PubMed:16166602 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/16166602","sourcedb":"PubMed","sourceid":"16166602","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/16166602","text":"Differential selectivity of hyaluronidase inhibitors toward acidic and basic hyaluronidases.\nHyaluronidase (HAase), a class of enzymes which degrade hyaluronic acid (HA), are involved in the spread of infections/toxins, ovum fertilization, and cancer progression. Thus, HAase inhibitors may have use in disease treatments. We evaluated 21 HAase inhibitors against HYAL-1, testicular, honeybee, and Streptomyces HAases. Among these inhibitors, polymers of poly (styrene-4-sulfonate) (PSS) (i.e., molecular weight 1400-990,000 or PSS 1400-PSS 990,000) and O-sulfated HA (sHA) derivatives (sHA2.0, 2.5, and 2.75) were the most effective. HYAL-1 and bee HAases were the most sensitive, followed by testicular HAase; Streptomyces HAase was resistant to all inhibitors, except PSS 990,000 and VERSA-TL 502 (i.e., PSS 10(6) dalton). The length of the PSS polymer determined their potency (e.g., IC50 for HYAL-1, PSS 990,000: 0.0096 microM; PSS 210 no inhibition; IC50 for testicular HAase, PSS 990,000: 0.042 microM; PSS 210 no inhibition). The presence, but not the number, of sulfate groups on the sHA molecule determined its potency (e.g., IC50 for HYAL-1: sHA2.0, 0.019 microM; sHA2.75, 0.0083 microM). Other known HAase inhibitors, such as gossypol, sodium-aurothiomalate, 1-tetradecane sulfonic acid, and glycerrhizic acid, were not effective. Both PSS and sHA inhibited HAases by a mixed inhibition mechanism (i.e., competitive + uncompetitive) and were 5- to 17-fold better as uncompetitive inhibitors than as competitive inhibitors. These results demonstrate that HAase inhibitors show selectivity toward the different types of HAases, which could be exploited to inhibit specific HAases involved in a variety of pathophysiologic conditions.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":364,"end":368},"obj":"http://purl.obolibrary.org/obo/UBERON_3000101"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":635,"end":639},"obj":"http://purl.obolibrary.org/obo/UBERON_3000101"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":897,"end":901},"obj":"http://purl.obolibrary.org/obo/UBERON_3000101"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":1145,"end":1149},"obj":"http://purl.obolibrary.org/obo/UBERON_3000101"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"performance-test"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":244,"end":250},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":166,"end":168},"obj":"http://www.uniprot.org/uniprot/P69208"},{"id":"T2","span":{"begin":565,"end":567},"obj":"http://www.uniprot.org/uniprot/P69208"},{"id":"T3","span":{"begin":902,"end":908},"obj":"http://www.uniprot.org/uniprot/P48651"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-human"},{"subj":"T2","pred":"source","obj":"uniprot-human"},{"subj":"T3","pred":"source","obj":"uniprot-human"}]},{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":902,"end":908},"obj":"http://www.uniprot.org/uniprot/Q99LH2"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-mouse"}]},{"project":"GlycoBiology-MAT","denotations":[{"id":"T1","span":{"begin":220,"end":224},"obj":"http://purl.obolibrary.org/obo/MAT_0000213"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-MAT"}]},{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":244,"end":250},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/6754"},{"id":"T2","span":{"begin":364,"end":368},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/199485"},{"id":"T3","span":{"begin":398,"end":410},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/1883"},{"id":"T4","span":{"begin":635,"end":639},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/199485"},{"id":"T5","span":{"begin":712,"end":724},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/1883"},{"id":"T6","span":{"begin":897,"end":901},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/199485"},{"id":"T7","span":{"begin":1079,"end":1085},"obj":"http://purl.bioontology.org/ontology/STY/T096"},{"id":"T8","span":{"begin":1145,"end":1149},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/199485"},{"id":"T9","span":{"begin":1399,"end":1408},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/127244"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T2","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T3","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T4","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T5","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T6","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T7","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T8","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T9","pred":"source","obj":"GlycoBiology-NCBITAXON"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":93,"end":263},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":264,"end":322},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":323,"end":418},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":419,"end":634},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":635,"end":825},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":826,"end":917},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":918,"end":995},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":996,"end":1033},