PubMed:15643879 JSONTXT

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T1","span":{"begin":276,"end":290},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G00054MO"},{"id":"A2","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO"}],"text":"Synthesis of postulated molecular probes: stereoselective free-radical-mediated C-glycosylation in tandem with hydrogen transfer.\nReported herein is a strategy employing an addition reaction in tandem with a hydrogen-transfer reaction for the elaboration of C-glycoside-based sialyl Lewis X (sLe(X)) analogues. Significant stereocontrol was noted when alkyl radicals were reacted with a series of alkoxytaconates. Transition states were proposed to explain the obtained selectivity. Further reaction between an anomeric-centered fucosyl-derived radical and a galactosylated hydroxytaconate provided easy access to C,O-diglycosides as mimics of sLe(X). In this case, two 1,3-distant stereocenters were created with high diastereoselectivity using free radical intermediates in a tandem process."}

{"project":"GlyCosmos-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":276,"end":290},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"}],"attributes":[{"id":"A1","pred":"glycoepitope_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0012"}],"text":"Synthesis of postulated molecular probes: stereoselective free-radical-mediated C-glycosylation in tandem with hydrogen transfer.\nReported herein is a strategy employing an addition reaction in tandem with a hydrogen-transfer reaction for the elaboration of C-glycoside-based sialyl Lewis X (sLe(X)) analogues. Significant stereocontrol was noted when alkyl radicals were reacted with a series of alkoxytaconates. Transition states were proposed to explain the obtained selectivity. Further reaction between an anomeric-centered fucosyl-derived radical and a galactosylated hydroxytaconate provided easy access to C,O-diglycosides as mimics of sLe(X). In this case, two 1,3-distant stereocenters were created with high diastereoselectivity using free radical intermediates in a tandem process."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T1","span":{"begin":0,"end":129},"obj":"Sentence"},{"id":"T2","span":{"begin":130,"end":310},"obj":"Sentence"},{"id":"T3","span":{"begin":311,"end":413},"obj":"Sentence"},{"id":"T4","span":{"begin":414,"end":482},"obj":"Sentence"},{"id":"T5","span":{"begin":483,"end":651},"obj":"Sentence"},{"id":"T6","span":{"begin":652,"end":793},"obj":"Sentence"}],"text":"Synthesis of postulated molecular probes: stereoselective free-radical-mediated C-glycosylation in tandem with hydrogen transfer.\nReported herein is a strategy employing an addition reaction in tandem with a hydrogen-transfer reaction for the elaboration of C-glycoside-based sialyl Lewis X (sLe(X)) analogues. Significant stereocontrol was noted when alkyl radicals were reacted with a series of alkoxytaconates. Transition states were proposed to explain the obtained selectivity. Further reaction between an anomeric-centered fucosyl-derived radical and a galactosylated hydroxytaconate provided easy access to C,O-diglycosides as mimics of sLe(X). In this case, two 1,3-distant stereocenters were created with high diastereoselectivity using free radical intermediates in a tandem process."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T1","span":{"begin":276,"end":290},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G00054MO"},{"id":"A2","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO"}],"text":"Synthesis of postulated molecular probes: stereoselective free-radical-mediated C-glycosylation in tandem with hydrogen transfer.\nReported herein is a strategy employing an addition reaction in tandem with a hydrogen-transfer reaction for the elaboration of C-glycoside-based sialyl Lewis X (sLe(X)) analogues. Significant stereocontrol was noted when alkyl radicals were reacted with a series of alkoxytaconates. Transition states were proposed to explain the obtained selectivity. Further reaction between an anomeric-centered fucosyl-derived radical and a galactosylated hydroxytaconate provided easy access to C,O-diglycosides as mimics of sLe(X). In this case, two 1,3-distant stereocenters were created with high diastereoselectivity using free radical intermediates in a tandem process."}

{"project":"GlyCosmos15-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":276,"end":290},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"}],"attributes":[{"id":"A1","pred":"glycoepitope_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0012"}],"text":"Synthesis of postulated molecular probes: stereoselective free-radical-mediated C-glycosylation in tandem with hydrogen transfer.\nReported herein is a strategy employing an addition reaction in tandem with a hydrogen-transfer reaction for the elaboration of C-glycoside-based sialyl Lewis X (sLe(X)) analogues. Significant stereocontrol was noted when alkyl radicals were reacted with a series of alkoxytaconates. Transition states were proposed to explain the obtained selectivity. Further reaction between an anomeric-centered fucosyl-derived radical and a galactosylated hydroxytaconate provided easy access to C,O-diglycosides as mimics of sLe(X). In this case, two 1,3-distant stereocenters were created with high diastereoselectivity using free radical intermediates in a tandem process."}

{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":292,"end":295},"obj":"Phenotype"},{"id":"T2","span":{"begin":644,"end":647},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002725"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0002725"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Synthesis of postulated molecular probes: stereoselective free-radical-mediated C-glycosylation in tandem with hydrogen transfer.\nReported herein is a strategy employing an addition reaction in tandem with a hydrogen-transfer reaction for the elaboration of C-glycoside-based sialyl Lewis X (sLe(X)) analogues. Significant stereocontrol was noted when alkyl radicals were reacted with a series of alkoxytaconates. Transition states were proposed to explain the obtained selectivity. Further reaction between an anomeric-centered fucosyl-derived radical and a galactosylated hydroxytaconate provided easy access to C,O-diglycosides as mimics of sLe(X). In this case, two 1,3-distant stereocenters were created with high diastereoselectivity using free radical intermediates in a tandem process."}