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c_corpus

Id Subject Object Predicate Lexical cue
T2 8-14 PR:Q54WX4 denotes aurora
T1 8-14 CHEBI:3416 denotes aurora
T7 17-22 PR:P59241 denotes STK15
T8 17-22 PR:000004515 denotes STK15
T10 17-22 PR:P97477 denotes STK15
T11 17-22 PR:O14965 denotes STK15
T9 17-22 GO:0047696 denotes STK15
T12 23-27 PR:P59241 denotes BTAK
T13 23-27 PR:000004515 denotes BTAK
T14 23-27 PR:P97477 denotes BTAK
T15 23-27 PR:O14965 denotes BTAK
T16 59-69 SO:1000009 denotes transition
T17 93-109 D044584 denotes ductal carcinoma
T18 93-109 D044584 denotes ductal carcinoma
T21 117-123 UBERON:0000310 denotes breast
T24 182-206 D002285 denotes ductal carcinoma in situ
T25 182-206 D002285 denotes ductal carcinoma in situ
T31 208-212 CVCL_5552 denotes DCIS
T30 208-212 D002285 denotes DCIS
T32 208-212 D002285 denotes DCIS
T33 226-232 UBERON:0000310 denotes breast
T34 226-239 D001943 denotes breast cancer
T35 226-239 D001943 denotes breast cancer
T37 318-324 PR:Q54WX4 denotes Aurora
T36 318-324 CHEBI:3416 denotes Aurora
T42 327-332 PR:P59241 denotes STK15
T43 327-332 PR:000004515 denotes STK15
T45 327-332 PR:P97477 denotes STK15
T46 327-332 PR:O14965 denotes STK15
T44 327-332 GO:0047696 denotes STK15
T47 333-337 PR:P59241 denotes BTAK
T48 333-337 PR:000004515 denotes BTAK
T49 333-337 PR:P97477 denotes BTAK
T50 333-337 PR:O14965 denotes BTAK
T51 350-360 GO:0005813 denotes centrosome
T53 410-420 SO:0000340 denotes chromosome
T52 410-420 GO:0005694 denotes chromosome
T54 410-432 GO:0007059 denotes chromosome segregation
T55 450-455 D006801 denotes human
T56 456-462 UBERON:0000310 denotes breast
T57 456-469 D001943 denotes breast cancer
T58 456-469 D001943 denotes breast cancer
T59 498-504 UBERON:0000310 denotes breast
T60 505-511 UBERON:0000479 denotes tissue
T62 550-554 CVCL_5552 denotes DCIS
T61 550-554 D002285 denotes DCIS
T63 550-554 D002285 denotes DCIS
T64 586-595 D002277 denotes carcinoma
T65 586-595 D002277 denotes carcinoma
T66 637-642 UBERON:0000058 denotes ducts
T71 697-702 PR:P59241 denotes STK15
T72 697-702 PR:000004515 denotes STK15
T74 697-702 PR:P97477 denotes STK15
T75 697-702 PR:O14965 denotes STK15
T73 697-702 GO:0047696 denotes STK15
T80 763-768 PR:P59241 denotes STK15
T81 763-768 PR:000004515 denotes STK15
T83 763-768 PR:P97477 denotes STK15
T84 763-768 PR:O14965 denotes STK15
T82 763-768 GO:0047696 denotes STK15
T85 835-840 UBERON:0000058 denotes ducts
T87 857-861 CVCL_5552 denotes DCIS
T86 857-861 D002285 denotes DCIS
T88 857-861 D002285 denotes DCIS
T89 901-911 GO:0005813 denotes centrosome
T90 1009-1019 D000782 denotes aneuploidy
T91 1009-1019 D000782 denotes aneuploidy
T93 1047-1057 SO:0000340 denotes chromosome
T92 1047-1057 GO:0005694 denotes chromosome
T98 1094-1099 PR:P59241 denotes STK15
T99 1094-1099 PR:000004515 denotes STK15
T101 1094-1099 PR:P97477 denotes STK15
T102 1094-1099 PR:O14965 denotes STK15
T100 1094-1099 GO:0047696 denotes STK15
T103 1131-1141 GO:0005813 denotes centrosome
T104 1154-1164 D000782 denotes aneuploidy
T105 1154-1164 D000782 denotes aneuploidy
T107 1168-1172 CVCL_5552 denotes DCIS
T106 1168-1172 D002285 denotes DCIS
T108 1168-1172 D002285 denotes DCIS
T113 1186-1191 PR:P59241 denotes STK15
T114 1186-1191 PR:000004515 denotes STK15
T116 1186-1191 PR:P97477 denotes STK15
T117 1186-1191 PR:O14965 denotes STK15
T115 1186-1191 GO:0047696 denotes STK15
T118 1268-1274 UBERON:0000310 denotes breast
T119 1268-1284 D001943 denotes breast carcinoma
T120 1268-1284 D001943 denotes breast carcinoma

