> top > docs > PubMed:16166602 > annotations

PubMed:16166602 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-92 Sentence denotes Differential selectivity of hyaluronidase inhibitors toward acidic and basic hyaluronidases.
TextSentencer_T2 93-263 Sentence denotes Hyaluronidase (HAase), a class of enzymes which degrade hyaluronic acid (HA), are involved in the spread of infections/toxins, ovum fertilization, and cancer progression.
TextSentencer_T3 264-322 Sentence denotes Thus, HAase inhibitors may have use in disease treatments.
TextSentencer_T4 323-418 Sentence denotes We evaluated 21 HAase inhibitors against HYAL-1, testicular, honeybee, and Streptomyces HAases.
TextSentencer_T5 419-634 Sentence denotes Among these inhibitors, polymers of poly (styrene-4-sulfonate) (PSS) (i.e., molecular weight 1400-990,000 or PSS 1400-PSS 990,000) and O-sulfated HA (sHA) derivatives (sHA2.0, 2.5, and 2.75) were the most effective.
TextSentencer_T6 635-825 Sentence denotes HYAL-1 and bee HAases were the most sensitive, followed by testicular HAase; Streptomyces HAase was resistant to all inhibitors, except PSS 990,000 and VERSA-TL 502 (i.e., PSS 10(6) dalton).
TextSentencer_T7 826-917 Sentence denotes The length of the PSS polymer determined their potency (e.g., IC50 for HYAL-1, PSS 990,000:
TextSentencer_T8 918-995 Sentence denotes 0.0096 microM; PSS 210 no inhibition; IC50 for testicular HAase, PSS 990,000:
TextSentencer_T9 996-1033 Sentence denotes 0.042 microM; PSS 210 no inhibition).
TextSentencer_T10 1034-1199 Sentence denotes The presence, but not the number, of sulfate groups on the sHA molecule determined its potency (e.g., IC50 for HYAL-1: sHA2.0, 0.019 microM; sHA2.75, 0.0083 microM).
TextSentencer_T11 1200-1342 Sentence denotes Other known HAase inhibitors, such as gossypol, sodium-aurothiomalate, 1-tetradecane sulfonic acid, and glycerrhizic acid, were not effective.
TextSentencer_T12 1343-1534 Sentence denotes Both PSS and sHA inhibited HAases by a mixed inhibition mechanism (i.e., competitive + uncompetitive) and were 5- to 17-fold better as uncompetitive inhibitors than as competitive inhibitors.
TextSentencer_T13 1535-1743 Sentence denotes These results demonstrate that HAase inhibitors show selectivity toward the different types of HAases, which could be exploited to inhibit specific HAases involved in a variety of pathophysiologic conditions.
T1 0-92 Sentence denotes Differential selectivity of hyaluronidase inhibitors toward acidic and basic hyaluronidases.
T2 93-263 Sentence denotes Hyaluronidase (HAase), a class of enzymes which degrade hyaluronic acid (HA), are involved in the spread of infections/toxins, ovum fertilization, and cancer progression.
T3 264-322 Sentence denotes Thus, HAase inhibitors may have use in disease treatments.
T4 323-418 Sentence denotes We evaluated 21 HAase inhibitors against HYAL-1, testicular, honeybee, and Streptomyces HAases.
T5 419-634 Sentence denotes Among these inhibitors, polymers of poly (styrene-4-sulfonate) (PSS) (i.e., molecular weight 1400-990,000 or PSS 1400-PSS 990,000) and O-sulfated HA (sHA) derivatives (sHA2.0, 2.5, and 2.75) were the most effective.
T6 635-825 Sentence denotes HYAL-1 and bee HAases were the most sensitive, followed by testicular HAase; Streptomyces HAase was resistant to all inhibitors, except PSS 990,000 and VERSA-TL 502 (i.e., PSS 10(6) dalton).
