PubMed:14514715 JSON TXT

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Glycan-Motif

{"project":"Glycan-Motif","denotations":[{"id":"T1","span":{"begin":156,"end":162},"obj":"https://glytoucan.org/Structures/Glycans/G82576YO"},{"id":"T2","span":{"begin":180,"end":199},"obj":"https://glytoucan.org/Structures/Glycans/G64581RP"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

GGDB-2020

{"project":"GGDB-2020","denotations":[{"id":"T1","span":{"begin":124,"end":128},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"T2","span":{"begin":421,"end":425},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"T3","span":{"begin":581,"end":585},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"T4","span":{"begin":878,"end":882},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"T5","span":{"begin":1136,"end":1140},"obj":"https://acgg.asia/db/ggdb/info/gg009"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

ggdb-test

{"project":"ggdb-test","denotations":[{"id":"T1","span":{"begin":124,"end":128},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"T2","span":{"begin":421,"end":425},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"T3","span":{"begin":581,"end":585},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"T4","span":{"begin":878,"end":882},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"T5","span":{"begin":1136,"end":1140},"obj":"https://acgg.asia/db/ggdb/info/gg009"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

GlyCosmos6-Glycan-Motif-Image

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T1","span":{"begin":156,"end":162},"obj":"Glycan_Motif"},{"id":"T2","span":{"begin":180,"end":199},"obj":"Glycan_Motif"}],"attributes":[{"id":"A1","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO"},{"id":"A2","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

GlyCosmos6-Glycan-Motif-Structure

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":156,"end":162},"obj":"https://glytoucan.org/Structures/Glycans/G82576YO"},{"id":"T2","span":{"begin":180,"end":199},"obj":"https://glytoucan.org/Structures/Glycans/G64581RP"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

Glycosmos6-MAT

{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":324,"end":330},"obj":"http://purl.obolibrary.org/obo/MAT_0000226"},{"id":"T2","span":{"begin":373,"end":378},"obj":"http://purl.obolibrary.org/obo/MAT_0000399"},{"id":"T3","span":{"begin":399,"end":405},"obj":"http://purl.obolibrary.org/obo/MAT_0000226"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

GlycoBiology-FMA

uniprot-human

{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":124,"end":128},"obj":"http://www.uniprot.org/uniprot/Q9BYC5"},{"id":"T2","span":{"begin":421,"end":425},"obj":"http://www.uniprot.org/uniprot/Q9BYC5"},{"id":"T3","span":{"begin":581,"end":585},"obj":"http://www.uniprot.org/uniprot/Q9BYC5"},{"id":"T4","span":{"begin":878,"end":882},"obj":"http://www.uniprot.org/uniprot/Q9BYC5"},{"id":"T5","span":{"begin":1136,"end":1140},"obj":"http://www.uniprot.org/uniprot/Q9BYC5"},{"id":"T6","span":{"begin":525,"end":527},"obj":"http://www.uniprot.org/uniprot/Q9NUQ9"},{"id":"T7","span":{"begin":532,"end":534},"obj":"http://www.uniprot.org/uniprot/Q401N2"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

uniprot-mouse

{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":525,"end":527},"obj":"http://www.uniprot.org/uniprot/P11369"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

GlycoBiology-NCBITAXON

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/190658"},{"id":"T2","span":{"begin":0,"end":8},"obj":"http://purl.bioontology.org/ontology/STY/T052"},{"id":"T3","span":{"begin":13,"end":19},"obj":"http://purl.bioontology.org/ontology/STY/T024"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

sentences

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":105,"end":236},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":237,"end":331},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":332,"end":389},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":390,"end":438},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":439,"end":614},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":615,"end":698},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":699,"end":795},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":796,"end":843},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":844,"end":966},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":967,"end":1024},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1025,"end":1349},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"T2","span":{"begin":105,"end":236},"obj":"Sentence"},{"id":"T3","span":{"begin":237,"end":331},"obj":"Sentence"},{"id":"T4","span":{"begin":332,"end":389},"obj":"Sentence"},{"id":"T5","span":{"begin":390,"end":438},"obj":"Sentence"},{"id":"T6","span":{"begin":439,"end":614},"obj":"Sentence"},{"id":"T7","span":{"begin":615,"end":1024},"obj":"Sentence"},{"id":"T8","span":{"begin":1025,"end":1349},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"T2","span":{"begin":105,"end":236},"obj":"Sentence"},{"id":"T3","span":{"begin":237,"end":331},"obj":"Sentence"},{"id":"T4","span":{"begin":332,"end":389},"obj":"Sentence"},{"id":"T5","span":{"begin":390,"end":438},"obj":"Sentence"},{"id":"T6","span":{"begin":439,"end":614},"obj":"Sentence"},{"id":"T7","span":{"begin":615,"end":698},"obj":"Sentence"},{"id":"T8","span":{"begin":699,"end":795},"obj":"Sentence"},{"id":"T9","span":{"begin":796,"end":843},"obj":"Sentence"},{"id":"T10","span":{"begin":844,"end":966},"obj":"Sentence"},{"id":"T11","span":{"begin":967,"end":1024},"obj":"Sentence"},{"id":"T12","span":{"begin":1025,"end":1349},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

