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PubMed:1327803 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Leukotriene B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6.
T2 99-177 Sentence denotes Leukotriene B4 (LTB4) is a notable participant in inflammation and chemotaxis.
T3 178-333 Sentence denotes It is, however, still unclear whether LTB4 acts in this regard directly or indirectly by stimulating the release of chemotactic and inflammatory cytokines.
T4 334-476 Sentence denotes Here we report that LTB4 induces synthesis of interleukin (IL)-6 by human blood monocytes through transcriptional activation of the IL-6 gene.
T5 477-747 Sentence denotes We furthermore demonstrate that this process involves activation of the transcription factor NF-chi B and, to a lesser extent, of NF-IL6, while the activity of the transcription factor AP-1, shown to otherwise confer IL-6 inducibility, appeared to be unaffected by LTB4.
T6 748-889 Sentence denotes Involvement of NF-chi B and NF-IL6 in induction of IL-6 transcription by monocytes was demonstrated using deleted forms of the IL-6 promoter.
T7 890-1063 Sentence denotes Activation of the IL-6 promoter by LTB4 was not only associated with accumulation of the respective transcripts but resulted in synthesis of functional IL-6 protein as well.
T8 1064-1218 Sentence denotes In addition, LTB4 mediated transactivation of a heterologous promoter construct containing the NF-chi B or the NF-IL6 enhancer, but not the AP-1 enhancer.
T9 1219-1412 Sentence denotes The signaling events mediating this effect appeared to involve the release of H2O2, since LTB4 failed to induce NF-chi B or NF-IL6 in the presence of the scavenger of H2O2, N-acetyl-L-cysteine.
T1 0-98 Sentence denotes Leukotriene B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6.
T2 99-177 Sentence denotes Leukotriene B4 (LTB4) is a notable participant in inflammation and chemotaxis.
T3 178-333 Sentence denotes It is, however, still unclear whether LTB4 acts in this regard directly or indirectly by stimulating the release of chemotactic and inflammatory cytokines.
T4 334-476 Sentence denotes Here we report that LTB4 induces synthesis of interleukin (IL)-6 by human blood monocytes through transcriptional activation of the IL-6 gene.
T5 477-747 Sentence denotes We furthermore demonstrate that this process involves activation of the transcription factor NF-chi B and, to a lesser extent, of NF-IL6, while the activity of the transcription factor AP-1, shown to otherwise confer IL-6 inducibility, appeared to be unaffected by LTB4.
T6 748-889 Sentence denotes Involvement of NF-chi B and NF-IL6 in induction of IL-6 transcription by monocytes was demonstrated using deleted forms of the IL-6 promoter.
T7 890-1063 Sentence denotes Activation of the IL-6 promoter by LTB4 was not only associated with accumulation of the respective transcripts but resulted in synthesis of functional IL-6 protein as well.
T8 1064-1218 Sentence denotes In addition, LTB4 mediated transactivation of a heterologous promoter construct containing the NF-chi B or the NF-IL6 enhancer, but not the AP-1 enhancer.
T9 1219-1412 Sentence denotes The signaling events mediating this effect appeared to involve the release of H2O2, since LTB4 failed to induce NF-chi B or NF-IL6 in the presence of the scavenger of H2O2, N-acetyl-L-cysteine.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 43-56 protein denotes interleukin-6
T2 78-86 protein denotes NK-chi B
T3 91-97 protein denotes NF-IL6
T4 310-332 protein denotes inflammatory cytokines
T5 380-398 protein denotes interleukin (IL)-6
T6 402-423 cell_type denotes human blood monocytes
T7 466-475 DNA denotes IL-6 gene
T8 549-569 protein denotes transcription factor
T9 570-578 protein denotes NF-chi B
T10 607-613 protein denotes NF-IL6
T11 641-661 protein denotes transcription factor
T12 662-666 protein denotes AP-1
T13 694-698 protein denotes IL-6
T14 763-771 protein denotes NF-chi B
T15 776-782 protein denotes NF-IL6
T16 799-803 protein denotes IL-6
T17 875-888 DNA denotes IL-6 promoter
T18 908-921 DNA denotes IL-6 promoter
T19 1042-1054 protein denotes IL-6 protein
T20 1112-1143 DNA denotes heterologous promoter construct
T21 1159-1167 DNA denotes NF-chi B
T22 1175-1190 DNA denotes NF-IL6 enhancer
T23 1204-1217 DNA denotes AP-1 enhancer
T24 1331-1339 protein denotes NF-chi B
T25 1343-1349 protein denotes NF-IL6

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-98 Sentence denotes Leukotriene B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6.
