PubMed:1541828
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 60-79 | protein | denotes | human cytokine IL-4 |
| T2 | 81-85 | protein | denotes | IL-4 |
| T3 | 98-115 | cell_type | denotes | activated T cells |
| T4 | 121-141 | protein | denotes | pleiotropic cytokine |
| T5 | 209-216 | cell_type | denotes | T cells |
| T6 | 218-225 | cell_type | denotes | B cells |
| T7 | 231-241 | cell_type | denotes | mast cells |
| T8 | 263-291 | DNA | denotes | upstream regulatory elements |
| T9 | 299-318 | DNA | denotes | human IL-4 promoter |
| T10 | 322-371 | DNA | denotes | novel T cell-specific negative regulatory element |
| T11 | 373-376 | DNA | denotes | NRE |
| T12 | 461-470 | DNA | denotes | IL-4 gene |
| T13 | 491-496 | DNA | denotes | NRE-I |
| T14 | 526-532 | DNA | denotes | NRE-II |
| T15 | 537-560 | protein | denotes | T cell-specific protein |
| T16 | 561-566 | protein | denotes | Neg-1 |
| T17 | 573-591 | protein | denotes | ubiquitous protein |
| T18 | 592-597 | protein | denotes | Neg-2 |
| T19 | 609-614 | DNA | denotes | NRE-I |
| T20 | 619-625 | DNA | denotes | NRE-II |
| T21 | 673-700 | DNA | denotes | positive regulatory element |
| T22 | 711-727 | DNA | denotes | 45 bp downstream |
| T23 | 735-738 | DNA | denotes | NRE |
| T24 | 769-772 | DNA | denotes | PRE |
| T25 | 808-811 | DNA | denotes | NRE |
| T26 | 849-862 | DNA | denotes | IL-4 promoter |
| T27 | 905-908 | DNA | denotes | NRE |
| T28 | 931-967 | DNA | denotes | enhancer positive regulatory element |
| T29 | 1031-1035 | protein | denotes | IL-4 |
| T30 | 1050-1057 | cell_type | denotes | T cells |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 56-79 | NP | denotes | the human cytokine IL-4 |
| C2 | 81-85 | NP | denotes | IL-4 |
| C3 | 98-115 | NP | denotes | activated T cells |
| C4 | 209-216 | NP | denotes | T cells |
| C5 | 320-377 | NP | denotes | A novel T cell-specific negative regulatory element (NRE) |
| C6 | 457-470 | NP | denotes | the IL-4 gene |
| C7 | 490-497 | NP | denotes | (NRE-I) |
| C8 | 525-533 | NP | denotes | (NRE-II) |
| C9 | 609-614 | NP | denotes | NRE-I |
| C10 | 619-625 | NP | denotes | NRE-II |
| C11 | 671-700 | NP | denotes | a positive regulatory element |
| C12 | 731-738 | NP | denotes | the NRE |
| C13 | 765-772 | NP | denotes | the PRE |
| C14 | 804-811 | NP | denotes | the NRE |
| C15 | 902-908 | NP | denotes | an NRE |
| C16 | 927-967 | NP | denotes | the enhancer positive regulatory element |
| C17 | 1050-1057 | NP | denotes | T cells |
| R1 | C2 | C1 | coref-ident | IL-4,the human cytokine IL-4 |
| R2 | C4 | C3 | coref-other | T cells,activated T cells |
| R3 | C6 | C2 | coref-ident | the IL-4 gene,IL-4 |
| R4 | C9 | C7 | coref-ident | NRE-I,(NRE-I) |
| R5 | C10 | C8 | coref-ident | NRE-II,(NRE-II) |
| R6 | C12 | C5 | coref-ident | the NRE,A novel T cell-specific negative regulatory element (NRE) |
| R7 | C13 | C11 | coref-ident | the PRE,a positive regulatory element |
| R8 | C14 | C12 | coref-ident | the NRE,the NRE |
| R9 | C15 | C14 | coref-ident | an NRE,the NRE |
| R10 | C16 | C13 | coref-ident | the enhancer positive regulatory element,the PRE |
| R11 | C17 | C4 | coref-ident | T cells,T cells |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-80 | Sentence | denotes | T cell-specific negative regulation of transcription of the human cytokine IL-4. |
