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PubMed:1327574 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-90 Sentence denotes Polymicrobial sepsis disrupts normal neutrophil extracellular matrix protein interactions.
T2 91-275 Sentence denotes The purpose of this study was to examine how intra-abdominal sepsis and extracellular matrix proteins (fibronectin, laminin) affect adherent polymorphonuclear leukocyte (PMN) function.
T3 276-309 Sentence denotes Two groups of swine were studied:
T4 310-408 Sentence denotes Group I (n = 5) underwent sham laparotomy; Group II (n = 8) underwent cecal ligation and incision.
T5 409-1000 Sentence denotes PMN adherent to either fibronectin (F) or laminin (L) had increased candicidal activity over buffer (B) by Group I but not by post-operative day 8 Group II PMN. (Percent specific release 51Cr-Group I--35.00, 68.25, 64.75% for B, F, and L; P less than 0.001 comparing B vs. F or L; Group II--14.25, 12.50, 12.75% for B, F, and L; P = NS comparing B vs. F or L.) To determine the mechanism for this finding, PMN priming was then assessed by evaluating both PMN adherence to extracellular matrix proteins and the cell surface expression of CR1/CR3 by using sheep RBC opsonized with C3b or C3bi.
T6 1001-1108 Sentence denotes PMN activation was assayed by using MTT-Formazan, myeloperoxidase, and hypochlorous acid (HOCl) production.
T7 1109-1224 Sentence denotes Fibronectin and laminin increased PMN adherence and CR1/CR3 expression over buffer by Group I and Group II animals.
T8 1225-1364 Sentence denotes Fibronectin and laminin increased MTT-Formazan, myeloperoxidase, and HOCl production over buffer by Group I PMN but not POD 8 Group II PMN.
T9 1365-1639 Sentence denotes These results suggest that untreated intra-abdominal sepsis partially abrogates the effect of extracellular matrix proteins on PMN function; in particular, the activation but not priming of adherent PMN by extracellular matrix proteins is reduced in this clinical situation.
T1 0-90 Sentence denotes Polymicrobial sepsis disrupts normal neutrophil extracellular matrix protein interactions.
T2 91-275 Sentence denotes The purpose of this study was to examine how intra-abdominal sepsis and extracellular matrix proteins (fibronectin, laminin) affect adherent polymorphonuclear leukocyte (PMN) function.
T3 276-309 Sentence denotes Two groups of swine were studied:
T4 310-408 Sentence denotes Group I (n = 5) underwent sham laparotomy; Group II (n = 8) underwent cecal ligation and incision.
T5 409-1000 Sentence denotes PMN adherent to either fibronectin (F) or laminin (L) had increased candicidal activity over buffer (B) by Group I but not by post-operative day 8 Group II PMN. (Percent specific release 51Cr-Group I--35.00, 68.25, 64.75% for B, F, and L; P less than 0.001 comparing B vs. F or L; Group II--14.25, 12.50, 12.75% for B, F, and L; P = NS comparing B vs. F or L.) To determine the mechanism for this finding, PMN priming was then assessed by evaluating both PMN adherence to extracellular matrix proteins and the cell surface expression of CR1/CR3 by using sheep RBC opsonized with C3b or C3bi.
T6 1001-1108 Sentence denotes PMN activation was assayed by using MTT-Formazan, myeloperoxidase, and hypochlorous acid (HOCl) production.
T7 1109-1224 Sentence denotes Fibronectin and laminin increased PMN adherence and CR1/CR3 expression over buffer by Group I and Group II animals.
T8 1225-1364 Sentence denotes Fibronectin and laminin increased MTT-Formazan, myeloperoxidase, and HOCl production over buffer by Group I PMN but not POD 8 Group II PMN.
T9 1365-1639 Sentence denotes These results suggest that untreated intra-abdominal sepsis partially abrogates the effect of extracellular matrix proteins on PMN function; in particular, the activation but not priming of adherent PMN by extracellular matrix proteins is reduced in this clinical situation.