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sentences

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.
T2 113-400 Sentence denotes The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region was fused to the luciferase (Luc) reporter gene and studied in a transient transfection system in three TNF producing cell lines, the U937 macrophage cell line, the MLA 144 T cell line, and the 729-6 B cell line.
T3 401-518 Sentence denotes This full length promoter construct can be induced by phorbol 13-myristate acetate (PMA) in each of these cell types.
T4 519-690 Sentence denotes Analysis of a series of 5'-truncations showed several peaks of basal and PMA induced activity suggesting the presence of several positive and negative regulatory elements.
T5 691-806 Sentence denotes A PMA responsive element was localized to a region between -95 and -36 bp relative to the transcription start site.
T6 807-885 Sentence denotes Within this region, single AP-2- and AP-1-like consensus sequences were noted.
T7 886-960 Sentence denotes These AP-2 and AP-1 sites were each modified with a double point mutation.
T8 961-1055 Sentence denotes A modest (20-50%) reduction in TNF promoter activity was observed with the AP-2 site mutation.
T9 1056-1162 Sentence denotes However, mutation of the AP-1 site markedly diminished both the basal and PMA-activated promoter activity.
T10 1163-1320 Sentence denotes Also co-transfections of the wild-type promoter construct with an AP-1/c-jun expression vector resulted in augmented basal and PMA-induced promoter activity.
T1 0-112 Sentence denotes The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.
T2 113-400 Sentence denotes The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region was fused to the luciferase (Luc) reporter gene and studied in a transient transfection system in three TNF producing cell lines, the U937 macrophage cell line, the MLA 144 T cell line, and the 729-6 B cell line.
T3 401-518 Sentence denotes This full length promoter construct can be induced by phorbol 13-myristate acetate (PMA) in each of these cell types.
T4 519-690 Sentence denotes Analysis of a series of 5'-truncations showed several peaks of basal and PMA induced activity suggesting the presence of several positive and negative regulatory elements.
T5 691-806 Sentence denotes A PMA responsive element was localized to a region between -95 and -36 bp relative to the transcription start site.
T6 807-885 Sentence denotes Within this region, single AP-2- and AP-1-like consensus sequences were noted.
T7 886-960 Sentence denotes These AP-2 and AP-1 sites were each modified with a double point mutation.
T8 961-1055 Sentence denotes A modest (20-50%) reduction in TNF promoter activity was observed with the AP-2 site mutation.
T9 1056-1162 Sentence denotes However, mutation of the AP-1 site markedly diminished both the basal and PMA-activated promoter activity.
T10 1163-1320 Sentence denotes Also co-transfections of the wild-type promoter construct with an AP-1/c-jun expression vector resulted in augmented basal and PMA-induced promoter activity.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 138-143 HP_0002664 denotes tumor

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 22-71 DNA denotes human tumor necrosis factor alpha promoter region
T2 75-85 cell_line denotes macrophage
T3 87-93 cell_line denotes T cell
T4 99-111 cell_line denotes B cell lines
T5 117-187 DNA denotes 1311-base pair human tumor necrosis factor (TNF) alpha promoter region
T6 205-235 DNA denotes luciferase (Luc) reporter gene
T7 292-316 cell_line denotes TNF producing cell lines
T8 322-347 cell_line denotes U937 macrophage cell line
T9 353-372 cell_line denotes MLA 144 T cell line
T10 382-399 cell_line denotes 729-6 B cell line
T11 543-557 DNA denotes 5'-truncations
T12 648-656 DNA denotes positive
T13 693-715 DNA denotes PMA responsive element
T14 750-764 DNA denotes -95 and -36 bp
T15 781-805 DNA denotes transcription start site
T16 834-873 DNA denotes AP-2- and AP-1-like consensus sequences
T17 892-896 DNA denotes AP-2
T18 901-911 DNA denotes AP-1 sites
T19 992-1004 DNA denotes TNF promoter
T20 1036-1054 DNA denotes AP-2 site mutation
T21 1081-1090 DNA denotes AP-1 site
T22 1192-1220 DNA denotes wild-type promoter construct
T23 1229-1257 DNA denotes AP-1/c-jun expression vector

