PubMed:1533441
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-14 | protein | denotes | Nuclear factor |
| T2 | 18-35 | cell_type | denotes | activated T cells |
| T3 | 45-48 | protein | denotes | Fos |
| T4 | 53-56 | protein | denotes | Jun |
| T5 | 62-82 | protein | denotes | nuclear factor NF-AT |
| T6 | 106-113 | cell_type | denotes | T cells |
| T7 | 137-164 | protein | denotes | T-cell receptor/CD3 complex |
| T8 | 186-211 | DNA | denotes | interleukin-2 (IL-2) gene |
| T9 | 232-237 | protein | denotes | NF-AT |
| T10 | 382-387 | protein | denotes | NF-AT |
| T11 | 540-557 | protein | denotes | nuclear component |
| T12 | 601-618 | protein | denotes | nuclear component |
| T13 | 622-627 | protein | denotes | NF-AT |
| T14 | 635-655 | protein | denotes | transcription factor |
| T15 | 656-660 | protein | denotes | AP-1 |
| T16 | 705-710 | protein | denotes | NF-AT |
| T17 | 720-723 | protein | denotes | Fos |
| T18 | 728-731 | protein | denotes | Jun |
| T19 | 769-802 | protein | denotes | pre-existing NF-AT-binding factor |
| T20 | 844-864 | cell_type | denotes | unstimulated T cells |
| T21 | 968-973 | protein | denotes | NF-AT |
| T22 | 1091-1104 | protein | denotes | NF-AT complex |
| T23 | 1178-1181 | protein | denotes | Fos |
| T24 | 1185-1201 | protein | denotes | Fos/Jun proteins |
| T25 | 1209-1229 | protein | denotes | pre-existing complex |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C2 | 18-35 | NP | denotes | activated T cells |
| C1 | 0-35 | NP | denotes | Nuclear factor of activated T cells |
| C3 | 45-56 | NP | denotes | Fos and Jun |
| C4 | 58-82 | NP | denotes | The nuclear factor NF-AT |
| C5 | 106-164 | NP | denotes | T cells stimulated through the T-cell receptor/CD3 complex |
| C6 | 232-237 | NP | denotes | NF-AT |
| C7 | 294-296 | NP | denotes | it |
| C8 | 340-359 | NP | denotes | cyclosporin A (CsA) |
| C9 | 382-387 | NP | denotes | NF-AT |
| C10 | 447-450 | NP | denotes | CsA |
| C11 | 511-514 | NP | denotes | CsA |
| C12 | 538-557 | NP | denotes | a nuclear component |
| C14 | 622-627 | NP | denotes | NF-AT |
| C13 | 579-627 | NP | denotes | the newly synthesized nuclear component of NF-AT |
| C15 | 631-660 | NP | denotes | the transcription factor AP-1 |
| C16 | 705-710 | NP | denotes | NF-AT |
| C17 | 720-740 | NP | denotes | Fos and Jun proteins |
| C18 | 767-802 | NP | denotes | a pre-existing NF-AT-binding factor |
| C19 | 803-807 | NP | denotes | that |
| C20 | 968-973 | NP | denotes | NF-AT |
| C21 | 1007-1010 | NP | denotes | CsA |
| C22 | 1074-1104 | NP | denotes | the pre-existing NF-AT complex |
| C23 | 1112-1115 | NP | denotes | CsA |
| C24 | 1205-1229 | NP | denotes | the pre-existing complex |
| R1 | C4 | C1 | coref-other | The nuclear factor NF-AT,Nuclear factor of activated T cells |
| R2 | C5 | C2 | coref-other | T cells stimulated through the T-cell receptor/CD3 complex,activated T cells |
| R3 | C6 | C4 | coref-ident | NF-AT,The nuclear factor NF-AT |
| R4 | C7 | C6 | coref-pron | it,NF-AT |
| R5 | C9 | C6 | coref-ident | NF-AT,NF-AT |
| R6 | C10 | C8 | coref-ident | CsA,cyclosporin A (CsA) |
| R7 | C11 | C10 | coref-ident | CsA,CsA |
| R8 | C14 | C9 | coref-ident | NF-AT,NF-AT |
| R9 | C13 | C12 | coref-other | the newly synthesized nuclear component of NF-AT,a nuclear component |
| R10 | C15 | C13 | coref-ident | the transcription factor AP-1,the newly synthesized nuclear component of NF-AT |
| R11 | C16 | C14 | coref-ident | NF-AT,NF-AT |
| R12 | C17 | C3 | coref-ident | Fos and Jun proteins,Fos and Jun |
| R13 | C19 | C18 | coref-relat | that,a pre-existing NF-AT-binding factor |
| R14 | C20 | C16 | coref-ident | NF-AT,NF-AT |
| R15 | C21 | C11 | coref-ident | CsA,CsA |
| R16 | C23 | C21 | coref-ident | CsA,CsA |
