PubMed:12810612
Annnotations
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 509-514 | gene:7057 | denotes | TSP-1 |
| T1 | 600-608 | disease:C0011847 | denotes | diabetes |
| T2 | 509-514 | gene:7057 | denotes | TSP-1 |
| T3 | 600-608 | disease:C0011849 | denotes | diabetes |
| R1 | T0 | T1 | associated_with | TSP-1,diabetes |
| R2 | T2 | T3 | associated_with | TSP-1,diabetes |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 12810612-10#24#29#gene7057 | 1468-1473 | gene7057 | denotes | TSP-1 |
| 12810612-10#50#58#diseaseC0011847 | 1494-1502 | diseaseC0011847 | denotes | diabetes |
| 12810612-10#50#58#diseaseC0011849 | 1494-1502 | diseaseC0011849 | denotes | diabetes |
| 12810612-10#92#100#diseaseC0011847 | 1536-1544 | diseaseC0011847 | denotes | diabetes |
| 12810612-10#92#100#diseaseC0011849 | 1536-1544 | diseaseC0011849 | denotes | diabetes |
| 12810612-10#133#143#diseaseC0333186 | 1577-1587 | diseaseC0333186 | denotes | restenosis |
| 24#29#gene705750#58#diseaseC0011847 | 12810612-10#24#29#gene7057 | 12810612-10#50#58#diseaseC0011847 | associated_with | TSP-1,diabetes |
| 24#29#gene705750#58#diseaseC0011849 | 12810612-10#24#29#gene7057 | 12810612-10#50#58#diseaseC0011849 | associated_with | TSP-1,diabetes |
| 24#29#gene705792#100#diseaseC0011847 | 12810612-10#24#29#gene7057 | 12810612-10#92#100#diseaseC0011847 | associated_with | TSP-1,diabetes |
| 24#29#gene705792#100#diseaseC0011849 | 12810612-10#24#29#gene7057 | 12810612-10#92#100#diseaseC0011849 | associated_with | TSP-1,diabetes |
| 24#29#gene7057133#143#diseaseC0333186 | 12810612-10#24#29#gene7057 | 12810612-10#133#143#diseaseC0333186 | associated_with | TSP-1,restenosis |
PubMed_Structured_Abstracts
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 92-653 | BACKGROUND | denotes | Thrombospondin-1 (TSP-1) expression in the vascular wall has been related to the development of atherosclerotic lesions and restenosis. TSP-1 promotes the development of neointima and has recently been associated with atherogenesis at a genetic level. Because TSP-1 expression is responsive to glucose stimulation in mesangial cells, we hypothesized that glucose may stimulate its production by vascular cells. Thus, TSP-1 expression in the blood vessel wall may increase, providing a molecular link between diabetes and accelerated vascular lesion development. |
| T2 | 675-1430 | RESULTS | denotes | To determine whether the expression level of TSP-1 in vessel wall is increased in diabetes, aorta and carotid arteries of Zucker rats were used for immunostaining, Western blotting, and in situ RNA hybridization. A significant increase in TSP-1 expression was found in the adventitia of blood vessels from diabetic rats. Consistent with the well-known antiangiogenic effect of TSP-1, the number of vasa vasorum was reduced in aortas from diabetic rats. In cultured endothelial cells, vascular smooth muscle cells, and fibroblasts, TSP-1 expression increased in response to glucose stimulation (>30-fold). After balloon catheter injury to carotid arteries, expression of TSP-1 protein and mRNA was higher at all time points in the vessels of diabetic rats. |
| T3 | 1444-1677 | CONCLUSIONS | denotes | Increased expression of TSP-1 in blood vessels in diabetes may represent a new link between diabetes, atherogenesis, and accelerated restenosis. This increase in TSP-1 production may be a direct response of vascular cells to glucose. |