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PubMed:1447188 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 48-59 Glycan_Motif denotes leukosialin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G78436BB|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T3 84-89 Glycan_Motif denotes Le(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC
T4 120-139 Glycan_Motif denotes N-acetyllactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T5 365-376 Glycan_Motif denotes leukosialin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G78436BB|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T7 378-389 Glycan_Motif denotes Leukosialin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G78436BB|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T9 940-951 Glycan_Motif denotes Leukosialin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G78436BB|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T11 1113-1118 Glycan_Motif denotes Le(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC
T12 1218-1223 Glycan_Motif denotes Le(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC
T13 1237-1248 Glycan_Motif denotes leukosialin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G78436BB|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T15 1315-1326 Glycan_Motif denotes Leukosialin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G78436BB|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T17 1457-1476 Glycan_Motif denotes N-acetyllactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T18 1510-1516 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T19 1892-1897 Glycan_Motif denotes Le(x) https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC
T20 1941-1947 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes Poly-N-acetyllactosaminyl O-glycans attached to leukosialin.
T2 61-114 Sentence denotes The presence of sialyl Le(x) structures in O-glycans.
T3 115-226 Sentence denotes Poly-N-acetyllactosamine extension has been found in O-glycans in addition to N-glycans and glycosphingolipids.
T4 227-377 Sentence denotes Attempts were made in HL-60 and K562 cells to determine the amount of poly-N-acetyllactosaminyl O-glycans in the major sialoglycoprotein, leukosialin.
T5 378-463 Sentence denotes Leukosialin was immunoprecipitated from [3H]glucosamine-labeled HL-60 and K562 cells.
T6 464-615 Sentence denotes Glycopeptides were prepared by Pronase digestion, and O-glycan-containing glycopeptides were isolated by affinity chromatography using Jacalin-agarose.
T7 616-788 Sentence denotes The glycopeptides bound to Jacalin-agarose and those unbound were treated with alkaline borohydride, and the released O-glycans were fractionated by Bio-Gel P-4 filtration.
T8 789-936 Sentence denotes Sequential glycosidase digestion of the O-glycans, with or without pretreatment by fucosidase or neuraminidase, revealed the following conclusions.
T9 937-1039 Sentence denotes 1) Leukosialin from HL-60 cells contains about 1-2 poly-N-acetyllactosaminyl O-glycan chains/molecule.
T10 1040-1196 Sentence denotes 2) About 50% of these poly-N-acetyllactosaminyl O-glycans contain sialyl Le(x) termini, NeuNAc alpha 2-->3Gal beta 1-->4 (Fuc alpha 1-->3)GlcNAc beta 1-->R.
T11 1197-1311 Sentence denotes The amount of sialyl Le(x) structure in leukosialin is roughly equivalent to that on cell surfaces of HL-60 cells.
T12 1312-1432 Sentence denotes 3) Leukosialin from K562 cells, on the other hand, contains no detectable amount of poly-N-acetyllactosaminyl O-glycans.
T13 1433-1559 Sentence denotes 4) The presence of poly-N-acetyllactosamine in O-glycans is dependent on the core 2 beta 1,6-N-acetylglucosaminyl transferase.
T14 1560-1808 Sentence denotes 5) Jacalin-agarose binds to sialylated small oligosaccharides such as NeuNAc alpha 2-->3Gal beta 1-->3(NeuNAc alpha 2-->6) GalNAc but not the hexasaccharide NeuNAc alpha 2-->3Gal beta 1-->3(NeuNAc alpha 2-->3Gal beta 1-->4GlcNAc beta 1-->6) GalNAc.
T15 1809-1958 Sentence denotes These results indicate that the formation of polylactosaminyl O-glycans and sialyl Le(x) structure in O-glycans is dependent on the core 2 formation.
T1 0-60 Sentence denotes Poly-N-acetyllactosaminyl O-glycans attached to leukosialin.
T2 61-114 Sentence denotes The presence of sialyl Le(x) structures in O-glycans.
T3 115-226 Sentence denotes Poly-N-acetyllactosamine extension has been found in O-glycans in addition to N-glycans and glycosphingolipids.
T4 227-377 Sentence denotes Attempts were made in HL-60 and K562 cells to determine the amount of poly-N-acetyllactosaminyl O-glycans in the major sialoglycoprotein, leukosialin.
T5 378-463 Sentence denotes Leukosialin was immunoprecipitated from [3H]glucosamine-labeled HL-60 and K562 cells.
T6 464-615 Sentence denotes Glycopeptides were prepared by Pronase digestion, and O-glycan-containing glycopeptides were isolated by affinity chromatography using Jacalin-agarose.
