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PubMed:15061869 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-139 Sentence denotes A single-nucleotide polymorphism in the human p27kip1 gene (-838C>A) affects basal promoter activity and the risk of myocardial infarction.
TextSentencer_T2 140-151 Sentence denotes BACKGROUND:
TextSentencer_T3 152-301 Sentence denotes Excessive proliferation of vascular smooth muscle cells and leukocytes within the artery wall is a major event in the development of atherosclerosis.
TextSentencer_T4 302-477 Sentence denotes The growth suppressor p27kip1 associates with several cyclin-dependent kinase/cyclin complexes, thereby abrogating their capacity to induce progression through the cell cycle.
TextSentencer_T5 478-558 Sentence denotes Recent studies have implicated p27kip1 in the control of neointimal hyperplasia.
TextSentencer_T6 559-718 Sentence denotes For instance, p27kip1 ablation in apolipoprotein-E-null mice enhanced arterial cell proliferation and accelerated atherogenesis induced by dietary cholesterol.
TextSentencer_T7 719-880 Sentence denotes Therefore, p27kip1 is a candidate gene to modify the risk of developing atherosclerosis and associated ischaemic events (i.e., myocardial infarction and stroke).
TextSentencer_T8 881-889 Sentence denotes RESULTS:
TextSentencer_T9 890-1023 Sentence denotes In this study we found three common single-nucleotide polymorphisms in the human p27kip1 gene (+326T>G [V109G], -79C>T, and -838C>A).
TextSentencer_T10 1024-1217 Sentence denotes The frequency of -838A carriers was significantly increased in myocardial infarction patients compared to healthy controls (odds ratio [OR] = 1.73, 95% confidence interval [95%CI] = 1.12-2.70).
TextSentencer_T11 1218-1479 Sentence denotes In addition, luciferase reporter constructs driven by the human p27kip1 gene promoter containing A at position -838 had decreased basal transcriptional activity when transiently transfected in Jurkat cells, compared with constructs bearing C in -838 (P = 0.04).
TextSentencer_T12 1480-1492 Sentence denotes CONCLUSIONS:
TextSentencer_T13 1493-1620 Sentence denotes These data suggest that -838A is associated with reduced p27kip1 promoter activity and increased risk of myocardial infarction.
T1 0-139 Sentence denotes A single-nucleotide polymorphism in the human p27kip1 gene (-838C>A) affects basal promoter activity and the risk of myocardial infarction.
T2 140-151 Sentence denotes BACKGROUND:
T3 152-301 Sentence denotes Excessive proliferation of vascular smooth muscle cells and leukocytes within the artery wall is a major event in the development of atherosclerosis.
T4 302-477 Sentence denotes The growth suppressor p27kip1 associates with several cyclin-dependent kinase/cyclin complexes, thereby abrogating their capacity to induce progression through the cell cycle.
T5 478-558 Sentence denotes Recent studies have implicated p27kip1 in the control of neointimal hyperplasia.
T6 559-718 Sentence denotes For instance, p27kip1 ablation in apolipoprotein-E-null mice enhanced arterial cell proliferation and accelerated atherogenesis induced by dietary cholesterol.
T7 719-880 Sentence denotes Therefore, p27kip1 is a candidate gene to modify the risk of developing atherosclerosis and associated ischaemic events (i.e., myocardial infarction and stroke).
T8 881-889 Sentence denotes RESULTS:
T9 890-1023 Sentence denotes In this study we found three common single-nucleotide polymorphisms in the human p27kip1 gene (+326T>G [V109G], -79C>T, and -838C>A).
T10 1024-1217 Sentence denotes The frequency of -838A carriers was significantly increased in myocardial infarction patients compared to healthy controls (odds ratio [OR] = 1.73, 95% confidence interval [95%CI] = 1.12-2.70).
T11 1218-1479 Sentence denotes In addition, luciferase reporter constructs driven by the human p27kip1 gene promoter containing A at position -838 had decreased basal transcriptional activity when transiently transfected in Jurkat cells, compared with constructs bearing C in -838 (P = 0.04).
T12 1480-1492 Sentence denotes CONCLUSIONS:
T13 1493-1620 Sentence denotes These data suggest that -838A is associated with reduced p27kip1 promoter activity and increased risk of myocardial infarction.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
15061869-0#46#53#gene1027 46-53 gene1027 denotes p27kip1
15061869-0#117#138#diseaseC0027051 117-138 diseaseC0027051 denotes myocardial infarction
15061869-5#11#18#gene1027 730-737 gene1027 denotes p27kip1
15061869-5#11#18#gene1027 730-737 gene1027 denotes p27kip1
15061869-5#72#87#diseaseC0003850 791-806 diseaseC0003850 denotes atherosclerosis
15061869-5#72#87#diseaseC0004153 791-806 diseaseC0004153 denotes atherosclerosis
15061869-5#153#159#diseaseC0038454 872-878 diseaseC0038454 denotes stroke
46#53#gene1027117#138#diseaseC0027051 15061869-0#46#53#gene1027 15061869-0#117#138#diseaseC0027051 associated_with p27kip1,myocardial infarction
11#18#gene102772#87#diseaseC0003850 15061869-5#11#18#gene1027 15061869-5#72#87#diseaseC0003850 associated_with p27kip1,atherosclerosis
11#18#gene102772#87#diseaseC0004153 15061869-5#11#18#gene1027 15061869-5#72#87#diseaseC0004153 associated_with p27kip1,atherosclerosis
11#18#gene1027153#159#diseaseC0038454 15061869-5#11#18#gene1027 15061869-5#153#159#diseaseC0038454 associated_with p27kip1,stroke
11#18#gene102772#87#diseaseC0003850 15061869-5#11#18#gene1027 15061869-5#72#87#diseaseC0003850 associated_with p27kip1,atherosclerosis
11#18#gene102772#87#diseaseC0004153 15061869-5#11#18#gene1027 15061869-5#72#87#diseaseC0004153 associated_with p27kip1,atherosclerosis
11#18#gene1027153#159#diseaseC0038454 15061869-5#11#18#gene1027 15061869-5#153#159#diseaseC0038454 associated_with p27kip1,stroke

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1386 730-737 gene:1027 denotes p27kip1
T1387 791-806 disease:C0003850 denotes atherosclerosis
R1 T1386 T1387 associated_with p27kip1,atherosclerosis
R2 T1386 T1387 associated_with p27kip1,atherosclerosis

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 234-240 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T2 629-637 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
PD-UBERON-AE-B_T3 234-245 http://purl.obolibrary.org/obo/UBERON_0000415 denotes artery wall

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 234-240 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T2 629-637 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
PD-UBERON-AE-B_T3 234-245 http://purl.obolibrary.org/obo/UBERON_0000415 denotes artery wall

DisGeNET

Id Subject Object Predicate Lexical cue
T0 46-53 gene:1027 denotes p27kip1
T1 117-138 disease:C0027051 denotes myocardial infarction
T2 730-737 gene:1027 denotes p27kip1
T3 791-806 disease:C0004153 denotes atherosclerosis
T4 730-737 gene:1027 denotes p27kip1
T5 791-806 disease:C0003850 denotes atherosclerosis
T6 730-737 gene:1027 denotes p27kip1
T7 872-878 disease:C0038454 denotes stroke
R1 T0 T1 associated_with p27kip1,myocardial infarction
R2 T2 T3 associated_with p27kip1,atherosclerosis
R3 T4 T5 associated_with p27kip1,atherosclerosis
R4 T6 T7 associated_with p27kip1,stroke