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PubMed:15671273 / 977-1516
Annnotations
PubMed_Structured_Abstracts
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3 | 0-539 | RESULTS | denotes | cPAF triggered significantly increased MT1-MMP, MMP-2, MMP-9, and TIMP-2 mRNA expression, followed by increased active MT1-MMP protein expression at 12 hours, whereas TIMP-2 protein increased at 24 hours. PAF also induced furin gene expression, followed by increased protein expression. Nona-D-arg-NH(2) blocked cPAF induction of MT1-MMP activity. PAF-treated myofibroblasts showed increased active MMP-9 protein, but unchanged MMP-2 activity. Pretreatment with BN 50730 blocked PAF-induced transcription and translation of these proteins. |
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T564 | 0-4 | C083283 | denotes | cPAF |
T565 | 0-4 | C083283 | denotes | cPAF |
T588 | 39-42 | CVCL_2501 | denotes | MT1 |
T573 | 39-42 | GO:0047152 | denotes | MT1 |
T582 | 39-42 | GO:0043791 | denotes | MT1 |
T591 | 39-42 | GO:0043834 | denotes | MT1 |
T607 | 39-46 | Q9XT90 | denotes | MT1-MMP |
T608 | 39-46 | P50281 | denotes | MT1-MMP |
T609 | 39-46 | Q9GLE4 | denotes | MT1-MMP |
T610 | 39-46 | PR:000010474 | denotes | MT1-MMP |
T611 | 39-46 | Q10739 | denotes | MT1-MMP |
T612 | 39-46 | Q95220 | denotes | MT1-MMP |
T614 | 39-46 | P53690 | denotes | MT1-MMP |
T613 | 39-46 | D053511 | denotes | MT1-MMP |
T617 | 43-46 | GO:0004235 | denotes | MMP |
T620 | 48-51 | CHEBI:340824 | denotes | MMP |
T623 | 48-51 | CHEBI:59761 | denotes | MMP |
T624 | 48-53 | PR:P08253 | denotes | MMP-2 |
T625 | 48-53 | Q9GLE5 | denotes | MMP-2 |
T626 | 48-53 | P08253 | denotes | MMP-2 |
T627 | 48-53 | Q90611 | denotes | MMP-2 |
T629 | 48-53 | PR:Q8MPP3 | denotes | MMP-2 |
T630 | 48-53 | P33436 | denotes | MMP-2 |
T631 | 48-53 | PR:Q90611 | denotes | MMP-2 |
T632 | 48-53 | PR:P33436 | denotes | MMP-2 |
T633 | 48-53 | PR:000010479 | denotes | MMP-2 |
T634 | 48-53 | PR:P33434 | denotes | MMP-2 |
T635 | 48-53 | P33434 | denotes | MMP-2 |
T636 | 48-53 | P50757 | denotes | MMP-2 |
T628 | 48-53 | GO:0004228 | denotes | MMP-2 |
T637 | 52-58 | PR:O04529 | denotes | 2, MMP |
T638 | 55-58 | CHEBI:340824 | denotes | MMP |
T641 | 55-58 | CHEBI:59761 | denotes | MMP |
T642 | 55-60 | PR:P50282 | denotes | MMP-9 |
T643 | 55-60 | PR:P14780 | denotes | MMP-9 |
T644 | 55-60 | P14780 | denotes | MMP-9 |
T645 | 55-60 | PR:P41245 | denotes | MMP-9 |
T646 | 55-60 | P41246 | denotes | MMP-9 |
T647 | 55-60 | P41245 | denotes | MMP-9 |
T648 | 55-60 | PR:P52176 | denotes | MMP-9 |
T649 | 55-60 | P50282 | denotes | MMP-9 |
T651 | 55-60 | PR:000010491 | denotes | MMP-9 |
T652 | 55-60 | P52176 | denotes | MMP-9 |
T653 | 55-60 | O18733 | denotes | MMP-9 |
T650 | 55-60 | GO:0004229 | denotes | MMP-9 |
