PubMed:1330796 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1330796","sourcedb":"PubMed","sourceid":"1330796","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1330796","text":"Hepatitis type C virus infection in patients with type B chronic liver disease.\nAnti-c100-3 (Ortho) was determined in the sera of 152 patients with HBs antigen-positive chronic liver diseases to assess coinfection of hepatitis B virus (HBV) and hepatitis C virus (HCV). Eleven patients (7.2%) were positive for anti-c100-3. Anti-CP-9 (Okamoto) and HCV-RNA (RT-PCR) were also examined in these 11 patients. Anti-CP-9 was detected in 7 patients and HCV-RNA was detected in all 11 patients. Four of the 11 anti-c100-3-positive patients were positive for HBe antigen (HBeAg) and others were negative. In 8 of the 11 patients, HCV was suspected to be superinfected by blood transfusion. In HBeAg-positive patients, serum glutamic pyruvic transaminase (SGPT) was elevated in relation to active replication of HBV shown by DNA-polymerase activity. The histological findings showed chronic active hepatitis, with or without cirrhosis. On the other hand, in HBeAg-negative patients, SGPT fluctuated without evidence of active replication of HBV. Active inflammation in the liver was observed in 3 of 5 HBeAg-negative patients by liver biopsy. These findings suggest that HBV might play an important role in chronic active inflammation in HBeAg-positive patients coinfected with HCV, and that HCV might be responsible for continuous inflammation in HBeAg-negative patients coinfected with HCV.","tracks":[{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":79},"obj":"Sentence"},{"id":"T2","span":{"begin":80,"end":269},"obj":"Sentence"},{"id":"T3","span":{"begin":270,"end":323},"obj":"Sentence"},{"id":"T4","span":{"begin":324,"end":405},"obj":"Sentence"},{"id":"T5","span":{"begin":406,"end":487},"obj":"Sentence"},{"id":"T6","span":{"begin":488,"end":596},"obj":"Sentence"},{"id":"T7","span":{"begin":597,"end":681},"obj":"Sentence"},{"id":"T8","span":{"begin":682,"end":840},"obj":"Sentence"},{"id":"T9","span":{"begin":841,"end":926},"obj":"Sentence"},{"id":"T10","span":{"begin":927,"end":1036},"obj":"Sentence"},{"id":"T11","span":{"begin":1037,"end":1133},"obj":"Sentence"},{"id":"T12","span":{"begin":1134,"end":1383},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":79},"obj":"Sentence"},{"id":"T2","span":{"begin":80,"end":269},"obj":"Sentence"},{"id":"T3","span":{"begin":270,"end":323},"obj":"Sentence"},{"id":"T4","span":{"begin":324,"end":405},"obj":"Sentence"},{"id":"T5","span":{"begin":406,"end":487},"obj":"Sentence"},{"id":"T6","span":{"begin":488,"end":596},"obj":"Sentence"},{"id":"T7","span":{"begin":597,"end":681},"obj":"Sentence"},{"id":"T8","span":{"begin":682,"end":840},"obj":"Sentence"},{"id":"T9","span":{"begin":841,"end":926},"obj":"Sentence"},{"id":"T10","span":{"begin":927,"end":1036},"obj":"Sentence"},{"id":"T11","span":{"begin":1037,"end":1133},"obj":"Sentence"},{"id":"T12","span":{"begin":1134,"end":1383},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Inflammaging","color":"#93d3ec","default":true}]}]}}