaxon denotes patients NCBITaxon:9606
2559 1252-1261 SequenceVariant denotes (CCTTT)14 c|DUP||CCTTT|14
2560 1373-1377 DiseaseOrPhenotypicFeature denotes POAG MESH:D005902
2561 1378-1386 OrganismTaxon denotes patients NCBITaxon:9606
2562 1394-1403 SequenceVariant denotes (CCTTT)10 c|DUP||CCTTT|10
2563 1408-1417 SequenceVariant denotes (CCTTT)13 c|DUP||CCTTT|13
2564 1449-1458 SequenceVariant denotes (CCTTT)14 c|DUP||CCTTT|14
2565 1669-1673 GeneOrGeneProduct denotes iNOS NCBIGene:4843
2566 1679-1683 DiseaseOrPhenotypicFeature denotes POAG MESH:D005902

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 62-70 DiseaseOrPhenotypicFeature denotes glaucoma 0005041
T2 539-547 DiseaseOrPhenotypicFeature denotes glaucoma 0005041
T3 687-706 DiseaseOrPhenotypicFeature denotes open angle glaucoma 0005338
T4 698-706 DiseaseOrPhenotypicFeature denotes glaucoma 0005041

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 16-47 GeneOrGeneProduct denotes inducible nitric oxide synthase
T2 71-76 GeneOrGeneProduct denotes based
T3 109-115 GeneOrGeneProduct denotes factor
T4 116-123 GeneOrGeneProduct denotes binding
T5 151-155 GeneOrGeneProduct denotes many
T6 202-207 GeneOrGeneProduct denotes right
T7 457-466 GeneOrGeneProduct denotes inducible
T8 475-496 GeneOrGeneProduct denotes Nitric Oxide Synthase
T9 498-502 GeneOrGeneProduct denotes iNOS
T10 560-565 GeneOrGeneProduct denotes major
T11 576-585 GeneOrGeneProduct denotes blindness
T12 670-674 GeneOrGeneProduct denotes iNOS
T13 687-691 GeneOrGeneProduct denotes open
T14 692-697 GeneOrGeneProduct denotes angle
T15 721-725 GeneOrGeneProduct denotes find
T16 800-807 GeneOrGeneProduct denotes METHODS
T17 925-929 GeneOrGeneProduct denotes iNOS
T18 1048-1055 GeneOrGeneProduct denotes protein
T19 1056-1063 GeneOrGeneProduct denotes binding
T20 1064-1074 GeneOrGeneProduct denotes capability
T21 1106-1111 GeneOrGeneProduct denotes shift
T22 1304-1312 GeneOrGeneProduct denotes activity
T23 1485-1492 GeneOrGeneProduct denotes binding
T24 1496-1512 GeneOrGeneProduct denotes nuclear proteins
T25 1556-1561 GeneOrGeneProduct denotes other
T26 1638-1642 GeneOrGeneProduct denotes time
T27 1669-1673 GeneOrGeneProduct denotes iNOS

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 16-47 GeneOrGeneProduct denotes inducible nitric oxide synthase
T2 109-115 GeneOrGeneProduct denotes factor
T3 116-123 GeneOrGeneProduct denotes binding
T4 457-466 GeneOrGeneProduct denotes inducible
T5 475-496 GeneOrGeneProduct denotes Nitric Oxide Synthase
T6 498-502 GeneOrGeneProduct denotes iNOS
T7 560-565 GeneOrGeneProduct denotes major
T8 670-674 GeneOrGeneProduct denotes iNOS
T9 925-929 GeneOrGeneProduct denotes iNOS
T10 1048-1055 GeneOrGeneProduct denotes protein
T11 1056-1063 GeneOrGeneProduct denotes binding
T12 1064-1074 GeneOrGeneProduct denotes capability
T13 1485-1492 GeneOrGeneProduct denotes binding
T14 1496-1512 GeneOrGeneProduct denotes nuclear proteins
T15 1556-1561 GeneOrGeneProduct denotes other
T16 1669-1673 GeneOrGeneProduct denotes iNOS

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 62-70 DiseaseOrPhenotypicFeature denotes glaucoma D005901
T2 367-389 DiseaseOrPhenotypicFeature denotes neurological disorders D009422
T3 539-547 DiseaseOrPhenotypicFeature denotes glaucoma D005901
T4 576-585 DiseaseOrPhenotypicFeature denotes blindness D001766
T5 679-706 DiseaseOrPhenotypicFeature denotes primary open angle glaucoma D005902
T6 791-798 DiseaseOrPhenotypicFeature denotes disease D004194

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 16-47 GeneOrGeneProduct denotes inducible nitric oxide synthase
T2 101-115 GeneOrGeneProduct denotes nuclear factor
T3 475-496 GeneOrGeneProduct denotes Nitric Oxide Synthase
T4 498-502 GeneOrGeneProduct denotes iNOS
T5 670-674 GeneOrGeneProduct denotes iNOS
T6 925-929 GeneOrGeneProduct denotes iNOS
T7 1048-1063 GeneOrGeneProduct denotes protein-binding
T8 1064-1074 GeneOrGeneProduct denotes capability
T9 1496-1512 GeneOrGeneProduct denotes nuclear proteins
T10 1669-1673 GeneOrGeneProduct denotes iNOS

