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UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-169 DRI_Background denotes Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet.
T2 170-297 DRI_Background denotes Stroke patients have increased levels of endothelin-1 (ET-1), a strong vasoconstrictor, in their plasma or cerebrospinal fluid.
T3 298-392 DRI_Outcome denotes Previously, we showed high level of ET-1 mRNA expression in astrocytes after hypoxia/ischemia.
T4 393-514 DRI_Challenge denotes It is unclear whether the contribution of ET-1 induction in astrocytes is protective or destructive in cerebral ischemia.
T5 515-563 DRI_Outcome denotes Here, we generated a transgenic mouse model that
T6 564-580 Token_Label.OUTSIDE denotes overexpress ET-1
T7 581-793 DRI_Outcome denotes in astrocytes (GET-1) using the glial fibrillary acidic protein promoter to examine the role of astrocytic ET-1 in ischemic stroke by challenging these mice with transient middle cerebral artery occlusion (MCAO).
T8 794-992 DRI_Background denotes Under normal condition, GET-1 mice showed no abnormality in brain morphology, cerebrovasculature, absolute cerebral blood flow, blood-brain barrier (BBB) integrity, and mean arterial blood pressure.
T9 993-1197 DRI_Background denotes Yet, GET-1 mice subjected to transient MCAO showed more severe neurologic deficits and increased infarct, which were partially normalized by administration of ABT-627 (ET(A) antagonist) 5 mins after MCAO.
T10 1198-1402 DRI_Outcome denotes In addition, GET-1 brains exhibited more Evans blue extravasation and showed decreased endothelial occludin expression after MCAO, correlating with higher brain water content and increased cerebral edema.
T11 1403-1519 DRI_Background denotes Aquaporin 4 expression was also more pronounced in astrocytic end-feet on blood vessels in GET-1 ipsilateral brains.
T12 1520-1700 DRI_Challenge denotes Our current data suggest that astrocytic ET-1 has deleterious effects on water homeostasis, cerebral edema and BBB integrity, which contribute to more severe ischemic brain injury.

c_corpus

Id Subject Object Predicate Lexical cue
T3 0-12 Q5NRQ1 denotes Endothelin-1
T4 0-12 P17322 denotes Endothelin-1
T6 0-12 PR:000006897 denotes Endothelin-1
T7 0-12 P05305 denotes Endothelin-1
T8 0-12 P97740 denotes Endothelin-1
T9 0-12 Q28469 denotes Endothelin-1
T10 0-12 P29560 denotes Endothelin-1
T11 0-12 P22388 denotes Endothelin-1
T12 0-12 P09558 denotes Endothelin-1
T14 0-12 P22387 denotes Endothelin-1
T15 0-12 P13206 denotes Endothelin-1
T16 0-12 Q9BG76 denotes Endothelin-1
T17 0-12 Q5NRP9 denotes Endothelin-1
T5 0-12 CHEBI:80240 denotes Endothelin-1
T13 0-12 D019332 denotes Endothelin-1
T18 0-12 D019332 denotes Endothelin-1
T19 68-73 UBERON:6110636 denotes brain
T20 68-73 UBERON:0000955 denotes brain
T21 68-79 D001929 denotes brain edema
T22 68-79 D001929 denotes brain edema
T25 86-108 UBERON:0001627 denotes middle cerebral artery
