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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 126-425 BACKGROUND denotes A novel pancreatic carcinoma cell line, FAMPAC, was identified from investigation of poorly differentiated pancreatic adenocarcinoma cells found in a patient with a familial predisposition to pancreatic carcinoma. A gene responsible for familial pancreatic carcinoma has not been identified to date.
T2 435-757 METHODS denotes The FAMPAC cell line was characterized by its morphology, growth rate, tumorigenicity, and chromosomal analysis. Three known tumor suppressor genes, p16/CDKN2, BRCA2, and p53, all of which are important in the development of pancreatic carcinoma and frequently are involved in a variety of cancer syndromes, were analyzed.
T3 767-1393 RESULTS denotes FAMPAC cells grew as an adhering monolayer in culture medium supplemented with 10% fetal bovine serum and formed tumors rapidly in nude mice. The doubling time ranged from 24 to 48 hours. Karyotype analysis demonstrated the complexity of chromosomal deletions and rearrangements. The cells were negative for ductal differentiation markers such as cytokeratin 7 and MUC1, indicating poor differentiation. Analysis of FAMPAC cells revealed overexpression of the mutated p53 gene (exon 5, codon 175: CGC --> CAC), the presence of a homozygous deletion in the p16 gene, and the presence of wild-type BRCA2 in the tested hot spots.
T4 1407-1772 CONCLUSIONS denotes To the authors' knowledge, FAMPAC is the first established human pancreatic carcinoma cell line associated with a familial background. FAMPAC is a tumorigenic cell line with a complex molecular pattern of mutations. These findings may be useful in understanding the mechanisms responsible for the development of sporadic or hereditary forms of pancreatic carcinoma.

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background.
TextSentencer_T2 114-125 Sentence denotes BACKGROUND:
TextSentencer_T3 126-339 Sentence denotes A novel pancreatic carcinoma cell line, FAMPAC, was identified from investigation of poorly differentiated pancreatic adenocarcinoma cells found in a patient with a familial predisposition to pancreatic carcinoma.
TextSentencer_T4 340-425 Sentence denotes A gene responsible for familial pancreatic carcinoma has not been identified to date.
TextSentencer_T5 426-434 Sentence denotes METHODS:
TextSentencer_T6 435-547 Sentence denotes The FAMPAC cell line was characterized by its morphology, growth rate, tumorigenicity, and chromosomal analysis.
TextSentencer_T7 548-757 Sentence denotes Three known tumor suppressor genes, p16/CDKN2, BRCA2, and p53, all of which are important in the development of pancreatic carcinoma and frequently are involved in a variety of cancer syndromes, were analyzed.
TextSentencer_T8 758-908 Sentence denotes RESULTS: FAMPAC cells grew as an adhering monolayer in culture medium supplemented with 10% fetal bovine serum and formed tumors rapidly in nude mice.
TextSentencer_T9 909-954 Sentence denotes The doubling time ranged from 24 to 48 hours.
TextSentencer_T10 955-1046 Sentence denotes Karyotype analysis demonstrated the complexity of chromosomal deletions and rearrangements.
TextSentencer_T11 1047-1170 Sentence denotes The cells were negative for ductal differentiation markers such as cytokeratin 7 and MUC1, indicating poor differentiation.
TextSentencer_T12 1171-1393 Sentence denotes Analysis of FAMPAC cells revealed overexpression of the mutated p53 gene (exon 5, codon 175: CGC --> CAC), the presence of a homozygous deletion in the p16 gene, and the presence of wild-type BRCA2 in the tested hot spots.
TextSentencer_T13 1394-1406 Sentence denotes CONCLUSIONS:
TextSentencer_T14 1407-1541 Sentence denotes To the authors' knowledge, FAMPAC is the first established human pancreatic carcinoma cell line associated with a familial background.
TextSentencer_T15 1542-1622 Sentence denotes FAMPAC is a tumorigenic cell line with a complex molecular pattern of mutations.
TextSentencer_T16 1623-1772 Sentence denotes These findings may be useful in understanding the mechanisms responsible for the development of sporadic or hereditary forms of pancreatic carcinoma.
T1 0-113 Sentence denotes Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background.
