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PubMed:15833836 JSONTXT

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DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15833836-0#18#24#gene5458 18-24 gene5458 denotes Brn-3b
15833836-0#76#82#gene3315 76-82 gene3315 denotes HSP-27
15833836-0#76#82#gene3316 76-82 gene3316 denotes HSP-27
15833836-0#76#82#gene8988 76-82 gene8988 denotes HSP-27
15833836-0#155#161#gene3315 155-161 gene3315 denotes HSP-27
15833836-0#155#161#gene3316 155-161 gene3316 denotes HSP-27
15833836-0#155#161#gene8988 155-161 gene8988 denotes HSP-27
15833836-0#86#99#diseaseC0006142 86-99 diseaseC0006142 denotes breast cancer
15833836-0#86#99#diseaseC0678222 86-99 diseaseC0678222 denotes breast cancer
15833836-0#86#99#diseaseC0006142 86-99 diseaseC0006142 denotes breast cancer
15833836-0#86#99#diseaseC0678222 86-99 diseaseC0678222 denotes breast cancer
15833836-0#86#99#diseaseC0006142 86-99 diseaseC0006142 denotes breast cancer
15833836-0#86#99#diseaseC0678222 86-99 diseaseC0678222 denotes breast cancer
15833836-0#86#99#diseaseC0006142 86-99 diseaseC0006142 denotes breast cancer
15833836-0#86#99#diseaseC0678222 86-99 diseaseC0678222 denotes breast cancer
15833836-0#86#99#diseaseC0006142 86-99 diseaseC0006142 denotes breast cancer
15833836-0#86#99#diseaseC0678222 86-99 diseaseC0678222 denotes breast cancer
15833836-0#86#99#diseaseC0006142 86-99 diseaseC0006142 denotes breast cancer
15833836-0#86#99#diseaseC0678222 86-99 diseaseC0678222 denotes breast cancer
15833836-0#86#99#diseaseC0006142 86-99 diseaseC0006142 denotes breast cancer
15833836-0#86#99#diseaseC0678222 86-99 diseaseC0678222 denotes breast cancer
15833836-9#68#70#gene2099 1625-1627 gene2099 denotes ER
15833836-9#178#191#diseaseC0006142 1735-1748 diseaseC0006142 denotes breast cancer
15833836-9#178#191#diseaseC0678222 1735-1748 diseaseC0678222 denotes breast cancer
18#24#gene545886#99#diseaseC0006142 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0006142 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0678222 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0678222 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0006142 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0006142 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0678222 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0678222 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0006142 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0006142 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0678222 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0678222 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0006142 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0006142 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0678222 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0678222 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0006142 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0006142 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0678222 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0678222 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0006142 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0006142 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0678222 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0678222 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0006142 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0006142 associated_with Brn-3b,breast cancer
18#24#gene545886#99#diseaseC0678222 15833836-0#18#24#gene5458 15833836-0#86#99#diseaseC0678222 associated_with Brn-3b,breast cancer
76#82#gene331586#99#diseaseC0006142 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0678222 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0006142 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0678222 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0006142 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0678222 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0006142 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0678222 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0006142 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0678222 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0006142 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0678222 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0006142 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331586#99#diseaseC0678222 15833836-0#76#82#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0006142 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0678222 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0006142 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0678222 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0006142 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0678222 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0006142 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0678222 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0006142 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0678222 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0006142 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0678222 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0006142 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene331686#99#diseaseC0678222 15833836-0#76#82#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0006142 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0678222 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0006142 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0678222 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0006142 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0678222 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0006142 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0678222 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0006142 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0678222 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0006142 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0678222 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0006142 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
76#82#gene898886#99#diseaseC0678222 15833836-0#76#82#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0006142 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0678222 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0006142 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0678222 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0006142 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0678222 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0006142 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0678222 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0006142 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0678222 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0006142 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0678222 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0006142 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331586#99#diseaseC0678222 15833836-0#155#161#gene3315 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0006142 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0678222 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0006142 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0678222 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0006142 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0678222 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0006142 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0678222 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0006142 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0678222 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0006142 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0678222 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0006142 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene331686#99#diseaseC0678222 15833836-0#155#161#gene3316 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0006142 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0678222 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0006142 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0678222 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0006142 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0678222 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0006142 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0678222 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0006142 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0678222 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0006142 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0678222 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0006142 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0006142 associated_with HSP-27,breast cancer
155#161#gene898886#99#diseaseC0678222 15833836-0#155#161#gene8988 15833836-0#86#99#diseaseC0678222 associated_with HSP-27,breast cancer
68#70#gene2099178#191#diseaseC0006142 15833836-9#68#70#gene2099 15833836-9#178#191#diseaseC0006142 associated_with ER,breast cancer
68#70#gene2099178#191#diseaseC0678222 15833836-9#68#70#gene2099 15833836-9#178#191#diseaseC0678222 associated_with ER,breast cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T584 1625-1627 gene:2099 denotes ER
T585 1735-1748 disease:C0006142 denotes breast cancer
T588 18-24 gene:5458 denotes Brn-3b
T589 86-99 disease:C0006142 denotes breast cancer
T590 76-82 gene:3315 denotes HSP-27
T591 155-161 gene:3315 denotes HSP-27
R1 T584 T585 associated_with ER,breast cancer
R2 T584 T585 associated_with ER,breast cancer
R1 T588 T589 associated_with Brn-3b,breast cancer
R2 T588 T589 associated_with Brn-3b,breast cancer
R3 T590 T589 associated_with HSP-27,breast cancer
R4 T590 T589 associated_with HSP-27,breast cancer
R5 T590 T589 associated_with HSP-27,breast cancer
R6 T590 T589 associated_with HSP-27,breast cancer
R7 T590 T589 associated_with HSP-27,breast cancer
R8 T590 T589 associated_with HSP-27,breast cancer
R9 T591 T589 associated_with HSP-27,breast cancer
R10 T591 T589 associated_with HSP-27,breast cancer
R11 T591 T589 associated_with HSP-27,breast cancer
R12 T591 T589 associated_with HSP-27,breast cancer
R13 T591 T589 associated_with HSP-27,breast cancer
R14 T591 T589 associated_with HSP-27,breast cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 86-92 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 175-181 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 504-510 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 741-747 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 781-787 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1735-1741 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-171 Sentence denotes Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.
