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UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-192 DRI_Background denotes Atorvastatin downregulates tissue plasminogen activator-aggravated genes mediating coagulation and vascular permeability in single cerebral endothelial cells captured by laser microdissection.
T2 193-319 DRI_Background denotes The effects of statins on gene expression of cerebral endothelial cells (ECs) in vivo have not been investigated after stroke.
T3 320-602 DRI_Challenge denotes We developed a rapid double immunofluorescent staining protocol with antibodies against von Willebrand factor (a marker for endothelium) and glial fibrillary acidic protein (a marker for astrocytes) for laser capture microdissection to isolate single ECs in brain tissue of the rat.
T4 603-865 DRI_Outcome denotes Using this protocol in combination with real-time PCR, we found that stroke significantly increased mRNA levels of protease-activated receptor 1 (PAR-1) and tissue factor (TF) in ECs isolated from ischemic cerebral microvessels compared with nonischemic vessels.
T5 866-1193 DRI_Background denotes Treatment of embolic stroke with recombinant human tissue plasminogen activator (rht-PA) 4 h after stroke further elevated PAR-1 mRNA levels nearly 1000-fold in the core and 500-fold in the boundary above the nonstroke group 30 h after stroke, while TF mRNA levels were elevated approximately 10 fold above the nonstroke group.
T6 1194-1355 DRI_Background denotes Furthermore, stroke significantly increased matrix metalloproteinase (MMP) 2 and 9 mRNA levels in the ischemic core and boundary regions 6 and 30 h after stroke.
T7 1356-1370 DRI_Background denotes Treatment with
T8 1371-1394 Token_Label.OUTSIDE denotes rht-PA-upregulated MMP2
T9 1395-1440 DRI_Background denotes expression in the ischemic boundary and core.
T10 1441-1592 DRI_Background denotes Atorvastatin completely blocked rht-PA upregulation of the above genes, when atorvastatin in combination with rht-PA was administered 4 h after stroke.
T11 1593-1717 DRI_Background denotes Monotherapy of atorvastatin 4 h after stroke did not significantly reduce expression of genes examined in the present study.
T12 1718-1988 DRI_Challenge denotes These data provide evidence that atorvastatin reduces exogenous tPA-aggravated cerebral endothelial genes that mediate thrombosis and blood-brain barrier permeability, which could contribute to the beneficial effects of statins on thrombolytic treatment of acute stroke.

c_corpus

Id Subject Object Predicate Lexical cue
T4 0-12 83367 denotes Atorvastatin
T1 0-12 D000069059 denotes Atorvastatin
T2 0-12 CHEBI:39548 denotes Atorvastatin
T3 0-12 D000069059 denotes Atorvastatin
T5 27-33 UBERON:0000479 denotes tissue
T6 27-55 D010959 denotes tissue plasminogen activator
T7 27-55 D010959 denotes tissue plasminogen activator
T26 34-55 P17811 denotes plasminogen activator
T28 83-94 GO:0050817 denotes coagulation
T29 208-215 D019161 denotes statins
T30 208-215 CHEBI:87631 denotes statins
T31 208-215 D019161 denotes statins
T32 219-223 SO:0000704 denotes gene
T33 219-234 GO:0010467 denotes gene expression
T34 266-269 CVCL_Z893 denotes ECs
T35 341-347 SO:0000985 denotes double
T36 389-399 D000906 denotes antibodies
T37 408-422 D014842 denotes von Willebrand
T38 408-422 D014842 denotes von Willebrand
