PubMed:14711836 JSONTXT

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":129,"end":146},"obj":"Cell"},{"id":"T2","span":{"begin":321,"end":335},"obj":"Cell"},{"id":"T4","span":{"begin":634,"end":650},"obj":"Cell"},{"id":"T5","span":{"begin":982,"end":1000},"obj":"Cell"},{"id":"T6","span":{"begin":1014,"end":1046},"obj":"Cell"},{"id":"T7","span":{"begin":1014,"end":1022},"obj":"Cell"},{"id":"T9","span":{"begin":1048,"end":1051},"obj":"Cell"},{"id":"T10","span":{"begin":1113,"end":1130},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000115"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000451"},{"id":"A3","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0001056"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000115"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000988"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0011031"},{"id":"A7","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A8","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A9","pred":"cl_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL:0000451"},{"id":"A10","pred":"cl_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL:0000115"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T1","span":{"begin":1210,"end":1217},"obj":"Glycan_Motif"},{"id":"T2","span":{"begin":1231,"end":1237},"obj":"Glycan_Motif"},{"id":"T3","span":{"begin":1278,"end":1287},"obj":"Glycan_Motif"}],"attributes":[{"id":"A1","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ"},{"id":"A2","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO"},{"id":"A3","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT"},{"id":"A4","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":171},"obj":"Sentence"},{"id":"T2","span":{"begin":172,"end":450},"obj":"Sentence"},{"id":"T3","span":{"begin":451,"end":553},"obj":"Sentence"},{"id":"T4","span":{"begin":554,"end":860},"obj":"Sentence"},{"id":"T5","span":{"begin":861,"end":1053},"obj":"Sentence"},{"id":"T6","span":{"begin":1054,"end":1192},"obj":"Sentence"},{"id":"T7","span":{"begin":1193,"end":1288},"obj":"Sentence"},{"id":"T8","span":{"begin":1289,"end":1452},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":1210,"end":1217},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T2","span":{"begin":1231,"end":1237},"obj":"https://glytoucan.org/Structures/Glycans/G82576YO"},{"id":"T3","span":{"begin":1278,"end":1287},"obj":"https://glytoucan.org/Structures/Glycans/G65889KE"},{"id":"T4","span":{"begin":1278,"end":1287},"obj":"https://glytoucan.org/Structures/Glycans/G68158BT"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":150,"end":155},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"T2","span":{"begin":160,"end":170},"obj":"http://purl.obolibrary.org/obo/MAT_0000197"},{"id":"T3","span":{"begin":160,"end":170},"obj":"http://purl.obolibrary.org/obo/MAT_0000442"},{"id":"T4","span":{"begin":160,"end":165},"obj":"http://purl.obolibrary.org/obo/MAT_0000055"},{"id":"T5","span":{"begin":602,"end":607},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"T6","span":{"begin":612,"end":622},"obj":"http://purl.obolibrary.org/obo/MAT_0000197"},{"id":"T7","span":{"begin":612,"end":622},"obj":"http://purl.obolibrary.org/obo/MAT_0000442"},{"id":"T8","span":{"begin":612,"end":617},"obj":"http://purl.obolibrary.org/obo/MAT_0000055"},{"id":"T9","span":{"begin":896,"end":901},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"T10","span":{"begin":906,"end":916},"obj":"http://purl.obolibrary.org/obo/MAT_0000197"},{"id":"T11","span":{"begin":906,"end":916},"obj":"http://purl.obolibrary.org/obo/MAT_0000442"},{"id":"T12","span":{"begin":906,"end":911},"obj":"http://purl.obolibrary.org/obo/MAT_0000055"},{"id":"T13","span":{"begin":1140,"end":1145},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"T14","span":{"begin":1150,"end":1160},"obj":"http://purl.obolibrary.org/obo/MAT_