T2 114-125 Sentence denotes BACKGROUND:
T3 126-339 Sentence denotes A novel pancreatic carcinoma cell line, FAMPAC, was identified from investigation of poorly differentiated pancreatic adenocarcinoma cells found in a patient with a familial predisposition to pancreatic carcinoma.
T4 340-425 Sentence denotes A gene responsible for familial pancreatic carcinoma has not been identified to date.
T5 426-434 Sentence denotes METHODS:
T6 435-547 Sentence denotes The FAMPAC cell line was characterized by its morphology, growth rate, tumorigenicity, and chromosomal analysis.
T7 548-757 Sentence denotes Three known tumor suppressor genes, p16/CDKN2, BRCA2, and p53, all of which are important in the development of pancreatic carcinoma and frequently are involved in a variety of cancer syndromes, were analyzed.
T8 758-908 Sentence denotes RESULTS: FAMPAC cells grew as an adhering monolayer in culture medium supplemented with 10% fetal bovine serum and formed tumors rapidly in nude mice.
T9 909-954 Sentence denotes The doubling time ranged from 24 to 48 hours.
T10 955-1046 Sentence denotes Karyotype analysis demonstrated the complexity of chromosomal deletions and rearrangements.
T11 1047-1170 Sentence denotes The cells were negative for ductal differentiation markers such as cytokeratin 7 and MUC1, indicating poor differentiation.
T12 1171-1393 Sentence denotes Analysis of FAMPAC cells revealed overexpression of the mutated p53 gene (exon 5, codon 175: CGC --> CAC), the presence of a homozygous deletion in the p16 gene, and the presence of wild-type BRCA2 in the tested hot spots.
T13 1394-1406 Sentence denotes CONCLUSIONS:
T14 1407-1541 Sentence denotes To the authors' knowledge, FAMPAC is the first established human pancreatic carcinoma cell line associated with a familial background.
T15 1542-1622 Sentence denotes FAMPAC is a tumorigenic cell line with a complex molecular pattern of mutations.
T16 1623-1772 Sentence denotes These findings may be useful in understanding the mechanisms responsible for the development of sporadic or hereditary forms of pancreatic carcinoma.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15112280-4#40#45#gene1017 588-593 gene1017 denotes CDKN2
15112280-4#40#45#gene1029 588-593 gene1029 denotes CDKN2
15112280-4#47#52#gene675 595-600 gene675 denotes BRCA2
15112280-4#112#132#diseaseC0235974 660-680 diseaseC0235974 denotes pancreatic carcinoma
15112280-9#64#67#gene7157 1235-1238 gene7157 denotes p53
15112280-9#101#104#gene760 1272-1275 gene760 denotes CAC
15112280-9#101#104#gene788 1272-1275 gene788 denotes CAC
15112280-9#192#197#gene675 1363-1368 gene675 denotes BRCA2
15112280-9#216#221#diseaseC0015230 1387-1392 diseaseC0015230 denotes spots
15112280-9#216#221#diseaseC0848332 1387-1392 diseaseC0848332 denotes spots
15112280-9#216#221#diseaseC0015230 1387-1392 diseaseC0015230 denotes spots
15112280-9#216#221#diseaseC0848332 1387-1392 diseaseC0848332 denotes spots
15112280-9#216#221#diseaseC0015230 1387-1392 diseaseC0015230 denotes spots
15112280-9#216#221#diseaseC0848332 1387-1392 diseaseC0848332 denotes spots
15112280-9#216#221#diseaseC0015230 1387-1392 diseaseC0015230 denotes spots
15112280-9#216#221#diseaseC0848332 1387-1392 diseaseC0848332 denotes spots
40#45#gene1017112#132#diseaseC0235974 15112280-4#40#45#gene1017 15112280-4#112#132#diseaseC0235974 associated_with CDKN2,pancreatic carcinoma