T45 408-429 11274 denotes von Willebrand factor
T41 408-429 Q8CIZ8 denotes von Willebrand factor
T42 408-429 P04275 denotes von Willebrand factor
T43 408-429 Q62935 denotes von Willebrand factor
T44 408-429 Q28833 denotes von Willebrand factor
T46 408-429 Q28295 denotes von Willebrand factor
T47 408-429 P80012 denotes von Willebrand factor
T48 408-429 PR:000017364 denotes von Willebrand factor
T39 408-429 D014841 denotes von Willebrand factor
T40 408-429 D014841 denotes von Willebrand factor
T51 423-432 P18266 denotes factor (a
T52 423-432 P18265 denotes factor (a
T49 423-432 C413332 denotes factor (a
T50 423-432 C413332 denotes factor (a
T53 423-432 CHEBI:79381 denotes factor (a
T54 444-455 UBERON:0001986 denotes endothelium
T55 461-492 P47819 denotes glial fibrillary acidic protein
T57 461-492 P14136 denotes glial fibrillary acidic protein
T58 461-492 PR:000007939 denotes glial fibrillary acidic protein
T59 461-492 Q28115 denotes glial fibrillary acidic protein
T60 461-492 Q58EE9 denotes glial fibrillary acidic protein
T61 461-492 Q5RA72 denotes glial fibrillary acidic protein
T63 461-492 P03995 denotes glial fibrillary acidic protein
T64 461-492 P48677 denotes glial fibrillary acidic protein
T56 461-492 GO:0045101 denotes glial fibrillary acidic protein
T65 461-492 GO:0045098 denotes glial fibrillary acidic protein
T62 461-492 D005904 denotes glial fibrillary acidic protein
T70 485-492 SO:0000104 denotes protein
T71 485-495 Q9J7Z2 denotes protein (a
T72 485-495 P03064 denotes protein (a
T73 485-495 Q66929 denotes protein (a
T74 485-495 Q9IMM4 denotes protein (a
T75 485-495 Q9DIC5 denotes protein (a
T76 485-495 Q86XJ0 denotes protein (a
T77 485-495 Q992J0 denotes protein (a
T78 485-495 P18164 denotes protein (a
T79 485-495 Q96631 denotes protein (a
T80 485-495 Q993M1 denotes protein (a
T83 485-495 Q9QAZ8 denotes protein (a
T81 485-495 D013205 denotes protein (a
T82 485-495 D013205 denotes protein (a
T84 571-574 CVCL_Z893 denotes ECs
T85 578-583 UBERON:6110636 denotes brain
T86 578-583 UBERON:0000955 denotes brain
T87 584-590 UBERON:0000479 denotes tissue
T88 598-601 10116 denotes rat
T92 598-601 D051381 denotes rat
T89 598-601 PR:P63003-1 denotes rat
T90 598-601 PR:Q2G0B1 denotes rat
T91 598-601 PR:Q8VHJ4 denotes rat
T93 653-656 Q41249 denotes PCR
T94 653-656 O66148 denotes PCR
T95 653-656 Q59987 denotes PCR
T96 653-656 Q01289 denotes PCR
T97 653-656 O80333 denotes PCR
T98 653-656 P15904 denotes PCR
T99 653-656 Q9SDT1 denotes PCR
T100 653-656 Q39617 denotes PCR
T103 703-707 SO:0000234 denotes mRNA
T101 703-707 D012333 denotes mRNA
T102 703-707 CHEBI:33699 denotes mRNA
T104 718-726 P68985 denotes protease
T105 718-726 P30202 denotes protease
T106 718-726 P42672 denotes protease
T107 718-726 P11826 denotes protease
T108 718-726 Q5TJ03 denotes protease
T109 718-726 O71070 denotes protease
T110 718-726 P63122 denotes protease
T111 718-726 P63131 denotes protease
T112 718-726 Q9IIH4 denotes protease
T113 718-726 P10270 denotes protease
T114 718-726 Q8JN66 denotes protease
T115 718-726 O40958 denotes protease
T116 718-726 P10265 denotes protease
T117 718-726 Q9QM72 denotes protease
T118 718-726 P63119 denotes protease
T119 718-726 Q9WF19 denotes protease
T120 718-726 P63120 denotes protease
T121 718-726 P63125 denotes protease
T122 718-726 P63124 denotes protease
T123 718-726 P68986 denotes protease