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1034,"end":1199},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1200,"end":1342},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1343,"end":1534},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1535,"end":1743},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T2","span":{"begin":93,"end":263},"obj":"Sentence"},{"id":"T3","span":{"begin":264,"end":322},"obj":"Sentence"},{"id":"T4","span":{"begin":323,"end":418},"obj":"Sentence"},{"id":"T5","span":{"begin":419,"end":634},"obj":"Sentence"},{"id":"T6","span":{"begin":635,"end":825},"obj":"Sentence"},{"id":"T7","span":{"begin":826,"end":917},"obj":"Sentence"},{"id":"T8","span":{"begin":918,"end":995},"obj":"Sentence"},{"id":"T9","span":{"begin":996,"end":1033},"obj":"Sentence"},{"id":"T10","span":{"begin":1034,"end":1199},"obj":"Sentence"},{"id":"T11","span":{"begin":1200,"end":1342},"obj":"Sentence"},{"id":"T12","span":{"begin":1343,"end":1534},"obj":"Sentence"},{"id":"T13","span":{"begin":1535,"end":1743},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T2","span":{"begin":93,"end":263},"obj":"Sentence"},{"id":"T3","span":{"begin":264,"end":322},"obj":"Sentence"},{"id":"T4","span":{"begin":323,"end":418},"obj":"Sentence"},{"id":"T5","span":{"begin":419,"end":634},"obj":"Sentence"},{"id":"T6","span":{"begin":635,"end":825},"obj":"Sentence"},{"id":"T7","span":{"begin":826,"end":917},"obj":"Sentence"},{"id":"T8","span":{"begin":918,"end":995},"obj":"Sentence"},{"id":"T9","span":{"begin":996,"end":1033},"obj":"Sentence"},{"id":"T10","span":{"begin":1034,"end":1199},"obj":"Sentence"},{"id":"T11","span":{"begin":1200,"end":1342},"obj":"Sentence"},{"id":"T12","span":{"begin":1343,"end":1534},"obj":"Sentence"},{"id":"T13","span":{"begin":1535,"end":1743},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T12","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T13","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"}]},{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":141,"end":148},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T2","span":{"begin":225,"end":238},"obj":"http://purl.obolibrary.org/obo/GO_0009566"},{"id":"T3","span":{"begin":471,"end":480},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T4","span":{"begin":1285,"end":1293},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T5","span":{"begin":556,"end":564},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T6","span":{"begin":1071,"end":1078},"obj":"http://purl.obolibrary.org/obo/GO_0051923"},{"id":"T7","span":{"begin":671,"end":680},"obj":"http://purl.obolibrary.org/obo/GO_0046960"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-BP"},{"subj":"T2","pred":"source","obj":"GO-BP"},{"subj":"T3","pred":"source","obj":"GO-BP"},{"subj":"T4","pred":"source","obj":"GO-BP"},{"subj":"T5","pred":"source","obj":"GO-BP"},{"subj":"T6","pred":"source","obj":"GO-BP"},{"subj":"T7","pred":"source","obj":"GO-BP"}]},{"project":"EDAM-topics","denotations":[{"id":"T1","span":{"begin":212,"end":218},"obj":"http://edamontology.org/topic_0154"},{"id":"T2","span":{"begin":244,"end":250},"obj":"http://edamontology.org/topic_2640"},{"id":"T3","span":{"begin":303,"end":310},"obj":"http://edamontology.org/topic_0634"},{"id":"T4","span":{"begin":1097,"end":1105},"obj":"http://edamontology.org/topic_2839"}],"attributes":[{"subj":"T1","pred":"source","obj":"EDAM-topics"},{"subj":"T2","pred":"source","obj":"EDAM-topics"},{"subj":"T3","pred":"source","obj":"EDAM-topics"},{"subj":"T4","pred":"source","obj":"EDAM-topics"}]},{"project":"EDAM-DFO","denotations":[{"id":"T1","span":{"begin":1549,"end":1560},"obj":"http://edamontology.org/operation_2246"},{"id":"T2","span":{"begin":1621,"end":1626},"obj":"http://edamontology.org/data_2100"}],"attributes":[{"subj":"T1","pred":"source","obj":"EDAM-DFO"},{"subj":"T2","pred":"source","obj":"EDAM-DFO"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":384,"end":392},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":398,"end":410},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":646,"end":649},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":712,"end":724},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"7460"},{"id":"A2","pred":"db_id","subj":"T2","obj":"1883"},{"id":"A3","pred":"db_id","subj":"T3","obj":"34735"},{"id":"A4","pred":"db_id","subj":"T3","obj":"7460"},{"id":"A5","pred":"db_id","subj":"T5","obj":"1883"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"},{"subj":"T3","pred":"source","obj":"NCBITAXON"},{"subj":"T5","pred":"source","obj":"NCBITAXON"}]},{"project":"GlyTouCan-IUPAC","denotations":[{"id":"GlycanIUPAC_T1","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G41652MJ\""},{"id":"GlycanIUPAC_T2","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G20761YC\""},{"id":"GlycanIUPAC_T3","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G19807HM\""},{"id":"GlycanIUPAC_T4","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G20351TE\""},{"id":"GlycanIUPAC_T5","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G71957MR\""},{"id":"GlycanIUPAC_T6","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G59040AE\""},{"id":"GlycanIUPAC_T7","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G14987PW\""},{"id":"GlycanIUPAC_T8","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G95064PC\""},{"id":"GlycanIUPAC_T9","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G39143AQ\""},{"id":"GlycanIUPAC_T10","