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 226-239 HP_0003002 denotes breast cancer
T2 226-239 HP_0100013 denotes breast cancer
T3 233-239 HP_0002664 denotes cancer
T4 456-469 HP_0003002 denotes breast cancer
T5 456-469 HP_0100013 denotes breast cancer
T6 463-469 HP_0002664 denotes cancer
T7 796-802 HP_0002664 denotes cancer
T8 1268-1284 HP_0003002 denotes breast carcinoma

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-124 DRI_Background denotes Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast.
T2 125-265 DRI_Background denotes The biological mechanisms involved in the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are not fully understood.
T3 266-470 DRI_Outcome denotes We previously have shown that the putative oncogene Aurora-A/STK15/BTAK, encoding a centrosome-associated kinase that regulates centrosomes and chromosome segregation, is amplified in human breast cancer.
T4 471-703 DRI_Background denotes In this study, 37 archival breast tissue specimens of histologically confirmed DCIS lesions with adjacent invasive carcinoma and morphologically nonmalignant mammary ducts were analyzed immunohistochemically for expression of STK15.
T5 704-883 DRI_Background denotes Statistically significant differences in overexpression of STK15 was found between invasive cancer and either nonmalignant mammary ducts (P < 0.0001) or DCIS lesions (P < 0.0005).
T6 884-1067 DRI_Outcome denotes Abnormalities in centrosome size and number was detected in the samples analyzed and 56% (14 of 25) of the cases also showed aneuploidy reflected in >2 signals of chromosome 3 and 17.
T7 1068-1285 DRI_Outcome denotes Our data demonstrate that STK15 overexpression correlates with centrosome anomaly and aneuploidy in DCIS, and loss of STK15 overexpression is associated with progression of in situ to ductal invasive breast carcinoma.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 125-265 DRI_Background denotes The biological mechanisms involved in the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are not fully understood.
T2 266-470 DRI_Outcome denotes We previously have shown that the putative oncogene Aurora-A/STK15/BTAK, encoding a centrosome-associated kinase that regulates centrosomes and chromosome segregation, is amplified in human breast cancer.
T3 471-703 DRI_Background denotes In this study, 37 archival breast tissue specimens of histologically confirmed DCIS lesions with adjacent invasive carcinoma and morphologically nonmalignant mammary ducts were analyzed immunohistochemically for expression of STK15.
T4 704-883 DRI_Background denotes Statistically significant differences in overexpression of STK15 was found between invasive cancer and either nonmalignant mammary ducts (P < 0.0001) or DCIS lesions (P < 0.0005).
T5 884-1067 DRI_Outcome denotes Abnormalities in centrosome size and number was detected in the samples analyzed and 56% (14 of 25) of the cases also showed aneuploidy reflected in >2 signals of chromosome 3 and 17.
T6 1068-1285 DRI_Outcome denotes Our data demonstrate that STK15 overexpression correlates with centrosome anomaly and aneuploidy in DCIS, and loss of STK15 overexpression is associated with progression of in situ to ductal invasive breast carcinoma.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
14693746-0#17#22#gene6790 17-22 gene6790 denotes STK15
14693746-0#23#27#gene6790 23-27 gene6790 denotes BTAK
14693746-0#84#123#diseaseC1134719 84-123 diseaseC1134719 denotes invasive ductal carcinoma of the breast
14693746-2#67#71#gene6790 333-337 gene6790 denotes BTAK
14693746-2#190#203#diseaseC0006142 456-469 diseaseC0006142 denotes breast cancer
14693746-2#190#203#diseaseC0678222 456-469 diseaseC0678222 denotes breast cancer
14693746-3#226#231#gene6790 697-702 gene6790 denotes STK15
14693746-3#106#124#diseaseC1334274 577-595 diseaseC1334274 denotes invasive carcinoma
14693746-4#59#64#gene6790 763-768 gene6790 denotes STK15
14693746-4#83#98#diseaseC0677898 787-802 diseaseC0677898 denotes invasive cancer
14693746-6#26#31#gene6790 1094-1099 gene6790 denotes STK15
14693746-6#118#123#gene6790 1186-1191 gene6790 denotes STK15
14693746-6#100#104#diseaseC0007124 1168-1172 diseaseC0007124 denotes DCIS
17#22#gene679084#123#diseaseC1134719 14693746-0#17#22#gene6790 14693746-0#84#123#diseaseC1134719 associated_with STK15,invasive ductal carcinoma of the breast
23#27#gene679084#123#diseaseC1134719 14693746-0#23#27#gene6790 14693746-0#84#123#diseaseC1134719 associated_with BTAK,invasive ductal carcinoma of the breast
67#71#gene6790190#203#diseaseC0006142 14693746-2#67#71#gene6790 14693746-2#190#203#diseaseC0006142 associated_with BTAK,breast cancer
67#71#gene6790190#203#diseaseC0678222 14693746-2#67#71#gene6790 14693746-2#190#203#diseaseC0678222 associated_with BTAK,breast cancer
226#231#gene6790106#124#diseaseC1334274 14693746-3#226#231#gene6790 14693746-3#106#124#diseaseC1334274 associated_with STK15,invasive carcinoma
59#64#gene679083#98#diseaseC0677898 14693746-4#59#64#gene6790 14693746-4#83#98#diseaseC0677898 associated_with STK15,invasive cancer
26#31#gene6790100#104#diseaseC0007124 14693746-6#26#31#gene6790 14693746-6#100#104#diseaseC0007124 associated_with STK15,DCIS
118#123#gene6790100#104#diseaseC0007124 14693746-6#118#123#gene6790 14693746-6#100#104#diseaseC0007124 associated_with STK15,DCIS