T7 826-917 Sentence denotes The length of the PSS polymer determined their potency (e.g., IC50 for HYAL-1, PSS 990,000:
T8 918-995 Sentence denotes 0.0096 microM; PSS 210 no inhibition; IC50 for testicular HAase, PSS 990,000:
T9 996-1033 Sentence denotes 0.042 microM; PSS 210 no inhibition).
T10 1034-1199 Sentence denotes The presence, but not the number, of sulfate groups on the sHA molecule determined its potency (e.g., IC50 for HYAL-1: sHA2.0, 0.019 microM; sHA2.75, 0.0083 microM).
T11 1200-1342 Sentence denotes Other known HAase inhibitors, such as gossypol, sodium-aurothiomalate, 1-tetradecane sulfonic acid, and glycerrhizic acid, were not effective.
T12 1343-1534 Sentence denotes Both PSS and sHA inhibited HAases by a mixed inhibition mechanism (i.e., competitive + uncompetitive) and were 5- to 17-fold better as uncompetitive inhibitors than as competitive inhibitors.
T13 1535-1743 Sentence denotes These results demonstrate that HAase inhibitors show selectivity toward the different types of HAases, which could be exploited to inhibit specific HAases involved in a variety of pathophysiologic conditions.
T1 0-92 Sentence denotes Differential selectivity of hyaluronidase inhibitors toward acidic and basic hyaluronidases.
T2 93-263 Sentence denotes Hyaluronidase (HAase), a class of enzymes which degrade hyaluronic acid (HA), are involved in the spread of infections/toxins, ovum fertilization, and cancer progression.
T3 264-322 Sentence denotes Thus, HAase inhibitors may have use in disease treatments.
T4 323-418 Sentence denotes We evaluated 21 HAase inhibitors against HYAL-1, testicular, honeybee, and Streptomyces HAases.
T5 419-634 Sentence denotes Among these inhibitors, polymers of poly (styrene-4-sulfonate) (PSS) (i.e., molecular weight 1400-990,000 or PSS 1400-PSS 990,000) and O-sulfated HA (sHA) derivatives (sHA2.0, 2.5, and 2.75) were the most effective.
T6 635-825 Sentence denotes HYAL-1 and bee HAases were the most sensitive, followed by testicular HAase; Streptomyces HAase was resistant to all inhibitors, except PSS 990,000 and VERSA-TL 502 (i.e., PSS 10(6) dalton).
T7 826-917 Sentence denotes The length of the PSS polymer determined their potency (e.g., IC50 for HYAL-1, PSS 990,000:
T8 918-995 Sentence denotes 0.0096 microM; PSS 210 no inhibition; IC50 for testicular HAase, PSS 990,000:
T9 996-1033 Sentence denotes 0.042 microM; PSS 210 no inhibition).
T10 1034-1199 Sentence denotes The presence, but not the number, of sulfate groups on the sHA molecule determined its potency (e.g., IC50 for HYAL-1: sHA2.0, 0.019 microM; sHA2.75, 0.0083 microM).
T11 1200-1342 Sentence denotes Other known HAase inhibitors, such as gossypol, sodium-aurothiomalate, 1-tetradecane sulfonic acid, and glycerrhizic acid, were not effective.
T12 1343-1534 Sentence denotes Both PSS and sHA inhibited HAases by a mixed inhibition mechanism (i.e., competitive + uncompetitive) and were 5- to 17-fold better as uncompetitive inhibitors than as competitive inhibitors.
T13 1535-1743 Sentence denotes These results demonstrate that HAase inhibitors show selectivity toward the different types of HAases, which could be exploited to inhibit specific HAases involved in a variety of pathophysiologic conditions.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 220-224 http://purl.obolibrary.org/obo/MAT_0000213 denotes ovum