S2 99-177 Sentence denotes Leukotriene B4 (LTB4) is a notable participant in inflammation and chemotaxis.
S3 178-333 Sentence denotes It is, however, still unclear whether LTB4 acts in this regard directly or indirectly by stimulating the release of chemotactic and inflammatory cytokines.
S4 334-476 Sentence denotes Here we report that LTB4 induces synthesis of interleukin (IL)-6 by human blood monocytes through transcriptional activation of the IL-6 gene.
S5 477-747 Sentence denotes We furthermore demonstrate that this process involves activation of the transcription factor NF-chi B and, to a lesser extent, of NF-IL6, while the activity of the transcription factor AP-1, shown to otherwise confer IL-6 inducibility, appeared to be unaffected by LTB4.
S6 748-889 Sentence denotes Involvement of NF-chi B and NF-IL6 in induction of IL-6 transcription by monocytes was demonstrated using deleted forms of the IL-6 promoter.
S7 890-1063 Sentence denotes Activation of the IL-6 promoter by LTB4 was not only associated with accumulation of the respective transcripts but resulted in synthesis of functional IL-6 protein as well.
S8 1064-1218 Sentence denotes In addition, LTB4 mediated transactivation of a heterologous promoter construct containing the NF-chi B or the NF-IL6 enhancer, but not the AP-1 enhancer.
S9 1219-1412 Sentence denotes The signaling events mediating this effect appeared to involve the release of H2O2, since LTB4 failed to induce NF-chi B or NF-IL6 in the presence of the scavenger of H2O2, N-acetyl-L-cysteine.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-14 NP denotes Leukotriene B4
C2 43-56 NP denotes interleukin-6
C3 78-86 NP denotes NK-chi B
C4 91-97 NP denotes NF-IL6
C5 99-120 NP denotes Leukotriene B4 (LTB4)
C6 216-220 NP denotes LTB4
C7 354-358 NP denotes LTB4
C8 380-398 NP denotes interleukin (IL)-6
C9 402-423 NP denotes human blood monocytes
C11 466-470 NP denotes IL-6
C10 432-475 NP denotes transcriptional activation of the IL-6 gene
C12 509-521 NP denotes this process
C13 545-578 NP denotes the transcription factor NF-chi B
C14 607-613 NP denotes NF-IL6
C15 637-666 NP denotes the transcription factor AP-1
C16 694-698 NP denotes IL-6
C17 742-746 NP denotes LTB4
C18 763-771 NP denotes NF-chi B
C19 776-782 NP denotes NF-IL6
C20 799-803 NP denotes IL-6
C21 821-830 NP denotes monocytes
C23 875-879 NP denotes IL-6
C22 871-888 NP denotes the IL-6 promoter
C24 904-921 NP denotes the IL-6 promoter
C25 925-929 NP denotes LTB4
C26 1042-1046 NP denotes IL-6
C27 1077-1081 NP denotes LTB4
C28 1159-1167 NP denotes NF-chi B
C29 1175-1181 NP denotes NF-IL6
C30 1204-1208 NP denotes AP-1
C31 1297-1301 NP denotes H2O2
C32 1309-1313 NP denotes LTB4
C33 1331-1339 NP denotes NF-chi B
C34 1343-1349 NP denotes NF-IL6
C36 1386-1390 NP denotes H2O2
C35 1369-1390 NP denotes the scavenger of H2O2
C37 1392-1411 NP denotes N-acetyl-L-cysteine
R1 C5 C1 coref-ident Leukotriene B4 (LTB4),Leukotriene B4
R2 C6 C5 coref-ident LTB4,Leukotriene B4 (LTB4)
R3 C7 C6 coref-ident LTB4,LTB4
R4 C8 C2 coref-ident interleukin (IL)-6,interleukin-6