DisGeNET

Id Subject Object Predicate Lexical cue
T0 17-22 gene:6790 denotes STK15
T1 84-123 disease:C1134719 denotes invasive ductal carcinoma of the breast
T2 23-27 gene:6790 denotes BTAK
T3 84-123 disease:C1134719 denotes invasive ductal carcinoma of the breast
T4 333-337 gene:6790 denotes BTAK
T5 456-469 disease:C0678222 denotes breast cancer
T6 333-337 gene:6790 denotes BTAK
T7 456-469 disease:C0006142 denotes breast cancer
T8 697-702 gene:6790 denotes STK15
T9 550-554 disease:C0007124 denotes DCIS
T10 697-702 gene:6790 denotes STK15
T11 577-595 disease:C1334274 denotes invasive carcinoma
T12 763-768 gene:6790 denotes STK15
T13 857-861 disease:C0007124 denotes DCIS
T14 763-768 gene:6790 denotes STK15
T15 787-802 disease:C0677898 denotes invasive cancer
T16 1094-1099 gene:6790 denotes STK15
T17 1168-1172 disease:C0007124 denotes DCIS
T18 1094-1099 gene:6790 denotes STK15
T19 1252-1284 disease:C1134719 denotes ductal invasive breast carcinoma
T20 1186-1191 gene:6790 denotes STK15
T21 1168-1172 disease:C0007124 denotes DCIS
T22 1186-1191 gene:6790 denotes STK15
T23 1252-1284 disease:C1134719 denotes ductal invasive breast carcinoma
R1 T0 T1 associated_with STK15,invasive ductal carcinoma of the breast
R2 T2 T3 associated_with BTAK,invasive ductal carcinoma of the breast
R3 T4 T5 associated_with BTAK,breast cancer
R4 T6 T7 associated_with BTAK,breast cancer
R5 T8 T9 associated_with STK15,DCIS
R6 T10 T11 associated_with STK15,invasive carcinoma
R7 T12 T13 associated_with STK15,DCIS
R8 T14 T15 associated_with STK15,invasive cancer
R9 T16 T17 associated_with STK15,DCIS
R10 T18 T19 associated_with STK15,ductal invasive breast carcinoma
R11 T20 T21 associated_with STK15,DCIS
R12 T22 T23 associated_with STK15,ductal invasive breast carcinoma