PubMed:1537389 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	43-60	cell_line	denotes	human B cell line
T2	66-92	cell_type	denotes	IgM-secreting plasma cells
T3	108-113	DNA	denotes	c-fos
T4	131-150	DNA	denotes	protooncogene c-fos
T5	154-172	protein	denotes	interleukin (IL) 6
T6	250-254	protein	denotes	IL 6
T7	300-316	RNA	denotes	c-fos sense mRNA
T8	449-454	DNA	denotes	c-fos
T9	479-483	protein	denotes	IL 6
T10	492-495	protein	denotes	IgM
T11	510-523	cell_line	denotes	SKW 6.4 cells
T12	646-651	DNA	denotes	c-fos
T13	667-671	protein	denotes	IL 6
T14	699-712	cell_line	denotes	SKW 6.4 cells
T15	718-737	cell_line	denotes	IgM-secreting cells

Id	Subject	Object	Predicate	Lexical cue
C3	0-13	NP	denotes	Interleukin 6
C2	0-37	NP	denotes	Interleukin 6-induced differentiation
C1	0-60	NP	denotes	Interleukin 6-induced differentiation of a human B cell line
C4	66-92	NP	denotes	IgM-secreting plasma cells
C5	108-113	NP	denotes	c-fos
C6	127-150	NP	denotes	the protooncogene c-fos
C8	154-172	NP	denotes	interleukin (IL) 6
C7	154-203	NP	denotes	interleukin (IL) 6-induced B cell differentiation
C9	231-244	NP	denotes	SKW 6.4 cells
C10	250-254	NP	denotes	IL 6
C11	449-454	NP	denotes	c-fos
C12	510-523	NP	denotes	SKW 6.4 cells
C13	646-651	NP	denotes	c-fos
C15	667-671	NP	denotes	IL 6
C14	667-695	NP	denotes	IL 6-induced differentiation
C16	699-712	NP	denotes	SKW 6.4 cells
C17	718-737	NP	denotes	IgM-secreting cells
R1	C6	C5	coref-ident	the protooncogene c-fos,c-fos
R2	C8	C3	coref-ident	interleukin (IL) 6,Interleukin 6
R3	C7	C1	coref-ident	interleukin (IL) 6-induced B cell differentiation,Interleukin 6-induced differentiation of a human B cell line
R4	C10	C8	coref-ident	IL 6,interleukin (IL) 6
R5	C11	C6	coref-ident	c-fos,the protooncogene c-fos
R6	C12	C9	coref-ident	SKW 6.4 cells,SKW 6.4 cells
R7	C13	C11	coref-ident	c-fos,c-fos
R8	C15	C10	coref-ident	IL 6,IL 6
R9	C14	C2	coref-ident	IL 6-induced differentiation,Interleukin 6-induced differentiation
R10	C16	C12	coref-ident	SKW 6.4 cells,SKW 6.4 cells
R11	C17	C4	coref-ident	IgM-secreting cells,IgM-secreting plasma cells

Id	Subject	Object	Predicate	Lexical cue
S1	0-114	Sentence	denotes	Interleukin 6-induced differentiation of a human B cell line into IgM-secreting plasma cells is mediated by c-fos.
S2	115-217	Sentence	denotes	The role of the protooncogene c-fos in interleukin (IL) 6-induced B cell differentiation was assessed.
S3	218-328	Sentence	denotes	Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c-fos sense mRNA expression.
S4	329-402	Sentence	denotes	The effect appeared within 30 min and returned to basal levels after 2 h.
S5	403-603	Sentence	denotes	The addition of antisense oligonucleotides to c-fos significantly inhibited IL 6-induced IgM production by SKW 6.4 cells (p less than 0.001), whereas control oligonucleotides had no inhibitory effect.
S6	604-738	Sentence	denotes	These results indicate that activation of c-fos is involved in IL 6-induced differentiation of SKW 6.4 cells into IgM-secreting cells.

Id	Subject	Object	Predicate	Lexical cue
T1	0-37	other_name	denotes	Interleukin 6-induced differentiation
T2	43-60	cell_line	denotes	human B cell line
T3	66-92	cell_type	denotes	IgM-secreting plasma cells
T4	108-113	DNA_domain_or_region	denotes	c-fos
T5	131-150	DNA_domain_or_region	denotes	protooncogene c-fos
T6	154-172	protein_molecule	denotes	interleukin (IL) 6
T7	250-254	protein_molecule	denotes	IL 6
T8	300-316	RNA_molecule	denotes	c-fos sense mRNA
T9	419-445	polynucleotide	denotes	antisense oligonucleotides
T10	449-454	DNA_domain_or_region	denotes	c-fos
T11	479-483	protein_molecule	denotes	IL 6
T12	492-495	protein_family_or_group	denotes	IgM
T13	510-523	cell_line	denotes	SKW 6.4 cells
T14	553-577	polynucleotide	denotes	control oligonucleotides
T15	646-651	DNA_domain_or_region	denotes	c-fos
T16	667-671	protein_molecule	denotes	IL 6
T17	699-712	cell_line	denotes	SKW 6.4 cells
T18	718-737	cell_line	denotes	IgM-secreting cells