PubMed:16252083 / 568-953 JSONTXT

{"project":"PubTator4TogoVar","denotations":[{"id":"16252083_0","span":{"begin":154,"end":191},"obj":"ProteinMutation"},{"id":"16252083_1","span":{"begin":278,"end":309},"obj":"ProteinMutation"}],"attributes":[{"id":"16252083_0_ProteinMutation","pred":"proteinmutation","subj":"16252083_0","obj":"rs17217772"},{"id":"16252083_1_ProteinMutation","pred":"proteinmutation","subj":"16252083_1","obj":"rs4987188"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-sentences","denotations":[{"id":"T5","span":{"begin":0,"end":385},"obj":"Sentence"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":182,"end":187},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":300,"end":305},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:79338"},{"id":"A2","pred":"db_id","subj":"T2","obj":"NCBItxid:79338"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-entities","denotations":[{"id":"2445","span":{"begin":91,"end":96},"obj":"GeneOrGeneProduct"},{"id":"2446","span":{"begin":106,"end":140},"obj":"SequenceVariant"},{"id":"2447","span":{"begin":154,"end":191},"obj":"SequenceVariant"},{"id":"2448","span":{"begin":197,"end":206},"obj":"SequenceVariant"},{"id":"2449","span":{"begin":227,"end":262},"obj":"SequenceVariant"},{"id":"2450","span":{"begin":278,"end":309},"obj":"SequenceVariant"},{"id":"2451","span":{"begin":315,"end":324},"obj":"SequenceVariant"},{"id":"2452","span":{"begin":343,"end":356},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2453","span":{"begin":366,"end":372},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A12","pred":"db_id","subj":"2445","obj":"NCBIGene:4436"},{"id":"A13","pred":"db_id","subj":"2446","obj":"DBSNP:rs17217772"},{"id":"A14","pred":"db_id","subj":"2447","obj":"DBSNP:rs17217772"},{"id":"A15","pred":"db_id","subj":"2448","obj":"DBSNP:rs17217772"},{"id":"A16","pred":"db_id","subj":"2449","obj":"DBSNP:rs4987188"},{"id":"A17","pred":"db_id","subj":"2450","obj":"DBSNP:rs4987188"},{"id":"A18","pred":"db_id","subj":"2451","obj":"DBSNP:rs4987188"},{"id":"A19","pred":"db_id","subj":"2452","obj":"MESH:D001943"},{"id":"A20","pred":"db_id","subj":"2453","obj":"MESH:D009369"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin_Mondo","denotations":[{"id":"T8","span":{"begin":343,"end":356},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":350,"end":356},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":366,"end":372},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0007254"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0004992"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0004992"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-SeqVar","denotations":[{"id":"T1","span":{"begin":197,"end":206},"obj":"SequenceVariant"},{"id":"T2","span":{"begin":315,"end":324},"obj":"SequenceVariant"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T12","span":{"begin":15,"end":19},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":37,"end":41},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":91,"end":96},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":103,"end":113},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":154,"end":157},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":162,"end":165},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":273,"end":277},"obj":"GeneOrGeneProduct"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T8","span":{"begin":91,"end":96},"obj":"GeneOrGeneProduct"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T7","span":{"begin":343,"end":356},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":366,"end":372},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"originalLabel","subj":"T7","obj":"D001943"},{"id":"A8","pred":"originalLabel","subj":"T8","obj":"D009369"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T4","span":{"begin":91,"end":96},"obj":"GeneOrGeneProduct"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T7","span":{"begin":343,"end":356},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0007254"},{"id":"A8","pred":"mondo_id","subj":"T7","obj":"0004989"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T7","span":{"begin":343,"end":356},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":366,"end":372},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"ID:","subj":"T7","obj":"D001943"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D009369"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T7","span":{"begin":343,"end":356},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":366,"end":372},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"#label","subj":"T7","obj":"D001943"},{"id":"A8","pred":"#label","subj":"T8","obj":"D009369"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":154,"end":157},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":162,"end":165},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":278,"end":281},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":286,"end":289},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_50347"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_22653"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