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sentences

Id Subject Object Predicate Lexical cue
T1 0-75 Sentence denotes Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.
T2 76-167 Sentence denotes The transcription factor NF-kappaB plays important roles in inflammation and cell survival.
T3 168-342 Sentence denotes NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB family members, including p65 (RelA), c-Rel (Rel), RelB, NF-kappaB1/p50, and NF-kappaB2/p52.
T4 343-464 Sentence denotes Here we report the identification and characterization of a novel ZU5 and death domain-containing protein designated ZUD.
T5 465-658 Sentence denotes In reporter gene assays, overexpression of ZUD inhibited NF-kappaB-dependent transcription induced by both tumor necrosis factor (TNF) and interleukin-1 and their downstream signaling proteins.
T6 659-771 Sentence denotes Gel shift assays indicated that the overexpression of ZUD inhibited binding of NF-kappaB to its target sequence.
T7 772-920 Sentence denotes ZUD is a cytoplasmic protein, and coimmunoprecipitation assays indicated that ZUD interacted with the NF-kappaB subunit p105 and transactivator p65.
T8 921-1101 Sentence denotes Consistent with its role in inhibition of NF-kappaB-dependent transcription, ZUD sensitized cells to apoptosis induced by TNF and the TNF-related apoptosis-inducing ligand (TRAIL).
T9 1102-1279 Sentence denotes Our findings suggest that ZUD is an inhibitor of NF-kappaB activation and that this protein may provide an alternative regulatory mechanism for NF-kappaB-mediated transcription.

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-75 Sentence denotes Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.
T2 76-167 Sentence denotes The transcription factor NF-kappaB plays important roles in inflammation and cell survival.
T3 168-342 Sentence denotes NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB family members, including p65 (RelA), c-Rel (Rel), RelB, NF-kappaB1/p50, and NF-kappaB2/p52.
T4 343-464 Sentence denotes Here we report the identification and characterization of a novel ZU5 and death domain-containing protein designated ZUD.
T5 465-658 Sentence denotes In reporter gene assays, overexpression of ZUD inhibited NF-kappaB-dependent transcription induced by both tumor necrosis factor (TNF) and interleukin-1 and their downstream signaling proteins.
T6 659-771 Sentence denotes Gel shift assays indicated that the overexpression of ZUD inhibited binding of NF-kappaB to its target sequence.
T7 772-920 Sentence denotes ZUD is a cytoplasmic protein, and coimmunoprecipitation assays indicated that ZUD interacted with the NF-kappaB subunit p105 and transactivator p65.
T8 921-1101 Sentence denotes Consistent with its role in inhibition of NF-kappaB-dependent transcription, ZUD sensitized cells to apoptosis induced by TNF and the TNF-related apoptosis-inducing ligand (TRAIL).
T9 1102-1279 Sentence denotes Our findings suggest that ZUD is an inhibitor of NF-kappaB activation and that this protein may provide an alternative regulatory mechanism for NF-kappaB-mediated transcription.
T1 0-75 Sentence denotes Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.
T2 76-167 Sentence denotes The transcription factor NF-kappaB plays important roles in inflammation and cell survival.
T3 168-342 Sentence denotes NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB family members, including p65 (RelA), c-Rel (Rel), RelB, NF-kappaB1/p50, and NF-kappaB2/p52.
T4 343-464 Sentence denotes Here we report the identification and characterization of a novel ZU5 and death domain-containing protein designated ZUD.
T5 465-658 Sentence denotes In reporter gene assays, overexpression of ZUD inhibited NF-kappaB-dependent transcription induced by both tumor necrosis factor (TNF) and interleukin-1 and their downstream signaling proteins.
T6 659-771 Sentence denotes Gel shift assays indicated that the overexpression of ZUD inhibited binding of NF-kappaB to its target sequence.
T7 772-920 Sentence denotes ZUD is a cytoplasmic protein, and coimmunoprecipitation assays indicated that ZUD interacted with the NF-kappaB subunit p105 and transactivator p65.
T8 921-1101 Sentence denotes Consistent with its role in inhibition of NF-kappaB-dependent transcription, ZUD sensitized cells to apoptosis induced by TNF and the TNF-related apoptosis-inducing ligand (TRAIL).
T9 1102-1279 Sentence denotes Our findings suggest that ZUD is an inhibitor of NF-kappaB activation and that this protein may provide an alternative regulatory mechanism for NF-kappaB-mediated transcription.

relna

Id Subject Object Predicate Lexical cue
T1 236-239 DNA denotes Rel
T2 276-279 DNA denotes p65
T3 281-285 DNA denotes RelA
T4 288-293 DNA denotes c-Rel
T5 295-298 DNA denotes Rel
T6 301-305 DNA denotes RelB
T7 318-321 DNA denotes p50
T8 338-341 DNA denotes p52
T9 460-463 Protein denotes ZUD
T10 508-511 Protein denotes ZUD
T11 713-716 Protein denotes ZUD
T12 772-775 Protein denotes ZUD
T13 850-853 Protein denotes ZUD
T14 892-896 DNA denotes p105
T15 916-919 DNA denotes p65
T16 998-1001 Protein denotes ZUD
T17 1128-1131 Protein denotes ZUD
R0 T13 T14 linked ZUD,p105
R1 T13 T15 linked ZUD,p65

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 572-577 HP_0002664 denotes tumor

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 136-148 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 572-577 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 781-792 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 572-577 Phenotype denotes tumor HP:0002664