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 28-49 NP denotes tumor necrosis factor
C1 18-71 NP denotes the human tumor necrosis factor alpha promoter region
C3 75-111 NP denotes macrophage, T cell, and B cell lines
C5 138-165 NP denotes tumor necrosis factor (TNF)
C4 113-187 NP denotes The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region
C7 292-295 NP denotes TNF
C6 286-316 NP denotes three TNF producing cell lines
C8 318-399 NP denotes the U937 macrophage cell line, the MLA 144 T cell line, and the 729-6 B cell line
C9 401-436 NP denotes This full length promoter construct
C10 455-489 NP denotes phorbol 13-myristate acetate (PMA)
C11 501-517 NP denotes these cell types
C13 592-595 NP denotes PMA
C12 582-612 NP denotes basal and PMA induced activity
C14 693-696 NP denotes PMA
C15 733-805 NP denotes a region between -95 and -36 bp relative to the transcription start site
C16 814-825 NP denotes this region
C17 827-873 NP denotes single AP-2- and AP-1-like consensus sequences
C18 886-911 NP denotes These AP-2 and AP-1 sites
C19 992-995 NP denotes TNF
C20 1111-1161 NP denotes both the basal and PMA-activated promoter activity
C21 1270-1319 NP denotes augmented basal and PMA-induced promoter activity
R1 C5 C2 coref-ident tumor necrosis factor (TNF),tumor necrosis factor
R2 C4 C1 coref-ident The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region,the human tumor necrosis factor alpha promoter region
R3 C7 C5 coref-ident TNF,tumor necrosis factor (TNF)
R4 C6 C3 coref-ident three TNF producing cell lines,"macrophage, T cell, and B cell lines"
R5 C8 C6 coref-appos "the U937 macrophage cell line, the MLA 144 T cell line, and the 729-6 B cell line",three TNF producing cell lines
R6 C9 C4 coref-ident This full length promoter construct,The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region
R7 C11 C6 coref-other these cell types,three TNF producing cell lines
R8 C13 C10 coref-ident PMA,phorbol 13-myristate acetate (PMA)
R9 C14 C13 coref-ident PMA,PMA
R10 C16 C15 coref-ident this region,a region between -95 and -36 bp relative to the transcription start site
R11 C18 C17 coref-ident These AP-2 and AP-1 sites,single AP-2- and AP-1-like consensus sequences
R12 C19 C7 coref-ident TNF,TNF
R13 C20 C12 coref-ident both the basal and PMA-activated promoter activity,basal and PMA induced activity
R14 C21 C20 coref-other augmented basal and PMA-induced promoter activity,both the basal and PMA-activated promoter activity

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-112 Sentence denotes The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.
S2 113-400 Sentence denotes The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region was fused to the luciferase (Luc) reporter gene and studied in a transient transfection system in three TNF producing cell lines, the U937 macrophage cell line, the MLA 144 T cell line, and the 729-6 B cell line.
S3 401-518 Sentence denotes This full length promoter construct can be induced by phorbol 13-myristate acetate (PMA) in each of these cell types.
S4 519-690 Sentence denotes Analysis of a series of 5'-truncations showed several peaks of basal and PMA induced activity suggesting the presence of several positive and negative regulatory elements.
S5 691-806 Sentence denotes A PMA responsive element was localized to a region between -95 and -36 bp relative to the transcription start site.
S6 807-885 Sentence denotes Within this region, single AP-2- and AP-1-like consensus sequences were noted.
S7 886-960 Sentence denotes These AP-2 and AP-1 sites were each modified with a double point mutation.
S8 961-1055 Sentence denotes A modest (20-50%) reduction in TNF promoter activity was observed with the AP-2 site mutation.
S9 1056-1162 Sentence denotes However, mutation of the AP-1 site markedly diminished both the basal and PMA-activated promoter activity.
S10 1163-1320 Sentence denotes Also co-transfections of the wild-type promoter construct with an AP-1/c-jun expression vector resulted in augmented basal and PMA-induced promoter activity.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 22-71 DNA_domain_or_region denotes human tumor necrosis factor alpha promoter region
T2 75-85 cell_line denotes macrophage
T3 87-93 cell_line denotes T cell
T4 99-111 cell_line denotes B cell lines
T5 117-187 DNA_domain_or_region denotes 1311-base pair human tumor necrosis factor (TNF) alpha promoter region
T6 205-235 DNA_molecule denotes luciferase (Luc) reporter gene
T7 253-282 other_name denotes transient transfection system
T8 292-316 cell_line denotes TNF producing cell lines
T9 322-347 cell_line denotes U937 macrophage cell line
T10 353-372 cell_line denotes MLA 144 T cell line
T11 382-399 cell_line denotes 729-6 B cell line
T12 455-483 other_organic_compound denotes phorbol 13-myristate acetate
T13 485-488 other_organic_compound denotes PMA
T14 543-557 DNA_molecule denotes 5'-truncations
T15 648-656 DNA_domain_or_region denotes positive
T16 693-696 other_organic_compound denotes PMA
T17 750-764 DNA_domain_or_region denotes -95 and -36 bp
T18 781-805 DNA_domain_or_region denotes transcription start site
T19 892-896 DNA_domain_or_region denotes AP-2
T20 901-911 DNA_domain_or_region denotes AP-1 sites
T21 938-959 other_name denotes double point mutation
T22 992-1004 DNA_domain_or_region denotes TNF promoter
T23 1036-1054 DNA_domain_or_region denotes AP-2 site mutation
T24 1065-1073 other_name denotes mutation
T25 1081-1090 DNA_domain_or_region denotes AP-1 site
T26 1130-1161 other_name denotes PMA-activated promoter activity
T27 1192-1220 DNA_molecule denotes wild-type promoter construct
T28 1229-1257 DNA_molecule denotes AP-1/c-jun expression vector
T29 1290-1293 other_organic_compound denotes PMA

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 28-33 Phenotype denotes tumor HP:0002664
T2 138-143 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 28-33 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 138-143 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 485-488 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T5 592-595 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T7 693-696 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T9 1130-1133 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T11 1290-1293 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 22-27 OrganismTaxon denotes human 9606
T2 132-137 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 75-85 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T2 87-93 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T3 99-105 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T4 327-337 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T5 361-367 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T6 388-394 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 75-85 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T3 87-93 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T4 99-105 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T5 327-337 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T7 361-367 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T8 388-394 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T9 582-587 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T10 1120-1125 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T11 1280-1285 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324