40#45#gene1029112#132#diseaseC0235974 15112280-4#40#45#gene1029 15112280-4#112#132#diseaseC0235974 associated_with CDKN2,pancreatic carcinoma
47#52#gene675112#132#diseaseC0235974 15112280-4#47#52#gene675 15112280-4#112#132#diseaseC0235974 associated_with BRCA2,pancreatic carcinoma
64#67#gene7157216#221#diseaseC0015230 15112280-9#64#67#gene7157 15112280-9#216#221#diseaseC0015230 associated_with p53,spots
64#67#gene7157216#221#diseaseC0848332 15112280-9#64#67#gene7157 15112280-9#216#221#diseaseC0848332 associated_with p53,spots
64#67#gene7157216#221#diseaseC0015230 15112280-9#64#67#gene7157 15112280-9#216#221#diseaseC0015230 associated_with p53,spots
64#67#gene7157216#221#diseaseC0848332 15112280-9#64#67#gene7157 15112280-9#216#221#diseaseC0848332 associated_with p53,spots
64#67#gene7157216#221#diseaseC0015230 15112280-9#64#67#gene7157 15112280-9#216#221#diseaseC0015230 associated_with p53,spots
64#67#gene7157216#221#diseaseC0848332 15112280-9#64#67#gene7157 15112280-9#216#221#diseaseC0848332 associated_with p53,spots
64#67#gene7157216#221#diseaseC0015230 15112280-9#64#67#gene7157 15112280-9#216#221#diseaseC0015230 associated_with p53,spots
64#67#gene7157216#221#diseaseC0848332 15112280-9#64#67#gene7157 15112280-9#216#221#diseaseC0848332 associated_with p53,spots
101#104#gene760216#221#diseaseC0015230 15112280-9#101#104#gene760 15112280-9#216#221#diseaseC0015230 associated_with CAC,spots
101#104#gene760216#221#diseaseC0848332 15112280-9#101#104#gene760 15112280-9#216#221#diseaseC0848332 associated_with CAC,spots
101#104#gene760216#221#diseaseC0015230 15112280-9#101#104#gene760 15112280-9#216#221#diseaseC0015230 associated_with CAC,spots
101#104#gene760216#221#diseaseC0848332 15112280-9#101#104#gene760 15112280-9#216#221#diseaseC0848332 associated_with CAC,spots
101#104#gene760216#221#diseaseC0015230 15112280-9#101#104#gene760 15112280-9#216#221#diseaseC0015230 associated_with CAC,spots
101#104#gene760216#221#diseaseC0848332 15112280-9#101#104#gene760 15112280-9#216#221#diseaseC0848332 associated_with CAC,spots
101#104#gene760216#221#diseaseC0015230 15112280-9#101#104#gene760 15112280-9#216#221#diseaseC0015230 associated_with CAC,spots
101#104#gene760216#221#diseaseC0848332 15112280-9#101#104#gene760 15112280-9#216#221#diseaseC0848332 associated_with CAC,spots
101#104#gene788216#221#diseaseC0015230 15112280-9#101#104#gene788 15112280-9#216#221#diseaseC0015230 associated_with CAC,spots
101#104#gene788216#221#diseaseC0848332 15112280-9#101#104#gene788 15112280-9#216#221#diseaseC0848332 associated_with CAC,spots
101#104#gene788216#221#diseaseC0015230 15112280-9#101#104#gene788 15112280-9#216#221#diseaseC0015230 associated_with CAC,spots
101#104#gene788216#221#diseaseC0848332 15112280-9#101#104#gene788 15112280-9#216#221#diseaseC0848332 associated_with CAC,spots
101#104#gene788216#221#diseaseC0015230 15112280-9#101#104#gene788 15112280-9#216#221#diseaseC0015230 associated_with CAC,spots
101#104#gene788216#221#diseaseC0848332 15112280-9#101#104#gene788 15112280-9#216#221#diseaseC0848332 associated_with CAC,spots
101#104#gene788216#221#diseaseC0015230 15112280-9#101#104#gene788 15112280-9#216#221#diseaseC0015230 associated_with CAC,spots
101#104#gene788216#221#diseaseC0848332 15112280-9#101#104#gene788 15112280-9#216#221#diseaseC0848332 associated_with CAC,spots