T26 86-118 D020244 denotes middle cerebral artery occlusion
T27 86-118 D020244 denotes middle cerebral artery occlusion
T35 123-132 GO:0015250 denotes aquaporin
T40 123-134 Q5I4F9 denotes aquaporin 4
T41 123-134 P55088 denotes aquaporin 4
T42 123-134 Q923J4 denotes aquaporin 4
T43 123-134 O77750 denotes aquaporin 4
T45 123-134 P55087 denotes aquaporin 4
T46 123-134 P47863 denotes aquaporin 4
T47 123-134 PR:000004184 denotes aquaporin 4
T48 123-134 G5CTG1 denotes aquaporin 4
T44 123-134 D051401 denotes aquaporin 4
T51 211-223 Q5NRQ1 denotes endothelin-1
T52 211-223 P17322 denotes endothelin-1
T54 211-223 PR:000006897 denotes endothelin-1
T55 211-223 P05305 denotes endothelin-1
T56 211-223 P97740 denotes endothelin-1
T57 211-223 Q28469 denotes endothelin-1
T58 211-223 P29560 denotes endothelin-1
T59 211-223 P22388 denotes endothelin-1
T60 211-223 P09558 denotes endothelin-1
T62 211-223 P22387 denotes endothelin-1
T63 211-223 P13206 denotes endothelin-1
T64 211-223 Q9BG76 denotes endothelin-1
T65 211-223 Q5NRP9 denotes endothelin-1
T53 211-223 CHEBI:80240 denotes endothelin-1
T61 211-223 D019332 denotes endothelin-1
T66 211-223 D019332 denotes endothelin-1
T67 225-229 Q5NRQ1 denotes ET-1
T68 225-229 PR:F4JU69 denotes ET-1
T69 225-229 P17322 denotes ET-1
T70 225-229 PR:000006897 denotes ET-1
T71 225-229 P97740 denotes ET-1
T72 225-229 Q28469 denotes ET-1
T73 225-229 P29560 denotes ET-1
T74 225-229 P22388 denotes ET-1
T75 225-229 P09558 denotes ET-1
T76 225-229 P13206 denotes ET-1
T77 225-229 Q9BG76 denotes ET-1
T78 225-229 Q5NRP9 denotes ET-1
T79 225-229 P22387 denotes ET-1
T80 267-273 UBERON:0001969 denotes plasma
T81 277-296 UBERON:0001359 denotes cerebrospinal fluid
T83 334-338 Q5NRQ1 denotes ET-1
T84 334-338 PR:F4JU69 denotes ET-1
T85 334-338 P17322 denotes ET-1
T86 334-338 PR:000006897 denotes ET-1
T87 334-338 P97740 denotes ET-1
T88 334-338 Q28469 denotes ET-1
T89 334-338 P29560 denotes ET-1
T90 334-338 P22388 denotes ET-1
T91 334-338 P09558 denotes ET-1
T92 334-338 P13206 denotes ET-1
T93 334-338 Q9BG76 denotes ET-1
T94 334-338 Q5NRP9 denotes ET-1
T95 334-338 P22387 denotes ET-1
T98 339-343 SO:0000234 denotes mRNA
T96 339-343 D012333 denotes mRNA
T97 339-343 CHEBI:33699 denotes mRNA
T99 375-382 D000860 denotes hypoxia
T100 375-382 D000860 denotes hypoxia
T101 383-391 D007511 denotes ischemia
T102 383-391 D007511 denotes ischemia
T103 435-439 Q5NRQ1 denotes ET-1
T104 435-439 PR:F4JU69 denotes ET-1
T105 435-439 P17322 denotes ET-1
T106 435-439 PR:000006897 denotes ET-1
T107 435-439 P97740 denotes ET-1
T108 435-439 Q28469 denotes ET-1
T109 435-439 P29560 denotes ET-1
T110 435-439 P22388 denotes ET-1
T111 435-439 P09558 denotes ET-1
T112 435-439 P13206 denotes ET-1
T113 435-439 Q9BG76 denotes ET-1
T114 435-439 Q5NRP9 denotes ET-1
T115 435-439 P22387 denotes ET-1
T116 496-513 D002545 denotes cerebral ischemia
T117 496-513 D002545 denotes cerebral ischemia
T120 536-546 SO:0000781 denotes transgenic
