PubMed:1313226 JSON TXT

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jnlpba-st-training

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":65,"end":69},"obj":"protein"},{"id":"T2","span":{"begin":90,"end":105},"obj":"cell_type"},{"id":"T3","span":{"begin":176,"end":200},"obj":"protein"},{"id":"T4","span":{"begin":227,"end":258},"obj":"DNA"},{"id":"T5","span":{"begin":304,"end":319},"obj":"protein"},{"id":"T6","span":{"begin":348,"end":360},"obj":"DNA"},{"id":"T7","span":{"begin":422,"end":432},"obj":"DNA"},{"id":"T8","span":{"begin":484,"end":494},"obj":"RNA"},{"id":"T9","span":{"begin":533,"end":565},"obj":"cell_type"},{"id":"T10","span":{"begin":667,"end":672},"obj":"DNA"},{"id":"T11","span":{"begin":753,"end":763},"obj":"RNA"},{"id":"T12","span":{"begin":812,"end":817},"obj":"DNA"},{"id":"T13","span":{"begin":889,"end":894},"obj":"DNA"},{"id":"T14","span":{"begin":899,"end":909},"obj":"RNA"},{"id":"T15","span":{"begin":1070,"end":1080},"obj":"DNA"},{"id":"T16","span":{"begin":1096,"end":1106},"obj":"DNA"},{"id":"T17","span":{"begin":1117,"end":1134},"obj":"cell_type"},{"id":"T18","span":{"begin":1145,"end":1160},"obj":"protein"},{"id":"T19","span":{"begin":1176,"end":1188},"obj":"DNA"},{"id":"T20","span":{"begin":1209,"end":1218},"obj":"cell_type"},{"id":"T21","span":{"begin":1245,"end":1249},"obj":"protein"},{"id":"T22","span":{"begin":1270,"end":1286},"obj":"protein"},{"id":"T23","span":{"begin":1362,"end":1371},"obj":"protein"},{"id":"T24","span":{"begin":1419,"end":1440},"obj":"protein"},{"id":"T25","span":{"begin":1449,"end":1453},"obj":"protein"},{"id":"T26","span":{"begin":1462,"end":1485},"obj":"protein"}],"text":"Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes.\nWe have examined the effect of leukotriene B4 (LTB4), a potent lipid proinflammatory mediator, on the expression of the proto-oncogenes c-jun and c-fos. In addition, we looked at the modulation of nuclear factors binding specifically to the AP-1 element after LTB4 stimulation. LTB4 increased the expression of the c-fos gene in a time- and concentration-dependent manner. The c-jun mRNA, which is constitutively expressed in human peripheral-blood monocytes at relatively high levels, was also slightly augmented by LTB4, although to a much lower extent than c-fos. The kinetics of expression of the two genes were also slightly different, with c-fos mRNA reaching a peak at 15 min after stimulation and c-jun at 30 min. Both messages rapidly declined thereafter. Stability of the c-fos and c-jun mRNA was not affected by LTB4, as assessed after actinomycin D treatment. Nuclear transcription studies in vitro showed that LTB4 increased the transcription of the c-fos gene 7-fold and the c-jun gene 1.4-fold. Resting monocytes contained nuclear factors binding to the AP-1 element, but stimulation of monocytes with LTB4 induced greater AP-1-binding activity of nuclear proteins. These results indicate that LTB4 may regulate the production of different cytokines by modulating the yield and/or the function of transcription factors such as AP-1-binding proto-oncogene products."}

semrep-sample

pubmed-sentences-benchmark

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":106},"obj":"Sentence"},{"id":"S2","span":{"begin":107,"end":259},"obj":"Sentence"},{"id":"S3","span":{"begin":260,"end":384},"obj":"Sentence"},{"id":"S4","span":{"begin":385,"end":479},"obj":"Sentence"},{"id":"S5","span":{"begin":480,"end":673},"obj":"Sentence"},{"id":"S6","span":{"begin":674,"end":828},"obj":"Sentence"},{"id":"S7","span":{"begin":829,"end":871},"obj":"Sentence"},{"id":"S8","span":{"begin":872,"end":978},"obj":"Sentence"},{"id":"S9","span":{"begin":979,"end":1116},"obj":"Sentence"},{"id":"S10","span":{"begin":1117,"end":1287},"obj":"Sentence"},{"id":"S11","span":{"begin":1288,"end":1486},"obj":"Sentence"}],"text":"Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes.\nWe have examined the effect of leukotriene B4 (LTB4), a potent lipid proinflammatory mediator, on the expression of the proto-oncogenes c-jun and c-fos. In addition, we looked at the modulation of nuclear factors binding specifically to the AP-1 element after LTB4 stimulation. LTB4 increased the expression of the c-fos gene in a time- and concentration-dependent manner. The c-jun mRNA, which is constitutively expressed in human peripheral-blood monocytes at relatively high levels, was also slightly augmented by LTB4, although to a much lower extent than c-fos. The kinetics of expression of the two genes were also slightly different, with c-fos mRNA reaching a peak at 15 min after stimulation and c-jun at 30 min. Both messages rapidly declined thereafter. Stability of the c-fos and c-jun mRNA was not affected by LTB4, as assessed after actinomycin D treatment. Nuclear transcription studies in vitro showed that LTB4 increased the transcription of the c-fos gene 7-fold and the c-jun gene 1.4-fold. Resting monocytes contained nuclear factors binding to the AP-1 element, but stimulation of monocytes with LTB4 induced greater AP-1-binding activity of nuclear proteins. These results indicate that LTB4 may regulate the production of different cytokines by modulating the yield and/or the function of transcription factors such as AP-1-binding proto-oncogene products."}

genia-medco-coref

GENIAcorpus

metamap-sample