T7 616-788 Sentence denotes The glycopeptides bound to Jacalin-agarose and those unbound were treated with alkaline borohydride, and the released O-glycans were fractionated by Bio-Gel P-4 filtration.
T8 789-936 Sentence denotes Sequential glycosidase digestion of the O-glycans, with or without pretreatment by fucosidase or neuraminidase, revealed the following conclusions.
T9 937-1039 Sentence denotes 1) Leukosialin from HL-60 cells contains about 1-2 poly-N-acetyllactosaminyl O-glycan chains/molecule.
T10 1040-1196 Sentence denotes 2) About 50% of these poly-N-acetyllactosaminyl O-glycans contain sialyl Le(x) termini, NeuNAc alpha 2-->3Gal beta 1-->4 (Fuc alpha 1-->3)GlcNAc beta 1-->R.
T11 1197-1311 Sentence denotes The amount of sialyl Le(x) structure in leukosialin is roughly equivalent to that on cell surfaces of HL-60 cells.
T12 1312-1432 Sentence denotes 3) Leukosialin from K562 cells, on the other hand, contains no detectable amount of poly-N-acetyllactosaminyl O-glycans.
T13 1433-1559 Sentence denotes 4) The presence of poly-N-acetyllactosamine in O-glycans is dependent on the core 2 beta 1,6-N-acetylglucosaminyl transferase.
T14 1560-1808 Sentence denotes 5) Jacalin-agarose binds to sialylated small oligosaccharides such as NeuNAc alpha 2-->3Gal beta 1-->3(NeuNAc alpha 2-->6) GalNAc but not the hexasaccharide NeuNAc alpha 2-->3Gal beta 1-->3(NeuNAc alpha 2-->3Gal beta 1-->4GlcNAc beta 1-->6) GalNAc.
T15 1809-1958 Sentence denotes These results indicate that the formation of polylactosaminyl O-glycans and sialyl Le(x) structure in O-glycans is dependent on the core 2 formation.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 48-59 https://glytoucan.org/Structures/Glycans/G50850NI denotes leukosialin
T2 48-59 https://glytoucan.org/Structures/Glycans/G78436BB denotes leukosialin
T3 84-89 https://glytoucan.org/Structures/Glycans/G01187XC denotes Le(x)
T4 120-139 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine
T5 365-376 https://glytoucan.org/Structures/Glycans/G50850NI denotes leukosialin
T6 365-376 https://glytoucan.org/Structures/Glycans/G78436BB denotes leukosialin
T7 378-389 https://glytoucan.org/Structures/Glycans/G50850NI denotes Leukosialin
T8 378-389 https://glytoucan.org/Structures/Glycans/G78436BB denotes Leukosialin
T9 940-951 https://glytoucan.org/Structures/Glycans/G50850NI denotes Leukosialin
T10 940-951 https://glytoucan.org/Structures/Glycans/G78436BB denotes Leukosialin
T11 1113-1118 https://glytoucan.org/Structures/Glycans/G01187XC denotes Le(x)
T12 1218-1223 https://glytoucan.org/Structures/Glycans/G01187XC denotes Le(x)
T13 1237-1248 https://glytoucan.org/Structures/Glycans/G50850NI denotes leukosialin
T14 1237-1248 https://glytoucan.org/Structures/Glycans/G78436BB denotes leukosialin
T15 1315-1326 https://glytoucan.org/Structures/Glycans/G50850NI denotes Leukosialin
T16 1315-1326 https://glytoucan.org/Structures/Glycans/G78436BB denotes Leukosialin
T17 1457-1476 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine
T18 1892-1897 https://glytoucan.org/Structures/Glycans/G01187XC denotes Le(x)

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1357-1361 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 1178-1184 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 1526-1546 chem:24139 denotes N-acetylglucosaminyl

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1357-1361 Body_part denotes hand http://purl.obolibrary.org/obo/MAT_0000091

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1128-1134 Glycan denotes NeuNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 1510-1516 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T3 1630-1636 Glycan denotes NeuNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 1663-1669 Glycan denotes NeuNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T5 1683-1689 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T6 1717-1723 Glycan denotes NeuNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T7 1750-1756 Glycan denotes NeuNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T8 1801-1807 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T9 1941-1947 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 0-4 Cell denotes Poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T3 115-119 Cell denotes Poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T5 297-301 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T7 988-992 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T9 1062-1066 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T11 1396-1400 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T13 1452-1456 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 140-149 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T2 1357-1361 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1357-1361 Body_part denotes hand http://purl.obolibrary.org/obo/MAT_0000091

sentences

Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes Poly-N-acetyllactosaminyl O-glycans attached to leukosialin.
