PubMed:15671273 / 977-1516
Annnotations
PubMed_Structured_Abstracts
{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T3","span":{"begin":0,"end":539},"obj":"RESULTS"}],"text":"cPAF triggered significantly increased MT1-MMP, MMP-2, MMP-9, and TIMP-2 mRNA expression, followed by increased active MT1-MMP protein expression at 12 hours, whereas TIMP-2 protein increased at 24 hours. PAF also induced furin gene expression, followed by increased protein expression. Nona-D-arg-NH(2) blocked cPAF induction of MT1-MMP activity. PAF-treated myofibroblasts showed increased active MMP-9 protein, but unchanged MMP-2 activity. Pretreatment with BN 50730 blocked PAF-induced transcription and translation of these proteins."}
c_corpus
{"project":"c_corpus","denotations":[{"id":"T564","span":{"begin":0,"end":4},"obj":"C083283"},{"id":"T565","span":{"begin":0,"end":4},"obj":"C083283"},{"id":"T588","span":{"begin":39,"end":42},"obj":"CVCL_2501"},{"id":"T573","span":{"begin":39,"end":42},"obj":"GO:0047152"},{"id":"T582","span":{"begin":39,"end":42},"obj":"GO:0043791"},{"id":"T591","span":{"begin":39,"end":42},"obj":"GO:0043834"},{"id":"T607","span":{"begin":39,"end":46},"obj":"Q9XT90"},{"id":"T608","span":{"begin":39,"end":46},"obj":"P50281"},{"id":"T609","span":{"begin":39,"end":46},"obj":"Q9GLE4"},{"id":"T610","span":{"begin":39,"end":46},"obj":"PR:000010474"},{"id":"T611","span":{"begin":39,"end":46},"obj":"Q10739"},{"id":"T612","span":{"begin":39,"end":46},"obj":"Q95220"},{"id":"T614","span":{"begin":39,"end":46},"obj":"P53690"},{"id":"T613","span":{"begin":39,"end":46},"obj":"D053511"},{"id":"T617","span":{"begin":43,"end":46},"obj":"GO:0004235"},{"id":"T620","span":{"begin":48,"end":51},"obj":"CHEBI:340824"},{"id":"T623","span":{"begin":48,"end":51},"obj":"CHEBI:59761"},{"id":"T624","span":{"begin":48,"end":53},"obj":"PR:P08253"},{"id":"T625","span":{"begin":48,"end":53},"obj":"Q9GLE5"},{"id":"T626","span":{"begin":48,"end":53},"obj":"P08253"},{"id":"T627","span":{"begin":48,"end":53},"obj":"Q90611"},{"id":"T629","span":{"begin":48,"end":53},"obj":"PR:Q8MPP3"},{"id":"T630","span":{"begin":48,"end":53},"obj":"P33436"},{"id":"T631","span":{"begin":48,"end":53},"obj":"PR:Q90611"},{"id":"T632","span":{"begin":48,"end":53},"obj":"PR:P33436"},{"id":"T633","span":{"begin":48,"end":53},"obj":"PR:000010479"},{"id":"T634","span":{"begin":48,"end":53},"obj":"PR:P33434"},{"id":"T635","span":{"begin":48,"end":53},"obj":"P33434"},{"id":"T636","span":{"begin":48,"end":53},"obj":"P50757"},{"id":"T628","span":{"begin":48,"end":53},"obj":"GO:0004228"},{"id":"T637","span":{"begin":52,"end":58},"obj":"PR:O04529"},{"id":"T638","span":{"begin":55,"end":58},"obj":"CHEBI:340824"},{"id":"T641","span":{"begin":55,"end":58},"obj":"CHEBI:59761"},{"id":"T642","span":{"begin":55,"end":60},"obj":"PR:P50282"},{"id":"T643","span":{"begin":55,"end":60},"obj":"PR:P14780"},{"id":"T644","span":{"begin":55,"end":60},"obj":"P14780"},{"id":"T645","span":{"begin":55,"end":60},"obj":"PR:P41245"},{"id":"T646","span":{"begin":55,"end":