PubMed:16200390 JSONTXT

{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":111},"obj":"Sentence"},{"id":"T2","span":{"begin":112,"end":237},"obj":"Sentence"},{"id":"T3","span":{"begin":238,"end":398},"obj":"Sentence"},{"id":"T4","span":{"begin":399,"end":750},"obj":"Sentence"},{"id":"T5","span":{"begin":751,"end":1031},"obj":"Sentence"},{"id":"T6","span":{"begin":1032,"end":1186},"obj":"Sentence"},{"id":"T7","span":{"begin":1187,"end":1419},"obj":"Sentence"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":618,"end":623},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:9606"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-entities","denotations":[{"id":"2387","span":{"begin":73,"end":81},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2388","span":{"begin":112,"end":120},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2389","span":{"begin":154,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2390","span":{"begin":248,"end":264},"obj":"ChemicalEntity"},{"id":"2391","span":{"begin":265,"end":284},"obj":"ChemicalEntity"},{"id":"2392","span":{"begin":286,"end":290},"obj":"ChemicalEntity"},{"id":"2393","span":{"begin":292,"end":301},"obj":"ChemicalEntity"},{"id":"2394","span":{"begin":389,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2395","span":{"begin":495,"end":499},"obj":"ChemicalEntity"},{"id":"2396","span":{"begin":535,"end":543},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2397","span":{"begin":618,"end":623},"obj":"OrganismTaxon"},{"id":"2398","span":{"begin":624,"end":646},"obj":"GeneOrGeneProduct"},{"id":"2399","span":{"begin":648,"end":651},"obj":"GeneOrGeneProduct"},{"id":"2400","span":{"begin":654,"end":678},"obj":"GeneOrGeneProduct"},{"id":"2401","span":{"begin":680,"end":684},"obj":"GeneOrGeneProduct"},{"id":"2402","span":{"begin":690,"end":709},"obj":"GeneOrGeneProduct"},{"id":"2403","span":{"begin":711,"end":715},"obj":"GeneOrGeneProduct"},{"id":"2404","span":{"begin":726,"end":734},"obj":"DiseaseOrPhenotypicFeature"},{"id":"2405","span":{"begin":1340,"end":1343},"obj":"GeneOrGeneProduct"},{"id":"2406","span":{"begin":1345,"end":1349},"obj":"GeneOrGeneProduct"},{"id":"2407","span":{"begin":1354,"end":1358},"obj":"GeneOrGeneProduct"},{"id":"2408","span":{"begin":1395,"end":1403},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A13","pred":"db_id","subj":"2399","obj":"NCBIGene:7166"},{"id":"A5","pred":"db_id","subj":"2391","obj":"MESH:D012701"},{"id":"A16","pred":"db_id","subj":"2402","obj":"NCBIGene:4128"},{"id":"A21","pred":"db_id","subj":"2407","obj":"NCBIGene:4128"},{"id":"A9","pred":"db_id","subj":"2395","obj":"MESH:D012701"},{"id":"A15","pred":"db_id","subj":"2401","obj":"NCBIGene:1644"},{"id":"A8","pred":"db_id","subj":"2394","obj":"MESH:D008881"},{"id":"A10","pred":"db_id","subj":"2396","obj":"MESH:D008881"},{"id":"A19","pred":"db_id","subj":"2405","obj":"NCBIGene:7166"},{"id":"A14","pred":"db_id","subj":"2400","obj":"NCBIGene:1644"},{"id":"A11","pred":"db_id","subj":"2397","obj":"NCBITaxon:9606"},{"id":"A4","pred":"db_id","subj":"2390","obj":"MESH:D018377"},{"id":"A22","pred":"db_id","subj":"2408","obj":"MESH:D008881"},{"id":"A7","pred":"db_id","subj":"2393","obj":"MESH:D012701"},{"id":"A17","pred":"db_id","subj":"2403","obj":"NCBIGene:4128"},{"id":"A12","pred":"db_id","subj":"2398","obj":"NCBIGene:7166"},{"id":"A1","pred":"db_id","subj":"2387","obj":"MESH:D008881"},{"id":"A20","pred":"db_id","subj":"2406","obj":"NCBIGene:1644"},{"id":"A2","pred":"db_id","subj":"2388","obj":"MESH:D008881"},{"id":"A18","pred":"db_id","subj":"2404","obj":"MESH:D008881"},{"id":"A6","pred":"db_id","subj":"2392","obj":"MESH:D012701"},{"id":"A3","pred":"db_id","subj":"2389","obj":"MESH:D020773"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":154,"end":171},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0021146"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":62,"end":69},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":73,"end":81},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":88,"end":93},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":112,"end":120},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":210,"end":216},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":242,"end":247},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":286,"end":290},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":389,"end":397},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":465,"end":472},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":495,"end":499},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":500,"end":508},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":535,"end":543},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":624,"end":646},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":648,"end":651},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":654,"end":678},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":680,"end":684},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":690,"end":709},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":711,"end":715},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":726,"end":734},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":789,"end":793},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":897,"end":903},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":925,"end":936},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1146,"end":1151},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1219,"end":1223},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":1246,"end":1252},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":1340,"end":1343},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":1345,"end":1349},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":1354,"end":1358},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":1395,"end":1403},"obj":"GeneOrGeneProduct"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":73,"end":81},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