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 244-250 HP_0002664 denotes cancer

uniprot-human

Id Subject Object Predicate Lexical cue
T1 166-168 http://www.uniprot.org/uniprot/P69208 denotes HA
T2 565-567 http://www.uniprot.org/uniprot/P69208 denotes HA
T3 902-908 http://www.uniprot.org/uniprot/P48651 denotes 1, PSS

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 902-908 http://www.uniprot.org/uniprot/Q99LH2 denotes 1, PSS

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 244-250 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T2 364-368 http://purl.bioontology.org/ontology/NCBITAXON/199485 denotes HYAL
T3 398-410 http://purl.bioontology.org/ontology/NCBITAXON/1883 denotes Streptomyces
T4 635-639 http://purl.bioontology.org/ontology/NCBITAXON/199485 denotes HYAL
T5 712-724 http://purl.bioontology.org/ontology/NCBITAXON/1883 denotes Streptomyces
T6 897-901 http://purl.bioontology.org/ontology/NCBITAXON/199485 denotes HYAL
T7 1079-1085 http://purl.bioontology.org/ontology/STY/T096 denotes groups
T8 1145-1149 http://purl.bioontology.org/ontology/NCBITAXON/199485 denotes HYAL
T9 1399-1408 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism

GO-BP

Id Subject Object Predicate Lexical cue
T1 141-148 http://purl.obolibrary.org/obo/GO_0009056 denotes degrade
T2 225-238 http://purl.obolibrary.org/obo/GO_0009566 denotes fertilization
T3 471-480 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfonate
T4 1285-1293 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfonic
T5 556-564 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfated
T6 1071-1078 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T7 671-680 http://purl.obolibrary.org/obo/GO_0046960 denotes sensitive

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 212-218 http://edamontology.org/topic_0154 denotes toxins
T2 244-250 http://edamontology.org/topic_2640 denotes cancer
T3 303-310 http://edamontology.org/topic_0634 denotes disease
T4 1097-1105 http://edamontology.org/topic_2839 denotes molecule

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 1549-1560 http://edamontology.org/operation_2246 denotes demonstrate
T2 1621-1626 http://edamontology.org/data_2100 denotes types

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 220-224 http://purl.obolibrary.org/obo/MAT_0000213 denotes ovum

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 569-572 https://acgg.asia/db/lfdb/LfDB0226 denotes sHA
Lectin_T2 1093-1096 https://acgg.asia/db/lfdb/LfDB0226 denotes sHA
Lectin_T3 1356-1359 https://acgg.asia/db/lfdb/LfDB0226 denotes sHA
Lectin_T4 793-795 https://acgg.asia/db/lfdb/LfDB0385 denotes TL

