PubMed:1537389 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1537389","sourcedb":"PubMed","sourceid":"1537389","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1537389","text":"Interleukin 6-induced differentiation of a human B cell line into IgM-secreting plasma cells is mediated by c-fos.\nThe role of the protooncogene c-fos in interleukin (IL) 6-induced B cell differentiation was assessed. Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c-fos sense mRNA expression. The effect appeared within 30 min and returned to basal levels after 2 h. The addition of antisense oligonucleotides to c-fos significantly inhibited IL 6-induced IgM production by SKW 6.4 cells (p less than 0.001), whereas control oligonucleotides had no inhibitory effect. These results indicate that activation of c-fos is involved in IL 6-induced differentiation of SKW 6.4 cells into IgM-secreting 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