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PubMed:15917430 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 137-144 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 302-309 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T3 615-622 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T4 752-759 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T5 991-998 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T6 1175-1182 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T7 1577-1584 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 137-144 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 302-309 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T3 615-622 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T4 752-759 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T5 991-998 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T6 1175-1182 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T7 1577-1584 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 137-144 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 302-309 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T3 615-622 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T4 752-759 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T5 991-998 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T6 1175-1182 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T7 1577-1584 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 572-577 http://purl.obolibrary.org/obo/MAT_0000488 denotes later

GlycoBiology-PACDB

Id Subject Object Predicate Lexical cue
_T1 191-219 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC512 denotes human immunodeficiency virus
_T2 191-226 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC355,LEC479,LEC567,LEC587 denotes human immunodeficiency virus type 1

ICD10

Id Subject Object Predicate Lexical cue
T1 197-213 http://purl.bioontology.org/ontology/ICD10/D84.9 denotes immunodeficiency
T2 257-274 http://purl.bioontology.org/ontology/ICD10/B34.9 denotes viral infectivity

uniprot-human

Id Subject Object Predicate Lexical cue
T1 535-538 http://www.uniprot.org/uniprot/P01730 denotes CD4
T2 550-555 http://www.uniprot.org/uniprot/Q14624 denotes gp120
T3 1194-1199 http://www.uniprot.org/uniprot/Q14624 denotes gp120
T4 1317-1322 http://www.uniprot.org/uniprot/Q14624 denotes gp120
T5 1365-1370 http://www.uniprot.org/uniprot/Q14624 denotes gp120
T6 1278-1281 http://www.uniprot.org/uniprot/P35270 denotes SPR
T7 1278-1281 http://www.uniprot.org/uniprot/P25103 denotes SPR

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 535-538 http://www.uniprot.org/uniprot/P06332 denotes CD4
T2 1278-1281 http://www.uniprot.org/uniprot/Q64105 denotes SPR
T3 1278-1281 http://www.uniprot.org/uniprot/P30548 denotes SPR
T4 1388-1391 http://www.uniprot.org/uniprot/P11370 denotes Env

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 106-116 http://purl.bioontology.org/ontology/NCBITAXON/608684 denotes monoclonal
T2 132-136 http://purl.bioontology.org/ontology/NCBITAXON/9973 denotes Many
T3 191-219 http://purl.bioontology.org/ontology/NCBITAXON/11709 denotes human immunodeficiency virus
T4 191-219 http://purl.bioontology.org/ontology/NCBITAXON/11676 denotes human immunodeficiency virus
T5 191-219 http://purl.bioontology.org/ontology/NCBITAXON/12721 denotes human immunodeficiency virus
T6 191-219 http://purl.bioontology.org/ontology/NCBITAXON/11723 denotes human immunodeficiency virus
T7 197-219 http://purl.bioontology.org/ontology/NCBITAXON/11673 denotes immunodeficiency virus
T8 214-219 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus
T9 578-584 http://purl.bioontology.org/ontology/STY/T051 denotes events
T10 588-593 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus

GO-BP

Id Subject Object Predicate Lexical cue
T1 55-64 http://purl.obolibrary.org/obo/GO_0046960 denotes sensitive
T2 1459-1468 http://purl.obolibrary.org/obo/GO_0046960 denotes sensitive
T3 81-94 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T4 1489-1502 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T5 145-169 http://purl.obolibrary.org/obo/GO_0032091 denotes binding proteins inhibit
T6 257-274 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infectivity