| S2 | 81-242 | Sentence | denotes | IL-4 secreted by activated T cells is a pleiotropic cytokine affecting growth and differentiation of diverse cell types such as T cells, B cells, and mast cells. |
| S3 | 243-319 | Sentence | denotes | We investigated the upstream regulatory elements of the human IL-4 promoter. |
| S4 | 320-534 | Sentence | denotes | A novel T cell-specific negative regulatory element (NRE) composed of two protein-binding sites were mapped in the 5' flanking region of the IL-4 gene: -311CTCCCTTCT-303 (NRE-I) and -288CTTTTTGCTT-TGC-300 (NRE-II). |
| S5 | 535-657 | Sentence | denotes | A T cell-specific protein Neg-1 and a ubiquitous protein Neg-2 binding to NRE-I and NRE-II, respectively, were identified. |
| S6 | 658-739 | Sentence | denotes | Furthermore, a positive regulatory element was found 45 bp downstream of the NRE. |
| S7 | 740-824 | Sentence | denotes | The enhancer activity of the PRE was completely suppressed when the NRE was present. |
| S8 | 825-968 | Sentence | denotes | These data suggest that IL-4 promoter activity is normally down-regulated by an NRE via repression of the enhancer positive regulatory element. |
| S9 | 969-1058 | Sentence | denotes | These data may have implications for the stringent control of IL-4 expression in T cells. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-35 | other_name | denotes | T cell-specific negative regulation |
| T2 | 60-79 | protein_molecule | denotes | human cytokine IL-4 |
| T3 | 81-85 | protein_molecule | denotes | IL-4 |
| T4 | 98-115 | cell_type | denotes | activated T cells |
| T5 | 121-141 | protein_family_or_group | denotes | pleiotropic cytokine |
| T6 | 209-216 | cell_type | denotes | T cells |
| T7 | 218-225 | cell_type | denotes | B cells |
| T8 | 231-241 | cell_type | denotes | mast cells |
| T9 | 263-291 | DNA_domain_or_region | denotes | upstream regulatory elements |
| T10 | 299-318 | DNA_domain_or_region | denotes | human IL-4 promoter |
| T11 | 322-371 | DNA_domain_or_region | denotes | novel T cell-specific negative regulatory element |
| T12 | 373-376 | DNA_domain_or_region | denotes | NRE |
| T13 | 461-470 | DNA_domain_or_region | denotes | IL-4 gene |
| T14 | 472-489 | polynucleotide | denotes | -311CTCCCTTCT-303 |
| T15 | 491-496 | DNA_domain_or_region | denotes | NRE-I |
| T16 | 502-524 | polynucleotide | denotes | -288CTTTTTGCTT-TGC-300 |
| T17 | 526-532 | DNA_domain_or_region | denotes | NRE-II |
| T18 | 537-560 | protein_family_or_group | denotes | T cell-specific protein |
| T19 | 561-566 | protein_molecule | denotes | Neg-1 |
| T20 | 573-591 | protein_family_or_group | denotes | ubiquitous protein |
| T21 | 592-597 | protein_molecule | denotes | Neg-2 |
| T22 | 609-614 | DNA_domain_or_region | denotes | NRE-I |
| T23 | 619-625 | DNA_domain_or_region | denotes | NRE-II |
| T24 | 673-700 | DNA_domain_or_region | denotes | positive regulatory element |
| T25 | 711-727 | DNA_domain_or_region | denotes | 45 bp downstream |
| T26 | 735-738 | DNA_domain_or_region | denotes | NRE |
| T27 | 769-772 | DNA_domain_or_region | denotes | PRE |
| T28 | 808-811 | DNA_domain_or_region | denotes | NRE |
| T29 | 849-862 | DNA_domain_or_region | denotes | IL-4 promoter |
| T30 | 905-908 | DNA_domain_or_region | denotes | NRE |
| T31 | 931-967 | DNA_domain_or_region | denotes | enhancer positive regulatory element |
| T32 | 1031-1035 | protein_molecule | denotes | IL-4 |
| T33 | 1050-1057 | cell_type | denotes | T cells |