0000197"},{"id":"T15","span":{"begin":1150,"end":1160},"obj":"http://purl.obolibrary.org/obo/MAT_0000442"},{"id":"T16","span":{"begin":1150,"end":1155},"obj":"http://purl.obolibrary.org/obo/MAT_0000055"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"NGLY1-deficiency","denotations":[{"id":"PD-NGLY1-deficiency-B_T1","span":{"begin":1219,"end":1225},"obj":"chem:24139"}],"namespaces":[{"prefix":"hgnc","uri":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:"},{"prefix":"omim","uri":"https://www.omim.org/entry/"},{"prefix":"chem","uri":"https://pubchem.ncbi.nlm.nih.gov/compound/"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"Lectin-Jamboree-small","denotations":[{"id":"T1","span":{"begin":401,"end":408},"obj":"Lectin"},{"id":"T2","span":{"begin":415,"end":422},"obj":"Lectin"},{"id":"T3","span":{"begin":842,"end":849},"obj":"Lectin"},{"id":"T4","span":{"begin":1382,"end":1389},"obj":"Lectin"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"GL_001382"},{"id":"A2","pred":"glycosmos_id","subj":"T2","obj":"GL_001382"},{"id":"A3","pred":"glycosmos_id","subj":"T3","obj":"GL_001382"},{"id":"A4","pred":"glycosmos_id","subj":"T4","obj":"GL_001382"}],"namespaces":[{"prefix":"_base","uri":"https://glycosmos.org/lectins/"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"Lectin-Jamboree-Sentence","blocks":[{"id":"T1","span":{"begin":0,"end":171},"obj":"Sentence"},{"id":"T2","span":{"begin":172,"end":450},"obj":"Sentence"},{"id":"T3","span":{"begin":451,"end":553},"obj":"Sentence"},{"id":"T4","span":{"begin":554,"end":860},"obj":"Sentence"},{"id":"T5","span":{"begin":861,"end":1053},"obj":"Sentence"},{"id":"T6","span":{"begin":1054,"end":1192},"obj":"Sentence"},{"id":"T7","span":{"begin":1193,"end":1288},"obj":"Sentence"},{"id":"T8","span":{"begin":1289,"end":1452},"obj":"Sentence"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"Lectin_function","denotations":[{"id":"T1","span":{"begin":28,"end":41},"obj":"GL_000114"},{"id":"T2","span":{"begin":28,"end":41},"obj":"GL_000115"},{"id":"T3","span":{"begin":35,"end":41},"obj":"GX_000027"},{"id":"T4","span":{"begin":35,"end":41},"obj":"GX_000045"},{"id":"T5","span":{"begin":178,"end":191},"obj":"GL_000114"},{"id":"T6","span":{"begin":178,"end":191},"obj":"GL_000115"},{"id":"T7","span":{"begin":185,"end":191},"obj":"GX_000027"},{"id":"T8","span":{"begin":185,"end":191},"obj":"GX_000045"},{"id":"T9","span":{"begin":294,"end":307},"obj":"GL_000114"},{"id":"T10","span":{"begin":294,"end":307},"obj":"GL_000115"},{"id":"T11","span":{"begin":301,"end":307},"obj":"GX_000027"},{"id":"T12","span":{"begin":301,"end":307},"obj":"GX_000045"},{"id":"T13","span":{"begin":401,"end":408},"obj":"GX_000001"},{"id":"T14","span":{"begin":401,"end":408},"obj":"GX_000012"},{"id":"T15","span":{"begin":401,"end":408},"obj":"GX_000016"},{"id":"T16","span":{"begin":401,"end":408},"obj":"GL_001382"},{"id":"T17","span":{"begin":415,"end":422},"obj":"GX_000001"},{"id":"T18","span":{"begin":415,"end":422},"obj":"GX_000012"},{"id":"T19","span":{"begin":415,"end":422},"obj":"GX_000016"},{"id":"T20","span":{"begin":415,"end":422},"obj":"GL_001382"},{"id":"T21","span":{"begin":562,"end":575},"obj":"GL_000114"},{"id":"T22","span":{"begin":562,"end":575},"obj":"GL_000115"},{"id":"T23","span":{"begin":569,"end":575},"obj":"GX_000027"},{"id":"T24","span":{"begin":569,"end":575},"obj":"GX_000045"},{"id":"T25","span":{"begin":651,"end":664},"obj":"GL_000114"},{"id":"T26","span":{"begin":651,"end":664},"obj":"GL_000115"},{"id":"T27","span":{"begin":658,"end":664},"obj":"GX_000027"},{"id":"T28","span":{"begin":658,"end":664},"obj":"GX_000045"},{"id":"T29","span":{"begin":761,"end":774},"obj":"GL_000114"},{"id":"T30","span":{"begin":761,"end":774},"obj":"GL_000115"},{"id":"T31","span":{"begin":768,"end":774},"obj":"GX_000027"},{"id":"T32","span":{"begin":768,"end":774},"obj":"GX_000045"},{"id":