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 62-70 DiseaseOrPhenotypicFeature denotes glaucoma 0005041
T2 224-227 DiseaseOrPhenotypicFeature denotes can 0012833
T3 367-389 DiseaseOrPhenotypicFeature denotes neurological disorders 0005071
T4 539-547 DiseaseOrPhenotypicFeature denotes glaucoma 0005041
T5 576-585 DiseaseOrPhenotypicFeature denotes blindness 0001941
T6 679-706 DiseaseOrPhenotypicFeature denotes primary open angle glaucoma 0007665
T7 708-712 DiseaseOrPhenotypicFeature denotes POAG 0007665
T8 952-956 DiseaseOrPhenotypicFeature denotes POAG 0007665
T9 1373-1377 DiseaseOrPhenotypicFeature denotes POAG 0007665
T10 1679-1683 DiseaseOrPhenotypicFeature denotes POAG 0007665

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 62-70 DiseaseOrPhenotypicFeature denotes glaucoma D005901
T2 346-389 DiseaseOrPhenotypicFeature denotes neurological and non-neurological disorders DISEASE
T3 512-547 DiseaseOrPhenotypicFeature denotes neuropathological disorder glaucoma DISEASE
T4 576-585 DiseaseOrPhenotypicFeature denotes blindness D001766
T5 679-706 DiseaseOrPhenotypicFeature denotes primary open angle glaucoma D005902
T6 708-712 DiseaseOrPhenotypicFeature denotes POAG DISEASE
T7 791-798 DiseaseOrPhenotypicFeature denotes disease D004194
T8 952-956 DiseaseOrPhenotypicFeature denotes POAG DISEASE
T9 1373-1377 DiseaseOrPhenotypicFeature denotes POAG DISEASE
T10 1679-1683 DiseaseOrPhenotypicFeature denotes POAG DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 62-70 DiseaseOrPhenotypicFeature denotes glaucoma D005901
T2 346-389 DiseaseOrPhenotypicFeature denotes neurological and non-neurological disorders DISEASE
T3 512-547 DiseaseOrPhenotypicFeature denotes neuropathological disorder glaucoma DISEASE
T4 576-585 DiseaseOrPhenotypicFeature denotes blindness D001766
T5 679-706 DiseaseOrPhenotypicFeature denotes primary open angle glaucoma D005902
T6 708-712 DiseaseOrPhenotypicFeature denotes POAG DISEASE
T7 952-956 DiseaseOrPhenotypicFeature denotes POAG DISEASE
T8 1373-1377 DiseaseOrPhenotypicFeature denotes POAG DISEASE
T9 1679-1683 DiseaseOrPhenotypicFeature denotes POAG DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 26-47 ChemicalEntity denotes nitric oxide synthase D019001
T2 134-146 ChemicalEntity denotes Nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T3 475-496 ChemicalEntity denotes Nitric Oxide Synthase D019001

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 184-189 OrganismTaxon denotes human
T2 957-965 OrganismTaxon denotes patients
T3 1229-1237 OrganismTaxon denotes patients
T4 1378-1386 OrganismTaxon denotes patients
T5 1638-1645 OrganismTaxon denotes time, a

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T3 475-496 ChemicalEntity denotes Nitric Oxide Synthase D019001
T2 134-146 ChemicalEntity denotes Nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T1 26-47 ChemicalEntity denotes nitric oxide synthase D019001
T10 1669-1673 GeneOrGeneProduct denotes iNOS
T9 1496-1512 GeneOrGeneProduct denotes nuclear proteins
T8 1064-1074 GeneOrGeneProduct denotes capability
T7 1048-1063 GeneOrGeneProduct denotes protein-binding
T6 925-929 GeneOrGeneProduct denotes iNOS
T5 670-674 GeneOrGeneProduct denotes iNOS
T4 498-502 GeneOrGeneProduct denotes iNOS
T31184 475-496 GeneOrGeneProduct denotes Nitric Oxide Synthase
T74811 101-115 GeneOrGeneProduct denotes nuclear factor
T21286 16-47 GeneOrGeneProduct denotes inducible nitric oxide synthase
T99485 1679-1683 DiseaseOrPhenotypicFeature denotes POAG DISEASE
T26403 1373-1377 DiseaseOrPhenotypicFeature denotes POAG DISEASE
T6481 952-956 DiseaseOrPhenotypicFeature denotes POAG DISEASE
T73675 708-712 DiseaseOrPhenotypicFeature denotes POAG DISEASE
T88947 679-706 DiseaseOrPhenotypicFeature denotes primary open angle glaucoma D005902
T74053 576-585 DiseaseOrPhenotypicFeature denotes blindness D001766
T50349 512-547 DiseaseOrPhenotypicFeature denotes neuropathological disorder glaucoma DISEASE
T27754 346-389 DiseaseOrPhenotypicFeature denotes neurological and non-neurological disorders DISEASE
T43926 62-70 DiseaseOrPhenotypicFeature denotes glaucoma D005901
T38418 1638-1645 OrganismTaxon denotes time, a
T4112 1378-1386 OrganismTaxon denotes patients
T21509 1229-1237 OrganismTaxon denotes patients
T56191 957-965 OrganismTaxon denotes patients
T19901 184-189 OrganismTaxon denotes human

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 367-389 HP_0000707 denotes neurological disorders
T2 539-547 HP_0000501 denotes glaucoma
T3 576-585 HP_0000618 denotes blindness
T4 679-706 HP_0012108 denotes primary open angle glaucoma
T5 698-706 HP_0000501 denotes glaucoma