PubMed:1541828 JSONTXT

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{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":56,"end":79},"obj":"NP"},{"id":"C2","span":{"begin":81,"end":85},"obj":"NP"},{"id":"C3","span":{"begin":98,"end":115},"obj":"NP"},{"id":"C4","span":{"begin":209,"end":216},"obj":"NP"},{"id":"C5","span":{"begin":320,"end":377},"obj":"NP"},{"id":"C6","span":{"begin":457,"end":470},"obj":"NP"},{"id":"C7","span":{"begin":490,"end":497},"obj":"NP"},{"id":"C8","span":{"begin":525,"end":533},"obj":"NP"},{"id":"C9","span":{"begin":609,"end":614},"obj":"NP"},{"id":"C10","span":{"begin":619,"end":625},"obj":"NP"},{"id":"C11","span":{"begin":671,"end":700},"obj":"NP"},{"id":"C12","span":{"begin":731,"end":738},"obj":"NP"},{"id":"C13","span":{"begin":765,"end":772},"obj":"NP"},{"id":"C14","span":{"begin":804,"end":811},"obj":"NP"},{"id":"C15","span":{"begin":902,"end":908},"obj":"NP"},{"id":"C16","span":{"begin":927,"end":967},"obj":"NP"},{"id":"C17","span":{"begin":1050,"end":1057},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-other","subj":"C4","obj":"C3"},{"id":"R3","pred":"coref-ident","subj":"C6","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C9","obj":"C7"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C8"},{"id":"R6","pred":"coref-ident","subj":"C12","obj":"C5"},{"id":"R7","pred":"coref-ident","subj":"C13","obj":"C11"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C12"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C14"},{"id":"R10","pred":"coref-ident","subj":"C16","obj":"C13"},{"id":"R11","pred":"coref-ident","subj":"C17","obj":"C4"}],"text":"T cell-specific negative regulation of transcription of the human cytokine IL-4.\nIL-4 secreted by activated T cells is a pleiotropic cytokine affecting growth and differentiation of diverse cell types such as T cells, B cells, and mast cells. We investigated the upstream regulatory elements of the human IL-4 promoter. A novel T cell-specific negative regulatory element (NRE) composed of two protein-binding sites were mapped in the 5' flanking region of the IL-4 gene: -311CTCCCTTCT-303 (NRE-I) and -288CTTTTTGCTT-TGC-300 (NRE-II). A T cell-specific protein Neg-1 and a ubiquitous protein Neg-2 binding to NRE-I and NRE-II, respectively, were identified. Furthermore, a positive regulatory element was found 45 bp downstream of the NRE. The enhancer activity of the PRE was completely suppressed when the NRE was present. These data suggest that IL-4 promoter activity is normally down-regulated by an NRE via repression of the enhancer positive regulatory element. These data may have implications for the stringent control of IL-4 expression in T cells."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":80},"obj":"Sentence"},{"id":"S2","span":{"begin":81,"end":242},"obj":"Sentence"},{"id":"S3","span":{"begin":243,"end":319},"obj":"Sentence"},{"id":"S4","span":{"begin":320,"end":534},"obj":"Sentence"},{"id":"S5","span":{"begin":535,"end":657},"obj":"Sentence"},{"id":"S6","span":{"begin":658,"end":739},"obj":"Sentence"},{"id":"S7","span":{"begin":740,"end":824},"obj":"Sentence"},{"id":"S8","span":{"begin":825,"end":968},"obj":"Sentence"},{"id":"S9","span":{"begin":969,"end":1058},"obj":"Sentence"}],"text":"T cell-specific negative regulation of transcription of the human cytokine IL-4.\nIL-4 secreted by activated T cells is a pleiotropic cytokine affecting growth and differentiation of diverse cell types such as T cells, B cells, and mast cells. We investigated the upstream regulatory elements of the human IL-4 promoter. A novel T cell-specific negative regulatory element (NRE) composed of two protein-binding sites were mapped in the 5' flanking region of the IL-4 gene: -311CTCCCTTCT-303 (NRE-I) and -288CTTTTTGCTT-TGC-300 (NRE-II). A T cell-specific protein Neg-1 and a ubiquitous protein Neg-2 binding to NRE-I and NRE-II, respectively, were identified. Furthermore, a positive regulatory element was found 45 bp downstream of the NRE. The enhancer activity of the PRE was completely suppressed when the NRE was present. These data suggest that IL-4 promoter activity is normally down-regulated by an NRE via repression of the enhancer positive regulatory element. These data may have implications for the stringent control of IL-4 expression in T cells."}

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