"T33","span":{"begin":842,"end":849},"obj":"GX_000001"},{"id":"T34","span":{"begin":842,"end":849},"obj":"GX_000012"},{"id":"T35","span":{"begin":842,"end":849},"obj":"GX_000016"},{"id":"T36","span":{"begin":842,"end":849},"obj":"GL_001382"},{"id":"T37","span":{"begin":1382,"end":1389},"obj":"GX_000001"},{"id":"T38","span":{"begin":1382,"end":1389},"obj":"GX_000012"},{"id":"T39","span":{"begin":1382,"end":1389},"obj":"GX_000016"},{"id":"T40","span":{"begin":1382,"end":1389},"obj":"GL_001382"},{"id":"T41","span":{"begin":1436,"end":1442},"obj":"GX_000027"},{"id":"T42","span":{"begin":1436,"end":1442},"obj":"GX_000045"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":926,"end":931},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":1134,"end":1139},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"9606"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":129,"end":146},"obj":"Body_part"},{"id":"T2","span":{"begin":150,"end":155},"obj":"Body_part"},{"id":"T3","span":{"begin":160,"end":170},"obj":"Body_part"},{"id":"T4","span":{"begin":238,"end":248},"obj":"Body_part"},{"id":"T5","span":{"begin":321,"end":335},"obj":"Body_part"},{"id":"T6","span":{"begin":602,"end":607},"obj":"Body_part"},{"id":"T7","span":{"begin":612,"end":622},"obj":"Body_part"},{"id":"T8","span":{"begin":634,"end":650},"obj":"Body_part"},{"id":"T9","span":{"begin":698,"end":706},"obj":"Body_part"},{"id":"T12","span":{"begin":896,"end":901},"obj":"Body_part"},{"id":"T13","span":{"begin":906,"end":916},"obj":"Body_part"},{"id":"T14","span":{"begin":982,"end":1000},"obj":"Body_part"},{"id":"T15","span":{"begin":1014,"end":1022},"obj":"Body_part"},{"id":"T17","span":{"begin":1031,"end":1046},"obj":"Body_part"},{"id":"T18","span":{"begin":1048,"end":1051},"obj":"Body_part"},{"id":"T19","span":{"begin":1113,"end":1130},"obj":"Body_part"},{"id":"T20","span":{"begin":1140,"end":1145},"obj":"Body_part"},{"id":"T21","span":{"begin":1150,"end":1160},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/GO_0005694"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/GO_0016020"},{"id":"A10","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0000094"},{"id":"A11","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CL_0000988"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A16","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}

{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":150,"end":155},"obj":"Body_part"},{"id":"T2","span":{"begin":160,"end":170},"obj":"Body_part"},{"id":"T4","span":{"begin":602,"end":607},"obj":"Body_part"},{"id":"T5","span":{"begin":612,"end":622},"obj":"Body_part"},{"id":"T7","span":{"begin":896,"end":901},"obj":"Body_part"},{"id":"T8","span":{"begin":906,"end":916},"obj":"Body_part"},{"id":"T10","span":{"begin":1140,"end":1145},"obj":"Body_part"},{"id":"T11","span":{"begin":1150,"end":1160},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000197"},{"id":"A3","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000442"},{"id":"A4","pred":"mat_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"A5","pred":"mat_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MAT_0000197"},{"id":"A6","pred":"mat_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MAT_0000442"},{"id":"A7","pred":"mat_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"A8","pred":"mat_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MAT_0000197"},{"id":"A9","pred":"mat_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MAT_0000442"},{"id":"A10","pred":"mat_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"A11","pred":"mat_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MAT_0000197"},{"id":"A12","pred":"mat_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MAT_0000442"}],"text":"Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.\nA new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor."}