PubMed:12239140
Annnotations
Inflammaging
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-125 | Sentence | denotes | Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. |
T2 | 126-288 | Sentence | denotes | We have identified and cloned a novel human cytokine with homology to cytokines of the interleukin-17 (IL-17) family, which we have termed human IL-17E (hIL-17E). |
T3 | 289-415 | Sentence | denotes | With the identification of several IL-17 family members, it is critical to understand the in vivo function of these molecules. |
T4 | 416-523 | Sentence | denotes | We have generated transgenic mice overexpressing hIL-17E using an apolipoprotein E (ApoE) hepatic promoter. |
T5 | 524-699 | Sentence | denotes | These mice displayed changes in the peripheral blood, particularly, a 3-fold increase in total leukocytes consisting of increases in eosinophils, lymphocytes, and neutrophils. |
T6 | 700-819 | Sentence | denotes | Splenomegaly and lymphoadenopathy were predominant and included marked eosinophil infiltrates and lymphoid hyperplasia. |
T7 | 820-936 | Sentence | denotes | CCR3(+) eosinophils increased in the blood and lymph nodes of the transgenic mice by 50- and 300-fold, respectively. |
T8 | 937-1022 | Sentence | denotes | Eosinophils also increased 8- to 18-fold in the bone marrow and spleen, respectively. |
T9 | 1023-1094 | Sentence | denotes | In the bone marrow, most of the eosinophils had an immature appearance. |
T10 | 1095-1303 | Sentence | denotes | CD19(+) B cells increased 2- to 5-fold in the peripheral blood, 2-fold in the spleen, and 10-fold in the lymph nodes of transgenic mice, whereas CD4(+) T lymphocytes increased 2-fold in both blood and spleen. |
T11 | 1304-1440 | Sentence | denotes | High serum levels of the cytokines IL-2, IL-4, IL-5, granulocyte colony-stimulating factor, eotaxin, and interferon gamma were observed. |
T12 | 1441-1551 | Sentence | denotes | Consistent with B-lymphocyte increases, serum immunoglobulin (Ig) M, IgG, and IgE were significantly elevated. |
T13 | 1552-1720 | Sentence | denotes | Antigenic challenge of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease in anti-KLH IgG accompanied by increases of anti-KLH IgA and IgE. |
T14 | 1721-1851 | Sentence | denotes | In situ hybridization of transgenic tissues revealed that IL-17Rh1 (IL-17BR/Evi27), a receptor that binds IL-17E, is up-regulated. |
T15 | 1852-2007 | Sentence | denotes | Taken together, these data indicate that IL-17E regulates hematopoietic and immune functions, stimulating the development of eosinophils and B lymphocytes. |
T16 | 2008-2215 | Sentence | denotes | The fact that hIL-17E overexpression results in high levels of circulating eosinophils, IL-4, IL-5, eotaxin, and IgE suggests that IL-17E may be a proinflammatory cytokine favoring Th2-type immune responses. |
T1 | 0-125 | Sentence | denotes | Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. |
T2 | 126-288 | Sentence | denotes | We have identified and cloned a novel human cytokine with homology to cytokines of the interleukin-17 (IL-17) family, which we have termed human IL-17E (hIL-17E). |
T3 | 289-415 | Sentence | denotes | With the identification of several IL-17 family members, it is critical to understand the in vivo function of these molecules. |