| R17 | C24 | C22 | coref-ident | the pre-existing complex,the pre-existing NF-AT complex |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-57 | Sentence | denotes | Nuclear factor of activated T cells contains Fos and Jun. |
| S2 | 58-222 | Sentence | denotes | The nuclear factor NF-AT (ref. 1) is induced in T cells stimulated through the T-cell receptor/CD3 complex, and is required for interleukin-2 (IL-2) gene induction. |
| S3 | 223-381 | Sentence | denotes | Although NF-AT has not been cloned or purified, there is evidence that it is a major target for immunosuppression by cyclosporin A (CsA) and FK506 (refs 2-7). |
| S4 | 382-558 | Sentence | denotes | NF-AT induction may require two activation-dependent events: the CsA-sensitive translocation of a pre-existing component and the CsA-resistant synthesis of a nuclear component. |
| S5 | 559-661 | Sentence | denotes | Here we report that the newly synthesized nuclear component of NF-AT is the transcription factor AP-1. |
| S6 | 662-741 | Sentence | denotes | We show that the inducible nuclear form of NF-AT contains Fos and Jun proteins. |
| S7 | 742-865 | Sentence | denotes | Furthermore, we identify a pre-existing NF-AT-binding factor that is present in hypotonic extracts of unstimulated T cells. |
| S8 | 866-1230 | Sentence | denotes | On the basis of binding, reconstitution and cotransfection experiments, we propose that activation of NF-AT occurs in at least two stages: a CsA-sensitive stage involving modification and/or translocation of the pre-existing NF-AT complex, and a CsA-insensitive stage involving the addition of newly synthesized Fos or Fos/Jun proteins to the pre-existing complex. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-14 | protein_family_or_group | denotes | Nuclear factor |
| T2 | 18-35 | cell_type | denotes | activated T cells |
| T3 | 45-48 | protein_molecule | denotes | Fos |
| T4 | 53-56 | protein_family_or_group | denotes | Jun |
| T5 | 62-82 | protein_molecule | denotes | nuclear factor NF-AT |
| T6 | 106-113 | cell_type | denotes | T cells |
| T7 | 137-164 | protein_complex | denotes | T-cell receptor/CD3 complex |
| T8 | 186-199 | protein_molecule | denotes | interleukin-2 |
| T9 | 201-205 | protein_molecule | denotes | IL-2 |
| T10 | 232-237 | protein_molecule | denotes | NF-AT |
| T11 | 340-353 | other_organic_compound | denotes | cyclosporin A |
| T12 | 355-358 | other_organic_compound | denotes | CsA |
| T13 | 364-369 | other_organic_compound | denotes | FK506 |
| T14 | 382-387 | protein_molecule | denotes | NF-AT |
| T15 | 447-450 | other_organic_compound | denotes | CsA |
| T16 | 511-514 | other_organic_compound | denotes | CsA |
| T17 | 540-557 | protein_family_or_group | denotes | nuclear component |
| T18 | 601-618 | protein_molecule | denotes | nuclear component |
| T19 | 622-627 | protein_molecule | denotes | NF-AT |
| T20 | 635-655 | protein_family_or_group | denotes | transcription factor |
| T21 | 656-660 | protein_molecule | denotes | AP-1 |
| T22 | 705-710 | protein_molecule | denotes | NF-AT |
| T23 | 720-723 | protein_molecule | denotes | Fos |
| T24 | 728-731 | protein_family_or_group | denotes | Jun |
| T25 | 769-781 | protein_molecule | denotes | pre-existing |
| T26 | 782-787 | protein_molecule | denotes | NF-AT |
| T27 | 844-856 | cell_type | denotes | unstimulated |
| T28 | 857-864 | cell_type | denotes | T cells |
| T29 | 968-973 | protein_molecule | denotes | NF-AT |
| T30 | 1007-1010 | other_organic_compound | denotes | CsA |
| T31 | 1091-1096 | protein_molecule | denotes | NF-AT |
| T32 | 1112-1115 | other_organic_compound | denotes | CsA |
| T33 | 1178-1181 | protein_molecule | denotes | Fos |
| T34 | 1185-1201 | protein_molecule | denotes | Fos/Jun proteins |
| T35 | 1209-1229 | protein_complex | denotes | pre-existing complex |