192#197#gene675216#221#diseaseC0015230 15112280-9#192#197#gene675 15112280-9#216#221#diseaseC0015230 associated_with BRCA2,spots
192#197#gene675216#221#diseaseC0848332 15112280-9#192#197#gene675 15112280-9#216#221#diseaseC0848332 associated_with BRCA2,spots
192#197#gene675216#221#diseaseC0015230 15112280-9#192#197#gene675 15112280-9#216#221#diseaseC0015230 associated_with BRCA2,spots
192#197#gene675216#221#diseaseC0848332 15112280-9#192#197#gene675 15112280-9#216#221#diseaseC0848332 associated_with BRCA2,spots
192#197#gene675216#221#diseaseC0015230 15112280-9#192#197#gene675 15112280-9#216#221#diseaseC0015230 associated_with BRCA2,spots
192#197#gene675216#221#diseaseC0848332 15112280-9#192#197#gene675 15112280-9#216#221#diseaseC0848332 associated_with BRCA2,spots
192#197#gene675216#221#diseaseC0015230 15112280-9#192#197#gene675 15112280-9#216#221#diseaseC0015230 associated_with BRCA2,spots
192#197#gene675216#221#diseaseC0848332 15112280-9#192#197#gene675 15112280-9#216#221#diseaseC0848332 associated_with BRCA2,spots

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 863-868 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 145-154 HP:0030731 denotes carcinoma
TI1 64-73 HP:0030731 denotes carcinoma
AB2 233-258 HP:0006725 denotes pancreatic adenocarcinoma
AB3 329-338 HP:0030731 denotes carcinoma
AB4 383-392 HP:0030731 denotes carcinoma
AB5 671-680 HP:0030731 denotes carcinoma
AB6 1483-1492 HP:0030731 denotes carcinoma
AB7 1762-1771 HP:0030731 denotes carcinoma

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 363-392 ORDO:1333 denotes familial pancreatic carcinoma

DisGeNET

Id Subject Object Predicate Lexical cue
T0 595-600 gene:675 denotes BRCA2
T1 725-731 disease:C1306459 denotes cancer
T2 595-600 gene:675 denotes BRCA2
T3 725-731 disease:C0006826 denotes cancer
T4 595-600 gene:675 denotes BRCA2
T5 660-680 disease:C0235974 denotes pancreatic carcinoma
T6 588-593 gene:1029 denotes CDKN2
T7 725-731 disease:C1306459 denotes cancer
T8 588-593 gene:1017 denotes CDKN2
T9 660-680 disease:C0235974 denotes pancreatic carcinoma
T10 588-593 gene:1029 denotes CDKN2
T11 660-680 disease:C0235974 denotes pancreatic carcinoma
T12 588-593 gene:1029 denotes CDKN2
T13 725-731 disease:C0006826 denotes cancer
T14 588-593 gene:1017 denotes CDKN2
T15 725-731 disease:C1306459 denotes cancer
T16 588-593 gene:1017 denotes CDKN2
T17 725-731 disease:C0006826 denotes cancer
T18 1363-1368 gene:675 denotes BRCA2
T19 1383-1392 disease:C0263214 denotes hot spots
T20 1272-1275 gene:788 denotes CAC
T21 1383-1392 disease:C0263214 denotes hot spots
T22 1272-1275 gene:760 denotes CAC
T23 1383-1392 disease:C0263214 denotes hot spots
T24 1235-1238 gene:7157 denotes p53
T25 1383-1392 disease:C0263214 denotes hot spots
R1 T0 T1 associated_with BRCA2,cancer
R2 T2 T3 associated_with BRCA2,cancer
R3 T4 T5 associated_with BRCA2,pancreatic carcinoma
R4 T6 T7 associated_with CDKN2,cancer
R5 T8 T9 associated_with CDKN2,pancreatic carcinoma
R6 T10 T11 associated_with CDKN2,pancreatic carcinoma
R7 T12 T13 associated_with CDKN2,cancer
R8 T14 T15 associated_with CDKN2,cancer
R9 T16 T17 associated_with CDKN2,cancer
R10 T18 T19 associated_with BRCA2,hot spots
R11 T20 T21 associated_with CAC,hot spots
R12 T22 T23 associated_with CAC,hot spots
R13 T24 T25 associated_with p53,hot spots