T4 | 416-523 | Sentence | denotes | We have generated transgenic mice overexpressing hIL-17E using an apolipoprotein E (ApoE) hepatic promoter. |
T5 | 524-699 | Sentence | denotes | These mice displayed changes in the peripheral blood, particularly, a 3-fold increase in total leukocytes consisting of increases in eosinophils, lymphocytes, and neutrophils. |
T6 | 700-819 | Sentence | denotes | Splenomegaly and lymphoadenopathy were predominant and included marked eosinophil infiltrates and lymphoid hyperplasia. |
T7 | 820-936 | Sentence | denotes | CCR3(+) eosinophils increased in the blood and lymph nodes of the transgenic mice by 50- and 300-fold, respectively. |
T8 | 937-1022 | Sentence | denotes | Eosinophils also increased 8- to 18-fold in the bone marrow and spleen, respectively. |
T9 | 1023-1094 | Sentence | denotes | In the bone marrow, most of the eosinophils had an immature appearance. |
T10 | 1095-1303 | Sentence | denotes | CD19(+) B cells increased 2- to 5-fold in the peripheral blood, 2-fold in the spleen, and 10-fold in the lymph nodes of transgenic mice, whereas CD4(+) T lymphocytes increased 2-fold in both blood and spleen. |
T11 | 1304-1440 | Sentence | denotes | High serum levels of the cytokines IL-2, IL-4, IL-5, granulocyte colony-stimulating factor, eotaxin, and interferon gamma were observed. |
T12 | 1441-1551 | Sentence | denotes | Consistent with B-lymphocyte increases, serum immunoglobulin (Ig) M, IgG, and IgE were significantly elevated. |
T13 | 1552-1720 | Sentence | denotes | Antigenic challenge of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease in anti-KLH IgG accompanied by increases of anti-KLH IgA and IgE. |
T14 | 1721-1851 | Sentence | denotes | In situ hybridization of transgenic tissues revealed that IL-17Rh1 (IL-17BR/Evi27), a receptor that binds IL-17E, is up-regulated. |
T15 | 1852-2007 | Sentence | denotes | Taken together, these data indicate that IL-17E regulates hematopoietic and immune functions, stimulating the development of eosinophils and B lymphocytes. |
T16 | 2008-2215 | Sentence | denotes | The fact that hIL-17E overexpression results in high levels of circulating eosinophils, IL-4, IL-5, eotaxin, and IgE suggests that IL-17E may be a proinflammatory cytokine favoring Th2-type immune responses. |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 700-712 | HP_0001744 | denotes | Splenomegaly |
FSU-PRGE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 35-41 | protein | denotes | IL-17E |
T2 | 170-178 | protein | denotes | cytokine |
T3 | 196-205 | protein | denotes | cytokines |
T4 | 213-242 | protein | denotes | interleukin-17 (IL-17) family |
T5 | 271-277 | protein | denotes | IL-17E |
T6 | 279-286 | protein | denotes | hIL-17E |
T7 | 324-336 | protein | denotes | IL-17 family |
T8 | 465-472 | protein | denotes | hIL-17E |
T9 | 482-498 | protein | denotes | apolipoprotein E |
T10 | 500-504 | protein | denotes | ApoE |
T11 | 820-824 | protein | denotes | CCR3 |
T12 | 1095-1099 | protein | denotes | CD19 |
T13 | 1240-1243 | protein | denotes | CD4 |
T14 | 1329-1338 | protein | denotes | cytokines |
T15 | 1339-1343 | protein | denotes | IL-2 |
T16 | 1345-1349 | protein | denotes | IL-4 |