T2 61-114 Sentence denotes The presence of sialyl Le(x) structures in O-glycans.
T3 115-226 Sentence denotes Poly-N-acetyllactosamine extension has been found in O-glycans in addition to N-glycans and glycosphingolipids.
T4 227-377 Sentence denotes Attempts were made in HL-60 and K562 cells to determine the amount of poly-N-acetyllactosaminyl O-glycans in the major sialoglycoprotein, leukosialin.
T5 378-463 Sentence denotes Leukosialin was immunoprecipitated from [3H]glucosamine-labeled HL-60 and K562 cells.
T6 464-615 Sentence denotes Glycopeptides were prepared by Pronase digestion, and O-glycan-containing glycopeptides were isolated by affinity chromatography using Jacalin-agarose.
T7 616-788 Sentence denotes The glycopeptides bound to Jacalin-agarose and those unbound were treated with alkaline borohydride, and the released O-glycans were fractionated by Bio-Gel P-4 filtration.
T8 789-936 Sentence denotes Sequential glycosidase digestion of the O-glycans, with or without pretreatment by fucosidase or neuraminidase, revealed the following conclusions.
T9 937-1039 Sentence denotes 1) Leukosialin from HL-60 cells contains about 1-2 poly-N-acetyllactosaminyl O-glycan chains/molecule.
T10 1040-1196 Sentence denotes 2) About 50% of these poly-N-acetyllactosaminyl O-glycans contain sialyl Le(x) termini, NeuNAc alpha 2-->3Gal beta 1-->4 (Fuc alpha 1-->3)GlcNAc beta 1-->R.
T11 1197-1311 Sentence denotes The amount of sialyl Le(x) structure in leukosialin is roughly equivalent to that on cell surfaces of HL-60 cells.
T12 1312-1432 Sentence denotes 3) Leukosialin from K562 cells, on the other hand, contains no detectable amount of poly-N-acetyllactosaminyl O-glycans.
T13 1433-1559 Sentence denotes 4) The presence of poly-N-acetyllactosamine in O-glycans is dependent on the core 2 beta 1,6-N-acetylglucosaminyl transferase.
T14 1560-1808 Sentence denotes 5) Jacalin-agarose binds to sialylated small oligosaccharides such as NeuNAc alpha 2-->3Gal beta 1-->3(NeuNAc alpha 2-->6) GalNAc but not the hexasaccharide NeuNAc alpha 2-->3Gal beta 1-->3(NeuNAc alpha 2-->3Gal beta 1-->4GlcNAc beta 1-->6) GalNAc.
T15 1809-1958 Sentence denotes These results indicate that the formation of polylactosaminyl O-glycans and sialyl Le(x) structure in O-glycans is dependent on the core 2 formation.
T1 0-60 Sentence denotes Poly-N-acetyllactosaminyl O-glycans attached to leukosialin.
T2 61-114 Sentence denotes The presence of sialyl Le(x) structures in O-glycans.
T3 115-226 Sentence denotes Poly-N-acetyllactosamine extension has been found in O-glycans in addition to N-glycans and glycosphingolipids.
T4 227-377 Sentence denotes Attempts were made in HL-60 and K562 cells to determine the amount of poly-N-acetyllactosaminyl O-glycans in the major sialoglycoprotein, leukosialin.
T5 378-463 Sentence denotes Leukosialin was immunoprecipitated from [3H]glucosamine-labeled HL-60 and K562 cells.
T6 464-615 Sentence denotes Glycopeptides were prepared by Pronase digestion, and O-glycan-containing glycopeptides were isolated by affinity chromatography using Jacalin-agarose.
T7 616-788 Sentence denotes The glycopeptides bound to Jacalin-agarose and those unbound were treated with alkaline borohydride, and the released O-glycans were fractionated by Bio-Gel P-4 filtration.
T8 789-936 Sentence denotes Sequential glycosidase digestion of the O-glycans, with or without pretreatment by fucosidase or neuraminidase, revealed the following conclusions.
T9 937-1039 Sentence denotes 1) Leukosialin from HL-60 cells contains about 1-2 poly-N-acetyllactosaminyl O-glycan chains/molecule.
T10 1040-1196 Sentence denotes 2) About 50% of these poly-N-acetyllactosaminyl O-glycans contain sialyl Le(x) termini, NeuNAc alpha 2-->3Gal beta 1-->4 (Fuc alpha 1-->3)GlcNAc beta 1-->R.