GO-MF

Id Subject Object Predicate Lexical cue
T1 15-22 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 145-152 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 539-546 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 687-694 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 760-767 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 807-814 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T7 1306-1313 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T8 1354-1361 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T9 1377-1384 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T10 1519-1526 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T11 15-22 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T12 145-152 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T13 539-546 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T14 687-694 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T15 760-767 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T16 807-814 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T17 1306-1313 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T18 1354-1361 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T19 1377-1384 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T20 1519-1526 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T21 15-22 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T22 145-152 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T23 539-546 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T24 687-694 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T25 760-767 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T26 807-814 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T27 1306-1313 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T28 1354-1361 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T29 1377-1384 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T30 1519-1526 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T31 15-22 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T32 145-152 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T33 539-546 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T34 687-694 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T35 760-767 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T36 807-814 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T37 1306-1313 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T38 1354-1361 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T39 1377-1384 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T40 1519-1526 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T41 117-125 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T42 401-409 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T43 899-907 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T44 497-507 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T45 1550-1560 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T46 137-152 http://purl.obolibrary.org/obo/GO_0005537 denotes mannose-binding
T47 752-767 http://purl.obolibrary.org/obo/GO_0005537 denotes mannose-binding
T48 145-161 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T49 760-776 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T50 1519-1542 http://purl.obolibrary.org/obo/GO_0005515 denotes binding to the proteins

GO-CC

Id Subject Object Predicate Lexical cue
T1 30-38 http://purl.obolibrary.org/obo/GO_0009274 denotes envelope
T2 710-718 http://purl.obolibrary.org/obo/GO_0009274 denotes envelope
T3 861-869 http://purl.obolibrary.org/obo/GO_0009274 denotes envelope

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 572-577 http://purl.obolibrary.org/obo/MAT_0000488 denotes later

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-131 Sentence denotes Concanavalin A binding to HIV envelope protein is less sensitive to mutations in glycosylation sites than monoclonal antibody 2G12.
TextSentencer_T2 132-448 Sentence denotes Many mannose-binding proteins inhibit divergent strains of human immunodeficiency virus type 1 (HIV-1) in in vitro models of viral infectivity, suggesting that targeting mannose residues in vaccine applications might offset the strain restriction typically observed in antibody responses to HIV vaccine preparations.
TextSentencer_T3 449-600 Sentence denotes Concanavalin A (ConA) behaves like neutralizing antibodies that do not interfere with CD4 binding of gp120 but rather with later events in virus entry.
TextSentencer_T4 601-777 Sentence denotes The design of mannose-based vaccines, therefore, depends on understanding the mode of binding of ConA to the envelope protein in comparison with other mannose-binding proteins.
TextSentencer_T5 778-913 Sentence denotes Here, we further compare the binding affinity and fine specificity of ConA for the envelope protein to that of the human antibody 2G12.
TextSentencer_T6 914-1036 Sentence denotes The 2G12 antibody is of unusual structure recognizing a cluster of 12 linked mannose residues associated with Man9GlcNAc2.
TextSentencer_T7 1037-1371 Sentence denotes Molecular structure comparison for Man9GlcNAc2 recognition by ConA and 2G12 indicates that 2G12 has a more restricted specificity to high mannose glycans of gp120 which correlates with kinetic analysis assessed by surface plasmon resonance (SPR) and ConA inhibits 2G12 binding to gp120 but 2G12 does not inhibit ConA binding to gp120.
TextSentencer_T8 1372-1543 Sentence denotes ConA binding to Env proteins from four different HIV strains proves significantly less sensitive to mutations in the glycosylation sites than 2G12 binding to the proteins.
TextSentencer_T9 1544-1701 Sentence denotes Thus, antibodies directed toward mannose epitopes reactive with ConA may prove to be more effective in the long run to thwart HIV infection and transmission.
T1 0-131 Sentence denotes Concanavalin A binding to HIV envelope protein is less sensitive to mutations in glycosylation sites than monoclonal antibody 2G12.
T2 132-448 Sentence denotes Many mannose-binding proteins inhibit divergent strains of human immunodeficiency virus type 1 (HIV-1) in in vitro models of viral infectivity, suggesting that targeting mannose residues in vaccine applications might offset the strain restriction typically observed in antibody responses to HIV vaccine preparations.
T3 449-600 Sentence denotes Concanavalin A (ConA) behaves like neutralizing antibodies that do not interfere with CD4 binding of gp120 but rather with later events in virus entry.
T4 601-777 Sentence denotes The design of mannose-based vaccines, therefore, depends on understanding the mode of binding of ConA to the envelope protein in comparison with other mannose-binding proteins.
T5 778-913 Sentence denotes Here, we further compare the binding affinity and fine specificity of ConA for the envelope protein to that of the human antibody 2G12.
T6 914-1036 Sentence denotes The 2G12 antibody is of unusual structure recognizing a cluster of 12 linked mannose residues associated with Man9GlcNAc2.
T7 1037-1371 Sentence denotes Molecular structure comparison for Man9GlcNAc2 recognition by ConA and 2G12 indicates that 2G12 has a more restricted specificity to high mannose glycans of gp120 which correlates with kinetic analysis assessed by surface plasmon resonance (SPR) and ConA inhibits 2G12 binding to gp120 but 2G12 does not inhibit ConA binding to gp120.
T8 1372-1543 Sentence denotes ConA binding to Env proteins from four different HIV strains proves significantly less sensitive to mutations in the glycosylation sites than 2G12 binding to the proteins.
T9 1544-1701 Sentence denotes Thus, antibodies directed toward mannose epitopes reactive with ConA may prove to be more effective in the long run to thwart HIV infection and transmission.
T1 0-131 Sentence denotes Concanavalin A binding to HIV envelope protein is less sensitive to mutations in glycosylation sites than monoclonal antibody 2G12.
T2 132-448 Sentence denotes Many mannose-binding proteins inhibit divergent strains of human immunodeficiency virus type 1 (HIV-1) in in vitro models of viral infectivity, suggesting that targeting mannose residues in vaccine applications might offset the strain restriction typically observed in antibody responses to HIV vaccine preparations.
T3 449-600 Sentence denotes Concanavalin A (ConA) behaves like neutralizing antibodies that do not interfere with CD4 binding of gp120 but rather with later events in virus entry.
T4 601-777 Sentence denotes The design of mannose-based vaccines, therefore, depends on understanding the mode of binding of ConA to the envelope protein in comparison with other mannose-binding proteins.
T5 778-913 Sentence denotes Here, we further compare the binding affinity and fine specificity of ConA for the envelope protein to that of the human antibody 2G12.
T6 914-1036 Sentence denotes The 2G12 antibody is of unusual structure recognizing a cluster of 12 linked mannose residues associated with Man9GlcNAc2.
T7 1037-1371 Sentence denotes Molecular structure comparison for Man9GlcNAc2 recognition by ConA and 2G12 indicates that 2G12 has a more restricted specificity to high mannose glycans of gp120 which correlates with kinetic analysis assessed by surface plasmon resonance (SPR) and ConA inhibits 2G12 binding to gp120 but 2G12 does not inhibit ConA binding to gp120.
T8 1372-1543 Sentence denotes ConA binding to Env proteins from four different HIV strains proves significantly less sensitive to mutations in the glycosylation sites than 2G12 binding to the proteins.
T9 1544-1701 Sentence denotes Thus, antibodies directed toward mannose epitopes reactive with ConA may prove to be more effective in the long run to thwart HIV infection and transmission.