60},"obj":"P41246"},{"id":"T647","span":{"begin":55,"end":60},"obj":"P41245"},{"id":"T648","span":{"begin":55,"end":60},"obj":"PR:P52176"},{"id":"T649","span":{"begin":55,"end":60},"obj":"P50282"},{"id":"T651","span":{"begin":55,"end":60},"obj":"PR:000010491"},{"id":"T652","span":{"begin":55,"end":60},"obj":"P52176"},{"id":"T653","span":{"begin":55,"end":60},"obj":"O18733"},{"id":"T650","span":{"begin":55,"end":60},"obj":"GO:0004229"},{"id":"T658","span":{"begin":66,"end":72},"obj":"PR:P16035"},{"id":"T659","span":{"begin":66,"end":72},"obj":"PR:000016353"},{"id":"T660","span":{"begin":66,"end":72},"obj":"O42146"},{"id":"T661","span":{"begin":66,"end":72},"obj":"Q9TRZ7"},{"id":"T662","span":{"begin":66,"end":72},"obj":"Q9TTY1"},{"id":"T663","span":{"begin":66,"end":72},"obj":"Q60453"},{"id":"T664","span":{"begin":66,"end":72},"obj":"P16035"},{"id":"T666","span":{"begin":66,"end":72},"obj":"P25785"},{"id":"T667","span":{"begin":66,"end":72},"obj":"P16368"},{"id":"T668","span":{"begin":66,"end":72},"obj":"O77717"},{"id":"T669","span":{"begin":66,"end":72},"obj":"PR:P25785"},{"id":"T670","span":{"begin":66,"end":72},"obj":"P30121"},{"id":"T671","span":{"begin":66,"end":72},"obj":"Q9WUC6"},{"id":"T672","span":{"begin":66,"end":72},"obj":"PR:P30121"},{"id":"T673","span":{"begin":66,"end":72},"obj":"PR:O42146"},{"id":"T665","span":{"begin":66,"end":72},"obj":"D019716"},{"id":"T676","span":{"begin":73,"end":77},"obj":"SO:0000234"},{"id":"T674","span":{"begin":73,"end":77},"obj":"D012333"},{"id":"T675","span":{"begin":73,"end":77},"obj":"CHEBI:33699"},{"id":"T699","span":{"begin":119,"end":122},"obj":"CVCL_2501"},{"id":"T684","span":{"begin":119,"end":122},"obj":"GO:0047152"},{"id":"T693","span":{"begin":119,"end":122},"obj":"GO:0043791"},{"id":"T702","span":{"begin":119,"end":122},"obj":"GO:0043834"},{"id":"T718","span":{"begin":119,"end":126},"obj":"Q9XT90"},{"id":"T719","span":{"begin":119,"end":126},"obj":"P50281"},{"id":"T720","span":{"begin":119,"end":126},"obj":"Q9GLE4"},{"id":"T721","span":{"begin":119,"end":126},"obj":"PR:000010474"},{"id":"T722","span":{"begin":119,"end":126},"obj":"Q10739"},{"id":"T723","span":{"begin":119,"end":126},"obj":"Q95220"},{"id":"T725","span":{"begin":119,"end":126},"obj":"P53690"},{"id":"T724","span":{"begin":119,"end":126},"obj":"D053511"},{"id":"T728","span":{"begin":123,"end":126},"obj":"GO:0004235"},{"id":"T731","span":{"begin":127,"end":134},"obj":"GO:0003675"},{"id":"T735","span":{"begin":127,"end":134},"obj":"SO:0000104"},{"id":"T734","span":{"begin":127,"end":134},"obj":"PR:000000001"},{"id":"T732","span":{"begin":127,"end":134},"obj":"CHEBI:36080"},{"id":"T733","span":{"begin":127,"end":134},"obj":"CHEBI:11122"},{"id":"T740","span":{"begin":167,"end":173},"obj":"PR:P16035"},{"id":"T741","span":{"begin":167,"end":173},"obj":"PR:000016353"},{"id":"T742","span":{"begin":167,"end":173},"obj":"O42146"},{"id":"T743","span":{"begin":167,"end":173},"obj":"Q9TRZ7"},{"id":"T744","span":{"begin":167,"end":173},"obj":"Q9TTY1"},{"id":"T745","span":{"begin