T11 1197-1311 Sentence denotes The amount of sialyl Le(x) structure in leukosialin is roughly equivalent to that on cell surfaces of HL-60 cells.
T12 1312-1432 Sentence denotes 3) Leukosialin from K562 cells, on the other hand, contains no detectable amount of poly-N-acetyllactosaminyl O-glycans.
T13 1433-1559 Sentence denotes 4) The presence of poly-N-acetyllactosamine in O-glycans is dependent on the core 2 beta 1,6-N-acetylglucosaminyl transferase.
T14 1560-1808 Sentence denotes 5) Jacalin-agarose binds to sialylated small oligosaccharides such as NeuNAc alpha 2-->3Gal beta 1-->3(NeuNAc alpha 2-->6) GalNAc but not the hexasaccharide NeuNAc alpha 2-->3Gal beta 1-->3(NeuNAc alpha 2-->3Gal beta 1-->4GlcNAc beta 1-->6) GalNAc.
T15 1809-1958 Sentence denotes These results indicate that the formation of polylactosaminyl O-glycans and sialyl Le(x) structure in O-glycans is dependent on the core 2 formation.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes Poly-N-acetyllactosaminyl O-glycans attached to leukosialin.
T2 61-114 Sentence denotes The presence of sialyl Le(x) structures in O-glycans.
T3 115-226 Sentence denotes Poly-N-acetyllactosamine extension has been found in O-glycans in addition to N-glycans and glycosphingolipids.
T4 227-377 Sentence denotes Attempts were made in HL-60 and K562 cells to determine the amount of poly-N-acetyllactosaminyl O-glycans in the major sialoglycoprotein, leukosialin.
T5 378-463 Sentence denotes Leukosialin was immunoprecipitated from [3H]glucosamine-labeled HL-60 and K562 cells.
T6 464-615 Sentence denotes Glycopeptides were prepared by Pronase digestion, and O-glycan-containing glycopeptides were isolated by affinity chromatography using Jacalin-agarose.
T7 616-788 Sentence denotes The glycopeptides bound to Jacalin-agarose and those unbound were treated with alkaline borohydride, and the released O-glycans were fractionated by Bio-Gel P-4 filtration.
T8 789-936 Sentence denotes Sequential glycosidase digestion of the O-glycans, with or without pretreatment by fucosidase or neuraminidase, revealed the following conclusions.
T9 937-1039 Sentence denotes 1) Leukosialin from HL-60 cells contains about 1-2 poly-N-acetyllactosaminyl O-glycan chains/molecule.
T10 1040-1311 Sentence denotes 2) About 50% of these poly-N-acetyllactosaminyl O-glycans contain sialyl Le(x) termini, NeuNAc alpha 2-->3Gal beta 1-->4 (Fuc alpha 1-->3)GlcNAc beta 1-->R. The amount of sialyl Le(x) structure in leukosialin is roughly equivalent to that on cell surfaces of HL-60 cells.
T11 1312-1432 Sentence denotes 3) Leukosialin from K562 cells, on the other hand, contains no detectable amount of poly-N-acetyllactosaminyl O-glycans.
T12 1433-1559 Sentence denotes 4) The presence of poly-N-acetyllactosamine in O-glycans is dependent on the core 2 beta 1,6-N-acetylglucosaminyl transferase.
T13 1560-1808 Sentence denotes 5) Jacalin-agarose binds to sialylated small oligosaccharides such as NeuNAc alpha 2-->3Gal beta 1-->3(NeuNAc alpha 2-->6) GalNAc but not the hexasaccharide NeuNAc alpha 2-->3Gal beta 1-->3(NeuNAc alpha 2-->3Gal beta 1-->4GlcNAc beta 1-->6) GalNAc.
T14 1809-1958 Sentence denotes These results indicate that the formation of polylactosaminyl O-glycans and sialyl Le(x) structure in O-glycans is dependent on the core 2 formation.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1128-1134 Glycan denotes NeuNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 1510-1516 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T3 1630-1636 Glycan denotes NeuNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 1663-1669 Glycan denotes NeuNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T5 1683-1689 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T6 1717-1723 Glycan denotes NeuNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T7 1750-1756 Glycan denotes NeuNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T8 1801-1807 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T9 1941-1947 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 140-149 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T2 1357-1361 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 0-4 Cell denotes Poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T3 115-119 Cell denotes Poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T5 297-301 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T7 988-992 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T9 1062-1066 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T11 1396-1400 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T13 1452-1456 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775