PubMed:16200390
Annnotations
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-111 | Sentence | denotes | A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach. |
| T2 | 112-237 | Sentence | denotes | Migraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. |
| T3 | 238-398 | Sentence | denotes | The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. |
| T4 | 399-750 | Sentence | denotes | With few genetic studies investigating biosynthetic and metabolic enzymes governing the rate of 5-HT activity and their relationship to migraine, it was the objective of this study to assess genetic variants within the human tryptophan hydroxylase (TPH), amino acid decarboxylase (AADC) and monoamine oxidase A (MAOA) genes in migraine susceptibility. |
| T5 | 751-1031 | Sentence | denotes | This objective was undertaken using a high-throughput DNA pooling experimental design, which proved to be a very accurate, sensitive and specific method of estimating allele frequencies for single nucleotide polymorphism, insertion deletion and variable number tandem repeat loci. |
| T6 | 1032-1186 | Sentence | denotes | Application of DNA pooling to a wide array of genetic loci provides greater scope in the assessment of population-based genetic association study designs. |
| T7 | 1187-1419 | Sentence | denotes | Despite the application of this high-throughput genotyping method, negative results from the two-stage DNA pooling design used to screen loci within the TPH, AADC and MAOA genes did not support their role in migraine susceptibility. |
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 618-623 | OrganismTaxon | denotes | human | NCBItxid:9606 |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 2387 | 73-81 | DiseaseOrPhenotypicFeature | denotes | migraine | MESH:D008881 |
| 2388 | 112-120 | DiseaseOrPhenotypicFeature | denotes | Migraine | MESH:D008881 |
| 2389 | 154-171 | DiseaseOrPhenotypicFeature | denotes | headache disorder | MESH:D020773 |
| 2390 | 248-264 | ChemicalEntity | denotes | neurotransmitter | MESH:D018377 |
| 2391 | 265-284 | ChemicalEntity | denotes | 5-hydroxytryptamine | MESH:D012701 |
| 2392 | 286-290 | ChemicalEntity | denotes | 5-HT | MESH:D012701 |
| 2393 | 292-301 | ChemicalEntity | denotes | serotonin | MESH:D012701 |
| 2394 | 389-397 | DiseaseOrPhenotypicFeature | denotes | migraine | MESH:D008881 |
| 2395 | 495-499 | ChemicalEntity | denotes | 5-HT | MESH:D012701 |
| 2396 | 535-543 | DiseaseOrPhenotypicFeature | denotes | migraine | MESH:D008881 |
| 2397 | 618-623 | OrganismTaxon | denotes | human | NCBITaxon:9606 |
| 2398 | 624-646 | GeneOrGeneProduct | denotes | tryptophan hydroxylase | NCBIGene:7166 |
| 2399 | 648-651 | GeneOrGeneProduct | denotes | TPH | NCBIGene:7166 |
| 2400 | 654-678 | GeneOrGeneProduct | denotes | amino acid decarboxylase | NCBIGene:1644 |
| 2401 | 680-684 | GeneOrGeneProduct | denotes | AADC | NCBIGene:1644 |
| 2402 | 690-709 | GeneOrGeneProduct | denotes | monoamine oxidase A | NCBIGene:4128 |
| 2403 | 711-715 | GeneOrGeneProduct | denotes | MAOA | NCBIGene:4128 |
| 2404 | 726-734 | DiseaseOrPhenotypicFeature | denotes | migraine | MESH:D008881 |
| 2405 | 1340-1343 | GeneOrGeneProduct | denotes | TPH | NCBIGene:7166 |
| 2406 | 1345-1349 | GeneOrGeneProduct | denotes | AADC | NCBIGene:1644 |
| 2407 | 1354-1358 | GeneOrGeneProduct | denotes | MAOA | NCBIGene:4128 |
