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PubMed:16267041 JSON TXT

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sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-69	Sentence	denotes	The role of the epsilon subunit in the Escherichia coli ATP synthase.
T2	70-134	Sentence	denotes	The C-terminal domain is required for efficient energy coupling.
T3	135-387	Sentence	denotes	The role of the C-domain of the epsilon subunit of ATP synthase was investigated by fusing either the 20-kDa flavodoxin (Fd) or the 5-kDa chitin binding domain (CBD) to the N termini of both full-length epsilon and a truncation mutant epsilon(88-stop).
T4	388-465	Sentence	denotes	All mutant epsilon proteins were stable in cells and supported F1F0 assembly.
T5	466-681	Sentence	denotes	Cells expressing the Fd-epsilon or Fd-epsilon(88-stop) mutants were unable to grow on acetate minimal medium, indicating their inability to carry out oxidative phosphorylation because of steric blockage of rotation.
T6	682-737	Sentence	denotes	The other forms of epsilon supported growth on acetate.
T7	738-915	Sentence	denotes	Membrane vesicles containing Fd-epsilon showed 23% of the wild type ATPase activity but no proton pumping, suggesting that the ATP synthase is intrinsically partially uncoupled.
T8	916-1100	Sentence	denotes	Vesicles containing CBD-epsilon were indistinguishable from the wild type in ATPase activity and proton pumping, indicating that the N-terminal fusions alone do not promote uncoupling.
T9	1101-1320	Sentence	denotes	Fd-epsilon(88-stop) caused higher rates of uncoupled ATP hydrolysis than Fd-epsilon, and epsilon(88-stop) showed an increased rate of membrane-bound ATP hydrolysis but decreased proton pumping relative to the wild type.
T10	1321-1383	Sentence	denotes	Both results demonstrate the role of the C-domain in coupling.
T11	1384-1611	Sentence	denotes	Analysis of the wild type and epsilon(88-stop) mutant membrane ATPase activities at concentrations of ATP from 50 mum to 8 mm showed no significant dependence of the ratio of bound/released ATPase activity on ATP concentration.
T12	1612-1809	Sentence	denotes	These results support the hypothesis that the main function of the C-domain in the Escherichia coli epsilon subunit is to reduce uncoupled ATPase activity, rather than to regulate coupled activity.

mondo_disease

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	296-299	Disease	denotes	CBD	http://purl.obolibrary.org/obo/MONDO_0010564
T2	936-939	Disease	denotes	CBD	http://purl.obolibrary.org/obo/MONDO_0010564

Glycan-GlyCosmos

Id	Subject	Object	Predicate	Lexical cue	image
T1	273-279	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

GlyCosmos15-MONDO

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	296-299	Disease	denotes	CBD	http://purl.obolibrary.org/obo/MONDO_0010564
T2	936-939	Disease	denotes	CBD	http://purl.obolibrary.org/obo/MONDO_0010564

GlyCosmos15-NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	39-55	OrganismTaxon	denotes	Escherichia coli	562
T2	1498-1501	OrganismTaxon	denotes	mum	41568
T3	1695-1711	OrganismTaxon	denotes	Escherichia coli	562

GlyCosmos15-CL

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	16-23	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T2	167-174	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T3	338-345	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T4	370-377	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T5	399-406	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T6	490-497	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T7	504-511	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T8	701-708	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T9	770-777	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T10	940-947	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T11	1104-1111	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T12	1177-1184	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T13	1190-1197	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T14	1414-1421	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T15	1712-1719	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025

GlyCosmos15-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	738-746	Body_part	denotes	Membrane	http://purl.obolibrary.org/obo/GO_0016020\|http://purl.obolibrary.org/obo/UBERON_0000094\|http://purl.obolibrary.org/obo/UBERON_0000158
T4	1235-1243	Body_part	denotes	membrane	http://purl.obolibrary.org/obo/GO_0016020\|http://purl.obolibrary.org/obo/UBERON_0000094\|http://purl.obolibrary.org/obo/UBERON_0000158
T7	1438-1446	Body_part	denotes	membrane	http://purl.obolibrary.org/obo/GO_0016020\|http://purl.obolibrary.org/obo/UBERON_0000094\|http://purl.obolibrary.org/obo/UBERON_0000158