T658 | 66-72 | PR:P16035 | denotes | TIMP-2 |
T659 | 66-72 | PR:000016353 | denotes | TIMP-2 |
T660 | 66-72 | O42146 | denotes | TIMP-2 |
T661 | 66-72 | Q9TRZ7 | denotes | TIMP-2 |
T662 | 66-72 | Q9TTY1 | denotes | TIMP-2 |
T663 | 66-72 | Q60453 | denotes | TIMP-2 |
T664 | 66-72 | P16035 | denotes | TIMP-2 |
T666 | 66-72 | P25785 | denotes | TIMP-2 |
T667 | 66-72 | P16368 | denotes | TIMP-2 |
T668 | 66-72 | O77717 | denotes | TIMP-2 |
T669 | 66-72 | PR:P25785 | denotes | TIMP-2 |
T670 | 66-72 | P30121 | denotes | TIMP-2 |
T671 | 66-72 | Q9WUC6 | denotes | TIMP-2 |
T672 | 66-72 | PR:P30121 | denotes | TIMP-2 |
T673 | 66-72 | PR:O42146 | denotes | TIMP-2 |
T665 | 66-72 | D019716 | denotes | TIMP-2 |
T676 | 73-77 | SO:0000234 | denotes | mRNA |
T674 | 73-77 | D012333 | denotes | mRNA |
T675 | 73-77 | CHEBI:33699 | denotes | mRNA |
T699 | 119-122 | CVCL_2501 | denotes | MT1 |
T684 | 119-122 | GO:0047152 | denotes | MT1 |
T693 | 119-122 | GO:0043791 | denotes | MT1 |
T702 | 119-122 | GO:0043834 | denotes | MT1 |
T718 | 119-126 | Q9XT90 | denotes | MT1-MMP |
T719 | 119-126 | P50281 | denotes | MT1-MMP |
T720 | 119-126 | Q9GLE4 | denotes | MT1-MMP |
T721 | 119-126 | PR:000010474 | denotes | MT1-MMP |
T722 | 119-126 | Q10739 | denotes | MT1-MMP |
T723 | 119-126 | Q95220 | denotes | MT1-MMP |
T725 | 119-126 | P53690 | denotes | MT1-MMP |
T724 | 119-126 | D053511 | denotes | MT1-MMP |
T728 | 123-126 | GO:0004235 | denotes | MMP |
T731 | 127-134 | GO:0003675 | denotes | protein |
T735 | 127-134 | SO:0000104 | denotes | protein |
T734 | 127-134 | PR:000000001 | denotes | protein |
T732 | 127-134 | CHEBI:36080 | denotes | protein |
T733 | 127-134 | CHEBI:11122 | denotes | protein |
T740 | 167-173 | PR:P16035 | denotes | TIMP-2 |
T741 | 167-173 | PR:000016353 | denotes | TIMP-2 |
T742 | 167-173 | O42146 | denotes | TIMP-2 |
T743 | 167-173 | Q9TRZ7 | denotes | TIMP-2 |
T744 | 167-173 | Q9TTY1 | denotes | TIMP-2 |
T745 | 167-173 | Q60453 | denotes | TIMP-2 |
T746 | 167-173 | P16035 | denotes | TIMP-2 |
T748 | 167-173 | P25785 | denotes | TIMP-2 |
T749 | 167-173 | P16368 | denotes | TIMP-2 |
T750 | 167-173 | O77717 | denotes | TIMP-2 |
T751 | 167-173 | PR:P25785 | denotes | TIMP-2 |
T752 | 167-173 | P30121 | denotes | TIMP-2 |
T753 | 167-173 | Q9WUC6 | denotes | TIMP-2 |
T754 | 167-173 | PR:P30121 | denotes | TIMP-2 |
T755 | 167-173 | PR:O42146 | denotes | TIMP-2 |
T747 | 167-173 | D019716 | denotes | TIMP-2 |
T756 | 174-181 | GO:0003675 | denotes | protein |
T760 | 174-181 | SO:0000104 | denotes | protein |
T759 | 174-181 | PR:000000001 | denotes | protein |
T757 | 174-181 | CHEBI:36080 | denotes | protein |
T758 | 174-181 | CHEBI:11122 | denotes | protein |
T762 | 205-208 | PR:Q6RIA2 | denotes | PAF |
T763 | 205-208 | PR:Q15004 | denotes | PAF |
T766 | 205-208 | PR:000012225 | denotes | PAF |