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G65149OO\""},{"id":"GlycanIUPAC_T11","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G02766SY\""},{"id":"GlycanIUPAC_T12","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G26019KJ\""},{"id":"GlycanIUPAC_T13","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G36429CZ\""},{"id":"GlycanIUPAC_T14","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G89633TP\""},{"id":"GlycanIUPAC_T15","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G28494FO\""},{"id":"GlycanIUPAC_T16","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G06219CP\""},{"id":"GlycanIUPAC_T17","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G44237SM\""},{"id":"GlycanIUPAC_T18","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G57948RL\""},{"id":"GlycanIUPAC_T19","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G64016DN\""},{"id":"GlycanIUPAC_T20","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G14536PC\""},{"id":"GlycanIUPAC_T21","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G14356FW\""},{"id":"GlycanIUPAC_T22","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G34565UO\""},{"id":"GlycanIUPAC_T23","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G67124MW\""},{"id":"GlycanIUPAC_T24","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G71457ZU\""},{"id":"GlycanIUPAC_T25","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G55228VZ\""},{"id":"GlycanIUPAC_T26","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G31034MJ\""},{"id":"GlycanIUPAC_T27","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G25776IP\""},{"id":"GlycanIUPAC_T28","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G64442BV\""},{"id":"GlycanIUPAC_T29","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G57018LE\""},{"id":"GlycanIUPAC_T30","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G61761GX\""},{"id":"GlycanIUPAC_T31","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G76318UX\""},{"id":"GlycanIUPAC_T32","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G61906ER\""},{"id":"GlycanIUPAC_T33","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G68723GR\""},{"id":"GlycanIUPAC_T34","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G19540LE\""},{"id":"GlycanIUPAC_T35","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G74944PO\""},{"id":"GlycanIUPAC_T36","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G89489ZJ\""},{"id":"GlycanIUPAC_T37","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G04434YU\""},{"id":"GlycanIUPAC_T38","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G21450PB\""},{"id":"GlycanIUPAC_T39","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G93629QY\""},{"id":"GlycanIUPAC_T40","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G02603TR\""},{"id":"GlycanIUPAC_T41","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G40280JP\""},{"id":"GlycanIUPAC_T42","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G95259IC\""},{"id":"GlycanIUPAC_T43","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G26900FE\""},{"id":"GlycanIUPAC_T44","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G21346KK\""},{"id":"GlycanIUPAC_T45","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G62509FF\""},{"id":"GlycanIUPAC_T46","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G83932AK\""},{"id":"GlycanIUPAC_T47","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G96978IB\""},{"id":"GlycanIUPAC_T48","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G34275DN\""},{"id":"GlycanIUPAC_T49","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G07071JF\""},{"id":"GlycanIUPAC_T50","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G80639QD\""},{"id":"GlycanIUPAC_T51","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G99460PJ\""},{"id":"GlycanIUPAC_T52","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G22024BZ\""},{"id":"GlycanIUPAC_T53","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G74097ZY\""},{"id":"GlycanIUPAC_T54","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G84439YP\""},{"id":"GlycanIUPAC_T55","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G52207WQ\""},{"id":"GlycanIUPAC_T56","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G90695MS\""},{"id":"GlycanIUPAC_T57","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G50398QX\""},{"id":"GlycanIUPAC_T58","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G12166ZT\""},{"id":"GlycanIUPAC_T59","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G48368BR\""},{"id":"GlycanIUPAC_T60","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G57407RW\""},{"id":"GlycanIUPAC_T61","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G00386TY\""},{"id":"GlycanIUPAC_T62","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G18723JK\""},{"id":"GlycanIUPAC_T63","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G93757OR\""},{"id":"GlycanIUPAC_T64","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G29006SI\""},{"id":"GlycanIUPAC_T65","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G03099OQ\""},{"id":"GlycanIUPAC_T66","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G53739OW\""},{"id":"GlycanIUPAC_T67","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G70440ZO\""},{"id":"GlycanIUPAC_T68","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G29951RR\""},{"id":"GlycanIUPAC_T69","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G58402TI\""},{"id":"GlycanIUPAC_T70","