T121 536-552 D008822 denotes transgenic mouse
T124 576-580 Q5NRQ1 denotes ET-1
T125 576-580 PR:F4JU69 denotes ET-1
T126 576-580 P17322 denotes ET-1
T127 576-580 PR:000006897 denotes ET-1
T128 576-580 P97740 denotes ET-1
T129 576-580 Q28469 denotes ET-1
T130 576-580 P29560 denotes ET-1
T131 576-580 P22388 denotes ET-1
T132 576-580 P09558 denotes ET-1
T133 576-580 P13206 denotes ET-1
T134 576-580 Q9BG76 denotes ET-1
T135 576-580 Q5NRP9 denotes ET-1
T136 576-580 P22387 denotes ET-1
T137 596-601 PR:Q5FWH3 denotes GET-1
T138 596-601 PR:P53192 denotes GET-1
T139 596-601 PR:Q5ACW6 denotes GET-1
T140 596-601 PR:Q9HGM2 denotes GET-1
T148 613-644 D005904 denotes glial fibrillary acidic protein
T141 613-644 P47819 denotes glial fibrillary acidic protein
T143 613-644 P14136 denotes glial fibrillary acidic protein
T144 613-644 PR:000007939 denotes glial fibrillary acidic protein
T145 613-644 Q28115 denotes glial fibrillary acidic protein
T146 613-644 Q58EE9 denotes glial fibrillary acidic protein
T147 613-644 Q5RA72 denotes glial fibrillary acidic protein
T149 613-644 P03995 denotes glial fibrillary acidic protein
T150 613-644 P48677 denotes glial fibrillary acidic protein
T142 613-644 GO:0045101 denotes glial fibrillary acidic protein
T151 613-644 GO:0045098 denotes glial fibrillary acidic protein
T156 637-644 SO:0000104 denotes protein
T157 645-653 SO:0000167 denotes promoter
T158 688-692 Q5NRQ1 denotes ET-1
T159 688-692 PR:F4JU69 denotes ET-1
T160 688-692 P17322 denotes ET-1
T161 688-692 PR:000006897 denotes ET-1
T162 688-692 P97740 denotes ET-1
T163 688-692 Q28469 denotes ET-1
T164 688-692 P29560 denotes ET-1
T165 688-692 P22388 denotes ET-1
T166 688-692 P09558 denotes ET-1
T167 688-692 P13206 denotes ET-1
T168 688-692 Q9BG76 denotes ET-1
T169 688-692 Q5NRP9 denotes ET-1
T170 688-692 P22387 denotes ET-1
T171 733-737 PR:000005054 denotes mice
T173 733-737 O89094 denotes mice
T172 733-737 D051379 denotes mice
T174 733-737 10095 denotes mice
T175 753-775 UBERON:0001627 denotes middle cerebral artery
T176 753-785 D020244 denotes middle cerebral artery occlusion
T177 753-785 D020244 denotes middle cerebral artery occlusion
T182 818-823 PR:Q5FWH3 denotes GET-1
T183 818-823 PR:P53192 denotes GET-1
T184 818-823 PR:Q5ACW6 denotes GET-1
T185 818-823 PR:Q9HGM2 denotes GET-1
T186 824-828 PR:000005054 denotes mice
T188 824-828 O89094 denotes mice
T187 824-828 D051379 denotes mice
T189 824-828 10095 denotes mice
T190 854-859 UBERON:6110636 denotes brain
T191 854-859 UBERON:0000955 denotes brain
T192 922-941 UBERON:0000120 denotes blood-brain barrier
T195 943-946 UBERON:0000120 denotes BBB
T196 968-982 UBERON:0013755 denotes arterial blood
T197 998-1003 PR:Q5FWH3 denotes GET-1
T198 998-1003 PR:P53192 denotes GET-1
T199 998-1003 PR:Q5ACW6 denotes GET-1
T200 998-1003 PR:Q9HGM2 denotes GET-1
T201 1004-1008 PR:000005054 denotes mice
T203 1004-1008 O89094 denotes mice
T202 1004-1008 D051379 denotes mice
T204 1004-1008 10095 denotes mice
