> top > docs > PubMed:15537790 > annotations

PubMed:15537790 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-114 Sentence denotes Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.
TextSentencer_T2 115-292 Sentence denotes In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD).
TextSentencer_T3 293-502 Sentence denotes Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal.
TextSentencer_T4 503-554 Sentence denotes In humans there are a total of three EDEM homologs.
TextSentencer_T5 555-708 Sentence denotes The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases).
TextSentencer_T6 709-822 Sentence denotes In this study, we characterize one of the EDEM homologs from Homo sapiens, which we have termed EDEM2 (C20orf31).
TextSentencer_T7 823-907 Sentence denotes Using recombinantly generated EDEM2, no alpha-1,2 mannosidase activity was observed.
TextSentencer_T8 908-1023 Sentence denotes In HEK293 cells, recombinant EDEM2 is localized to the ER where it can associate with misfolded alpha1-antitrypsin.
TextSentencer_T9 1024-1157 Sentence denotes Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD.
T1 0-114 Sentence denotes Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.
T2 115-292 Sentence denotes In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD).
T3 293-502 Sentence denotes Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal.
T4 503-554 Sentence denotes In humans there are a total of three EDEM homologs.
T5 555-708 Sentence denotes The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases).
T6 709-822 Sentence denotes In this study, we characterize one of the EDEM homologs from Homo sapiens, which we have termed EDEM2 (C20orf31).
T7 823-907 Sentence denotes Using recombinantly generated EDEM2, no alpha-1,2 mannosidase activity was observed.
T8 908-1023 Sentence denotes In HEK293 cells, recombinant EDEM2 is localized to the ER where it can associate with misfolded alpha1-antitrypsin.
T9 1024-1157 Sentence denotes Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD.
T1 0-114 Sentence denotes Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.
T2 115-292 Sentence denotes In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD).
T3 293-502 Sentence denotes Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal.
T4 503-554 Sentence denotes In humans there are a total of three EDEM homologs.
T5 555-708 Sentence denotes The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases).
T6 709-822 Sentence denotes In this study, we characterize one of the EDEM homologs from Homo sapiens, which we have termed EDEM2 (C20orf31).
T7 823-907 Sentence denotes Using recombinantly generated EDEM2, no alpha-1,2 mannosidase activity was observed.
T8 908-1023 Sentence denotes In HEK293 cells, recombinant EDEM2 is localized to the ER where it can associate with misfolded alpha1-antitrypsin.
T9 1024-1157 Sentence denotes Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD.

uniprot-human

Id Subject Object Predicate Lexical cue
T1 6-11 http://www.uniprot.org/uniprot/Q9NVE6 denotes EDEM2
T2 805-810 http://www.uniprot.org/uniprot/Q9NVE6 denotes EDEM2
T3 853-858 http://www.uniprot.org/uniprot/Q9NVE6 denotes EDEM2
T4 937-942 http://www.uniprot.org/uniprot/Q9NVE6 denotes EDEM2
T5 812-820 http://www.uniprot.org/uniprot/Q9NVE6 denotes C20orf31
T6 71-73 http://www.uniprot.org/uniprot/P03372 denotes ER
T7 145-147 http://www.uniprot.org/uniprot/P03372 denotes ER
T8 259-261 http://www.uniprot.org/uniprot/P03372 denotes ER
T9 335-337 http://www.uniprot.org/uniprot/P03372 denotes ER
T10 394-396 http://www.uniprot.org/uniprot/P03372 denotes ER
T11 963-965 http://www.uniprot.org/uniprot/P03372 denotes ER
T12 335-344 http://www.uniprot.org/uniprot/Q96DZ1 denotes ER lectin
T13 346-350 http://www.uniprot.org/uniprot/Q92611 denotes EDEM
T14 540-544 http://www.uniprot.org/uniprot/Q92611 denotes EDEM
T15 751-755 http://www.uniprot.org/uniprot/Q92611 denotes EDEM
T16 863-884 http://www.uniprot.org/uniprot/O60476 denotes alpha-1,2 mannosidase
T17 863-884 http://www.uniprot.org/uniprot/Q9UKM7 denotes alpha-1,2 mannosidase
T18 863-884 http://www.uniprot.org/uniprot/Q9BZQ6 denotes alpha-1,2 mannosidase
T19 863-884 http://www.uniprot.org/uniprot/Q5SRI9 denotes alpha-1,2 mannosidase
T20 863-884 http://www.uniprot.org/uniprot/Q9NR34 denotes alpha-1,2 mannosidase
T21 863-884 http://www.uniprot.org/uniprot/P33908 denotes alpha-1,2 mannosidase