| 2408 | 1395-1403 | DiseaseOrPhenotypicFeature | denotes | migraine | MESH:D008881 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 154-171 | DiseaseOrPhenotypicFeature | denotes | headache disorder | 0021146 |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 62-69 | GeneOrGeneProduct | denotes | enzymes |
| T2 | 73-81 | GeneOrGeneProduct | denotes | migraine |
| T3 | 88-93 | GeneOrGeneProduct | denotes | a DNA |
| T4 | 112-120 | GeneOrGeneProduct | denotes | Migraine |
| T5 | 210-216 | GeneOrGeneProduct | denotes | social |
| T6 | 242-247 | GeneOrGeneProduct | denotes | brain |
| T7 | 286-290 | GeneOrGeneProduct | denotes | 5-HT |
| T8 | 389-397 | GeneOrGeneProduct | denotes | migraine |
| T9 | 465-472 | GeneOrGeneProduct | denotes | enzymes |
| T10 | 495-499 | GeneOrGeneProduct | denotes | 5-HT |
| T11 | 500-508 | GeneOrGeneProduct | denotes | activity |
| T12 | 535-543 | GeneOrGeneProduct | denotes | migraine |
| T13 | 624-646 | GeneOrGeneProduct | denotes | tryptophan hydroxylase |
| T14 | 648-651 | GeneOrGeneProduct | denotes | TPH |
| T15 | 654-678 | GeneOrGeneProduct | denotes | amino acid decarboxylase |
| T16 | 680-684 | GeneOrGeneProduct | denotes | AADC |
| T17 | 690-709 | GeneOrGeneProduct | denotes | monoamine oxidase A |
| T18 | 711-715 | GeneOrGeneProduct | denotes | MAOA |
| T19 | 726-734 | GeneOrGeneProduct | denotes | migraine |
| T20 | 789-793 | GeneOrGeneProduct | denotes | high |
| T21 | 897-903 | GeneOrGeneProduct | denotes | method |
| T22 | 925-936 | GeneOrGeneProduct | denotes | frequencies |
| T23 | 1146-1151 | GeneOrGeneProduct | denotes | based |
| T24 | 1219-1223 | GeneOrGeneProduct | denotes | high |
| T25 | 1246-1252 | GeneOrGeneProduct | denotes | method |
| T26 | 1340-1343 | GeneOrGeneProduct | denotes | TPH |
| T27 | 1345-1349 | GeneOrGeneProduct | denotes | AADC |
| T28 | 1354-1358 | GeneOrGeneProduct | denotes | MAOA |
| T29 | 1395-1403 | GeneOrGeneProduct | denotes | migraine |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 73-81 | GeneOrGeneProduct | denotes | migraine |
| T2 | 112-120 | GeneOrGeneProduct | denotes | Migraine |
| T3 | 242-247 | GeneOrGeneProduct | denotes | brain |
| T4 | 286-290 | GeneOrGeneProduct | denotes | 5-HT |
| T5 | 389-397 | GeneOrGeneProduct | denotes | migraine |
| T6 | 495-499 | GeneOrGeneProduct | denotes | 5-HT |
| T7 | 535-543 | GeneOrGeneProduct | denotes | migraine |
| T8 | 624-646 | GeneOrGeneProduct | denotes | tryptophan hydroxylase |
| T9 | 648-651 | GeneOrGeneProduct | denotes | TPH |
| T10 | 654-678 | GeneOrGeneProduct | denotes | amino acid decarboxylase |
| T11 | 680-684 | GeneOrGeneProduct | denotes | AADC |
| T12 | 690-709 | GeneOrGeneProduct | denotes | monoamine oxidase A |
| T13 | 711-715 | GeneOrGeneProduct | denotes | MAOA |
| T14 | 726-734 | GeneOrGeneProduct | denotes | migraine |
| T15 | 789-793 | GeneOrGeneProduct | denotes | high |
| T16 | 897-903 | GeneOrGeneProduct | denotes | method |
| T17 | 1219-1223 | GeneOrGeneProduct | denotes | high |
| T18 | 1246-1252 | GeneOrGeneProduct | denotes | method |
| T19 | 1340-1343 | GeneOrGeneProduct | denotes | TPH |
| T20 | 1345-1349 | GeneOrGeneProduct | denotes | AADC |
| T21 | 1354-1358 | GeneOrGeneProduct | denotes | MAOA |
| T22 | 1395-1403 | GeneOrGeneProduct | denotes | migraine |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 73-81 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T2 | 112-120 | DiseaseOrPhenotypicFeature | denotes | Migraine | D008881 |
| T3 | 146-171 | DiseaseOrPhenotypicFeature | denotes | primary headache disorder | D051270 |
