PubMed:14693746 JSONTXT

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Statistically significant differences in overexpression of STK15 was found between invasive cancer and either nonmalignant mammary ducts (P \u003c 0.0001) or DCIS lesions (P \u003c 0.0005). Abnormalities in centrosome size and number was detected in the samples analyzed and 56% (14 of 25) of the cases also showed aneuploidy reflected in \u003e2 signals of chromosome 3 and 17. Our data demonstrate that STK15 overexpression correlates with centrosome anomaly and aneuploidy in DCIS, and loss of STK15 overexpression is associated with progression of in situ to ductal invasive breast 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