T768 | 205-208 | PR:Q9CQX4 | denotes | PAF |
T767 | 205-208 | CVCL_XY57 | denotes | PAF |
T764 | 205-208 | CHEBI:52450 | denotes | PAF |
T765 | 205-208 | CHEBI:44811 | denotes | PAF |
T769 | 222-227 | P09958 | denotes | furin |
T770 | 222-227 | P23188 | denotes | furin |
T771 | 222-227 | PR:000003137 | denotes | furin |
T773 | 222-227 | PR:P09958 | denotes | furin |
T774 | 222-227 | Q28193 | denotes | furin |
T775 | 222-227 | PR:P23188 | denotes | furin |
T776 | 222-227 | P23377 | denotes | furin |
T777 | 222-227 | PR:P23377 | denotes | furin |
T772 | 222-227 | D045683 | denotes | furin |
T778 | 228-232 | SO:0000704 | denotes | gene |
T779 | 228-243 | GO:0010467 | denotes | gene expression |
T780 | 267-274 | GO:0003675 | denotes | protein |
T784 | 267-274 | SO:0000104 | denotes | protein |
T783 | 267-274 | PR:000000001 | denotes | protein |
T781 | 267-274 | CHEBI:36080 | denotes | protein |
T782 | 267-274 | CHEBI:11122 | denotes | protein |
T785 | 287-291 | PR:Q04047 | denotes | Nona |
T786 | 292-297 | CHEBI:32693 | denotes | D-arg |
T787 | 292-297 | CHEBI:32691 | denotes | D-arg |
T788 | 292-297 | CHEBI:29953 | denotes | D-arg |
T790 | 294-297 | PR:000013890 | denotes | arg |
T792 | 294-297 | PR:P42684 | denotes | arg |
T793 | 294-297 | PR:Q9P2R6 | denotes | arg |
T795 | 294-297 | PR:Q4JIM5 | denotes | arg |
T799 | 294-297 | PR:000003583 | denotes | arg |
T789 | 294-297 | SO:0001451 | denotes | arg |
T800 | 294-302 | C069339 | denotes | arg-NH(2 |
T801 | 294-302 | C069339 | denotes | arg-NH(2 |
T809 | 312-316 | C083283 | denotes | cPAF |
T810 | 312-316 | C083283 | denotes | cPAF |
T818 | 330-333 | GO:0047152 | denotes | MT1 |
T827 | 330-333 | GO:0043791 | denotes | MT1 |
T836 | 330-333 | GO:0043834 | denotes | MT1 |
T833 | 330-333 | CVCL_2501 | denotes | MT1 |
T852 | 330-337 | Q9XT90 | denotes | MT1-MMP |
T853 | 330-337 | P50281 | denotes | MT1-MMP |
T854 | 330-337 | Q9GLE4 | denotes | MT1-MMP |
T855 | 330-337 | PR:000010474 | denotes | MT1-MMP |
T856 | 330-337 | Q10739 | denotes | MT1-MMP |
T857 | 330-337 | Q95220 | denotes | MT1-MMP |
T859 | 330-337 | P53690 | denotes | MT1-MMP |
T858 | 330-337 | D053511 | denotes | MT1-MMP |
T862 | 334-337 | GO:0004235 | denotes | MMP |
T867 | 348-351 | CHEBI:52450 | denotes | PAF |
T868 | 348-351 | CHEBI:44811 | denotes | PAF |
T865 | 348-351 | PR:Q6RIA2 | denotes | PAF |
T866 | 348-351 | PR:Q15004 | denotes | PAF |
T869 | 348-351 | PR:000012225 | denotes | PAF |
T871 | 348-351 | PR:Q9CQX4 | denotes | PAF |
T870 | 348-351 | CVCL_XY57 | denotes | PAF |
T872 | 399-402 | CHEBI:340824 | denotes | MMP |
T875 | 399-402 | CHEBI:59761 | denotes | MMP |
T876 | 399-404 | PR:P50282 | denotes | MMP-9 |
T877 | 399-404 | PR:P14780 | denotes | MMP-9 |
T878 | 399-404 | P14780 | denotes | MMP-9 |
T879 | 399-404 | PR:P41245 | denotes | MMP-9 |