T124 718-726 Q96629 denotes protease
T125 718-726 P63121 denotes protease
T126 718-726 P09569 denotes protease
T127 718-726 P03253 denotes protease
T128 718-726 P63129 denotes protease
T129 718-726 P10381 denotes protease
T130 718-726 P07885 denotes protease
T131 718-726 Q83906 denotes protease
T132 718-726 P19119 denotes protease
T133 718-726 P63127 denotes protease
T134 718-726 Q84177 denotes protease
T135 718-726 P19151 denotes protease
T136 718-726 Q9Y6I0 denotes protease
T137 718-726 P63123 denotes protease
T138 718-726 P68984 denotes protease
T139 718-726 P87563 denotes protease
T140 718-726 P03252 denotes protease
T141 718-726 O71150 denotes protease
T142 718-726 P11825 denotes protease
T143 718-747 D044463 denotes protease-activated receptor 1
T144 749-752 CVCL_E801 denotes PAR
T145 749-752 44741 denotes PAR
T146 749-754 P25116 denotes PAR-1
T147 749-754 P56488 denotes PAR-1
T148 749-754 PR:Q9HAB3 denotes PAR-1
T149 749-754 PR:P19880 denotes PAR-1
T150 749-754 PR:P25116 denotes PAR-1
T151 749-754 PR:P30558 denotes PAR-1
T152 749-754 PR:P26824 denotes PAR-1
T153 749-754 PR:Q10428 denotes PAR-1
T154 749-754 PR:Q1MTN7 denotes PAR-1
T155 749-754 PR:Q9TW45 denotes PAR-1
T156 749-754 P30558 denotes PAR-1
T157 749-754 P47749 denotes PAR-1
T158 749-754 PR:Q9SJH0 denotes PAR-1
T159 749-754 P26824 denotes PAR-1
T160 749-754 PR:000001661 denotes PAR-1
T161 749-754 PR:000008187 denotes PAR-1
T162 749-754 Q00991 denotes PAR-1
T163 749-754 A7YY44 denotes PAR-1
T164 760-766 UBERON:0000479 denotes tissue
T165 760-773 P30931 denotes tissue factor
T166 760-773 P13726 denotes tissue factor
T167 760-773 Q9JLU8 denotes tissue factor
T168 760-773 P24055 denotes tissue factor
T169 760-773 P42533 denotes tissue factor
T171 760-773 P20352 denotes tissue factor
T173 760-773 PR:000001940 denotes tissue factor
T170 760-773 D013925 denotes tissue factor
T172 760-773 D013925 denotes tissue factor
T174 782-785 CVCL_Z893 denotes ECs
T175 911-916 D006801 denotes human
T176 917-923 UBERON:0000479 denotes tissue
T177 917-945 D010959 denotes tissue plasminogen activator
T178 917-945 D010959 denotes tissue plasminogen activator
T197 924-945 P17811 denotes plasminogen activator
T199 951-956 CVCL_D695 denotes PA) 4
T200 989-992 CVCL_E801 denotes PAR
T201 989-992 44741 denotes PAR
T202 989-994 P25116 denotes PAR-1
T203 989-994 P56488 denotes PAR-1
T204 989-994 PR:Q9HAB3 denotes PAR-1
T205 989-994 PR:P19880 denotes PAR-1
T206 989-994 PR:P25116 denotes PAR-1
T207 989-994 PR:P30558 denotes PAR-1
T208 989-994 PR:P26824 denotes PAR-1
T209 989-994 PR:Q10428 denotes PAR-1
T210 989-994 PR:Q1MTN7 denotes PAR-1
T211 989-994 PR:Q9TW45 denotes PAR-1
T212 989-994 P30558 denotes PAR-1
T213 989-994 P47749 denotes PAR-1
T214 989-994 PR:Q9SJH0 denotes PAR-1
T215 989-994 P26824 denotes PAR-1
T216 989-994 PR:000001661 denotes PAR-1
T217 989-994 PR:000008187 denotes PAR-1
T218 989-994 Q00991 denotes PAR-1
T219 989-994 A7YY44 denotes PAR-1
T222 995-999 SO:0000234 denotes mRNA
T220 995-999 D012333 denotes mRNA
T221 995-999 CHEBI:33699 denotes mRNA
T223 1019-1023 PR:000022679 denotes fold
T224 1019-1023 PR:Q2FZJ6 denotes fold
T225 1019-1023 PR:A5I112 denotes fold
T226 1019-1023 PR:P24186 denotes fold
T227 1031-1035 GO:0019013 denotes core
T228 1044-1048 PR:000022679 denotes fold
T229 1044-1048 PR:Q2FZJ6 denotes fold