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G39875TP\""},{"id":"GlycanIUPAC_T71","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G83439QV\""},{"id":"GlycanIUPAC_T72","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G41762RC\""},{"id":"GlycanIUPAC_T73","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G91604UI\""},{"id":"GlycanIUPAC_T74","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G88447WE\""},{"id":"GlycanIUPAC_T75","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G93634BS\""},{"id":"GlycanIUPAC_T76","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G02587BH\""},{"id":"GlycanIUPAC_T77","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G43511MX\""},{"id":"GlycanIUPAC_T78","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G64958DH\""},{"id":"GlycanIUPAC_T79","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G30384TR\""},{"id":"GlycanIUPAC_T80","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G15624EX\""},{"id":"GlycanIUPAC_T81","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G22706ST\""},{"id":"GlycanIUPAC_T82","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G57408PI\""},{"id":"GlycanIUPAC_T83","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G86403XX\""},{"id":"GlycanIUPAC_T84","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G78043YB\""},{"id":"GlycanIUPAC_T85","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G18952JK\""},{"id":"GlycanIUPAC_T86","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G49020ND\""},{"id":"GlycanIUPAC_T87","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G63590YW\""},{"id":"GlycanIUPAC_T88","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G22793KS\""},{"id":"GlycanIUPAC_T89","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G64134SS\""},{"id":"GlycanIUPAC_T90","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G17338HY\""},{"id":"GlycanIUPAC_T91","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G99745XF\""},{"id":"GlycanIUPAC_T92","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G27782HN\""},{"id":"GlycanIUPAC_T93","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G57496DC\""},{"id":"GlycanIUPAC_T94","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G93169WB\""},{"id":"GlycanIUPAC_T95","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G05518TD\""},{"id":"GlycanIUPAC_T96","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G62603DN\""},{"id":"GlycanIUPAC_T97","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G59574FS\""},{"id":"GlycanIUPAC_T98","span":{"begin":748,"end":751},"obj":"\"http://rdf.glycoinfo.org/glycan/G47567WC\""}],"attributes":[{"subj":"GlycanIUPAC_T1","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T2","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T3","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T4","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T5","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T6","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T7","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T8","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T9","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T10","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T11","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T12","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T13","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T14","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T15","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T16","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T17","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T18","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T19","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T20","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T21","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T22","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T23","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T24","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T25","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T26","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T27","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T28","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T29","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T30","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T31","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T32","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T33","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T34","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T35","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T36","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T37","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T38","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T39","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T40","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T41","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T42","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T43","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T44","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T45","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T46","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T47","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T48","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