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 748-751 "http://rdf.glycoinfo.org/glycan/G41652MJ" denotes all
GlycanIUPAC_T2 748-751 "http://rdf.glycoinfo.org/glycan/G20761YC" denotes all
GlycanIUPAC_T3 748-751 "http://rdf.glycoinfo.org/glycan/G19807HM" denotes all
GlycanIUPAC_T4 748-751 "http://rdf.glycoinfo.org/glycan/G20351TE" denotes all
GlycanIUPAC_T5 748-751 "http://rdf.glycoinfo.org/glycan/G71957MR" denotes all
GlycanIUPAC_T6 748-751 "http://rdf.glycoinfo.org/glycan/G59040AE" denotes all
GlycanIUPAC_T7 748-751 "http://rdf.glycoinfo.org/glycan/G14987PW" denotes all
GlycanIUPAC_T8 748-751 "http://rdf.glycoinfo.org/glycan/G95064PC" denotes all
GlycanIUPAC_T9 748-751 "http://rdf.glycoinfo.org/glycan/G39143AQ" denotes all
GlycanIUPAC_T10 748-751 "http://rdf.glycoinfo.org/glycan/G65149OO" denotes all
GlycanIUPAC_T11 748-751 "http://rdf.glycoinfo.org/glycan/G02766SY" denotes all
GlycanIUPAC_T12 748-751 "http://rdf.glycoinfo.org/glycan/G26019KJ" denotes all
GlycanIUPAC_T13 748-751 "http://rdf.glycoinfo.org/glycan/G36429CZ" denotes all
GlycanIUPAC_T14 748-751 "http://rdf.glycoinfo.org/glycan/G89633TP" denotes all
GlycanIUPAC_T15 748-751 "http://rdf.glycoinfo.org/glycan/G28494FO" denotes all
GlycanIUPAC_T16 748-751 "http://rdf.glycoinfo.org/glycan/G06219CP" denotes all
GlycanIUPAC_T17 748-751 "http://rdf.glycoinfo.org/glycan/G44237SM" denotes all
GlycanIUPAC_T18 748-751 "http://rdf.glycoinfo.org/glycan/G57948RL" denotes all
GlycanIUPAC_T19 748-751 "http://rdf.glycoinfo.org/glycan/G64016DN" denotes all
GlycanIUPAC_T20 748-751 "http://rdf.glycoinfo.org/glycan/G14536PC" denotes all
GlycanIUPAC_T21 748-751 "http://rdf.glycoinfo.org/glycan/G14356FW" denotes all
GlycanIUPAC_T22 748-751 "http://rdf.glycoinfo.org/glycan/G34565UO" denotes all
GlycanIUPAC_T23 748-751 "http://rdf.glycoinfo.org/glycan/G67124MW" denotes all
GlycanIUPAC_T24 748-751 "http://rdf.glycoinfo.org/glycan/G71457ZU" denotes all
GlycanIUPAC_T25 748-751 "http://rdf.glycoinfo.org/glycan/G55228VZ" denotes all
GlycanIUPAC_T26 748-751 "http://rdf.glycoinfo.org/glycan/G31034MJ" denotes all
GlycanIUPAC_T27 748-751 "http://rdf.glycoinfo.org/glycan/G25776IP" denotes all
GlycanIUPAC_T28 748-751 "http://rdf.glycoinfo.org/glycan/G64442BV" denotes all
GlycanIUPAC_T29 748-751 "http://rdf.glycoinfo.org/glycan/G57018LE" denotes all
GlycanIUPAC_T30 748-751 "http://rdf.glycoinfo.org/glycan/G61761GX" denotes all
GlycanIUPAC_T31 748-751 "http://rdf.glycoinfo.org/glycan/G76318UX" denotes all
GlycanIUPAC_T32 748-751 "http://rdf.glycoinfo.org/glycan/G61906ER" denotes all
GlycanIUPAC_T33 748-751 "http://rdf.glycoinfo.org/glycan/G68723GR" denotes all
GlycanIUPAC_T34 748-751 "http://rdf.glycoinfo.org/glycan/G19540LE" denotes all
GlycanIUPAC_T35 748-751 "http://rdf.glycoinfo.org/glycan/G74944PO" denotes all
GlycanIUPAC_T36 748-751 "http://rdf.glycoinfo.org/glycan/G89489ZJ" denotes all
GlycanIUPAC_T37 748-751 "http://rdf.glycoinfo.org/glycan/G04434YU" denotes all
GlycanIUPAC_T38 748-751 "http://rdf.glycoinfo.org/glycan/G21450PB" denotes all