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 1170-1182 http://rdf.glycoinfo.org/glycan/G00028MO denotes high mannose

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 465-469 https://acgg.asia/db/lfdb/LfDB0170 denotes ConA
Lectin_T2 698-702 https://acgg.asia/db/lfdb/LfDB0170 denotes ConA
Lectin_T3 848-852 https://acgg.asia/db/lfdb/LfDB0170 denotes ConA
Lectin_T4 1099-1103 https://acgg.asia/db/lfdb/LfDB0170 denotes ConA
Lectin_T5 1287-1291 https://acgg.asia/db/lfdb/LfDB0170 denotes ConA
Lectin_T6 1349-1353 https://acgg.asia/db/lfdb/LfDB0170 denotes ConA
Lectin_T7 1372-1376 https://acgg.asia/db/lfdb/LfDB0170 denotes ConA
Lectin_T8 1608-1612 https://acgg.asia/db/lfdb/LfDB0170 denotes ConA

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 197-213 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T2 1670-1683 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 572-577 Body_part denotes later http://purl.obolibrary.org/obo/MAT_0000488

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 197-213 Phenotype denotes immunodeficiency HP:0002721

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 191-226 OrganismTaxon denotes human immunodeficiency virus type 1 11676
T2 893-898 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 30-38 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975
T2 710-718 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975
T3 861-869 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975