T49","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T50","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T51","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T52","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T53","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T54","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T55","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T56","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T57","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T58","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T59","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T60","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T61","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T62","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T63","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T64","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T65","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T66","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T67","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T68","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T69","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T70","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T71","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T72","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T73","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T74","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T75","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T76","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T77","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T78","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T79","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T80","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T81","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T82","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T83","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T84","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T85","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T86","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T87","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T88","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T89","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T90","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T91","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T92","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T93","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T94","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T95","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T96","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T97","pred":"source","obj":"GlyTouCan-IUPAC"},{"subj":"GlycanIUPAC_T98","pred":"source","obj":"GlyTouCan-IUPAC"}]},{"project":"Lectin","denotations":[{"id":"Lectin_T1","span":{"begin":569,"end":572},"obj":"https://acgg.asia/db/lfdb/LfDB0226"},{"id":"Lectin_T2","span":{"begin":1093,"end":1096},"obj":"https://acgg.asia/db/lfdb/LfDB0226"},{"id":"Lectin_T3","span":{"begin":1356,"end":1359},"obj":"https://acgg.asia/db/lfdb/LfDB0226"},{"id":"Lectin_T4","span":{"begin":793,"end":795},"obj":"https://acgg.asia/db/lfdb/LfDB0385"}],"attributes":[{"subj":"Lectin_T1","pred":"source","obj":"Lectin"},{"subj":"Lectin_T2","pred":"source","obj":"Lectin"},{"subj":"Lectin_T3","pred":"source","obj":"Lectin"},{"subj":"Lectin_T4","pred":"source","obj":"Lectin"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":201,"end":211},"obj":"Disease"},{"id":"T2","span":{"begin":244,"end":250},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":220,"end":224},"obj":"http://purl.obolibrary.org/obo/MAT_0000213"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":220,"end":224},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000213"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":220,"end":224},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000025"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":244,"end":250},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002664"},{"subj":"T1","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":220,"end":224},"obj":"Cell"},{"id":"T2","span":{"begin":455,"end":459},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000025"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000096"},{"id":"A3","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000775"},{"subj":"T1","pred":"source","obj":"CL-cell"},{"subj":"T2","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"performance-test","color":"#ec93a1","default":true},{"id":"PubmedHPO","color":"#93bbec"},{"id":"uniprot-human","color":"#d5ec93"},{"id":"uniprot-mouse","color":"#e893ec"},{"id":"GlycoBiology-MAT","color":"#93ecce"},{"id":"GlycoBiology-NCBITAXON","color":"#ecb493"},{"id":"sentences","color":"#9a93ec"},{"id":"GO-BP","color":"#a5ec93"},{"id":"EDAM-topics","color":"#ec93bf"},{"id":"EDAM-DFO","color":"#93d9ec"},{"id":"NCBITAXON","color":"#ece593"},{"id":"GlyTouCan-IUPAC","color":"#cb93ec"},{"id":"Lectin","color":"#93ecb1"},{"id":"mondo_disease","color":"#ec9693"},{"id":"Glycosmos6-MAT","color":"#93a9ec"},{"id":"Anatomy-MAT","color":"#c3ec93"},{"id":"Anatomy-UBERON","color":"#ec93dd"},{"id":"HP-phenotype","color":"#93ece1"},{"id":"CL-cell","color":"#ecc793"}]}]}}