PubMed:15061869
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/15061869","sourcedb":"PubMed","sourceid":"15061869","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/15061869","text":"A single-nucleotide polymorphism in the human p27kip1 gene (-838C\u003eA) affects basal promoter activity and the risk of myocardial infarction.\nBACKGROUND: Excessive proliferation of vascular smooth muscle cells and leukocytes within the artery wall is a major event in the development of atherosclerosis. The growth suppressor p27kip1 associates with several cyclin-dependent kinase/cyclin complexes, thereby abrogating their capacity to induce progression through the cell cycle. Recent studies have implicated p27kip1 in the control of neointimal hyperplasia. For instance, p27kip1 ablation in apolipoprotein-E-null mice enhanced arterial cell proliferation and accelerated atherogenesis induced by dietary cholesterol. Therefore, p27kip1 is a candidate gene to modify the risk of developing atherosclerosis and associated ischaemic events (i.e., myocardial infarction and stroke).\nRESULTS: In this study we found three common single-nucleotide polymorphisms in the human p27kip1 gene (+326T\u003eG [V109G], -79C\u003eT, and -838C\u003eA). The frequency of -838A carriers was significantly increased in myocardial infarction patients compared to healthy controls (odds ratio [OR] = 1.73, 95% confidence interval [95%CI] = 1.12-2.70). In addition, luciferase reporter constructs driven by the human p27kip1 gene promoter containing A at position -838 had decreased basal transcriptional activity when transiently transfected in Jurkat cells, compared with constructs bearing C in -838 (P = 0.04).\nCONCLUSIONS: These data suggest that -838A is associated with reduced p27kip1 promoter activity and increased risk of myocardial 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