":167,"end":173},"obj":"Q60453"},{"id":"T746","span":{"begin":167,"end":173},"obj":"P16035"},{"id":"T748","span":{"begin":167,"end":173},"obj":"P25785"},{"id":"T749","span":{"begin":167,"end":173},"obj":"P16368"},{"id":"T750","span":{"begin":167,"end":173},"obj":"O77717"},{"id":"T751","span":{"begin":167,"end":173},"obj":"PR:P25785"},{"id":"T752","span":{"begin":167,"end":173},"obj":"P30121"},{"id":"T753","span":{"begin":167,"end":173},"obj":"Q9WUC6"},{"id":"T754","span":{"begin":167,"end":173},"obj":"PR:P30121"},{"id":"T755","span":{"begin":167,"end":173},"obj":"PR:O42146"},{"id":"T747","span":{"begin":167,"end":173},"obj":"D019716"},{"id":"T756","span":{"begin":174,"end":181},"obj":"GO:0003675"},{"id":"T760","span":{"begin":174,"end":181},"obj":"SO:0000104"},{"id":"T759","span":{"begin":174,"end":181},"obj":"PR:000000001"},{"id":"T757","span":{"begin":174,"end":181},"obj":"CHEBI:36080"},{"id":"T758","span":{"begin":174,"end":181},"obj":"CHEBI:11122"},{"id":"T762","span":{"begin":205,"end":208},"obj":"PR:Q6RIA2"},{"id":"T763","span":{"begin":205,"end":208},"obj":"PR:Q15004"},{"id":"T766","span":{"begin":205,"end":208},"obj":"PR:000012225"},{"id":"T768","span":{"begin":205,"end":208},"obj":"PR:Q9CQX4"},{"id":"T767","span":{"begin":205,"end":208},"obj":"CVCL_XY57"},{"id":"T764","span":{"begin":205,"end":208},"obj":"CHEBI:52450"},{"id":"T765","span":{"begin":205,"end":208},"obj":"CHEBI:44811"},{"id":"T769","span":{"begin":222,"end":227},"obj":"P09958"},{"id":"T770","span":{"begin":222,"end":227},"obj":"P23188"},{"id":"T771","span":{"begin":222,"end":227},"obj":"PR:000003137"},{"id":"T773","span":{"begin":222,"end":227},"obj":"PR:P09958"},{"id":"T774","span":{"begin":222,"end":227},"obj":"Q28193"},{"id":"T775","span":{"begin":222,"end":227},"obj":"PR:P23188"},{"id":"T776","span":{"begin":222,"end":227},"obj":"P23377"},{"id":"T777","span":{"begin":222,"end":227},"obj":"PR:P23377"},{"id":"T772","span":{"begin":222,"end":227},"obj":"D045683"},{"id":"T778","span":{"begin":228,"end":232},"obj":"SO:0000704"},{"id":"T779","span":{"begin":228,"end":243},"obj":"GO:0010467"},{"id":"T780","span":{"begin":267,"end":274},"obj":"GO:0003675"},{"id":"T784","span":{"begin":267,"end":274},"obj":"SO:0000104"},{"id":"T783","span":{"begin":267,"end":274},"obj":"PR:000000001"},{"id":"T781","span":{"begin":267,"end":274},"obj":"CHEBI:36080"},{"id":"T782","span":{"begin":267,"end":274},"obj":"CHEBI:11122"},{"id":"T785","span":{"begin":287,"end":291},"obj":"PR:Q04047"},{"id":"T786","span":{"begin":292,"end":297},"obj":"CHEBI:32693"},{"id":"T787","span":{"begin":292,"end":297},"obj":"CHEBI:32691"},{"id":"T788","span":{"begin":292,"end":297},"obj":"CHEBI:29953"},{"id":"T790","span":{"begin":294,"end":297},"obj":"PR:000013890"},{"id":"T792","span":{"begin":294,"end":297},"obj":"PR:P42684"},{"id":"T793","span":{"begin":294,"end":297},"obj":"PR:Q9P2R6"},{"id":"T795","span":{"begin":294,"end":297},"obj":"PR:Q4JIM5"},{"id":"T799","span":{"begin":294,"end":297},"obj":"PR:000003583"},{"id":"T789","span":{"begin":294,