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 71-73 http://www.uniprot.org/uniprot/P19785 denotes ER
T2 145-147 http://www.uniprot.org/uniprot/P19785 denotes ER
T3 259-261 http://www.uniprot.org/uniprot/P19785 denotes ER
T4 335-337 http://www.uniprot.org/uniprot/P19785 denotes ER
T5 394-396 http://www.uniprot.org/uniprot/P19785 denotes ER
T6 963-965 http://www.uniprot.org/uniprot/P19785 denotes ER
T7 335-344 http://www.uniprot.org/uniprot/Q8VEH8 denotes ER lectin

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 559-579 http://purl.bioontology.org/ontology/STY/T087 denotes amino acid sequences
T2 647-654 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T3 770-774 http://purl.bioontology.org/ontology/NCBITAXON/9605 denotes Homo
T4 770-782 http://purl.bioontology.org/ontology/NCBITAXON/9606 denotes Homo sapiens
T5 798-804 http://purl.bioontology.org/ontology/NCBITAXON/62951 denotes termed
T6 918-923 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 74-113 http://purl.obolibrary.org/obo/GO_0097466 denotes associated degradation of glycoproteins
T2 85-96 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T3 273-284 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T4 210-218 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T5 85-113 http://purl.obolibrary.org/obo/GO_0006516 denotes degradation of glycoproteins
T6 210-236 http://purl.obolibrary.org/obo/GO_1903009 denotes degraded by the proteasome
T7 226-249 http://purl.obolibrary.org/obo/GO_0043161 denotes proteasome in a process
T8 286-290 http://purl.obolibrary.org/obo/GO_0030433 denotes ERAD
T9 1152-1156 http://purl.obolibrary.org/obo/GO_0030433 denotes ERAD
T10 668-682 http://purl.obolibrary.org/obo/GO_0004571 denotes I mannosidases
T11 863-884 http://purl.obolibrary.org/obo/GO_0004559 denotes alpha-1,2 mannosidase
T12 863-884 http://purl.obolibrary.org/obo/GO_0004571 denotes alpha-1,2 mannosidase
T13 863-893 http://purl.obolibrary.org/obo/GO_0004559 denotes alpha-1,2 mannosidase activity
T14 873-893 http://purl.obolibrary.org/obo/GO_0015923 denotes mannosidase activity
T15 946-955 http://purl.obolibrary.org/obo/GO_0051179 denotes localized
T16 946-965 http://purl.obolibrary.org/obo/GO_0051643 denotes localized to the ER

GO-CC

Id Subject Object Predicate Lexical cue
T1 71-73 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T2 145-147 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T3 259-261 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T4 335-337 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T5 394-396 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T6 963-965 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T7 122-143 http://purl.obolibrary.org/obo/GO_0005783 denotes endoplasmic reticulum
T8 198-205 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosol
T9 226-236 http://purl.obolibrary.org/obo/GO_0000502 denotes proteasome
T10 327-337 http://purl.obolibrary.org/obo/GO_0005788 denotes lumenal ER
T11 918-923 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

Lectin-Jamboree

Id Subject Object Predicate Lexical cue
T1 338-344 lectin denotes lectin
T2 623-630 lectin denotes lectins

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.
T2 115-292 Sentence denotes In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD).
T3 293-502 Sentence denotes Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal.
T4 503-554 Sentence denotes In humans there are a total of three EDEM homologs.
T5 555-708 Sentence denotes The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases).
T6 709-822 Sentence denotes In this study, we characterize one of the EDEM homologs from Homo sapiens, which we have termed EDEM2 (C20orf31).
T7 823-907 Sentence denotes Using recombinantly generated EDEM2, no alpha-1,2 mannosidase activity was observed.
T8 908-1023 Sentence denotes In HEK293 cells, recombinant EDEM2 is localized to the ER where it can associate with misfolded alpha1-antitrypsin.
T9 1024-1157 Sentence denotes Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-5 OrganismTaxon denotes Human 9606
T2 770-782 OrganismTaxon denotes Homo sapiens 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 134-143 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 198-205 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829