GlycanIUPAC_T39 748-751 "http://rdf.glycoinfo.org/glycan/G93629QY" denotes all
GlycanIUPAC_T40 748-751 "http://rdf.glycoinfo.org/glycan/G02603TR" denotes all
GlycanIUPAC_T41 748-751 "http://rdf.glycoinfo.org/glycan/G40280JP" denotes all
GlycanIUPAC_T42 748-751 "http://rdf.glycoinfo.org/glycan/G95259IC" denotes all
GlycanIUPAC_T43 748-751 "http://rdf.glycoinfo.org/glycan/G26900FE" denotes all
GlycanIUPAC_T44 748-751 "http://rdf.glycoinfo.org/glycan/G21346KK" denotes all
GlycanIUPAC_T45 748-751 "http://rdf.glycoinfo.org/glycan/G62509FF" denotes all
GlycanIUPAC_T46 748-751 "http://rdf.glycoinfo.org/glycan/G83932AK" denotes all
GlycanIUPAC_T47 748-751 "http://rdf.glycoinfo.org/glycan/G96978IB" denotes all
GlycanIUPAC_T48 748-751 "http://rdf.glycoinfo.org/glycan/G34275DN" denotes all
GlycanIUPAC_T49 748-751 "http://rdf.glycoinfo.org/glycan/G07071JF" denotes all
GlycanIUPAC_T50 748-751 "http://rdf.glycoinfo.org/glycan/G80639QD" denotes all
GlycanIUPAC_T51 748-751 "http://rdf.glycoinfo.org/glycan/G99460PJ" denotes all
GlycanIUPAC_T52 748-751 "http://rdf.glycoinfo.org/glycan/G22024BZ" denotes all
GlycanIUPAC_T53 748-751 "http://rdf.glycoinfo.org/glycan/G74097ZY" denotes all
GlycanIUPAC_T54 748-751 "http://rdf.glycoinfo.org/glycan/G84439YP" denotes all
GlycanIUPAC_T55 748-751 "http://rdf.glycoinfo.org/glycan/G52207WQ" denotes all
GlycanIUPAC_T56 748-751 "http://rdf.glycoinfo.org/glycan/G90695MS" denotes all
GlycanIUPAC_T57 748-751 "http://rdf.glycoinfo.org/glycan/G50398QX" denotes all
GlycanIUPAC_T58 748-751 "http://rdf.glycoinfo.org/glycan/G12166ZT" denotes all
GlycanIUPAC_T59 748-751 "http://rdf.glycoinfo.org/glycan/G48368BR" denotes all
GlycanIUPAC_T60 748-751 "http://rdf.glycoinfo.org/glycan/G57407RW" denotes all
GlycanIUPAC_T61 748-751 "http://rdf.glycoinfo.org/glycan/G00386TY" denotes all
GlycanIUPAC_T62 748-751 "http://rdf.glycoinfo.org/glycan/G18723JK" denotes all
GlycanIUPAC_T63 748-751 "http://rdf.glycoinfo.org/glycan/G93757OR" denotes all
GlycanIUPAC_T64 748-751 "http://rdf.glycoinfo.org/glycan/G29006SI" denotes all
GlycanIUPAC_T65 748-751 "http://rdf.glycoinfo.org/glycan/G03099OQ" denotes all
GlycanIUPAC_T66 748-751 "http://rdf.glycoinfo.org/glycan/G53739OW" denotes all
GlycanIUPAC_T67 748-751 "http://rdf.glycoinfo.org/glycan/G70440ZO" denotes all
GlycanIUPAC_T68 748-751 "http://rdf.glycoinfo.org/glycan/G29951RR" denotes all
GlycanIUPAC_T69 748-751 "http://rdf.glycoinfo.org/glycan/G58402TI" denotes all
GlycanIUPAC_T70 748-751 "http://rdf.glycoinfo.org/glycan/G39875TP" denotes all
GlycanIUPAC_T71 748-751 "http://rdf.glycoinfo.org/glycan/G83439QV" denotes all
GlycanIUPAC_T72 748-751 "http://rdf.glycoinfo.org/glycan/G41762RC" denotes all
GlycanIUPAC_T73 748-751 "http://rdf.glycoinfo.org/glycan/G91604UI" denotes all
GlycanIUPAC_T74 748-751 "http://rdf.glycoinfo.org/glycan/G88447WE" denotes all
GlycanIUPAC_T75 748-751 "http://rdf.glycoinfo.org/glycan/G93634BS" denotes all
GlycanIUPAC_T76 748-751 "http://rdf.glycoinfo.org/glycan/G02587BH" denotes all