"end":297},"obj":"SO:0001451"},{"id":"T800","span":{"begin":294,"end":302},"obj":"C069339"},{"id":"T801","span":{"begin":294,"end":302},"obj":"C069339"},{"id":"T809","span":{"begin":312,"end":316},"obj":"C083283"},{"id":"T810","span":{"begin":312,"end":316},"obj":"C083283"},{"id":"T818","span":{"begin":330,"end":333},"obj":"GO:0047152"},{"id":"T827","span":{"begin":330,"end":333},"obj":"GO:0043791"},{"id":"T836","span":{"begin":330,"end":333},"obj":"GO:0043834"},{"id":"T833","span":{"begin":330,"end":333},"obj":"CVCL_2501"},{"id":"T852","span":{"begin":330,"end":337},"obj":"Q9XT90"},{"id":"T853","span":{"begin":330,"end":337},"obj":"P50281"},{"id":"T854","span":{"begin":330,"end":337},"obj":"Q9GLE4"},{"id":"T855","span":{"begin":330,"end":337},"obj":"PR:000010474"},{"id":"T856","span":{"begin":330,"end":337},"obj":"Q10739"},{"id":"T857","span":{"begin":330,"end":337},"obj":"Q95220"},{"id":"T859","span":{"begin":330,"end":337},"obj":"P53690"},{"id":"T858","span":{"begin":330,"end":337},"obj":"D053511"},{"id":"T862","span":{"begin":334,"end":337},"obj":"GO:0004235"},{"id":"T867","span":{"begin":348,"end":351},"obj":"CHEBI:52450"},{"id":"T868","span":{"begin":348,"end":351},"obj":"CHEBI:44811"},{"id":"T865","span":{"begin":348,"end":351},"obj":"PR:Q6RIA2"},{"id":"T866","span":{"begin":348,"end":351},"obj":"PR:Q15004"},{"id":"T869","span":{"begin":348,"end":351},"obj":"PR:000012225"},{"id":"T871","span":{"begin":348,"end":351},"obj":"PR:Q9CQX4"},{"id":"T870","span":{"begin":348,"end":351},"obj":"CVCL_XY57"},{"id":"T872","span":{"begin":399,"end":402},"obj":"CHEBI:340824"},{"id":"T875","span":{"begin":399,"end":402},"obj":"CHEBI:59761"},{"id":"T876","span":{"begin":399,"end":404},"obj":"PR:P50282"},{"id":"T877","span":{"begin":399,"end":404},"obj":"PR:P14780"},{"id":"T878","span":{"begin":399,"end":404},"obj":"P14780"},{"id":"T879","span":{"begin":399,"end":404},"obj":"PR:P41245"},{"id":"T880","span":{"begin":399,"end":404},"obj":"P41246"},{"id":"T881","span":{"begin":399,"end":404},"obj":"P41245"},{"id":"T882","span":{"begin":399,"end":404},"obj":"PR:P52176"},{"id":"T883","span":{"begin":399,"end":404},"obj":"P50282"},{"id":"T885","span":{"begin":399,"end":404},"obj":"PR:000010491"},{"id":"T886","span":{"begin":399,"end":404},"obj":"P52176"},{"id":"T887","span":{"begin":399,"end":404},"obj":"O18733"},{"id":"T884","span":{"begin":399,"end":404},"obj":"GO:0004229"},{"id":"T892","span":{"begin":405,"end":412},"obj":"SO:0000104"},{"id":"T889","span":{"begin":405,"end":412},"obj":"CHEBI:36080"},{"id":"T890","span":{"begin":405,"end":412},"obj":"CHEBI:11122"},{"id":"T891","span":{"begin":405,"end":412},"obj":"PR:000000001"},{"id":"T888","span":{"begin":405,"end":412},"obj":"GO:0003675"},{"id":"T893","span":{"begin":428,"end":431},"obj":"CHEBI:340824"},{"id":"T896","span":{"begin":428,"end":431},"obj":"CHEBI:59761"},{"id":"T897","span":{"begin":428,"end":433},"obj":"PR:P08253"},{"id":"T898","span":{"begin":428,"end":433},"obj":"Q9GLE5"},{"id":"T899","span":{"begin":428,"end":433},"obj":"P08253