T205 1056-1075 D009461 denotes neurologic deficits
T206 1056-1075 D009461 denotes neurologic deficits
T207 1090-1097 D007238 denotes infarct
T208 1090-1097 D007238 denotes infarct
T210 1152-1159 D000077868 denotes ABT-627
T211 1152-1159 D000077868 denotes ABT-627
T212 1161-1165 P26684 denotes ET(A
T213 1161-1165 PR:000001221 denotes ET(A
T214 1161-1165 PR:000000735 denotes ET(A
T215 1161-1165 Q61614 denotes ET(A
T216 1161-1165 P21450 denotes ET(A
T217 1161-1165 Q95L55 denotes ET(A
T218 1161-1165 P25101 denotes ET(A
T219 1161-1165 Q29010 denotes ET(A
T220 1161-1165 Q5KSU9 denotes ET(A
T221 1167-1177 CHEBI:48706 denotes antagonist
T222 1211-1216 PR:Q5FWH3 denotes GET-1
T223 1211-1216 PR:P53192 denotes GET-1
T224 1211-1216 PR:Q5ACW6 denotes GET-1
T225 1211-1216 PR:Q9HGM2 denotes GET-1
T226 1239-1249 D005070 denotes Evans blue
T227 1239-1249 D005070 denotes Evans blue
T228 1239-1249 CHEBI:82467 denotes Evans blue
T230 1297-1305 Q91049 denotes occludin
T231 1297-1305 Q6P6T5 denotes occludin
T232 1297-1305 Q9PUN1 denotes occludin
T233 1297-1305 Q16625 denotes occludin
T234 1297-1305 PR:000002207 denotes occludin
T235 1297-1305 Q61146 denotes occludin
T236 1297-1305 Q28269 denotes occludin
T237 1297-1305 Q28793 denotes occludin
T238 1297-1305 Q5RFS5 denotes occludin
T229 1297-1305 D062793 denotes occludin
T239 1353-1358 UBERON:6110636 denotes brain
T240 1353-1358 UBERON:0000955 denotes brain
T241 1387-1401 D001929 denotes cerebral edema
T242 1387-1401 D001929 denotes cerebral edema
T248 1403-1412 GO:0015250 denotes Aquaporin
T253 1403-1414 Q5I4F9 denotes Aquaporin 4
T254 1403-1414 P55088 denotes Aquaporin 4
T255 1403-1414 Q923J4 denotes Aquaporin 4
T256 1403-1414 O77750 denotes Aquaporin 4
T258 1403-1414 P55087 denotes Aquaporin 4
T259 1403-1414 P47863 denotes Aquaporin 4
T260 1403-1414 PR:000004184 denotes Aquaporin 4
T261 1403-1414 G5CTG1 denotes Aquaporin 4
T257 1403-1414 D051401 denotes Aquaporin 4
T262 1477-1490 UBERON:0004537 denotes blood vessels
T263 1494-1499 PR:Q5FWH3 denotes GET-1
T264 1494-1499 PR:P53192 denotes GET-1
T265 1494-1499 PR:Q5ACW6 denotes GET-1
T266 1494-1499 PR:Q9HGM2 denotes GET-1
T267 1561-1565 Q5NRQ1 denotes ET-1
T268 1561-1565 PR:F4JU69 denotes ET-1
T269 1561-1565 P17322 denotes ET-1
T270 1561-1565 PR:000006897 denotes ET-1
T271 1561-1565 P97740 denotes ET-1
T272 1561-1565 Q28469 denotes ET-1
T273 1561-1565 P29560 denotes ET-1
T274 1561-1565 P22388 denotes ET-1
T275 1561-1565 P09558 denotes ET-1
T276 1561-1565 P13206 denotes ET-1
T277 1561-1565 Q9BG76 denotes ET-1
T278 1561-1565 Q5NRP9 denotes ET-1
T279 1561-1565 P22387 denotes ET-1
T280 1593-1610 GO:0030104 denotes water homeostasis
T282 1612-1626 D001929 denotes cerebral edema
T283 1612-1626 D001929 denotes cerebral edema
T286 1631-1634 UBERON:0000120 denotes BBB
T287 1687-1692 UBERON:6110636 denotes brain
T288 1687-1692 UBERON:0000955 denotes brain
T289 1687-1699 D001930 denotes brain injury
T290 1687-1699 D001930 denotes brain injury