GO-BP

{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":36,"end":42},"obj":"http://purl.obolibrary.org/obo/GO_0045292"},{"id":"T2","span":{"begin":90,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0009790"},{"id":"T3","span":{"begin":90,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0009792"},{"id":"T4","span":{"begin":90,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0009793"},{"id":"T5","span":{"begin":276,"end":287},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T6","span":{"begin":406,"end":417},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T7","span":{"begin":734,"end":745},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T8","span":{"begin":814,"end":825},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T9","span":{"begin":1075,"end":1086},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T10","span":{"begin":1141,"end":1152},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T11","span":{"begin":615,"end":626},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T12","span":{"begin":932,"end":945},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T13","span":{"begin":883,"end":892},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T14","span":{"begin":1171,"end":1198},"obj":"http://purl.obolibrary.org/obo/GO_0008417"},{"id":"T15","span":{"begin":1212,"end":1229},"obj":"http://purl.obolibrary.org/obo/GO_0004066"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

GO-CC

{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":218,"end":222},"obj":"http://purl.obolibrary.org/obo/GO_0019013"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

UBERON-AE

{"project":"UBERON-AE","denotations":[{"id":"T1","span":{"begin":13,"end":19},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"T2","span":{"begin":324,"end":330},"obj":"http://purl.obolibrary.org/obo/UBERON_0000922"},{"id":"T3","span":{"begin":399,"end":405},"obj":"http://purl.obolibrary.org/obo/UBERON_0000922"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

EDAM-topics

EDAM-DFO

{"project":"EDAM-DFO","denotations":[{"id":"T1","span":{"begin":237,"end":250},"obj":"http://edamontology.org/data_2866"},{"id":"T2","span":{"begin":251,"end":259},"obj":"http://edamontology.org/operation_2945"},{"id":"T3","span":{"begin":604,"end":626},"obj":"http://edamontology.org/operation_0372"},{"id":"T4","span":{"begin":848,"end":852},"obj":"http://edamontology.org/data_0006"},{"id":"T5","span":{"begin":932,"end":948},"obj":"http://edamontology.org/data_2769"},{"id":"T6","span":{"begin":1060,"end":1070},"obj":"http://edamontology.org/operation_3429"},{"id":"T7","span":{"begin":1141,"end":1156},"obj":"http://edamontology.org/data_2769"},{"id":"T8","span":{"begin":1272,"end":1282},"obj":"http://edamontology.org/data_2527"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

glycogenes

{"project":"glycogenes","denotations":[{"id":"PD-GlycoGenes20190927-B_T1","span":{"begin":124,"end":128},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"PD-GlycoGenes20190927-B_T2","span":{"begin":421,"end":425},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"PD-GlycoGenes20190927-B_T3","span":{"begin":581,"end":585},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"PD-GlycoGenes20190927-B_T4","span":{"begin":878,"end":882},"obj":"https://acgg.asia/db/ggdb/info/gg009"},{"id":"PD-GlycoGenes20190927-B_T5","span":{"begin":1136,"end":1140},"obj":"https://acgg.asia/db/ggdb/info/gg009"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

GlycoBiology-MAT

{"project":"GlycoBiology-MAT","denotations":[{"id":"T1","span":{"begin":324,"end":330},"obj":"http://purl.obolibrary.org/obo/MAT_0000226"},{"id":"T2","span":{"begin":373,"end":378},"obj":"http://purl.obolibrary.org/obo/MAT_0000399"},{"id":"T3","span":{"begin":399,"end":405},"obj":"http://purl.obolibrary.org/obo/MAT_0000226"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

GlycoBiology-Motifs

{"project":"GlycoBiology-Motifs","denotations":[{"id":"T1","span":{"begin":226,"end":235},"obj":"http://rdf.glycoinfo.org/glycan/G00027MO"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

GlycoBiology-Epitope

{"project":"GlycoBiology-Epitope","denotations":[{"id":"PD-GlycoEpitope-B_T1","span":{"begin":310,"end":313},"obj":"http://www.glycoepitope.jp/epitopes/AN0415"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

performance-test

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":561,"end":573},"obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":13,"end":19},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":324,"end":330},"obj":"http://purl.obolibrary.org/obo/UBERON_0000922"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":399,"end":405},"obj":"http://purl.obolibrary.org/obo/UBERON_0000922"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

Anatomy-MAT

{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":324,"end":330},"obj":"Body_part"},{"id":"T2","span":{"begin":373,"end":378},"obj":"Body_part"},{"id":"T3","span":{"begin":399,"end":405},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000226"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000399"},{"id":"A3","pred":"mat_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MAT_0000226"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

NCBITAXON

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":84,"end":89},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}

Anatomy-UBERON

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":13,"end":19},"obj":"Body_part"},{"id":"T2","span":{"begin":324,"end":330},"obj":"Body_part"},{"id":"T3","span":{"begin":373,"end":378},"obj":"Body_part"},{"id":"T4","span":{"begin":399,"end":405},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0000922"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000323"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000922"}],"text":"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.\nThe product of the FUT8 gene transfers an alpha1-6 fucose on the innermost N-acetylglucosamine of the chitobiose core of N-glycans. Northern blot analysis shows four main transcripts of 3.0, 3.3, 3.9, and 4.2 kb in the embryo. The larger forms around 4-kb decrease in fetus and adult. Fourteen embryo transcripts of FUT8 were cloned. Twelve exons comprising two new 5'untranslated-exons (A and B) and two new 3'UT-ends (L1 and L2) and the complete genomic organization of the FUT8 gene (330 kb) are described. Transcripts starting with the 5'UT-exon A are always associated with exons C and D. Exon B initiates another series of transcripts associated to exon C and D or directly to exon D. A third series of transcripts starts at exon C. The data suggest an expression of FUT8 regulated by three different promoters, starting transcription in exons A, B, or C. The A or C series are better expressed than the B series. After transfection with these cDNA constructs the transcripts with 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity, whereas the activity of the B series is about two-thirds lower for both parameters, suggesting that exon B reduces the expression of the transcripts."}