"},{"id":"T900","span":{"begin":428,"end":433},"obj":"Q90611"},{"id":"T902","span":{"begin":428,"end":433},"obj":"PR:Q8MPP3"},{"id":"T903","span":{"begin":428,"end":433},"obj":"P33436"},{"id":"T904","span":{"begin":428,"end":433},"obj":"PR:Q90611"},{"id":"T905","span":{"begin":428,"end":433},"obj":"PR:P33436"},{"id":"T906","span":{"begin":428,"end":433},"obj":"PR:000010479"},{"id":"T907","span":{"begin":428,"end":433},"obj":"PR:P33434"},{"id":"T908","span":{"begin":428,"end":433},"obj":"P33434"},{"id":"T909","span":{"begin":428,"end":433},"obj":"P50757"},{"id":"T901","span":{"begin":428,"end":433},"obj":"GO:0004228"},{"id":"T910","span":{"begin":462,"end":470},"obj":"C066686"},{"id":"T911","span":{"begin":462,"end":470},"obj":"C066686"},{"id":"T912","span":{"begin":479,"end":482},"obj":"PR:Q6RIA2"},{"id":"T913","span":{"begin":479,"end":482},"obj":"PR:Q15004"},{"id":"T916","span":{"begin":479,"end":482},"obj":"PR:000012225"},{"id":"T918","span":{"begin":479,"end":482},"obj":"PR:Q9CQX4"},{"id":"T917","span":{"begin":479,"end":482},"obj":"CVCL_XY57"},{"id":"T914","span":{"begin":479,"end":482},"obj":"CHEBI:52450"},{"id":"T915","span":{"begin":479,"end":482},"obj":"CHEBI:44811"},{"id":"T919","span":{"begin":491,"end":504},"obj":"GO:0006351"},{"id":"T920","span":{"begin":509,"end":520},"obj":"GO:0006412"},{"id":"T921","span":{"begin":530,"end":538},"obj":"CHEBI:36080"}],"text":"cPAF triggered significantly increased MT1-MMP, MMP-2, MMP-9, and TIMP-2 mRNA expression, followed by increased active MT1-MMP protein expression at 12 hours, whereas TIMP-2 protein increased at 24 hours. PAF also induced furin gene expression, followed by increased protein expression. Nona-D-arg-NH(2) blocked cPAF induction of MT1-MMP activity. PAF-treated myofibroblasts showed increased active MMP-9 protein, but unchanged MMP-2 activity. Pretreatment with BN 50730 blocked PAF-induced transcription and translation of these proteins."}
UseCases_ArguminSci_Discourse
{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T11","span":{"begin":0,"end":204},"obj":"DRI_Background"},{"id":"T12","span":{"begin":205,"end":286},"obj":"DRI_Background"},{"id":"T13","span":{"begin":287,"end":347},"obj":"DRI_Unspecified"},{"id":"T14","span":{"begin":348,"end":359},"obj":"REPLACED"},{"id":"T15","span":{"begin":360,"end":374},"obj":"Token_Label.OUTSIDE"},{"id":"T16","span":{"begin":375,"end":443},"obj":"DRI_Unspecified"},{"id":"T17","span":{"begin":444,"end":539},"obj":"DRI_Background"}],"text":"cPAF triggered significantly increased MT1-MMP, MMP-2, MMP-9, and TIMP-2 mRNA expression, followed by increased active MT1-MMP protein expression at 12 hours, whereas TIMP-2 protein increased at 24 hours. PAF also induced furin gene expression, followed by increased protein expression. Nona-D-arg-NH(2) blocked cPAF induction of MT1-MMP activity. PAF-treated myofibroblasts showed increased active MMP-9 protein, but unchanged MMP-2 activity. Pretreatment with BN 50730 blocked PAF-induced transcription and translation of these proteins."}