GlycanIUPAC_T77 748-751 "http://rdf.glycoinfo.org/glycan/G43511MX" denotes all
GlycanIUPAC_T78 748-751 "http://rdf.glycoinfo.org/glycan/G64958DH" denotes all
GlycanIUPAC_T79 748-751 "http://rdf.glycoinfo.org/glycan/G30384TR" denotes all
GlycanIUPAC_T80 748-751 "http://rdf.glycoinfo.org/glycan/G15624EX" denotes all
GlycanIUPAC_T81 748-751 "http://rdf.glycoinfo.org/glycan/G22706ST" denotes all
GlycanIUPAC_T82 748-751 "http://rdf.glycoinfo.org/glycan/G57408PI" denotes all
GlycanIUPAC_T83 748-751 "http://rdf.glycoinfo.org/glycan/G86403XX" denotes all
GlycanIUPAC_T84 748-751 "http://rdf.glycoinfo.org/glycan/G78043YB" denotes all
GlycanIUPAC_T85 748-751 "http://rdf.glycoinfo.org/glycan/G18952JK" denotes all
GlycanIUPAC_T86 748-751 "http://rdf.glycoinfo.org/glycan/G49020ND" denotes all
GlycanIUPAC_T87 748-751 "http://rdf.glycoinfo.org/glycan/G63590YW" denotes all
GlycanIUPAC_T88 748-751 "http://rdf.glycoinfo.org/glycan/G22793KS" denotes all
GlycanIUPAC_T89 748-751 "http://rdf.glycoinfo.org/glycan/G64134SS" denotes all
GlycanIUPAC_T90 748-751 "http://rdf.glycoinfo.org/glycan/G17338HY" denotes all
GlycanIUPAC_T91 748-751 "http://rdf.glycoinfo.org/glycan/G99745XF" denotes all
GlycanIUPAC_T92 748-751 "http://rdf.glycoinfo.org/glycan/G27782HN" denotes all
GlycanIUPAC_T93 748-751 "http://rdf.glycoinfo.org/glycan/G57496DC" denotes all
GlycanIUPAC_T94 748-751 "http://rdf.glycoinfo.org/glycan/G93169WB" denotes all
GlycanIUPAC_T95 748-751 "http://rdf.glycoinfo.org/glycan/G05518TD" denotes all
GlycanIUPAC_T96 748-751 "http://rdf.glycoinfo.org/glycan/G62603DN" denotes all
GlycanIUPAC_T97 748-751 "http://rdf.glycoinfo.org/glycan/G59574FS" denotes all
GlycanIUPAC_T98 748-751 "http://rdf.glycoinfo.org/glycan/G47567WC" denotes all

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 364-368 http://purl.obolibrary.org/obo/UBERON_3000101 denotes HYAL
PD-UBERON-AE-B_T2 635-639 http://purl.obolibrary.org/obo/UBERON_3000101 denotes HYAL
PD-UBERON-AE-B_T3 897-901 http://purl.obolibrary.org/obo/UBERON_3000101 denotes HYAL
PD-UBERON-AE-B_T4 1145-1149 http://purl.obolibrary.org/obo/UBERON_3000101 denotes HYAL

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 201-211 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T2 244-250 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 220-224 Body_part denotes ovum http://purl.obolibrary.org/obo/MAT_0000213

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 244-250 Phenotype denotes cancer HP:0002664

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 384-392 OrganismTaxon denotes honeybee 7460
T2 398-410 OrganismTaxon denotes Streptomyces 1883
T3 646-649 OrganismTaxon denotes bee 34735|7460
T5 712-724 OrganismTaxon denotes Streptomyces 1883

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 220-224 Body_part denotes ovum http://purl.obolibrary.org/obo/CL_0000025

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 220-224 Cell denotes ovum http://purl.obolibrary.org/obo/CL:0000025
T2 455-459 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775