| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-180 |
Sentence |
denotes |
Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion. |
| TextSentencer_T2 |
181-192 |
Sentence |
denotes |
BACKGROUND: |
| TextSentencer_T3 |
193-238 |
Sentence |
denotes |
Preeclampsia affects 3-5% of all pregnancies. |
| TextSentencer_T4 |
239-305 |
Sentence |
denotes |
It is a major cause of maternal and fetal morbidity and mortality. |
| TextSentencer_T5 |
306-454 |
Sentence |
denotes |
Recent studies demonstrate that autoantibodies against the angiotensin II type 1 (AT(1)) receptor are present in the serum of preeclamptic patients. |
| TextSentencer_T6 |
455-657 |
Sentence |
denotes |
In this study, we investigated the role of AT(1) receptor-agonistic autoantibody (AT1-AA) regarding interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (Pai-1) secretion in human mesangial cells. |
| TextSentencer_T7 |
658-666 |
Sentence |
denotes |
METHODS: |
| TextSentencer_T8 |
667-764 |
Sentence |
denotes |
The study included ten patients: five severely preeclamptic and five normotensive pregnant women. |
| TextSentencer_T9 |
765-822 |
Sentence |
denotes |
Immunoglobulin-G (IgG) was purified from each individual. |
| TextSentencer_T10 |
823-962 |
Sentence |
denotes |
The presence of AT1-AA was determined based on its ability to stimulate an increase in the contraction rate of rat neonatal cardiomyocytes. |
| TextSentencer_T11 |
963-1054 |
Sentence |
denotes |
Primary human mesangial cells were chosen to study IgG-induced secretion of IL-6 and Pai-1. |
| TextSentencer_T12 |
1055-1266 |
Sentence |
denotes |
Losartan and epitope peptides were used to determine whether AT1-AA interaction with AT(1) receptor was associated with stimulation of IL-6 and Pai-1 secretion and was mediated through AT(1) receptor activation. |
| TextSentencer_T13 |
1267-1275 |
Sentence |
denotes |
RESULTS: |
| TextSentencer_T14 |
1276-1383 |
Sentence |
denotes |
The IgG from preeclamptic patients stimulated an increased contraction rate in rat neonatal cardiomyocytes. |
| TextSentencer_T15 |
1384-1597 |
Sentence |
denotes |
The IgG from preeclamptic patients induced the AT(1) receptor-specific secretion of IL-6 and Pai-1 from human mesangial cells at a significantly higher level than that achieved with IgG from normotensive patients. |
| TextSentencer_T16 |
1598-1693 |
Sentence |
denotes |
Competition with an epitope peptide suggested that the AT(1) receptor was stimulated by AT1-AA. |
| TextSentencer_T17 |
1694-1706 |
Sentence |
denotes |
CONCLUSIONS: |
| TextSentencer_T18 |
1707-1880 |
Sentence |
denotes |
Our findings suggest that a maternal autoantibody with the ability to activate AT(1) receptors may account for the development of renal damage seen in preeclamptic patients. |
| T1 |
0-180 |
Sentence |
denotes |
Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion. |
| T2 |
181-192 |
Sentence |
denotes |
BACKGROUND: |
| T3 |
193-238 |
Sentence |
denotes |
Preeclampsia affects 3-5% of all pregnancies. |
| T4 |
239-305 |
Sentence |
denotes |
It is a major cause of maternal and fetal morbidity and mortality. |
| T5 |
306-454 |
Sentence |
denotes |
Recent studies demonstrate that autoantibodies against the angiotensin II type 1 (AT(1)) receptor are present in the serum of preeclamptic patients. |
| T6 |
455-657 |
Sentence |
denotes |
In this study, we investigated the role of AT(1) receptor-agonistic autoantibody (AT1-AA) regarding interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (Pai-1) secretion in human mesangial cells. |
| T7 |
658-666 |
Sentence |
denotes |
METHODS: |
| T8 |
667-764 |
Sentence |
denotes |
The study included ten patients: five severely preeclamptic and five normotensive pregnant women. |
| T9 |
765-822 |
Sentence |
denotes |
Immunoglobulin-G (IgG) was purified from each individual. |
| T10 |
823-962 |
Sentence |
denotes |
The presence of AT1-AA was determined based on its ability to stimulate an increase in the contraction rate of rat neonatal cardiomyocytes. |
| T11 |
963-1054 |
Sentence |
denotes |
Primary human mesangial cells were chosen to study IgG-induced secretion of IL-6 and Pai-1. |
| T12 |
1055-1266 |
Sentence |
denotes |
Losartan and epitope peptides were used to determine whether AT1-AA interaction with AT(1) receptor was associated with stimulation of IL-6 and Pai-1 secretion and was mediated through AT(1) receptor activation. |
| T13 |
1267-1275 |
Sentence |
denotes |
RESULTS: |
| T14 |
1276-1383 |
Sentence |
denotes |
The IgG from preeclamptic patients stimulated an increased contraction rate in rat neonatal cardiomyocytes. |
| T15 |
1384-1597 |
Sentence |
denotes |
The IgG from preeclamptic patients induced the AT(1) receptor-specific secretion of IL-6 and Pai-1 from human mesangial cells at a significantly higher level than that achieved with IgG from normotensive patients. |
| T16 |
1598-1693 |
Sentence |
denotes |
Competition with an epitope peptide suggested that the AT(1) receptor was stimulated by AT1-AA. |
| T17 |
1694-1706 |
Sentence |
denotes |
CONCLUSIONS: |
| T18 |
1707-1880 |
Sentence |
denotes |
Our findings suggest that a maternal autoantibody with the ability to activate AT(1) receptors may account for the development of renal damage seen in preeclamptic patients. |