TextSentencer_T2 172-442 Sentence denotes In breast cancer, overexpression of the small heat shock protein, HSP-27, is associated with increased anchorage-independent growth, increased invasiveness, and resistance to chemotherapeutic drugs and is associated with poor prognosis and reduced disease-free survival.
TextSentencer_T3 443-578 Sentence denotes Therefore, factors that increase the expression of HSP-27 in breast cancer are likely to affect the prognosis and outcome of treatment.
TextSentencer_T4 579-797 Sentence denotes In this study, we show a strong correlation between elevated levels of the Brn-3b POU transcription factor and high levels of HSP-27 protein in manipulated MCF-7 breast cancer cells as well as in human breast biopsies.
TextSentencer_T5 798-848 Sentence denotes Conversely, HSP-27 is decreased on loss of Brn-3b.
TextSentencer_T6 849-991 Sentence denotes In cotransfection assays, Brn-3b can strongly transactivate the HSP-27 promoter, supporting a role for direct regulation of HSP-27 expression.
TextSentencer_T7 992-1228 Sentence denotes Brn-3b also cooperates with the estrogen receptor (ER) to facilitate maximal stimulation of the HSP-27 promoter, with significantly enhanced activity of this promoter observed on coexpression of Brn-3b and ER compared with either alone.
TextSentencer_T8 1229-1437 Sentence denotes RNA interference and site-directed mutagenesis support the requirement for the Brn-3b binding site on the HSP-27 promoter, which facilitates maximal transactivation either alone or on interaction with the ER.
TextSentencer_T9 1438-1556 Sentence denotes Chromatin immunoprecipitation provides evidence for association of Brn-3b with the HSP-27 promoter in the intact cell.
TextSentencer_T10 1557-1755 Sentence denotes Thus, Brn-3b can, directly and indirectly (via interaction with the ER), activate HSP-27 expression, and this may represent one mechanism by which Brn-3b mediates its effects in breast cancer cells.
T1 0-171 Sentence denotes Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.
T2 172-442 Sentence denotes In breast cancer, overexpression of the small heat shock protein, HSP-27, is associated with increased anchorage-independent growth, increased invasiveness, and resistance to chemotherapeutic drugs and is associated with poor prognosis and reduced disease-free survival.
T3 443-578 Sentence denotes Therefore, factors that increase the expression of HSP-27 in breast cancer are likely to affect the prognosis and outcome of treatment.
T4 579-797 Sentence denotes In this study, we show a strong correlation between elevated levels of the Brn-3b POU transcription factor and high levels of HSP-27 protein in manipulated MCF-7 breast cancer cells as well as in human breast biopsies.
T5 798-848 Sentence denotes Conversely, HSP-27 is decreased on loss of Brn-3b.
T6 849-991 Sentence denotes In cotransfection assays, Brn-3b can strongly transactivate the HSP-27 promoter, supporting a role for direct regulation of HSP-27 expression.
T7 992-1228 Sentence denotes Brn-3b also cooperates with the estrogen receptor (ER) to facilitate maximal stimulation of the HSP-27 promoter, with significantly enhanced activity of this promoter observed on coexpression of Brn-3b and ER compared with either alone.
T8 1229-1437 Sentence denotes RNA interference and site-directed mutagenesis support the requirement for the Brn-3b binding site on the HSP-27 promoter, which facilitates maximal transactivation either alone or on interaction with the ER.
T9 1438-1556 Sentence denotes Chromatin immunoprecipitation provides evidence for association of Brn-3b with the HSP-27 promoter in the intact cell.
T10 1557-1755 Sentence denotes Thus, Brn-3b can, directly and indirectly (via interaction with the ER), activate HSP-27 expression, and this may represent one mechanism by which Brn-3b mediates its effects in breast cancer cells.

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 86-92 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 175-181 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 504-510 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 741-747 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 781-787 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1735-1741 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1563-1569 gene:5458 denotes Brn-3b
T1 1735-1748 disease:C0006142 denotes breast cancer
T2 1563-1569 gene:5458 denotes Brn-3b
T3 1735-1748 disease:C0678222 denotes breast cancer
T4 1625-1627 gene:2099 denotes ER
T5 1735-1748 disease:C0006142 denotes breast cancer
T6 1625-1627 gene:2099 denotes ER
T7 1735-1748 disease:C0678222 denotes breast cancer
T8 1704-1710 gene:5458 denotes Brn-3b
T9 1735-1748 disease:C0006142 denotes breast cancer
T10 1704-1710 gene:5458 denotes Brn-3b
T11 1735-1748 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with Brn-3b,breast cancer
R2 T2 T3 associated_with Brn-3b,breast cancer
R3 T4 T5 associated_with ER,breast cancer
R4 T6 T7 associated_with ER,breast cancer
R5 T8 T9 associated_with Brn-3b,breast cancer
R6 T10 T11 associated_with Brn-3b,breast cancer