R5 C11 C8 coref-ident IL-6,interleukin (IL)-6
R6 C12 C10 coref-ident this process,transcriptional activation of the IL-6 gene
R7 C13 C3 coref-ident the transcription factor NF-chi B,NK-chi B
R8 C14 C4 coref-ident NF-IL6,NF-IL6
R9 C16 C11 coref-ident IL-6,IL-6
R10 C17 C7 coref-ident LTB4,LTB4
R11 C18 C13 coref-ident NF-chi B,the transcription factor NF-chi B
R12 C19 C14 coref-ident NF-IL6,NF-IL6
R13 C20 C16 coref-ident IL-6,IL-6
R14 C21 C9 coref-other monocytes,human blood monocytes
R15 C23 C20 coref-ident IL-6,IL-6
R16 C24 C22 coref-ident the IL-6 promoter,the IL-6 promoter
R17 C25 C17 coref-ident LTB4,LTB4
R18 C26 C23 coref-ident IL-6,IL-6
R19 C27 C25 coref-ident LTB4,LTB4
R20 C28 C18 coref-ident NF-chi B,NF-chi B
R21 C29 C19 coref-ident NF-IL6,NF-IL6
R22 C30 C15 coref-ident AP-1,the transcription factor AP-1
R23 C32 C27 coref-ident LTB4,LTB4
R24 C33 C28 coref-ident NF-chi B,NF-chi B
R25 C34 C29 coref-ident NF-IL6,NF-IL6
R26 C36 C31 coref-ident H2O2,H2O2
R27 C37 C35 coref-appos N-acetyl-L-cysteine,the scavenger of H2O2

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-14 other_organic_compound denotes Leukotriene B4
T2 43-56 protein_molecule denotes interleukin-6
T3 78-86 protein_molecule denotes NK-chi B
T4 91-97 protein_molecule denotes NF-IL6
T5 99-113 other_organic_compound denotes Leukotriene B4
T6 115-119 other_organic_compound denotes LTB4
T7 149-161 other_name denotes inflammation
T8 166-176 other_name denotes chemotaxis
T9 216-220 other_organic_compound denotes LTB4
T10 294-309 other_name denotes chemotactic and
T11 310-332 protein_family_or_group denotes inflammatory cytokines
T12 354-358 other_organic_compound denotes LTB4
T13 380-398 protein_molecule denotes interleukin (IL)-6
T14 402-423 cell_type denotes human blood monocytes
T15 432-458 other_name denotes transcriptional activation
T16 466-470 protein_molecule denotes IL-6
T17 549-569 protein_family_or_group denotes transcription factor
T18 570-578 protein_molecule denotes NF-chi B
T19 607-613 protein_molecule denotes NF-IL6
T20 641-661 protein_family_or_group denotes transcription factor
T21 662-666 protein_molecule denotes AP-1
T22 694-698 protein_molecule denotes IL-6
T23 742-746 other_organic_compound denotes LTB4
T24 763-771 protein_molecule denotes NF-chi B
T25 776-782 protein_molecule denotes NF-IL6
T26 799-803 protein_molecule denotes IL-6
T27 875-879 protein_molecule denotes IL-6
T28 908-912 protein_molecule denotes IL-6
T29 925-929 other_organic_compound denotes LTB4
T30 1042-1046 protein_molecule denotes IL-6
T31 1077-1081 other_organic_compound denotes LTB4
T32 1112-1143 DNA_molecule denotes heterologous promoter construct
T33 1159-1167 protein_molecule denotes NF-chi B
T34 1175-1181 protein_molecule denotes NF-IL6
T35 1204-1208 protein_molecule denotes AP-1
T36 1297-1301 inorganic denotes H2O2
T37 1309-1313 other_organic_compound denotes LTB4
T38 1331-1339 protein_molecule denotes NF-chi B
T39 1343-1349 protein_molecule denotes NF-IL6
T40 1386-1390 inorganic denotes H2O2
T41 1392-1411 amino_acid_monomer denotes N-acetyl-L-cysteine