| T4 | 389-397 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T5 | 535-543 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T6 | 726-734 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T7 | 1395-1403 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 624-646 | GeneOrGeneProduct | denotes | tryptophan hydroxylase |
| T2 | 648-651 | GeneOrGeneProduct | denotes | TPH |
| T3 | 654-678 | GeneOrGeneProduct | denotes | amino acid decarboxylase |
| T4 | 680-684 | GeneOrGeneProduct | denotes | AADC |
| T5 | 690-709 | GeneOrGeneProduct | denotes | monoamine oxidase A |
| T6 | 711-715 | GeneOrGeneProduct | denotes | MAOA |
| T7 | 1340-1343 | GeneOrGeneProduct | denotes | TPH |
| T8 | 1345-1349 | GeneOrGeneProduct | denotes | AADC |
| T9 | 1354-1358 | GeneOrGeneProduct | denotes | MAOA |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 73-81 | DiseaseOrPhenotypicFeature | denotes | migraine | 0005277 |
| T2 | 112-120 | DiseaseOrPhenotypicFeature | denotes | Migraine | 0005277 |
| T3 | 154-171 | DiseaseOrPhenotypicFeature | denotes | headache disorder | 0021146 |
| T4 | 288-290 | DiseaseOrPhenotypicFeature | denotes | HT | 0007699 |
| T5 | 389-397 | DiseaseOrPhenotypicFeature | denotes | migraine | 0005277 |
| T6 | 497-499 | DiseaseOrPhenotypicFeature | denotes | HT | 0007699 |
| T7 | 535-543 | DiseaseOrPhenotypicFeature | denotes | migraine | 0005277 |
| T8 | 726-734 | DiseaseOrPhenotypicFeature | denotes | migraine | 0005277 |
| T9 | 874-883 | DiseaseOrPhenotypicFeature | denotes | sensitive | 0000605 |
| T10 | 1395-1403 | DiseaseOrPhenotypicFeature | denotes | migraine | 0005277 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 73-81 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T2 | 112-120 | DiseaseOrPhenotypicFeature | denotes | Migraine | D008881 |
| T3 | 146-171 | DiseaseOrPhenotypicFeature | denotes | primary headache disorder | D051270 |
| T4 | 389-397 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T5 | 535-543 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T6 | 726-734 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T7 | 1395-1403 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 73-81 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T2 | 112-120 | DiseaseOrPhenotypicFeature | denotes | Migraine | D008881 |
| T3 | 146-171 | DiseaseOrPhenotypicFeature | denotes | primary headache disorder | D051270 |
| T4 | 389-397 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T5 | 535-543 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T6 | 726-734 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
| T7 | 1395-1403 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 248-264 | ChemicalEntity | denotes | neurotransmitter | ChemicalEntity |
| T2 | 265-284 | ChemicalEntity | denotes | 5-hydroxytryptamine | D012701 |
| T3 | 286-290 | ChemicalEntity | denotes | 5-HT | D012701|http://purl.obolibrary.org/obo/CHEBI_28790 |
| T5 | 292-301 | ChemicalEntity | denotes | serotonin | D012701|http://purl.obolibrary.org/obo/CHEBI_350546|http://purl.obolibrary.org/obo/CHEBI_28790 |
| T8 | 495-499 | ChemicalEntity | denotes | 5-HT | D012701|http://purl.obolibrary.org/obo/CHEBI_28790 |
| T10 | 624-646 | ChemicalEntity | denotes | tryptophan hydroxylase | D014365 |
| T11 | 648-651 | ChemicalEntity | denotes | TPH | D014365 |
| T12 | 665-678 | ChemicalEntity | denotes | decarboxylase | D002262 |
| T13 | 690-707 | ChemicalEntity | denotes | monoamine oxidase | D008995 |