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-69	Sentence	denotes	The role of the epsilon subunit in the Escherichia coli ATP synthase.
T2	70-134	Sentence	denotes	The C-terminal domain is required for efficient energy coupling.
T3	135-387	Sentence	denotes	The role of the C-domain of the epsilon subunit of ATP synthase was investigated by fusing either the 20-kDa flavodoxin (Fd) or the 5-kDa chitin binding domain (CBD) to the N termini of both full-length epsilon and a truncation mutant epsilon(88-stop).
T4	388-465	Sentence	denotes	All mutant epsilon proteins were stable in cells and supported F1F0 assembly.
T5	466-681	Sentence	denotes	Cells expressing the Fd-epsilon or Fd-epsilon(88-stop) mutants were unable to grow on acetate minimal medium, indicating their inability to carry out oxidative phosphorylation because of steric blockage of rotation.
T6	682-737	Sentence	denotes	The other forms of epsilon supported growth on acetate.
T7	738-915	Sentence	denotes	Membrane vesicles containing Fd-epsilon showed 23% of the wild type ATPase activity but no proton pumping, suggesting that the ATP synthase is intrinsically partially uncoupled.
T8	916-1100	Sentence	denotes	Vesicles containing CBD-epsilon were indistinguishable from the wild type in ATPase activity and proton pumping, indicating that the N-terminal fusions alone do not promote uncoupling.
T9	1101-1320	Sentence	denotes	Fd-epsilon(88-stop) caused higher rates of uncoupled ATP hydrolysis than Fd-epsilon, and epsilon(88-stop) showed an increased rate of membrane-bound ATP hydrolysis but decreased proton pumping relative to the wild type.
T10	1321-1383	Sentence	denotes	Both results demonstrate the role of the C-domain in coupling.
T11	1384-1611	Sentence	denotes	Analysis of the wild type and epsilon(88-stop) mutant membrane ATPase activities at concentrations of ATP from 50 mum to 8 mm showed no significant dependence of the ratio of bound/released ATPase activity on ATP concentration.
T12	1612-1809	Sentence	denotes	These results support the hypothesis that the main function of the C-domain in the Escherichia coli epsilon subunit is to reduce uncoupled ATPase activity, rather than to regulate coupled activity.

GlyCosmos15-Sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-69	Sentence	denotes	The role of the epsilon subunit in the Escherichia coli ATP synthase.
T2	70-134	Sentence	denotes	The C-terminal domain is required for efficient energy coupling.
T3	135-387	Sentence	denotes	The role of the C-domain of the epsilon subunit of ATP synthase was investigated by fusing either the 20-kDa flavodoxin (Fd) or the 5-kDa chitin binding domain (CBD) to the N termini of both full-length epsilon and a truncation mutant epsilon(88-stop).
T4	388-465	Sentence	denotes	All mutant epsilon proteins were stable in cells and supported F1F0 assembly.
T5	466-681	Sentence	denotes	Cells expressing the Fd-epsilon or Fd-epsilon(88-stop) mutants were unable to grow on acetate minimal medium, indicating their inability to carry out oxidative phosphorylation because of steric blockage of rotation.
T6	682-737	Sentence	denotes	The other forms of epsilon supported growth on acetate.
T7	738-915	Sentence	denotes	Membrane vesicles containing Fd-epsilon showed 23% of the wild type ATPase activity but no proton pumping, suggesting that the ATP synthase is intrinsically partially uncoupled.
T8	916-1100	Sentence	denotes	Vesicles containing CBD-epsilon were indistinguishable from the wild type in ATPase activity and proton pumping, indicating that the N-terminal fusions alone do not promote uncoupling.
T9	1101-1320	Sentence	denotes	Fd-epsilon(88-stop) caused higher rates of uncoupled ATP hydrolysis than Fd-epsilon, and epsilon(88-stop) showed an increased rate of membrane-bound ATP hydrolysis but decreased proton pumping relative to the wild type.
T10	1321-1383	Sentence	denotes	Both results demonstrate the role of the C-domain in coupling.
T11	1384-1611	Sentence	denotes	Analysis of the wild type and epsilon(88-stop) mutant membrane ATPase activities at concentrations of ATP from 50 mum to 8 mm showed no significant dependence of the ratio of bound/released ATPase activity on ATP concentration.
T12	1612-1809	Sentence	denotes	These results support the hypothesis that the main function of the C-domain in the Escherichia coli epsilon subunit is to reduce uncoupled ATPase activity, rather than to regulate coupled activity.

GlyCosmos15-Glycan

Id	Subject	Object	Predicate	Lexical cue	image
T1	273-279	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	39-55	OrganismTaxon	denotes	Escherichia coli	562
T2	1498-1501	OrganismTaxon	denotes	mum	41568
T3	1695-1711	OrganismTaxon	denotes	Escherichia coli	562

Anatomy-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	738-746	Body_part	denotes	Membrane	http://purl.obolibrary.org/obo/GO_0016020\|http://purl.obolibrary.org/obo/UBERON_0000094\|http://purl.obolibrary.org/obo/UBERON_0000158
T4	1235-1243	Body_part	denotes	membrane	http://purl.obolibrary.org/obo/GO_0016020\|http://purl.obolibrary.org/obo/UBERON_0000094\|http://purl.obolibrary.org/obo/UBERON_0000158
T7	1438-1446	Body_part	denotes	membrane	http://purl.obolibrary.org/obo/GO_0016020\|http://purl.obolibrary.org/obo/UBERON_0000094\|http://purl.obolibrary.org/obo/UBERON_0000158

CL-cell

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	16-23	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T2	167-174	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T3	338-345	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T4	370-377	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T5	399-406	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T6	490-497	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T7	504-511	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T8	701-708	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T9	770-777	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T10	940-947	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T11	1104-1111	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T12	1177-1184	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T13	1190-1197	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T14	1414-1421	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025
T15	1712-1719	Cell	denotes	epsilon	http://purl.obolibrary.org/obo/CL:0003025