_17196"},{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_29999"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_17115"},{"id":"A6","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_15428"},{"id":"A7","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_29958"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_22660"},{"id":"A9","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_17053"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T7","span":{"begin":286,"end":289},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":278,"end":281},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":162,"end":165},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":154,"end":157},"obj":"ChemicalEntity"},{"id":"T37804","span":{"begin":91,"end":96},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":366,"end":372},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T26934","span":{"begin":343,"end":356},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5825","span":{"begin":315,"end":324},"obj":"SequenceVariant"},{"id":"T64918","span":{"begin":197,"end":206},"obj":"SequenceVariant"}],"attributes":[{"id":"A9","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_17053"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_22660"},{"id":"A7","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_29958"},{"id":"A6","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_15428"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_17115"},{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_29999"},{"id":"A3","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_17196"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_22653"},{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_50347"},{"id":"A1478","pred":"#label","subj":"T8","obj":"D009369"},{"id":"A38131","pred":"#label","subj":"T26934","obj":"D001943"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"16252083-4#315#324#geners4987188","span":{"begin":315,"end":324},"obj":"geners4987188"},{"id":"16252083-4#197#206#geners17217772","span":{"begin":197,"end":206},"obj":"geners17217772"},{"id":"16252083-4#366#384#diseaseC0178874","span":{"begin":366,"end":384},"obj":"diseaseC0178874"},{"id":"16252083-4#343#356#diseaseC0006142","span":{"begin":343,"end":356},"obj":"diseaseC0006142"},{"id":"16252083-4#343#356#diseaseC0678222","span":{"begin":343,"end":356},"obj":"diseaseC0678222"},{"id":"16252083-4#366#384#diseaseC0178874","span":{"begin":366,"end":384},"obj":"diseaseC0178874"}],"relations":[{"id":"315#324#geners4987188366#384#diseaseC0178874","pred":"associated_with","subj":"16252083-4#315#324#geners4987188","obj":"16252083-4#366#384#diseaseC0178874"},{"id":"315#324#geners4987188343#356#diseaseC0006142","pred":"associated_with","subj":"16252083-4#315#324#geners4987188","obj":"16252083-4#343#356#diseaseC0006142"},{"id":"315#324#geners4987188343#356#diseaseC0678222","pred":"associated_with","subj":"16252083-4#315#324#geners4987188","obj":"16252083-4#343#356#diseaseC0678222"},{"id":"315#324#geners4987188366#384#diseaseC0178874","pred":"associated_with","subj":"16252083-4#315#324#geners4987188","obj":"16252083-4#366#384#diseaseC0178874"},{"id":"197#206#geners17217772366#384#diseaseC0178874","pred":"associated_with","subj":"16252083-4#197#206#geners17217772","obj":"16252083-4#366#384#diseaseC0178874"},{"id":"197#206#geners17217772343#356#diseaseC0006142","pred":"associated_with","subj":"16252083-4#197#206#geners17217772","obj":"16252083-4#343#356#diseaseC0006142"},{"id":"197#206#geners17217772343#356#diseaseC0678222","pred":"associated_with","subj":"16252083-4#197#206#geners17217772","obj":"16252083-4#343#356#diseaseC0678222"},{"id":"197#206#geners17217772366#384#diseaseC0178874","pred":"associated_with","subj":"16252083-4#197#206#geners17217772","obj":"16252083-4#366#384#diseaseC0178874"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"16252083-4#91#96#gene4436","span":{"begin":91,"end":96},"obj":"gene4436"},{"id":"16252083-4#366#384#diseaseC0178874","span":{"begin":366,"end":384},"obj":"diseaseC0178874"}],"relations":[{"id":"91#96#gene4436366#384#diseaseC0178874","pred":"associated_with","subj":"16252083-4#91#96#gene4436","obj":"16252083-4#366#384#diseaseC0178874"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}

{"project":"tmVarCorpus","denotations":[{"id":"T1","span":{"begin":106,"end":140},"obj":"DNAMutation:|SUB|A|CODON127|G"},{"id":"T2","span":{"begin":154,"end":191},"obj":"ProteinMutation:p|SUB|N|127|S"},{"id":"T3","span":{"begin":197,"end":206},"obj":"ProteinMutation:p|SUB|N|127|S"},{"id":"T4","span":{"begin":227,"end":262},"obj":"DNAMutation:g|SUB|G|1032|A"},{"id":"T5","span":{"begin":278,"end":309},"obj":"ProteinMutation:p|SUB|G|322|D"},{"id":"T6","span":{"begin":315,"end":324},"obj":"ProteinMutation:p|SUB|G|322|D"}],"text":"We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --\u003e G transition at 127 position producing an Asn --\u003e Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --\u003e A transition at 1032 position resulting in a Gly --\u003e Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression."}