| T14 | 1340-1343 | ChemicalEntity | denotes | TPH | D014365 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 618-623 | OrganismTaxon | denotes | human |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T14 | 1340-1343 | ChemicalEntity | denotes | TPH | D014365 | |
| T13 | 690-707 | ChemicalEntity | denotes | monoamine oxidase | D008995 | |
| T12 | 665-678 | ChemicalEntity | denotes | decarboxylase | D002262 | |
| T11 | 648-651 | ChemicalEntity | denotes | TPH | D014365 | |
| T10 | 624-646 | ChemicalEntity | denotes | tryptophan hydroxylase | D014365 | |
| T8 | 495-499 | ChemicalEntity | denotes | 5-HT | http://purl.obolibrary.org/obo/CHEBI_28790|D012701 | |
| T5 | 292-301 | ChemicalEntity | denotes | serotonin | http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546|D012701 | |
| T3 | 286-290 | ChemicalEntity | denotes | 5-HT | http://purl.obolibrary.org/obo/CHEBI_28790|D012701 | |
| T2 | 265-284 | ChemicalEntity | denotes | 5-hydroxytryptamine | D012701 | |
| T1 | 248-264 | ChemicalEntity | denotes | neurotransmitter | ChemicalEntity | |
| T9 | 1354-1358 | GeneOrGeneProduct | denotes | MAOA | ||
| T57368 | 1345-1349 | GeneOrGeneProduct | denotes | AADC | ||
| T7 | 1340-1343 | GeneOrGeneProduct | denotes | TPH | ||
| T6 | 711-715 | GeneOrGeneProduct | denotes | MAOA | ||
| T30007 | 690-709 | GeneOrGeneProduct | denotes | monoamine oxidase A | ||
| T4 | 680-684 | GeneOrGeneProduct | denotes | AADC | ||
| T89820 | 654-678 | GeneOrGeneProduct | denotes | amino acid decarboxylase | ||
| T95821 | 648-651 | GeneOrGeneProduct | denotes | TPH | ||
| T80664 | 624-646 | GeneOrGeneProduct | denotes | tryptophan hydroxylase | ||
| T63097 | 1395-1403 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 | |
| T32450 | 726-734 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 | |
| T91210 | 535-543 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 | |
| T33622 | 389-397 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 | |
| T25031 | 146-171 | DiseaseOrPhenotypicFeature | denotes | primary headache disorder | D051270 | |
| T21482 | 112-120 | DiseaseOrPhenotypicFeature | denotes | Migraine | D008881 | |
| T84942 | 73-81 | DiseaseOrPhenotypicFeature | denotes | migraine | D008881 | |
| T46901 | 618-623 | OrganismTaxon | denotes | human |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 112-120 | HP_0002076 | denotes | Migraine |
| T2 | 154-162 | HP_0002315 | denotes | headache |
| T3 | 389-397 | HP_0002076 | denotes | migraine |
| T4 | 535-543 | HP_0002076 | denotes | migraine |
| T5 | 726-734 | HP_0002076 | denotes | migraine |
| T6 | 1395-1403 | HP_0002076 | denotes | migraine |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 690-709 | gene:4128 | denotes | monoamine oxidase A |
| T1 | 535-543 | disease:C0149931 | denotes | migraine |
| T2 | 690-709 | gene:4128 | denotes | monoamine oxidase A |
| T3 | 726-734 | disease:C0149931 | denotes | migraine |
| T4 | 711-715 | gene:4128 | denotes | MAOA |
| T5 | 726-734 | disease:C0149931 | denotes | migraine |
| T6 | 711-715 | gene:4128 | denotes | MAOA |
| T7 | 535-543 | disease:C0149931 | denotes | migraine |
| T8 | 1354-1358 | gene:4128 | denotes | MAOA |
| T9 | 1395-1403 | disease:C0149931 | denotes | migraine |
| R1 | T0 | T1 | associated_with | monoamine oxidase A,migraine |
| R2 | T2 | T3 | associated_with | monoamine oxidase A,migraine |
| R3 | T4 | T5 | associated_with | MAOA,migraine |
| R4 | T6 | T7 | associated_with | MAOA,migraine |
| R5 | T8 | T9 | associated_with | MAOA,migraine |