T17 | 1351-1355 | protein | denotes | IL-5 |
T18 | 1357-1394 | protein | denotes | granulocyte colony-stimulating factor |
T19 | 1396-1403 | protein | denotes | eotaxin |
T20 | 1409-1425 | protein | denotes | interferon gamma |
T21 | 1487-1508 | protein | denotes | immunoglobulin (Ig) M |
T22 | 1510-1513 | protein | denotes | IgG |
T23 | 1519-1522 | protein | denotes | IgE |
T24 | 1600-1625 | protein | denotes | keyhole limpet hemocyanin |
T25 | 1627-1630 | protein | denotes | KLH |
T26 | 1663-1666 | protein | denotes | KLH |
T27 | 1667-1670 | protein | denotes | IgG |
T28 | 1704-1707 | protein | denotes | KLH |
T29 | 1708-1711 | protein | denotes | IgA |
T30 | 1716-1719 | protein | denotes | IgE |
T31 | 1779-1787 | protein | denotes | IL-17Rh1 |
T32 | 1789-1796 | protein | denotes | IL-17BR |
T33 | 1797-1802 | protein | denotes | Evi27 |
T34 | 1827-1833 | protein | denotes | IL-17E |
T35 | 1893-1899 | protein | denotes | IL-17E |
T36 | 2022-2029 | protein | denotes | hIL-17E |
T37 | 2096-2100 | protein | denotes | IL-4 |
T38 | 2102-2106 | protein | denotes | IL-5 |
T39 | 2108-2115 | protein | denotes | eotaxin |
T40 | 2121-2124 | protein | denotes | IgE |
T41 | 2139-2145 | protein | denotes | IL-17E |
T42 | 2171-2179 | protein | denotes | cytokine |
PIR-corpus2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 29-41 | protein | denotes | human IL-17E |
T2 | 170-178 | protein | denotes | cytokine |
T3 | 196-205 | protein | denotes | cytokines |
T4 | 213-235 | protein | denotes | interleukin-17 (IL-17) |
T5 | 265-270 | protein | denotes | human |
T6 | 324-329 | protein | denotes | IL-17 |
T7 | 465-472 | protein | denotes | hIL-17E |
T8 | 482-505 | protein | denotes | apolipoprotein E (ApoE) |
T9 | 820-824 | protein | denotes | CCR3 |
T10 | 1095-1099 | protein | denotes | CD19 |
T11 | 1240-1243 | protein | denotes | CD4 |
T12 | 1329-1343 | protein | denotes | cytokines IL-2 |
T13 | 1345-1349 | protein | denotes | IL-4 |
T14 | 1351-1355 | protein | denotes | IL-5 |
T15 | 1357-1394 | protein | denotes | granulocyte colony-stimulating factor |
T16 | 1396-1403 | protein | denotes | eotaxin |
T17 | 1409-1419 | protein | denotes | interferon |
T18 | 1481-1486 | protein | denotes | serum |
T19 | 1510-1513 | protein | denotes | IgG |
T20 | 1519-1522 | protein | denotes | IgE |
T21 | 1600-1631 | protein | denotes | keyhole limpet hemocyanin (KLH) |
T22 | 1658-1670 | protein | denotes | anti-KLH IgG |
T23 | 1699-1711 | protein | denotes | anti-KLH IgA |
T24 | 1716-1719 | protein | denotes | IgE |
T25 | 1779-1787 | protein | denotes | IL-17Rh1 |
T26 | 1789-1796 | protein | denotes | IL-17BR |
T27 | 1797-1802 | protein | denotes | Evi27 |
T28 | 1807-1815 | protein | denotes | receptor |
T29 | 1827-1833 | protein | denotes | IL-17E |
T30 | 1893-1899 | protein | denotes | IL-17E |
T31 | 2022-2029 | protein | denotes | hIL-17E |
T32 | 2096-2100 | protein | denotes | IL-4 |
T33 | 2102-2106 | protein | denotes | IL-5 |
T34 | 2108-2115 | protein | denotes | eotaxin |
T35 | 2121-2124 | protein | denotes | IgE |
T36 | 2139-2145 | protein | denotes | IL-17E |
T37 | 2155-2179 | protein | denotes | proinflammatory cytokine |
T39 | 164-178 | long_form | denotes | human cytokine |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