T880 | 399-404 | P41246 | denotes | MMP-9 |
T881 | 399-404 | P41245 | denotes | MMP-9 |
T882 | 399-404 | PR:P52176 | denotes | MMP-9 |
T883 | 399-404 | P50282 | denotes | MMP-9 |
T885 | 399-404 | PR:000010491 | denotes | MMP-9 |
T886 | 399-404 | P52176 | denotes | MMP-9 |
T887 | 399-404 | O18733 | denotes | MMP-9 |
T884 | 399-404 | GO:0004229 | denotes | MMP-9 |
T892 | 405-412 | SO:0000104 | denotes | protein |
T889 | 405-412 | CHEBI:36080 | denotes | protein |
T890 | 405-412 | CHEBI:11122 | denotes | protein |
T891 | 405-412 | PR:000000001 | denotes | protein |
T888 | 405-412 | GO:0003675 | denotes | protein |
T893 | 428-431 | CHEBI:340824 | denotes | MMP |
T896 | 428-431 | CHEBI:59761 | denotes | MMP |
T897 | 428-433 | PR:P08253 | denotes | MMP-2 |
T898 | 428-433 | Q9GLE5 | denotes | MMP-2 |
T899 | 428-433 | P08253 | denotes | MMP-2 |
T900 | 428-433 | Q90611 | denotes | MMP-2 |
T902 | 428-433 | PR:Q8MPP3 | denotes | MMP-2 |
T903 | 428-433 | P33436 | denotes | MMP-2 |
T904 | 428-433 | PR:Q90611 | denotes | MMP-2 |
T905 | 428-433 | PR:P33436 | denotes | MMP-2 |
T906 | 428-433 | PR:000010479 | denotes | MMP-2 |
T907 | 428-433 | PR:P33434 | denotes | MMP-2 |
T908 | 428-433 | P33434 | denotes | MMP-2 |
T909 | 428-433 | P50757 | denotes | MMP-2 |
T901 | 428-433 | GO:0004228 | denotes | MMP-2 |
T910 | 462-470 | C066686 | denotes | BN 50730 |
T911 | 462-470 | C066686 | denotes | BN 50730 |
T912 | 479-482 | PR:Q6RIA2 | denotes | PAF |
T913 | 479-482 | PR:Q15004 | denotes | PAF |
T916 | 479-482 | PR:000012225 | denotes | PAF |
T918 | 479-482 | PR:Q9CQX4 | denotes | PAF |
T917 | 479-482 | CVCL_XY57 | denotes | PAF |
T914 | 479-482 | CHEBI:52450 | denotes | PAF |
T915 | 479-482 | CHEBI:44811 | denotes | PAF |
T919 | 491-504 | GO:0006351 | denotes | transcription |
T920 | 509-520 | GO:0006412 | denotes | translation |
T921 | 530-538 | CHEBI:36080 | denotes | proteins |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11 | 0-204 | DRI_Background | denotes | cPAF triggered significantly increased MT1-MMP, MMP-2, MMP-9, and TIMP-2 mRNA expression, followed by increased active MT1-MMP protein expression at 12 hours, whereas TIMP-2 protein increased at 24 hours. |
T12 | 205-286 | DRI_Background | denotes | PAF also induced furin gene expression, followed by increased protein expression. |
T13 | 287-347 | DRI_Unspecified | denotes | Nona-D-arg-NH(2) blocked cPAF induction of MT1-MMP activity. |
T14 | 348-359 | REPLACED | denotes | PAF-treated |
T15 | 360-374 | Token_Label.OUTSIDE | denotes | myofibroblasts |
T16 | 375-443 | DRI_Unspecified | denotes | showed increased active MMP-9 protein, but unchanged MMP-2 activity. |
T17 | 444-539 | DRI_Background | denotes | Pretreatment with BN 50730 blocked PAF-induced transcription and translation of these proteins. |