T230 1044-1048 PR:A5I112 denotes fold
T231 1044-1048 PR:P24186 denotes fold
T232 1056-1064 SO:0000699 denotes boundary
T235 1119-1123 SO:0000234 denotes mRNA
T233 1119-1123 D012333 denotes mRNA
T234 1119-1123 CHEBI:33699 denotes mRNA
T236 1162-1166 PR:000022679 denotes fold
T237 1162-1166 PR:Q2FZJ6 denotes fold
T238 1162-1166 PR:A5I112 denotes fold
T239 1162-1166 PR:P24186 denotes fold
T240 1238-1244 UBERON:0027368 denotes matrix
T241 1245-1270 D020778 denotes metalloproteinase (MMP) 2
T246 1264-1270 PR:P08253 denotes MMP) 2
T247 1264-1270 Q9GLE5 denotes MMP) 2
T248 1264-1270 P08253 denotes MMP) 2
T249 1264-1270 Q90611 denotes MMP) 2
T251 1264-1270 PR:Q8MPP3 denotes MMP) 2
T252 1264-1270 P33436 denotes MMP) 2
T253 1264-1270 PR:Q90611 denotes MMP) 2
T254 1264-1270 PR:P33436 denotes MMP) 2
T255 1264-1270 PR:000010479 denotes MMP) 2
T256 1264-1270 PR:P33434 denotes MMP) 2
T257 1264-1270 P33434 denotes MMP) 2
T258 1264-1270 P50757 denotes MMP) 2
T250 1264-1270 GO:0004228 denotes MMP) 2
T261 1277-1281 SO:0000234 denotes mRNA
T259 1277-1281 D012333 denotes mRNA
T260 1277-1281 CHEBI:33699 denotes mRNA
T262 1305-1309 GO:0019013 denotes core
T263 1314-1322 SO:0000699 denotes boundary
T264 1390-1393 CHEBI:340824 denotes MMP
T267 1390-1393 CHEBI:59761 denotes MMP
T268 1390-1394 PR:P08253 denotes MMP2
T269 1390-1394 Q9GLE5 denotes MMP2
T270 1390-1394 P08253 denotes MMP2
T271 1390-1394 Q90611 denotes MMP2
T273 1390-1394 PR:Q8MPP3 denotes MMP2
T274 1390-1394 P33436 denotes MMP2
T275 1390-1394 PR:Q90611 denotes MMP2
T276 1390-1394 PR:P33436 denotes MMP2
T277 1390-1394 PR:000010479 denotes MMP2
T278 1390-1394 PR:P33434 denotes MMP2
T279 1390-1394 P33434 denotes MMP2
T280 1390-1394 P50757 denotes MMP2
T272 1390-1394 GO:0004228 denotes MMP2
T281 1422-1430 SO:0000699 denotes boundary
T282 1435-1439 GO:0019013 denotes core
T286 1441-1453 83367 denotes Atorvastatin
T283 1441-1453 D000069059 denotes Atorvastatin
T284 1441-1453 CHEBI:39548 denotes Atorvastatin
T285 1441-1453 D000069059 denotes Atorvastatin
T290 1518-1530 83367 denotes atorvastatin
T287 1518-1530 D000069059 denotes atorvastatin
T288 1518-1530 CHEBI:39548 denotes atorvastatin
T289 1518-1530 D000069059 denotes atorvastatin
T294 1608-1620 83367 denotes atorvastatin
T291 1608-1620 D000069059 denotes atorvastatin
T292 1608-1620 CHEBI:39548 denotes atorvastatin
T293 1608-1620 D000069059 denotes atorvastatin
T298 1751-1763 83367 denotes atorvastatin
T295 1751-1763 D000069059 denotes atorvastatin
T296 1751-1763 CHEBI:39548 denotes atorvastatin
T297 1751-1763 D000069059 denotes atorvastatin
T302 1782-1785 Q28198 denotes tPA
T304 1782-1785 Q5R8J0 denotes tPA
T305 1782-1785 P19637 denotes tPA
T306 1782-1785 P00750 denotes tPA
T307 1782-1785 Q8SQ23 denotes tPA
T309 1782-1785 PR:000012825 denotes tPA
T310 1782-1785 P11214 denotes tPA
T299 1782-1785 CHEBI:53394 denotes tPA
T300 1782-1785 CHEBI:15702 denotes tPA
T301 1782-1785 CHEBI:61432 denotes tPA
T303 1782-1785 CHEBI:37537 denotes tPA
T308 1782-1785 GO:0031299 denotes tPA
T311 1837-1847 D013927 denotes thrombosis
T312 1837-1847 D013927 denotes thrombosis
T313 1852-1871 UBERON:0000120 denotes blood-brain barrier
T316 1938-1945 D019161 denotes statins
T317 1938-1945 CHEBI:87631 denotes statins
T318 1938-1945 D019161 denotes statins
T319 1975-1987 D020521 denotes acute stroke
T320 1975-1987 D020521 denotes acute stroke