12239140-0#35#41#gene64806 | 35-41 | gene64806 | denotes | IL-17E |
12239140-0#53#65#diseaseC0014457 | 53-65 | diseaseC0014457 | denotes | eosinophilia |
12239140-0#53#65#diseaseC1306759 | 53-65 | diseaseC1306759 | denotes | eosinophilia |
12239140-6#0#4#gene1232 | 820-824 | gene1232 | denotes | CCR3 |
12239140-6#8#29#diseaseC0014457 | 828-849 | diseaseC0014457 | denotes | eosinophils increased |
35#41#gene6480653#65#diseaseC0014457 | 12239140-0#35#41#gene64806 | 12239140-0#53#65#diseaseC0014457 | associated_with | IL-17E,eosinophilia |
35#41#gene6480653#65#diseaseC1306759 | 12239140-0#35#41#gene64806 | 12239140-0#53#65#diseaseC1306759 | associated_with | IL-17E,eosinophilia |
0#4#gene12328#29#diseaseC0014457 | 12239140-6#0#4#gene1232 | 12239140-6#8#29#diseaseC0014457 | associated_with | CCR3,eosinophils increased |
PIR-corpus1
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 35-41 | protein | denotes | IL-17E |
T2 | 170-178 | protein | denotes | cytokine |
T3 | 196-205 | protein | denotes | cytokines |
T4 | 271-277 | protein | denotes | IL-17E |
T5 | 279-286 | acronym | denotes | hIL-17E |
T6 | 405-414 | protein | denotes | molecules |
T7 | 465-472 | protein | denotes | hIL-17E |
T8 | 1329-1338 | protein | denotes | cytokines |
T9 | 1339-1343 | protein | denotes | IL-2 |
T10 | 1345-1349 | protein | denotes | IL-4 |
T11 | 1351-1355 | protein | denotes | IL-5 |
T12 | 1357-1394 | protein | denotes | granulocyte colony-stimulating factor |
T13 | 1396-1403 | protein | denotes | eotaxin |
T14 | 1409-1419 | protein | denotes | interferon |
T15 | 1487-1508 | protein | denotes | immunoglobulin (Ig) M |
T16 | 1510-1513 | protein | denotes | IgG |
T17 | 1519-1522 | protein | denotes | IgE |
T18 | 1600-1625 | protein | denotes | keyhole limpet hemocyanin |
T19 | 1627-1630 | acronym | denotes | KLH |
T20 | 1658-1670 | protein | denotes | anti-KLH IgG |
T21 | 1699-1719 | compound-protein | denotes | anti-KLH IgA and IgE |
T22 | 1779-1787 | protein | denotes | IL-17Rh1 |
T23 | 1789-1802 | protein | denotes | IL-17BR/Evi27 |
T24 | 1807-1815 | protein | denotes | receptor |
T25 | 1827-1833 | protein | denotes | IL-17E |
T26 | 1893-1899 | protein | denotes | IL-17E |
T27 | 2022-2029 | protein | denotes | hIL-17E |
T28 | 2096-2100 | protein | denotes | IL-4 |
T29 | 2102-2106 | protein | denotes | IL-5 |
T30 | 2108-2115 | protein | denotes | eotaxin |
T31 | 2121-2124 | protein | denotes | IgE |
T32 | 2139-2145 | protein | denotes | IL-17E |
T33 | 2171-2179 | protein | denotes | cytokine |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 35-41 | gene:64806 | denotes | IL-17E |
T1 | 53-65 | disease:C1636667 | denotes | eosinophilia |
T2 | 35-41 | gene:64806 | denotes | IL-17E |
T3 | 53-65 | disease:C0014457 | denotes | eosinophilia |
T4 | 35-41 | gene:64806 | denotes | IL-17E |
T5 | 53-65 | disease:C1306759 | denotes | eosinophilia |
T6 | 820-824 | gene:1232 | denotes | CCR3 |
T7 | 828-849 | disease:C0014457 | denotes | eosinophils increased |
R1 | T0 | T1 | associated_with | IL-17E,eosinophilia |
R2 | T2 | T3 | associated_with | IL-17E,eosinophilia |
R3 | T4 | T5 | associated_with | IL-17E,eosinophilia |
R4 | T6 | T7 | associated_with | CCR3,eosinophils increased |