":112,"end":120},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":242,"end":247},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":286,"end":290},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":389,"end":397},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":495,"end":499},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":535,"end":543},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":624,"end":646},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":648,"end":651},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":654,"end":678},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":680,"end":684},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":690,"end":709},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":711,"end":715},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":726,"end":734},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":789,"end":793},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":897,"end":903},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":1219,"end":1223},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1246,"end":1252},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1340,"end":1343},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1345,"end":1349},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1354,"end":1358},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1395,"end":1403},"obj":"GeneOrGeneProduct"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":73,"end":81},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":112,"end":120},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":146,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":389,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":535,"end":543},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":726,"end":734},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1395,"end":1403},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D008881"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D008881"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D051270"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D008881"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D008881"},{"id":"A6","pred":"originalLabel","subj":"T6","obj":"D008881"},{"id":"A7","pred":"originalLabel","subj":"T7","obj":"D008881"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":624,"end":646},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":648,"end":651},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":654,"end":678},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":680,"end":684},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":690,"end":709},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":711,"end":715},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":1340,"end":1343},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":1345,"end":1349},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1354,"end":1358},"obj":"GeneOrGeneProduct"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":73,"end":81},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":112,"end":120},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":154,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":288,"end":290},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":389,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":497,"end":499},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":535,"end":543},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":726,"end":734},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":874,"end":883},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1395,"end":1403},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0007699"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0000605"},{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005277"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005277"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0005277"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0005277"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0005277"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0021146"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0007699"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0005277"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":73,"end":81},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":112,"end":120},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":146,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":389,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":535,"end":543},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":726,"end":734},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1395,"end":1403},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D008881"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D008881"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D051270"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D008881"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D008881"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D008881"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D008881"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":73,"end":81},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":112,"end":120},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":146,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":389,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":535,"end":543},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":726,"end":734},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1395,"end":1403},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D008881"},{"id":"A2","pred":"#label","subj":"T2","obj":"D008881"},{"id":"A3","pred":"#label","subj":"T3","obj":"D051270"},{"id":"A4","pred":"#label","subj":"T4","obj":"D008881"},{"id":"A5","pred":"#label","subj":"T5","obj":"D008881"},{"id":"A6","pred":"#label","subj":"T6","obj":"D008881"},{"id":"A7","pred":"#label","subj":"T7","obj":"D008881"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":248,"end":264},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":265,"end":284},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":286,"end":290},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":292,"end":301},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":495,"end":499},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":624,"end":646},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":648,"end":651},"obj":"ChemicalEntity"},{"id":"T12","span":{"begin":665,"end":678},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":690,"end":707},"obj":"ChemicalEntity"},{"id":"T14","span":{"begin":1340,"end":1343},"obj":"ChemicalEntity"}],"attributes":[{"id":"A10","pred":"ID:","subj":"T10","obj":"D014365"},{"id":"A14","pred":"ID:","subj":"T14","obj":"D014365"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D002262"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D012701"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D012701"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D012701"},{"id":"A6","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_350546"},{"id":"A7","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D014365"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D008995"},{"id":"A1","pred":"ID:","subj":"T1","obj":"ChemicalEntity"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D012701"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":618,"end":623},"obj":"OrganismTaxon"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T14","span":{"begin":1340,"end":1343},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":690,"end":707},"obj":"ChemicalEntity"},{"id":"T12","span":{"begin":665,"end":678},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":648,"end":651},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":624,"end":646},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":495,"end":499},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":292,"end":301},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":286,"end":290},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":265,"end":284},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":248,"end":264},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":1354,"end":1358},"obj":"GeneOrGeneProduct"},{"id":"T57368","span":{"begin":1345,"end":1349},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":1340,"end":1343},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":711,"end":715},"obj":"GeneOrGeneProduct"},{"id":"T30007","span":{"begin":690,"end":709},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":680,"end":684},"obj":"GeneOrGeneProduct"},{"id":"T89820","span":{"begin":654,"end":678},"obj":"GeneOrGeneProduct"},{"id":"T95821","span":{"begin":648,"end":651},"obj":"GeneOrGeneProduct"},{"id":"T80664","span":{"begin":624,"end":646},"obj":"GeneOrGeneProduct"},{"id":"T63097","span":{"begin":1395,"end":1403},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T32450","span":{"begin":726,"end":734},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T91210","span":{"begin":535,"end":543},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T33622","span":{"begin":389,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T25031","span":{"begin":146,"end":171},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T21482","span":{"begin":112,"end":120},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T84942","span":{"begin":73,"end":81},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T46901","span":{"begin":618,"end":623},"obj":"OrganismTaxon"}],"attributes":[{"id":"A14","pred":"ID:","subj":"T14","obj":"D014365"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D008995"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D002262"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D014365"},{"id":"A10","pred":"ID:","subj":"T10","obj":"D014365"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D012701"},{"id":"A7","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A6","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_350546"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D012701"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D012701"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D012701"},{"id":"A1","pred":"ID:","subj":"T1","obj":"ChemicalEntity"},{"id":"A17466","pred":"#label","subj":"T63097","obj":"D008881"},{"id":"A27522","pred":"#label","subj":"T32450","obj":"D008881"},{"id":"A1610","pred":"#label","subj":"T91210","obj":"D008881"},{"id":"A19700","pred":"#label","subj":"T33622","obj":"D008881"},{"id":"A63517","pred":"#label","subj":"T25031","obj":"D051270"},{"id":"A40204","pred":"#label","subj":"T21482","obj":"D008881"},{"id":"A57899","pred":"#label","subj":"T84942","obj":"D008881"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":112,"end":120},"obj":"HP_0002076"},{"id":"T2","span":{"begin":154,"end":162},"obj":"HP_0002315"},{"id":"T3","span":{"begin":389,"end":397},"obj":"HP_0002076"},{"id":"T4","span":{"begin":535,"end":543},"obj":"HP_0002076"},{"id":"T5","span":{"begin":726,"end":734},"obj":"HP_0002076"},{"id":"T6","span":{"begin":1395,"end":1403},"obj":"HP_0002076"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":690,"end":709},"obj":"gene:4128"},{"id":"T1","span":{"begin":535,"end":543},"obj":"disease:C0149931"},{"id":"T2","span":{"begin":690,"end":709},"obj":"gene:4128"},{"id":"T3","span":{"begin":726,"end":734},"obj":"disease:C0149931"},{"id":"T4","span":{"begin":711,"end":715},"obj":"gene:4128"},{"id":"T5","span":{"begin":726,"end":734},"obj":"disease:C0149931"},{"id":"T6","span":{"begin":711,"end":715},"obj":"gene:4128"},{"id":"T7","span":{"begin":535,"end":543},"obj":"disease:C0149931"},{"id":"T8","span":{"begin":1354,"end":1358},"obj":"gene:4128"},{"id":"T9","span":{"begin":1395,"end":1403},"obj":"disease:C0149931"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.\nMigraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility."}